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HypoEvolve: Genetic Algorithms Enable Multi-Agent LLMs to Discover Scientific Hypotheses

HypoEvolve uses a generational genetic algorithm coordinating specialized LLM agents to generate scientific hypotheses, outperforming six baselines on cancer drug repurposing.

HypoEvolve is a framework that coordinates specialized LLM agents through a generational genetic algorithm to produce, revise, and retain scientific hypotheses with explicit collaboration roles. It evaluates drug repurposing hypotheses against external evidence from DepMap and Open Targets across 34 cancer types. It achieves the highest scores against six baselines, reaching DepMap selectivity of 0.171 versus 0.115 for the strongest baseline, and gains over single-pass generation generalize to held-out cancer types.

Hugging Face daily papersupdated · 2d agofirst · 3d agoAI research 2 sources

ZDI-26-655: PAPPL Printer IPP Processing Stack-based Buffer Overflow Local Privilege Escalation Vulnerability

ZDI-26-655: Stack-based buffer overflow in PAPPL printer IPP processing enables local privilege escalation, rated CVSS 7.8.

The Zero Day Initiative published advisory ZDI-26-655 for PAPPL. A stack-based buffer overflow in printer IPP processing allows local attackers to escalate privileges after obtaining low-privileged code execution. ZDI assigned a CVSS 7.8 rating. No CVE identifier was listed in the advisory text.

ZDI Published Advisories · 7d agoAdvisory 2 sources1

Training a coding model to paint watercolours with TRL and OpenEnv

Hugging Face tutorial trains a coding model with TRL and OpenEnv to paint watercolours through generated code.

A Hugging Face blog walkthrough uses the TRL reinforcement learning library and the OpenEnv environment framework to train a coding model. The target task is generating code that produces watercolour-style drawings, serving as a hands-on reinforcement learning training example. No article body was available in the feed, so specifics are limited to the title.

Hugging Face Blog · 14d agoAI tools & infra1

Metasploit Wrap Up: Lot of summer shells and fit http profiles

Metasploit 6.5 ships 13 new modules including RCEs for SonicWall SMA1000, Ghost CMS, Joomla JCE and Langflow, plus a Linux kernel LPE.

Rapid7's Metasploit wrap-up covers the 6.5 release, which adds 13 new modules, including remote code execution exploits for WordPress WP2Shell, Ghost CMS, Joomla JCE, Langflow, OpenCATS, Pterodactyl Panel, SonicWall SMA1000, Ray Dashboard and a Pix-for-WooCommerce plugin. The Fragnesia Linux kernel local privilege escalation (CVE-2026-46300) also landed. The release introduces HTTP malleable profiles, MCP functionality, Linux multi-fetch payloads and improved Windows on ARM support.

Rapid7 Blog · Aug 14, 2026ToolsCVE-2026-46300

Houthis Used Claude Code to Develop Missile Guidance Software: Anthropic

Anthropic's threat report details a Houthi-linked Yemeni cell using parallel Claude Code sessions to build missile guidance software, evading safeguards by fragmenting tasks.

Anthropic's September threat report describes a Yemen-based cell, assessed as highly likely Houthi-linked, that used Claude Code across multiple parallel instances to develop guidance software for a tactical guided rocket, a ballistic missile with over 2,000 km range, and a hypersonic glide vehicle concept called 'R2000'. The operators integrated open-source autopilot software, built six-degree-of-freedom trajectory simulations, and used reinforcement learning to tune flight-control algorithms, ultimately compiling an offline executable. The group test-fired a guided rocket that failed, then used Claude within hours to analyze launch telemetry. Anthropic blocked numerous requests, but operators evaded safeguards by obscuring intent and dividing work across separate conversations before accounts were banned; the case is one of six conventional-weapons cases (three China-linked, two Russia-linked) in a report covering disrupted operations from December 2025 to August 2026.

Hacker News · AI · 3d agoAI safety & securityHN 47↑ · 38 comments1

OpenBMB Releases MiniCPM5-2B: A 2.52B Dense Model Averaging 53.9 Across 34 Benchmarks and Built to Run On Device

OpenBMB released MiniCPM5-2B, a 2.52B-parameter Apache 2.0 on-device model averaging 53.9 across 34 benchmarks, ahead of Qwen3.5-4B.

