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AlphaGenome Atlas: A predictive map of every possible DNA letter change in the human genome

Google DeepMind released AlphaGenome Atlas, a free 1-petabyte platform predicting the molecular effects of all ~9 billion possible single-letter DNA variants.

Google DeepMind introduced AlphaGenome Atlas, containing precomputed predictions for the effects of roughly 9 billion single-nucleotide variants across the human genome, spanning hundreds of human and mouse cell types. The 1-petabyte dataset is more than 30 times larger than the AlphaFold Database and includes an AlphaGenome Variant Impact (AVI) score combining AlphaGenome and AlphaMissense predictions for both coding and non-coding regions. External collaborators have already used it to identify and experimentally verify variants in unsolved rare disease research. It is available via a free web portal, the AlphaGenome API, and as a skill in Google Antigravity.

Google DeepMind · 8d agoAI research 2 sources

Cybersecurity jobs available right now: March 10, 2026

Help Net Security's roundup lists open cybersecurity roles at BioNTech, AIG, ServiceNow and others across Europe, the Middle East and Canada.

A job-board roundup of cybersecurity openings including Associate Director Application Security at BioNTech (Germany), CISO at AIG (Israel), Cloud Security Professional at ServiceNow (Italy), and SOC/GRC, analyst, engineer and data governance roles in the UK, UAE, India, Canada and France. Roles span application security, cloud security, SOC operations, compliance and OT environments. Most listings are marked no longer accepting applications.

Help Net Security · 19d agoIndustry

AI-designed drug appears to turn back the body's biological clock in early trial

Insilico Medicine's AI-designed drug rentosertib showed reduced predicted biological age in IPF trial blood analysis, published in Nature Biotechnology.

Insilico Medicine reported that rentosertib, an AI-designed drug candidate in Phase III trials for idiopathic pulmonary fibrosis, showed reduced predicted biological age in blood protein analysis of 42 trial patients. Six independent aging-clock models built by teams at Harvard, Oxford, Beijing, and Insilico all predicted lower biological age versus placebo, with drops of three to four years by week 4 and up to six years on one clock. The drug targets TNIK and was developed with two generative AI systems in about 18 months; Eli Lilly recently invested in the company. Experts including Eric Topol and Harvard's Vadim Gladyshev called the results encouraging but not definitive, citing small sample size.

The Decoder · 9d agoAI industry

Biology-in-the-loop: Amortized Adaptive Hit Discovery in CRISPR Screens

Researchers release AssayBench-Loop, a 1,389-screen CRISPR benchmark, and AssayLoop, a framework that learns adaptive hit discovery policies.

The paper introduces AssayBench-Loop, a large-scale benchmark of 1,389 CRISPR screens across five phenotype categories for adaptive hit discovery under budget constraints. It also introduces AssayLoop, which combines AssayFormer, a transformer-based amortized acquisition policy trained across historical screens, with LLM-derived biological priors via an adaptive handoff. On temporally held-out screens, AssayLoop achieves 5.67-fold enrichment over random selection and recovers 27.7% of hits after assaying roughly 5% of the candidate library, outperforming existing adaptive-design methods and standalone LLMs.

arXiv cs.AI / cs.LG / cs.CL · 6d agoAI research1

NVIDIA Details BioNeMo Inference Runtime (BioIR): 2.90x Higher Boltz-2 Folding Throughput and 58.5K Residues per GPU-Hour on 8xH100

NVIDIA released BioNeMo Inference Runtime (BioIR), an open-source PyTorch-compatible library delivering 2.90x higher Boltz-2 protein-folding throughput on 8xH100 GPUs.

NVIDIA detailed BioIR, a Python library that accelerates Boltz-2, OpenFold2, and OpenFold3 structure-prediction inference on NVIDIA GPUs while preserving standard PyTorch workflows. On a matched benchmark of 1,000 human dimers on 8xH100 80GB GPUs, BioIR delivered 58.5K folded residues per GPU-hour versus 20.2K for a torch.compile baseline, a 2.90x throughput gain. BioIR already powered the AlphaFold Database expansion, generating about 31 million candidate complexes across 4,777 proteomes, with 1.81 million released as high-confidence predictions. Extrapolated to 1 million targets, estimated folding energy drops from 35 MWh to 11 MWh at 8-GPU TDP equivalents.

MarkTechPost · 6d agoAI tools & infra1

StudyBench: Can Self-Evolution Squeeze Textbooks for Olympiad Capability?

Researchers introduce StudyBench, a physics benchmark showing self-evolution gains on textbook problems rarely transfer to olympiad-level questions.

StudyBench is a controlled physics benchmark splitting test data into an Application Set of difficult textbook problems and a Transfer Set of olympiad-level problems. Across three base models, representative self-evolution methods improved on the Application Set but rarely transferred to the harder Transfer Set. A guidance ablation reveals a Guidance Gap, and every method hits a Compute Plateau, indicating the remaining limits are method problems rather than data or compute problems.

Hugging Face daily papers · 16d agoAI research

How a researcher uses Codex and ChatGPT to search for new antimicrobial molecules

OpenAI profiles César de la Fuente's lab using ChatGPT and Codex alongside deep-learning models to accelerate antimicrobial molecule discovery.

