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17 stories in the last 30d

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Biology-in-the-loop: Amortized Adaptive Hit Discovery in CRISPR Screens

Researchers release AssayBench-Loop, a 1,389-screen CRISPR benchmark, and AssayLoop, a framework that learns adaptive hit discovery policies.

The paper introduces AssayBench-Loop, a large-scale benchmark of 1,389 CRISPR screens across five phenotype categories for adaptive hit discovery under budget constraints. It also introduces AssayLoop, which combines AssayFormer, a transformer-based amortized acquisition policy trained across historical screens, with LLM-derived biological priors via an adaptive handoff. On temporally held-out screens, AssayLoop achieves 5.67-fold enrichment over random selection and recovers 27.7% of hits after assaying roughly 5% of the candidate library, outperforming existing adaptive-design methods and standalone LLMs.

arXiv cs.AI / cs.LG / cs.CL · 6d agoAI research1

Google Research Releases ToolGrad: Answer-First Framework Hits 99.8% Pass Rate for Tool-Use Data Generation

Google Research and partners introduce ToolGrad, a verified tool-chain-first data generation framework reaching 99.8% pass rate and boosting Gemma-3-12B to 83.1 on BFCL.

Researchers from Google, the University of Tokyo, RIKEN AIP, and Tohoku University released ToolGrad, which inverts query-first tool-use data generation by executing and verifying API chains before annotating them with user queries. On the ToolBench database of 16,000+ APIs, ToolGrad raised generation pass rate from 63.8% to 99.8% while increasing tool uses per sample from 2.1 to 3.4 and cutting tool-use steps from 34.3 to 20.0. Fine-tuning Gemma-3 at 1B, 4B, and 12B parameters on the 500-sample ToolGrad-500 dataset lifted ToolGrad-12B to 83.1 on the Berkeley Function Calling Leaderboard, near Gemini 2.5 Pro at 83.2 and ahead of GPT-5 at 74.4. Code is Apache-2.0, with the dataset, PyPI package, and models available on Hugging Face.

MarkTechPost · 6d agoAI research1

Evidence-Grounded Agentic Formulation Development in an Autonomous Laboratory

Andromeda 2, an agentic laboratory system, reaches a 50% high-performance hit rate for paclitaxel SEDDS formulations versus 17% for its predecessor and 2% for DoE.

Andromeda 2 is an agentic system that reasons over structured in-house experimental evidence and invokes computational and experimental tools to design and execute successive formulation batches for self-emulsifying drug delivery systems (SEDDS). For paclitaxel it achieved a 50% high-performance hit rate versus 17% for Andromeda 1 and 2% for a wet-lab DoE campaign, identifying 12 formulations meeting all four target product profile objectives versus 6 and 0. A selected full-TPP formulation reached approximately 19% w/w apparent paclitaxel loading, about 3.3-fold higher than a published paclitaxel S-SEDDS, and an ablation showed structured evidence access increased mean AUC by 34%.

arXiv cs.AI / cs.LG / cs.CL · 20h agoAI research

How well do agents use test/verification techniques?

Dan Luu's eval finds coding-agent testing instructions (TDD, formal methods, PBT, skills) mostly fail to beat defaults on Zstd implementation correctness.

The author ran 26 prompt conditions plus 4 skills on a Zstd-in-Rust implementation eval using codex with GPT-5.6, testing TDD, fuzzing, property-based testing, formal methods (Lean 4, TLA+, Verus, Kani, SMT solvers) and community skills. Nothing dramatically outperformed the default no-instruction condition, which did above average; at xhigh effort, fuzzing and PBT conditions did slightly better than formal methods. Pre-registered predictions included TDD underperforming and popular test skills (ECC, Hegel, Trail of Bits) not outperforming. Results are averages of 80 runs per condition plotted against cost.

Hacker News · security · 9d agoAI researchHN 131↑ · 50 comments

FLAT: Resampling Image and Text into 1D Flexible-Length Aligned Transmodal Tokens for Retrieval and Generation

FLAT jointly trains a multimodal encoder with text-to-image and image-to-text decoders, producing flexible-length tokens that hit 83.1 GenEval on T2I after fine-tuning.