OpenBMB released MiniCPM5-2B, a 2,516,756,480-parameter dense LlamaForCausalLM model with grouped-query attention and a 131,072-token context, under Apache 2.0, runnable via vLLM, SGLang, llama.cpp, and Ollama. It averages 53.9 across 34 benchmarks versus 51.1 for Qwen3.5-4B, with strong tool-use (97.1 on tau2-Bench Telecom) and code results (69.1 LiveCodeBench v6, 46.4 SWE-bench Verified). Training combined 400B tokens of deep-thinking SFT, critic-based JustRL II RL teachers, and on-policy distillation merging 16 RL experts; datasets and intermediate checkpoints were published alongside the weights.

MarkTechPost · 9d agoModel release

Evidence-Grounded Agentic Formulation Development in an Autonomous Laboratory

Andromeda 2, an agentic laboratory system, reaches a 50% high-performance hit rate for paclitaxel SEDDS formulations versus 17% for its predecessor and 2% for DoE.

Andromeda 2 is an agentic system that reasons over structured in-house experimental evidence and invokes computational and experimental tools to design and execute successive formulation batches for self-emulsifying drug delivery systems (SEDDS). For paclitaxel it achieved a 50% high-performance hit rate versus 17% for Andromeda 1 and 2% for a wet-lab DoE campaign, identifying 12 formulations meeting all four target product profile objectives versus 6 and 0. A selected full-TPP formulation reached approximately 19% w/w apparent paclitaxel loading, about 3.3-fold higher than a published paclitaxel S-SEDDS, and an ablation showed structured evidence access increased mean AUC by 34%.

arXiv cs.AI / cs.LG / cs.CL · 11h agoAI research

PIA-Bench: Towards Automated Privacy Impact Assessment with Large Language Models

Researchers release PIA-Bench, the first open benchmark evaluating how accurately LLMs can automate privacy impact assessments using 73 curated federal PIAs.

PIA-Bench is the first open benchmark for evaluating large language models on real-world privacy impact assessments (PIAs). The authors audited 499 expert-authored PIAs published by US federal agencies and curated 73 structured PIAs comprising 451 privacy risk items and 831 mitigation items. Off-the-shelf LLMs were found to produce meaningful assessments while identifying clear avenues for improvement. The paper calls for domain-specific LLM agent workflows, accountable LLM infrastructure, and new quality standards for PIAs.

arXiv cs.CR · 5d agoResearch1

Vibe-Terrorism: Inside the Yemen Cell That Used Claude to Build Guided Weapons

Anthropic's threat intelligence report says a small Yemen cell used Claude to help build guided weapons, a novel AI misuse case.

SOCRadar highlights a case from Anthropic's September 2026 threat intelligence report in which a small militant cell based in northern Yemen used Claude to help build guided weapons. The write-up coins the term "vibe-terrorism" for this AI-assisted weapons development. It is framed as a novel example of AI misuse outside typical cyber threat activity.

SOCRadar · 5d agoAI safety & security

Introducing @huggingface/kernels: 200+ WebGPU Kernels for Local AI

Hugging Face released @huggingface/kernels, a library offering 200+ WebGPU compute kernels to accelerate AI inference locally in browsers.

Hugging Face introduced the @huggingface/kernels package, bundling more than 200 optimized WebGPU compute kernels for running AI workloads locally. The release targets browser-based and on-device inference, reducing reliance on server-side compute. No article body was available beyond the title, so benchmark results and supported models are not specified.

Hugging Face Blog · 16d agoAI tools & infra

Product showcase: Doppler secures secrets for humans, pipelines, and AI agents

Doppler's secrets management platform centralizes credentials for engineers, CI/CD pipelines, MCP servers, and AI agents with runtime injection and dynamic secrets.

Doppler stores API keys, database URLs, tokens, and certificates in a single control plane and injects them at runtime, replacing .env files for human and machine identities including AI agents. It supports OIDC with short-lived identity tokens for Azure, AWS, and GCP, dynamic secrets scoped and time-boxed to single sessions, SCIM provisioning, 50+ integrations, and an MCP server that lets agents request configurations natively. Permissions are enforced at each layer so raw secrets stay out of logs, prompts, and model context, with versioning, rollback, SIEM log forwarding, and cloud or on-prem deployment.

