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Google DeepMind Releases AlphaGenome Atlas With Precomputed Molecular Effect Predictions and AVI Scores for 9 Billion Human DNA Variants

Google DeepMind launched AlphaGenome Atlas, precomputing molecular effect predictions and AVI impact scores for ~9 billion human single-nucleotide variants in a 1-petabyte catalogue.

Google DeepMind released AlphaGenome Atlas, a 1-petabyte catalogue of precomputed molecular effect predictions for roughly 9 billion possible single-nucleotide variants in the human genome. It introduces the AlphaGenome Variant Impact (AVI) score, combining AlphaGenome regulatory predictions with AlphaMissense, plus per-variant feature attributions and over 2,500 recurrent DNA sequence motifs. DeepMind reports best-in-class AVI performance on variant pathogenicity and rare disease benchmarks. Early users at the Broad Institute, University of Exeter, and Stowers Institute demonstrated rare-disease variant reprioritization and 22% more non-coding associations across 54,000+ UK Biobank genomes.

MarkTechPostSep 8, 19:00 UTC · 8d agoAI research2

[AINews] OpenAI reports Navier-Stokes singularity find in 88 hours using Astra-next, roughly 10,000 agents and 130B tokens (>$40M), a contender for second ever Millennium Prize awarded

OpenAI-linked accounts claim roughly 10,000 AI agents produced a Navier-Stokes singularity result in 88 hours, pending mathematical verification.

OpenAI-affiliated accounts claim a system of roughly 10,000 agents, trained over about a year with multi-agent reinforcement learning, produced a finite-time singularity result related to the Navier-Stokes Millennium Problem. The claimed 88-hour runtime and 130B-token cost circulate only via social posts, and no preprint, theorem statement, or proof artifact is available. Acceptance by the mathematics community is unresolved, so the claim's epistemic status remains unknown. The roundup also notes Cognition's $48B and Mistral's $24B fundraises, GPT Image 2.5, and Meta's Muse agent relaunch.

Latent SpaceSep 9, 05:04 UTC · 8d agoAI research1

Training a 3.8B LLM to 0.384 CORE for $998 – Hugo Vergnes

Independent developer Hugo Vergnes trained a 3.8B-parameter Llama-style model to 0.384 CORE on 65B tokens for $998 in 43 hours on rented B200s.

Hugo Vergnes trained little-lm, a 3.848B-parameter decoder-only LLM, on 65.3B tokens in 43 hours for $998 using rented NVIDIA B200s, scoring 0.384 on the CORE benchmark and beating nanochat d32 (0.310) at similar cost. The Llama-style architecture uses RMSNorm, RoPE, GQA with 24 query and 8 KV heads, relu-squared MLPs, QK-norm, and ResFormer-style value embeddings that account for 19% of parameters. Key wins included the Muon optimizer for matrix parameters, a trapezoidal learning-rate schedule with linear cooldown, FP8 training plus vocabulary padding for roughly 33% throughput gains, and the ClimMix dataset over FineWeb-Edu. The project, inspired by Karpathy's nanochat, was built as a config-driven YAML framework for small LLM training.

Hacker News · securitySep 10, 02:04 UTC · 7d agoAI research HN 28↑ · 2 comments1