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Google DeepMind Releases AlphaGenome Atlas

Google DeepMind released AlphaGenome Atlas, a 1-petabyte database pre-computing effects of all 9 billion single-nucleotide variants in the human genome, with a unified AVI score.

Google DeepMind launched AlphaGenome Atlas, a database that predicts the regulatory impact of every possible single nucleotide variant across the roughly 3 billion base pairs of the human genome, yielding a 1-petabyte dataset. It introduces the AlphaGenome Variant Impact (AVI) score, combining coding and non-coding predictions for rapid variant prioritization. Broad Institute researchers used it to support solving an unsolved rare disease case via a predicted DNM1 splice variant, and analysis of 54,000+ UK Biobank participants uncovered 22% more non-coding genetic associations, including 19 regions linked to BMI. The Atlas is available through a no-code web portal.

Hacker News · AI · 8d agoAI researchHN 44↑ · 4 comments

LLM-Driven Algorithm Design for Quantum Circuit Synthesis based on Binary Decision Diagrams

QuantumEvo uses an LLM to evolve BDD variable-ordering heuristics, achieving a 70.9% tie-or-win rate on quantum circuit cost versus baseline methods.

The QuantumEvo framework uses an LLM as a heuristic generator for quantum-cost-aware BDD variable ordering in reversible circuit synthesis, searching over heuristics initialized from multiple families and selecting them by downstream quantum circuit cost. The discovered heuristic HGA-QE modifies the sifting step inside a genetic algorithm and achieves a 70.9% tie-or-win rate against the per-function best baseline, with strict wins on 13.5% of functions. Advantages are clearer on benchmark suites not used for heuristic discovery.

arXiv cs.AI / cs.LG / cs.CL · 12d agoAI research1