FLAT (Flexible-Length Aligned Transmodal representations) is a pre-training framework that jointly optimizes a shared multimodal encoder with T2I and I2T decoders, combining contrastive alignment with bidirectional cross-modal generative objectives. It maps visual and textual inputs into a unified continuous 1D sequence space and uses nested dropout over prefix-K tokens for dynamic output lengths. A single pre-training stage supports cross-modal retrieval and generation (71.1 GenEval), with task-specific fine-tuning reaching 83.1 GenEval on T2I, 40.5 BLEU-4 and 138.6 CIDEr on MS-COCO captioning, and strong Recall@5 on MS-COCO and Flickr30K.

Hugging Face daily papers · 2d agoAI research1

Claude Fable 5.1 Solves the Cyphral Distich, a 370-year-old cipher

Claude Fable 5.1 solved Sir Thomas Urquhart's 370-year-old Cyphral Distich cipher, recovering a hidden royalist prayer for Charles II.

Vals AI reports that Claude Fable 5.1 solved the Cyphral Distich, a 64-number cryptogram from Sir Thomas Urquhart's Logopandecteision unsolved since 1653, in 44 minutes using 176k tokens with no human hints. The key insight was that the cipher's key was the book itself: each number indexes a word in the corresponding Proquiritation, taking the first letter, yielding 'O GOD UPHOLD KING CHARLS THE SECOND AND MAKE HIM THE SUPREME RULER OF THIS LAND'. The model also deciphered the larger Cyphral Octastich (285 numbers) from The Jewel (1652) using page-based word indexing, recovering all but nine letters of a royalist prayer. The puzzle had been listed among Klaus Schmeh's Top 50 unsolved encrypted messages.

Hacker News · AI · 3d agoAI researchHN 63↑ · 6 comments1· 1 read

Can LLMs Engineer Their Own Agent Harness? ByteDance Seed’s HarnessDev Says Only 34 of 64 Changes Generalize

ByteDance Seed's HarnessDev benchmark finds LLM-built agent harnesses trail human engineering on code and search, with only 34 of 64 revisions generalizing.

Researchers from ByteDance Seed, SUTD, Georgia Tech, M-A-P, and TokenWave.AI introduce HarnessDev, a benchmark that evaluates the runnable agent harness an LLM writes rather than its answers, using Creation and Evolution stages across SWE-bench Pro, Terminal-Bench 2.1, MLE-bench, EQ-Bench3, and BrowseComp (2,207 instances). Six creator models including Opus 4.8, GPT-5.5, Gemini 3.1 Pro, DeepSeek V4 Pro, Qwen 3.7 Max, and Seed 2.0 Pro were tested; Opus 4.8 posted the best average of 67.8 versus an 86.2 human-engineered reference. Self-built harnesses beat references on writing and ML experimentation but lag badly on code and search, and quality proved executor-specific: Opus 4.8 fell from 69.3 to 33.0 on SWE-bench Pro when the executor was switched to Gemini. Evolution gains were small and noisy: of 64 adjacent changes, feedback and held-out scores agreed only 34 times (53.1%), and much generated state and memory code never executed.

MarkTechPostupdated · 19h agofirst · 5d agoAI research 20 sources

Adaptive Gated Deepfake Detection for Low-Resolution and Resource-Constrained Environments

AdaGate-DF routes deepfake detection by image quality through dual multi-exit gates, hitting 0.9370 AUC on Celeb-DF with low inference latency.

AdaGate-DF is an adaptive gated deepfake detection framework that uses image-quality cues to send high-quality images through earlier exits, saving compute in resource-constrained settings. On Celeb-DF it achieves an AUC of 0.9370, outperforming MaD-CoRN and DefakeHop++, and reaches 0.9708 at 384x384 resolution. On FaceForensics++ it remains effective under class imbalance while balancing uncertainty-aware prediction and computational efficiency.

arXiv cs.AI / cs.LG / cs.CL · 12d agoAI research

Google Research Introduces Retrieve-for-Train (R4T): An RL-Compiled Diffusion Retriever for 12× to 20× Faster Query Fan-Out

Google Research introduced R4T, an RL-trained fan-out pipeline distilled into a 53.9M-parameter diffusion retriever achieving 12x-20x faster query fan-out.

