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Google DeepMind Releases AlphaGenome Atlas With Precomputed Molecular Effect Predictions and AVI Scores for 9 Billion Human DNA Variants

Google DeepMind launched AlphaGenome Atlas, precomputing molecular effect predictions and AVI impact scores for ~9 billion human single-nucleotide variants in a 1-petabyte catalogue.

Google DeepMind released AlphaGenome Atlas, a 1-petabyte catalogue of precomputed molecular effect predictions for roughly 9 billion possible single-nucleotide variants in the human genome. It introduces the AlphaGenome Variant Impact (AVI) score, combining AlphaGenome regulatory predictions with AlphaMissense, plus per-variant feature attributions and over 2,500 recurrent DNA sequence motifs. DeepMind reports best-in-class AVI performance on variant pathogenicity and rare disease benchmarks. Early users at the Broad Institute, University of Exeter, and Stowers Institute demonstrated rare-disease variant reprioritization and 22% more non-coding associations across 54,000+ UK Biobank genomes.

MarkTechPost · 8d agoAI research2

Google Research Introduces Retrieve-for-Train (R4T): An RL-Compiled Diffusion Retriever for 12× to 20× Faster Query Fan-Out

Google Research introduced R4T, an RL-trained fan-out pipeline distilled into a 53.9M-parameter diffusion retriever achieving 12x-20x faster query fan-out.

Google Research introduced Retrieve-for-Train (R4T), which trains a fan-out language model with GRPO plus soft PPO regularization, then distills query fan-out into a 53.9M-parameter diffusion transformer that generates all retrieval embeddings in a single non-autoregressive pass. A three-term reward (groundedness 0.6, diversity 0.2 via Vendi Score, alignment 0.2) prevents paraphrastic collapse and reward hacking during training. On the Polyvore dataset, Gemma3-4B R4T-FOLM averaged 49.1 versus 40.9 for Best-of-N, and the diffusion retriever cut fan-out latency from 1.46s to 0.07s at batch size 8, a consistent 12x-20x speedup over autoregressive methods.

MarkTechPost · 7h agoAI research1

Nunchux AI Introduces VC-Attention: A Training-Free Low-Bit Attention Kernel That Speeds Up Video Diffusion Transformers

Nunchux AI introduces VC-Attention, a training-free low-bit attention kernel that speeds up video diffusion transformers up to 3.58x.

Nunchux AI unveiled VC-Attention, a training-free attention kernel for video Diffusion Transformers combining V-Smooth (k-means value-token grouping with block-mean residual quantization) and ExpCast-FP8 (single multiply-add softmax exponentiation). Benchmarks on Wan2.2-T2V-A14B, LongCat-Video, HunyuanVideo-1.5, and MiniMax-H3 show 1.59x attention speedup on B200 at 8-bit and 3.58x on RTX 5090 at 4-bit, with end-to-end gains up to 1.70x. It beats SageAttention2 by 2.3 dB PSNR on Wan2.2 at 8-bit and SageAttention3 by up to 3.6 dB at 4-bit. No public kernel release yet; a proprietary extension runs in Nunchux's stack.

MarkTechPost · 13h agoAI research 2 sources1

Stanford Researchers Release Paper2Agent: Turning Research Papers Into AI Agents That Reproduce Results and Run on New Data

Stanford researchers released Paper2Agent, a Nature-published pipeline that turns research papers into MCP servers agents can execute.

A Stanford team led by Jiacheng Miao and James Zou published Paper2Agent in Nature on 16 September 2026. Built on Claude Code's agent SDK, it converts a paper and its codebase into a Model Context Protocol server with validated tools, resources, and prompts. In benchmarks, the AlphaGenome agent built 22 tools in about 45 minutes for US$14, scored 100% on 15 novel queries versus 78.7% for Claude Code with repository access, and cut median runtime 1.9x. In scale tests, 74 of 100 bioRxiv papers were converted and 593 of 599 proposed tools passed validation.

MarkTechPost · 15h agoAI research1

RLLBC-Lib: An Educational Code Library for Reinforcement Learning and Learning-Based Control

Researchers release RLLBC-Lib, an educational code library covering tabular and deep reinforcement learning with support for automated grading.