Help Net Security · 9d agoTools

openbmb/MiniCPM5-2B — new model trending #4 on Hugging Face

OpenBMB released MiniCPM5-2B, a dense 2B open-weights Transformer claiming 2B-class open-source SOTA for on-device deployment.

OpenBMB released MiniCPM5-2B, the second model in the MiniCPM5 series following MiniCPM5-1B, and it is trending #4 on Hugging Face. The dense 2B Transformer targets on-device, local, and resource-constrained deployment and claims 2B-class open-source SOTA while remaining competitive with 4B-class models. Reported strengths include coding, mathematics, long-context understanding, tool use, and agentic tasks; a tech report (arXiv 2506.07900), GitHub repo, and online demo accompany the release.

Hugging Face trending models · 10d agoModel release

openbmb/MiniCPM5-2B-GGUF — new model trending #30 on Hugging Face

OpenBMB released MiniCPM5-2B, a dense 2B on-device model claiming open-source SOTA among 2B-class models.

OpenBMB released MiniCPM5-2B, the second model in the MiniCPM5 series following MiniCPM5-1B, as a dense 2B Transformer built for on-device and resource-constrained deployment with GGUF weights on Hugging Face. The team claims 2B-class open-source state-of-the-art performance, remaining competitive with 4B-class models in coding, mathematics, long-context understanding, tool use and agentic tasks. The release includes a tech report, GitHub repository and online demo, and is currently trending on Hugging Face.

Hugging Face trending models · 12d agoModel release2

Fine-tuning a 350M Model for Better Structured Outputs in 100 GRPO Steps

Hugging Face guide fine-tunes a 350M-parameter model with 100 GRPO steps to improve structured output reliability.

A Hugging Face blog post demonstrates fine-tuning a 350M-parameter model using GRPO (Group Relative Policy Optimization) with TRL over 100 training steps. The stated goal is more reliable structured outputs from small language models. No article body was available, so details beyond the title are limited.

Hugging Face Blog · 14d agoAI tools & infra

VU#456290: Hugging Face Transformers library writes remote code to disk prior to consent check

CVE-2026-80047: Hugging Face Transformers 4.49.0 through 5.8.1 writes attacker-controlled Python files to disk before the trust_remote_code consent check.

CERT/CC vulnerability note VU#456290 describes CVE-2026-80047 in the Hugging Face Transformers library, affecting versions 4.49.0 through 5.8.1. The library performs a remote module fetch and writes attacker-controlled Python files to the local disk before evaluating the trust_remote_code consent prompt, without user authorization. This violates the security contract enforced across other dynamic module-loading paths in the library. Transformers is a primary framework for training and inference across NLP, vision, audio, video, and multimodal machine learning systems.

CERT/CC Vulnerability Notes · 15d agoVulnerabilityCVE-2026-800471

The 2026 PNPL Competition: Word Classification and Efficient Cross-Subject Generalisation in LibriBrain100

The 2026 PNPL competition releases LibriBrain100, a MEG speech dataset with 32 extra subjects, targeting word classification and cross-subject BCI generalization.

The 2025 PNPL competition on non-invasive speech decoding from MEG achieved F1-macro scores of 95.6% for speech detection and 73.6% for phoneme classification, built on LibriBrain's ~50 hours of single-subject data. The 2026 edition extends this with LibriBrain100, adding 32 subjects (~40 minutes each) plus ~80 hours of within-subject data. Two tracks target within-subject word classification at scale and cross-subject generalization with subject-specific fine-tuning shrinking from ~40 to ~20 to ~10 minutes, aiming at clinically feasible non-invasive BCIs for people with profound paralysis.

Hugging Face daily papers · 14d agoAI research

Perplexity Details Its GPU Embedding Stack: How Ivy, Tulip and ROSE Serve pplx-embed

Perplexity details its GPU embedding serving stack (Ivy, Tulip, ROSE), which reuses LLM prefill/decode kernels, CUDA graphs, and LazyTensors to cut launch overhead.

Perplexity engineers published a deep dive on the serving infrastructure behind pplx-embed, used across Perplexity Search and its API platform. The stack comprises Ivy (Rust HTTP gateway), Tulip (gRPC scheduling and batching), and ROSE (Runtime-Optimized Serving Engine), which reuses LLM prefill and decode kernels rather than running a separate embedding engine. Optimizations include whole-model CUDA graphs with lazy capture and a LazyTensor abstraction that overlaps CPU batch preparation with in-flight GPU work. Benchmarks are reported against vLLM v0.22.0 in BF16, with FlashAttention 4 generally fastest but FlashInfer 3 winning on Qwen-based models at very long sequence lengths.