Google Research introduced Retrieve-for-Train (R4T), which trains a fan-out language model with GRPO plus soft PPO regularization, then distills query fan-out into a 53.9M-parameter diffusion transformer that generates all retrieval embeddings in a single non-autoregressive pass. A three-term reward (groundedness 0.6, diversity 0.2 via Vendi Score, alignment 0.2) prevents paraphrastic collapse and reward hacking during training. On the Polyvore dataset, Gemma3-4B R4T-FOLM averaged 49.1 versus 40.9 for Best-of-N, and the diffusion retriever cut fan-out latency from 1.46s to 0.07s at batch size 8, a consistent 12x-20x speedup over autoregressive methods.

MarkTechPost · 7h agoAI research1

Det-LIME: Detector-Aware, Multi-Instance Local Interpretable Model-Agnostic Explanations for Automated Marine Mammal Detection

Det-LIME extends LIME to multi-instance object detection explanations, improving attribution for harbor seal aerial surveys.

Det-LIME adapts LIME to object detection by combining per-detection weighting, a proximity kernel emphasizing box-adjacent regions, and IoU-based matching to track instances across perturbations. It was evaluated on aerial drone imagery for harbor seal detection plus a seabird case study, and compared against vanilla LIME, Stabilized LIME, Deterministic LIME, and gradient-based attribution. Using Attribution Ratio and Max Saliency Hit Rate metrics, it consistently improved multi-instance attribution and produced box-aligned explanations useful for debugging and data augmentation.

arXiv cs.AI / cs.LG / cs.CL · 1d agoAI research

Unsolved Problem by Fields Medalist Breached by Two High School Students

Two high school students used Claude Opus 5 and GPT-5.6 Sol to help solve an open Lorentzian polynomials problem, posting a 75-page arXiv proof.

Aayush Bathija and Prince Rohatgi of Oak Park High School, mentored by UCLA postdoc Daniel Soskin, published the 75-page paper 'Bounded Ratios for Lorentzian Polynomials' (arXiv 2609.05341), solving an open problem in Fields Medalist June Huh's Lorentzian polynomial theory. The main structural theorem extends bounded coefficient-ratio characterization from quadratic to arbitrary-degree polynomials via discrete convexity conditions. The students used Claude Opus 5 and GPT-5.6 Sol for exploration and proof ideas but independently verified all arguments; the result follows an open letter from 25 Fields Medalists voicing concerns about AI's impact on mathematical rigor.

Hacker News · security · 3d agoAI researchHN 22↑ · 19 comments

TART: A Modular Tool for Technique-Aware Audio-to-Tablature Guitar Transcription

TART pipeline transcribes guitar audio to tablature with fingering and technique labels, outperforming prior baselines by up to 8.5 Tab F1 points.

TART is a modular four-stage pipeline for audio-to-tablature guitar transcription, combining an audio-to-MIDI transcription model, an expressive technique classifier, an audio-conditioned T5 encoder-decoder for string-fret assignment, and an automated tablature generator. In zero-shot evaluation on GuitarSet, EGDB, and two noisy augmented benchmarks, it averages 81.35% audio-to-MIDI F50 (+6.67 over the best baseline), 71.8% string-fret Tab F1 (+8.5), and 54.08% end-to-end Tab F1. The authors state it is the first framework to generate tablature with both fingering and expressive technique annotations directly from guitar audio.

arXiv cs.AI / cs.LG / cs.CL · 6d agoAI research2

Training a 3.8B LLM to 0.384 CORE for $998 – Hugo Vergnes

Independent developer Hugo Vergnes trained a 3.8B-parameter Llama-style model to 0.384 CORE on 65B tokens for $998 in 43 hours on rented B200s.