RLLBC-Lib is an educational code library aimed at lowering the entry barrier for students learning reinforcement learning in the context of learning-based control. It comprises a comprehensive library of tabular RL approaches, a deep RL library following the same design principles, and implementations contrasting RL with other learning-based control approaches. The library also serves as a basis for creating programming assignments with automated grading.

arXiv cs.AI / cs.LG / cs.CL · 20h agoAI research

Social Laws for Multi-agent Coordination in Stochastic Environments

Researchers extend social laws to stochastic, reward-based multi-agent environments, defining alpha-robustness and a verification method via Markov decision processes.

The paper extends the concept of social laws from deterministic, goal-based settings to stochastic, reward-based multi-agent environments. It introduces alpha-robustness, a measure of the guaranteed utility each agent retains while pursuing its optimal single-agent policy assuming all agents obey the social law. Robustness verification is reduced to solving a series of Markov decision processes, with empirical evaluations on toy environments.

arXiv cs.AI / cs.LG / cs.CL · 20h agoAI research

Fast Learning Rates for Physics-Informed Kernel Methods

Theoretical analysis proves finite-sample learning rates for physics-informed kernel estimators, showing differential observations can improve rates from n^-1/4 to n^-1/2.

The paper analyzes a physics-informed kernel estimator combining n value observations and m differential observations for a linear differential operator D, asking how much differential information improves prediction. The authors prove finite-sample bounds, supported by simulations, revealing a two-regime structure: when m is limited the rate depends jointly on n and m, and when m exceeds a problem-dependent threshold the rate saturates to the oracle rate. Examples in Sobolev spaces, including partial Laplacian constraints on the torus and gradient observations on bounded domains, illustrate improvements from the nonparametric n^-1/4 rate to the parametric n^-1/2 rate, plus physically consistent rates in a stronger norm.

arXiv cs.AI / cs.LG / cs.CL · 21h agoAI research

Context Engineering Inside the Harness: 4 Mechanisms That Beat Context Overflow and Goal Loss on Long-Horizon Tasks

Survey of four harness mechanisms—context budgeting, compaction, todo-state, and memory—that keep long-horizon LLM agents on task across 200+ tool calls.

The article details how agent harnesses, not larger context windows, solve context overflow and goal loss on long-horizon tasks, citing Chroma's Context Rot report showing 18 LLMs (GPT-4.1, Claude 4, Gemini 2.5, Qwen3) degrade on long inputs. Concrete implementations include LangChain Deep Agents offloading tool responses over 20,000 tokens to the filesystem and truncating old tool calls at 85% window usage, and Claude Code capping auto memory at 25KB while re-reading the 5 most recently modified files after compaction. OpenAI's Responses API now offers server-side compaction via context_management with a standalone /responses/compact endpoint, which Codex uses for long-running coding tasks. Manus reports a roughly 100:1 input-to-output token ratio per ~50-tool-call task, motivating todo.md state recitation to prevent goal drift.

MarkTechPost · 4d agoAI research2

Benign Loss Landscapes Can Coexist with Worst-Case Hardness

Theory paper shows tree tensor networks contain worst-case hard targets yet benign loss landscapes, with difficulty arising from degenerate saddles.

The paper studies tree tensor networks (TTNs), which generalize deep linear networks and Tucker decompositions and embed arbitrary read-once Boolean formulas. It proves that every local minimum that is minimum-norm is global for every realizable target, so bad local minima do not distinguish typical from worst-case problems. Instead, learning difficulty arises from high-order degenerate saddle points caused by rank-deficiency, illustrated via a parity function case study, linking landscape geometry to computational hardness.

arXiv cs.AI / cs.LG / cs.CL · 5d agoAI research

Controversy over OpenAI's Maths Breakthrough

OpenAI claims its internal model proved the Navier-Stokes equations 'blow up' — a Millennium Prize Problem — amid allegations it borrowed mathematicians' methods.