MarkTechPost · 11d agoAI tools & infra1

TaichuAI/ZDTaichu5.0-9B — new model trending #30 on Hugging Face

TaichuAI released ZDTaichu5.0-9B, an open multimodal VLM built on Qwen3.5-9B targeting spatial reasoning, embodied AI, and agentic tool use.

TaichuAI released ZDTaichu5.0-9B, a multimodal vision-language model pairing a Qwen3.5-9B language decoder with a C-RADIOv4-H vision encoder, supporting text, single/multiple images, and video with any-resolution input and a 128K-token context. It introduces Entropy-Gated Adaptive Recurrent Reasoning, which allocates extra latent refinement steps to harder tokens. Reported benchmarks include 87.7 on TAU2-Bench, 71.4 on Claw-Eval, 93.7 on IFEval, 48 on ERQA, and 56 on RoboSpatial, leading compared 10B-scale open VLMs on agent and spatial tasks. The weights are available on Hugging Face, GitHub, and ModelScope, where it is trending at #30.

Hugging Face trending models · 13d agoModel release

RLLBC-Lib: An Educational Code Library for Reinforcement Learning and Learning-Based Control

Researchers release RLLBC-Lib, an educational code library covering tabular and deep reinforcement learning with support for automated grading.

RLLBC-Lib is an educational code library aimed at lowering the entry barrier for students learning reinforcement learning in the context of learning-based control. It comprises a comprehensive library of tabular RL approaches, a deep RL library following the same design principles, and implementations contrasting RL with other learning-based control approaches. The library also serves as a basis for creating programming assignments with automated grading.

arXiv cs.AI / cs.LG / cs.CL · 11h agoAI research

DianShi-RxnDB: A Large-Scale, Fine-Grained Organic Reaction Data Platform Built via a Fully Automated Pipeline for Researchers and AI Agents

Researchers release DianShi-RxnDB, a database of roughly 24 million organic reaction instances extracted automatically from USPTO and EPO patents since 1976.

DianShi-RxnDB is built by a fully automated pipeline integrating patent text, images, and reaction schemes, yielding about 24 million reaction instances, of which 14.8 million (61.7%) pass automated qualification checks. Manual evaluation of 1,300 sampled instances showed 92.95% field-level accuracy, and comparisons with Pistachio found advantages in deduplicated record counts and granularity. The platform offers a web research workbench and a Model Context Protocol (MCP) service enabling AI agents to perform composable structured retrieval.

Hugging Face daily papers · 11d agoAI research

OpenSSL’s new alpha build speeds up post-quantum crypto

OpenSSL 4.1.0 alpha1 adds DTLS 1.3 support and speeds up ML-DSA and ML-KEM post-quantum operations across several architectures.

The OpenSSL project released the first alpha of OpenSSL 4.1.0, months before general availability. The build adds DTLS 1.3 (RFC 9147) to secure UDP-based traffic such as VPNs, video calls and IoT, and includes optimized ML-DSA and ML-KEM operations for ppc64le, s390x and x86_64 plus AVX-512 acceleration for SHAKE hashing and AES-CBC decryption. Breaking changes include a new Net::Curl::Easy dependency for tsget, dropped Windows-on-Itanium and Windows CE support, and replacement of the no-ecdsa/no-ecdh Configure options with no-ec. It also adds GREASE support (RFC 8701), a DTLS mode for the SSL listener API, IKEv2 KDF support, and initial Elbrus2000 processor architecture support.

Help Net Security · 7d agoTools

OpenSSL 4.1.0 Alpha1 Released With DTLS 1.3 and Faster Post-Quantum Cryptography

OpenSSL 4.1.0 Alpha1 adds DTLS 1.3 support, ML-DSA and ML-KEM post-quantum optimizations, and GREASE TLS compatibility, intended for testing only.

