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8 stories in the last 30d

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Biology-in-the-loop: Amortized Adaptive Hit Discovery in CRISPR Screens

Researchers release AssayBench-Loop, a 1,389-screen CRISPR benchmark, and AssayLoop, a framework that learns adaptive hit discovery policies.

The paper introduces AssayBench-Loop, a large-scale benchmark of 1,389 CRISPR screens across five phenotype categories for adaptive hit discovery under budget constraints. It also introduces AssayLoop, which combines AssayFormer, a transformer-based amortized acquisition policy trained across historical screens, with LLM-derived biological priors via an adaptive handoff. On temporally held-out screens, AssayLoop achieves 5.67-fold enrichment over random selection and recovers 27.7% of hits after assaying roughly 5% of the candidate library, outperforming existing adaptive-design methods and standalone LLMs.

arXiv cs.AI / cs.LG / cs.CL · 6d agoAI research1

Reduced-Space Multi-Fidelity Bayesian Optimization of Process Simulation Models

RS-MFBO couples global sensitivity analysis with fidelity-augmented Gaussian processes to slash costly high-fidelity simulation runs in industrial flowsheet optimization.

The paper presents RS-MFBO, a reduced-space multi-fidelity Bayesian optimization framework for high-dimensional, expensive black-box functions. It integrates Global Sensitivity Analysis for dimensionality reduction with a fidelity-augmented Gaussian process and a cost-aware acquisition strategy featuring cooldown and promotion mechanisms. Validation on a plasmid DNA bioprocess (SuperPro Designer) and a green fuel synthesis plant (Aspen HYSYS) shows substantial reductions in high-fidelity evaluations while remaining competitive with single-fidelity baselines.

arXiv cs.AI / cs.LG / cs.CL · 1d agoAI research

EvolveTrade: Experience-Driven Policy Refinement for Self-Evolving LLM Trading Agents

EvolveTrade lets LLM trading agents self-refine their tool-use policy from realized portfolio feedback, improving Sharpe ratios.

EvolveTrade treats a tool-using trading agent's system prompt as a text-parameterized policy that a Policy Agent revises after each update interval using accumulated decision traces and realized portfolio feedback, keeping the backbone LLM fixed. Experiments across multiple market regimes and two LLM backbones show improved Sharpe Ratio and Cumulative Return over fixed-policy baselines in most settings. Behavioral analyses show evolved policies increase code-mediated analysis and activate regime-relevant computations, with case-level attributions linking policy changes to returns.

Hugging Face daily papers · 2d agoAI research

The Last AI Built by Humans: Toward Genuine Recursive Self-Improvement

Position paper defines recursive self-improvement for AI, introduces the Headroom-Closed Index and an autonomy roadmap toward genuine recursive meta-improvement.

The paper uses the Headroom-Closed Index to diagnose limitations of existing LLMs and frames recursive self-improvement (RSI) as a staged roadmap: improvement-execution, improvement-strategy, experience-acquisition, and environment-adaptation autonomy, culminating in recursive meta-improvement. It examines RSI across scientific discovery, embodied intelligence, and software engineering, highlighting differing requirements and development speeds. Drawing on industry practices and preliminary empirical evidence, it connects RSI research with practical systems and identifies key challenges to achieving genuine RSI.

arXiv cs.AI / cs.LG / cs.CL · 6d agoAI research1

The Last AI Built by Humans: Toward Genuine Recursive Self-Improvement

Position paper maps recursive self-improvement across autonomy levels from execution to meta-improvement, connecting RSI research to science, robotics, and software engineering.

The paper introduces the Headroom-Closed Index (HCI) to reveal limitations of existing LLMs for recursive self-improvement (RSI), then lays out a roadmap spanning improvement-execution, improvement-strategy, experience-acquisition, and environment-adaptation autonomy up to recursive meta-improvement. It examines RSI across scenarios such as scientific discovery, embodied intelligence, and software engineering, highlighting distinct requirements and development speeds. Drawing on industry practices and preliminary empirical evidence, it identifies key challenges to achieving genuine RSI.

Hugging Face daily papers · 7d agoAI research1

Deep Learning-Based Detection of Electrical Faults and Power Quality Disturbances in Aerospace Power Systems

Compact ResNet detects electrical faults in 400 Hz aircraft power systems with 95.87 percent accuracy after deployment on Xilinx Zynq MPSoC.

The study targets multiclass fault and power quality disturbance detection in 400 Hz aerospace networks using a high-fidelity simulation model inspired by the Boeing 787 electrical architecture, covering 21 normal, disturbance, switching, open-circuit, and short-circuit conditions. Two 73,500-sample datasets are built from 1D waveforms and STFT time-frequency representations, augmented with domain randomization and class-specific GANs, and the time-series dataset is released via IEEE DataPort. A compact ResNet with 175,685 parameters achieved 96.94 percent software test accuracy, and 95.87 percent after 8-bit quantization on a Xilinx Zynq UltraScale Plus ZCU102 with 6.90 ms mean accelerator latency per record.

arXiv cs.AI / cs.LG / cs.CL · 7d agoAI research

CosmoH2G: A Hand-to-Gripper Transfer Dataset and Baseline Method for Object Manipulation with Complex Spatial Movements

Researchers release CosmoH2G, a 6,189-episode hand-to-gripper dataset with a two-stage method for complex spatial robot manipulation.

The paper introduces a scalable acquisition pipeline using a handheld gripper to collect paired hand-gripper demonstrations, producing 6,189 episodes across 1,254 unique objects with higher spatial complexity than existing benchmarks. A two-stage framework first predicts sparse gripper keyframes (initial and terminal), then generates the full continuous action sequence conditioned on them, while learning gripper orientation and post-optimizing translation via grasping heuristics and kinematic consistency. Simulation and real-robot experiments show stable, precise hand-to-gripper transfer of complex spatial manipulations, outperforming traditional baselines.

Hugging Face daily papers · 10d agoAI research

Technical Manual for a Toolkit for Measuring Contextual Individuation in Transformer Language Models

An open methodology toolkit measures whether transformer language models contextualize fixed word forms across domains using bridge forms and layer-wise silhouette analysis.

The manual documents an open toolkit built around 'bridge forms' - identical written words recurring across two or more subject domains with a different sense in each - to test whether transformer language models individuate word occurrences by context beyond the embedding layer. It covers declarative specification of bridge forms, Wikipedia corpus acquisition, occurrence localization, layer-wise representation extraction, domain-pairwise silhouette measurement, and visualization, justifying each choice against failure modes such as sense contamination and subword-tokenization misalignment. It is a methodological and implementation reference and reports no empirical results.

arXiv cs.AI / cs.LG / cs.CL · 12d agoAI research