OpenAI announced that an internal model produced a proof, certified in the Lean proof assistant, showing the Navier-Stokes equations can 'blow up,' implying infinite fluid speeds — a claimed solution to one of the seven $1-million Millennium Prize Problems. Mathematician Tristan Buckmaster alleged OpenAI, after learning of progress by him and Anthropic employee Levent Alpöge on 'blowing up' the related Euler equations, adopted a similar 'forcing' method; OpenAI's Sébastien Bubeck denied this, saying the model independently solved Euler by different means and produced the full Navier-Stokes proof over one weekend. Mathematicians including Diego Córdoba, co-developer of the forcing approach, remain cautious, and the community is still evaluating the competing proofs.

Quantifying the Engagement Trap: Impact of Short-form Video Recommender Systems on Users with ADHD

A 302-participant study finds engagement-optimized short-form video recommenders cause disproportionate time blindness and distress for users with ADHD.

Researchers ran a stratified Prolific study with 302 participants comparing short-form video recommendation experiences with and without ADHD. Participants with ADHD reported significantly higher time blindness, post-usage regret, and emotional distress despite perceiving recommendations as similarly relevant. The paper proposes neurodiversity-aware, human-centered design interventions to mitigate these algorithmic harms.

arXiv cs.AI / cs.LG / cs.CL · 9d agoAI research

H Company Releases NeoMME: A Family of 260M and 800M Single-Tower Multimodal Encoders That Drop the Vision Tower and Causal Decoder

H Company released NeoMME, 260M/800M single-tower multimodal encoders matching 3.75B ColQwen2.5 on ViDoRe v3 while being 14.4x smaller, under Apache 2.0.

H Company released NeoMME, a family of 262,937,906- and 793,715,032-parameter bidirectional encoders that process text and raw 32x32 image patches in a single tower, pretrained via masked diffusion and released under Apache 2.0 with day-zero Hugging Face Transformers support. NeoMME-Retriever-260M reaches 0.523 nDCG@10 on ViDoRe v3, matching 3.75B-parameter ColQwen2.5 while being 14.4x smaller; the 800M model scores 0.556. Hierarchical token pooling with int8 and binary quantization shrinks late-interaction indexes from roughly 1.5 MB to 6 kB per page while retaining 95.19% of nDCG@10; text-only BEIR retrieval remains a weak spot.

MarkTechPost · 10d agoAI research

Meta FAIR Introduces AI Research Preference Models (RPMs): Ranking ML Experiments Before Spending GPU Hours

Meta FAIR, Oxford and UCL introduce Research Preference Models that rank unexecuted ML experiments, lifting AIRS-Bench scores from 0.684 to 0.729 and cutting compute ~1.6×.

Researchers from Meta FAIR, Oxford, and UCL introduce Research Preference Models (RPMs), which use frozen pretrained LLMs (Qwen3.6-27B backbone, no fine-tuning) to rank unexecuted experiment candidates and execute only the winner of a pairwise knockout tournament. Two variants shipped: an inference-only LLM-as-a-judge and an agentic variant that runs small pilot experiments in an H200 sandbox. On AIRS-Bench (20 tasks, 24 hours on one H200, 10 seeds), scores rise from 0.684 (random) to 0.711 and 0.729 versus a 0.748 validation oracle, and both variants reach the baseline's 24-hour score in roughly 15 hours. The team reports new SOTA on WinoGrande (94.1% with Agentic RPM) and SVAMP (95.7% with inference-only).

MarkTechPost · 10d agoAI research

AI Doesn't Mean the End of Mathematics—at Least Not Yet

Schneier and Rafi argue frontier AI models produce notable mathematical results but cannot yet build genuinely new conceptual frameworks.

Bruce Schneier and Kasra Rafi, writing in The Guardian, argue current AI models are not yet as capable as experienced academic mathematicians despite striking results. They cite OpenAI's disproof of the unit distance conjecture, Anthropic's published cryptanalysis results, and Claude's attempt at the Riemann hypothesis as achievements in counterexample search and recombining known techniques. They contend AI has not yet developed substantial new conceptual frameworks, though they expect that capability sooner rather than later.

Schneier on Security · 20d agoAI research1