Hugo Vergnes trained little-lm, a 3.848B-parameter decoder-only LLM, on 65.3B tokens in 43 hours for $998 using rented NVIDIA B200s, scoring 0.384 on the CORE benchmark and beating nanochat d32 (0.310) at similar cost. The Llama-style architecture uses RMSNorm, RoPE, GQA with 24 query and 8 KV heads, relu-squared MLPs, QK-norm, and ResFormer-style value embeddings that account for 19% of parameters. Key wins included the Muon optimizer for matrix parameters, a trapezoidal learning-rate schedule with linear cooldown, FP8 training plus vocabulary padding for roughly 33% throughput gains, and the ClimMix dataset over FineWeb-Edu. The project, inspired by Karpathy's nanochat, was built as a config-driven YAML framework for small LLM training.

Hacker News · security · 7d agoAI researchHN 28↑ · 2 comments1

Benchmarking Qwen3.8 27B quantizations: 4-bit holds up, 1-bit collapses

Quesma benchmarks Qwen3.8 27B quantizations: 4-bit Q4_K_M matches BF16 on key benchmarks while 1-bit collapses to random chance.

Quesma spent roughly $3,000 on Modal GPUs testing Unsloth GGUF quantizations of Qwen3.8 27B across GPQA Diamond, IFBench, and Terminal-Bench 2.1. The 17 GB Q4_K_M quantization matched the 55 GB BF16 model on Terminal-Bench 2.1 and showed little degradation down to 4-bit, while the 2-bit UD-Q2_K_XL dropped noticeably. At 1-bit, scores on GPQA Diamond fell to random-guess levels, with longer reasoning making results worse, and reasoning effort settings significantly affected outcomes.

Hacker News · AI · 8d agoAI researchHN 56↑ · 30 comments1

Meta FAIR Introduces AI Research Preference Models (RPMs): Ranking ML Experiments Before Spending GPU Hours

Meta FAIR, Oxford and UCL introduce Research Preference Models that rank unexecuted ML experiments, lifting AIRS-Bench scores from 0.684 to 0.729 and cutting compute ~1.6×.

Researchers from Meta FAIR, Oxford, and UCL introduce Research Preference Models (RPMs), which use frozen pretrained LLMs (Qwen3.6-27B backbone, no fine-tuning) to rank unexecuted experiment candidates and execute only the winner of a pairwise knockout tournament. Two variants shipped: an inference-only LLM-as-a-judge and an agentic variant that runs small pilot experiments in an H200 sandbox. On AIRS-Bench (20 tasks, 24 hours on one H200, 10 seeds), scores rise from 0.684 (random) to 0.711 and 0.729 versus a 0.748 validation oracle, and both variants reach the baseline's 24-hour score in roughly 15 hours. The team reports new SOTA on WinoGrande (94.1% with Agentic RPM) and SVAMP (95.7% with inference-only).

MarkTechPost · 10d agoAI research

Why AI food looks like that

Experts explain why AI-generated food images look unappetizing, citing diffusion model limitations, weak structural reasoning, and stylized training data.

The Verge examines why AI-generated food imagery from restaurants and brands often appears grotesque, citing researchers from Oxford, Naples, Zurich, and London. Diffusion models recover coarse structure before fine texture, so structural errors like extra fingers or donut shrimp get baked in early. Researchers note the models are weak at thin, continuous, terminating structures such as noodles, and reproduce the glossy conventions of professional food photography without understanding the objects. Odd internet imagery and memes in training data further skew outputs toward strange textures and clustered holes.

The Verge · AI · 13d agoAI research

StudyBench: Can Self-Evolution Squeeze Textbooks for Olympiad Capability?

Researchers introduce StudyBench, a physics benchmark showing self-evolution gains on textbook problems rarely transfer to olympiad-level questions.

StudyBench is a controlled physics benchmark splitting test data into an Application Set of difficult textbook problems and a Transfer Set of olympiad-level problems. Across three base models, representative self-evolution methods improved on the Application Set but rarely transferred to the harder Transfer Set. A guidance ablation reveals a Guidance Gap, and every method hits a Compute Plateau, indicating the remaining limits are method problems rather than data or compute problems.

Hugging Face daily papers · 16d agoAI research