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Stanford Researchers Release Paper2Agent: Turning Research Papers Into AI Agents That Reproduce Results and Run on New Data

Stanford researchers released Paper2Agent, a Nature-published pipeline that turns research papers into MCP servers agents can execute.

A Stanford team led by Jiacheng Miao and James Zou published Paper2Agent in Nature on 16 September 2026. Built on Claude Code's agent SDK, it converts a paper and its codebase into a Model Context Protocol server with validated tools, resources, and prompts. In benchmarks, the AlphaGenome agent built 22 tools in about 45 minutes for US$14, scored 100% on 15 novel queries versus 78.7% for Claude Code with repository access, and cut median runtime 1.9x. In scale tests, 74 of 100 bioRxiv papers were converted and 593 of 599 proposed tools passed validation.

MarkTechPostSep 16, 21:59 UTC · 16h agoAI research1

Playing log(N)-Questions over Wikipedia Abstracts: Communication Efficiency Between Paired Frontier Models

Six frontier models play a two-agent log(N)-Questions game; Claude Opus 5 lags with 28/68 wins while the top five are near-tied.

The study evaluates six frontier models on a two-agent game where a questioner must identify one of N Wikipedia lead paragraphs in exactly log2 N yes/no questions, run over 408 games at $363 total API cost. Claude Opus 5 wins 28 of 68 games versus 45-56 for GLM-5.3, GPT-5.6 Sol, Grok 4.6, Gemini 3.8 Flash, and Kimi K3. Pooled top-five win rates decline with set size (r=-0.973) and fit win = p^(log2 N) with per-round reliability p=0.928, and information per question correlates with win rate at r=+0.88.

arXiv cs.AI / cs.LG / cs.CLSep 16, 17:41 UTC · 20h agoAI research 20 sources