The alpha preview of OpenSSL 4.1.0 implements RFC 9147 DTLS 1.3 for UDP-based applications and integrates DTLS into the SSL listener API. It accelerates ML-DSA signatures and ML-KEM encapsulation with AVX-512 and VAES optimizations on x86_64, and adds GREASE (RFC 8701), IKEv2 KDF support, and Elbrus2000 (e2k) targets. The release is intended for testing and development, not production, and removes Windows-on-Itanium and Windows CE build targets.

Cyber Security News · 6d agoTools

HOL Guard: Open-source antivirus for AI agents

HOL Guard is an open-source local guardrail that pauses AI coding agents before risky actions like secret access and prompt injection.

HOL Guard sits between AI coding agents (Claude Code, Cursor, Codex, Gemini CLI and others) and the host machine, intercepting risky commands before execution with checks taking under 50 milliseconds and running fully offline. It offers four sensitivity modes — Gentle, Balanced (default), Strict, and Paranoid — and parses command structure, environment, sensitive-path access and network destinations to decide when to interrupt. The core runtime is free and open source on GitHub, with 552,000 downloads reported; the vendor says it has no telemetry on adoption because collection is off by default.

Help Net Security · 16d agoAI tools & infra1

Implementation of Machine Learning Workflows with NVIDIA cuML, RAPIDS, GPU Benchmarking, Explainability, Clustering, and Model Inference

Hands-on tutorial implements NVIDIA cuML and RAPIDS to GPU-accelerate scikit-learn-style ML workflows with benchmarking, clustering, and inference.

The tutorial demonstrates NVIDIA cuML as a GPU-accelerated machine learning framework, using cuml.accel to speed up unmodified scikit-learn scripts with zero code changes and the native cuML API for CuPy/cuDF interoperability. It benchmarks CPU versus GPU implementations of PCA, K-Means, nearest-neighbor search, logistic regression, random forests, and DBSCAN on datasets up to 200,000 samples with 64 features. It also builds GPU pipelines with UMAP, t-SNE, and HDBSCAN, validates GPU-generated SHAP explanations, uses the FIL library for forest inference, and covers model serialization and GPU/CPU portability.

MarkTechPost · 4d agoAI tools & infra

DPRK APTs: Ted backdoor and curlRAT target South Korean media and automotive sectors

Rapid7 uncovered a DPRK-linked Linux toolkit using a HAProxy-embedded ted backdoor, SSH keylogger, and curlRAT against South Korean media and automotive firms.

Rapid7 Labs identified a previously undocumented framework attributed with medium confidence to DPRK actors, targeting South Korean automotive and media organizations likely since early 2025. The toolkit embeds a backdoor compiled into HAProxy 2.8.12 using its filter API, plus trojanized crond, agetty, atd, sshd, and polkitd, an SSH keylogger storing credentials under /var/lib/sshd/, and a curl-based RAT with a watchdog thread. It enables remote command execution, malicious script injection into served webpages (a watering-hole loop), credential harvesting, and long-term surveillance. Hardcoded C2s are associated with APT37 via ThreatFox, and exposed groupware portals and mail servers align with Kimsuky tradecraft; the initial access vector and any CVE remain unconfirmed.

Rapid7 Blog · 12d agoThreat actor in the wild1

HuggingFace: Security.txt

Hugging Face published a security.txt file, prompting limited Hacker News discussion of the RFC 9116 disclosure standard.

Hugging Face's security.txt file, which lists its security contact and disclosure channels per the RFC 9116 standard, drew attention on Hacker News. The RFC 9116 standard lets organizations publish where and how security researchers should report issues, but the submission received only one comment.

Hacker News · securityupdated · 5d agofirst · 5d agoIndustry 2 sourcesHN 22↑ · 1 comments

CoVeR: Coverage-Based Token Pruning for Multi-View 3D Reasoning in VLMs

CoVeR, a training-free coverage-based token pruner, preserves 93.5% of VLM 3D-reasoning performance using only about 8% of visual tokens.

Researchers introduce CoVeR, a deterministic, training-free selector that chooses visual tokens to cover every region of a multi-view 3D scene using only token coordinates. Unlike learned-importance and voxelization pruners, it enforces an exact per-scene token budget, avoids saturation plateaus, and prevents near-duplicate selections. Experiments across four vision-language models show it surpasses prior state of the art by 3.9 percentage points on average across three 3D reasoning benchmarks.

Hugging Face daily papers · 9d agoAI research