OpenAI published a case study on bioengineer César de la Fuente's lab, which uses ChatGPT and Codex for hypothesis brainstorming, code writing, dataset processing, and bridging knowledge gaps across biology, chemistry, and computer science. The lab's deep-learning models scan genome and protein databases for antimicrobial peptide candidates, potentially cutting initial searches from years to hours. Bacterial antimicrobial resistance was associated with about five million deaths in 2021, a toll projected to roughly double by 2050.

OpenAI News · 6d agoAI industry1

Medical device maker Boston Scientific says a cyberattack is causing a ‘global disruption’ to its operations

Boston Scientific says a cyberattack has caused global disruption to its operations, with no confirmation yet on device impact or data exfiltration.

Boston Scientific, a major medical device manufacturer, disclosed that a cyberattack is causing global disruption to its operations. The company has not confirmed whether medical devices are affected or whether any customer data was exfiltrated. The investigation appears to be ongoing, and healthcare-sector exposure raises patient-safety and supply-chain concerns.

TechCrunch · Security · 21d agoData breach

Can Edge-Deployable Vision-Language Models Identify Species?

Evaluation of 2-8B VLMs (Qwen3-VL, Gemma3) against BioCLIP on camera-trap species ID shows all models degrade sharply on field imagery.

The study tests whether edge-deployable 2-8B vision-language models carry genuine taxonomic knowledge, comparing Qwen3-VL 2B/4B/8B and Gemma3 4B against the 300M specialist BioCLIP on a 96-species task across clean iNaturalist photos and six LILA.science camera-trap collections. All models degrade 9.6-26.6 percentage points on field imagery, and BioCLIP outperforms every VLM by 33.2-59.2 points on an expanded 200-image sample, suggesting specialized data rather than scale drives the gap. Under open-set prompting, 5.9-9.6% of responses are syntactically valid but taxonomically nonexistent species names, with fabrication rankings replicating across evaluation sets.

arXiv cs.AI / cs.LG / cs.CL · 6d agoAI research1

From Hacks to Bioweapons, Claude Misuse Is Now Everywhere

Anthropic reports Claude was misused by Midnight Blizzard, ShinyHunters, disinformation campaigns, and bioweapon attempts; roundup also covers Xinbi takedown.

Anthropic's new report documents eight months of Claude misuse: Russian state-sponsored hackers (Microsoft-named Midnight Blizzard) used it for reconnaissance against Ukrainian and European government networks, stealing data and maintaining access, while ShinyHunters used it across hacking and extortion campaigns, and users attempted bioweapon development. Anthropic says it disrupted the activity. The WIRED roundup also covers the US seizure and sanctioning of Xinbi Guarantee, a Telegram black market with $30 billion-plus in sales mostly laundering pig-butchering scam proceeds, plus DOJ raids on 13 scam compounds in Madagascar and a four-year prison sentence for a Conti ransomware member. Meta faces scrutiny over AI child abuse ads and a class action over photo harvesting for AI training.

WIRED · Securityupdated · 9h agofirst · 4d agoAI safety & security in the wild 18 sources

Fly Language Model (FLM) Wires the Full Fruit Fly Connectome Into a Frozen 1.2B LLM, and Its Own Controls Show the Wiring Does Not Help

Researchers wire the full fruit fly connectome (166,700 nodes) into a frozen LiquidAI LFM2.5-1.2B LLM, but controls show no fly-specific benefit.

The Fly Language Model (FLM) couples the complete MaleCNS v1.0 fruit fly connectome (166,700 nodes, 25,582,938 edges) to a frozen LiquidAI LFM2.5-1.2B-Instruct backbone, training only a 278,528-parameter readout (~0.0238% of backbone parameters). The fly readout improved NLL by 0.0222 nats/token (perplexity 3.98 to 3.90) on 32 SmolTalk dialogues, but a direct-input control without the graph beat it in all three seeds. Relabeling node identities removes the gain and the recurrence contracts state differences by 0.6 per token, so the connectome adds no long-range memory. The MIT-licensed code runs locally on Python 3.12, but study artifacts remain private, limiting independent reproducibility.

MarkTechPost · 4d agoAI research1

Molecular Déjà Vu: Digit-Level Retrieval of Published Values in Frontier Language Models

Audit of 22 frontier models finds widespread verbatim retrieval of published molecular property values, with higher reasoning increasing recall of memorized numbers.

An arXiv audit tests 22 frontier LLMs across 12 molecular regression benchmarks for verbatim retrieval of published values. More than 50% of the LLMs show verbatim retrieval on five datasets, and identical experiments are flagged 89% more often at a high reasoning level than at the lowest one. Suppressing retrieval moves model prediction errors closer together in relative terms, suggesting predictive capability is not determined solely by memorized values.

arXiv cs.AI / cs.LG / cs.CL · 12d agoAI research1

Reduced-Space Multi-Fidelity Bayesian Optimization of Process Simulation Models

RS-MFBO couples global sensitivity analysis with fidelity-augmented Gaussian processes to slash costly high-fidelity simulation runs in industrial flowsheet optimization.

The paper presents RS-MFBO, a reduced-space multi-fidelity Bayesian optimization framework for high-dimensional, expensive black-box functions. It integrates Global Sensitivity Analysis for dimensionality reduction with a fidelity-augmented Gaussian process and a cost-aware acquisition strategy featuring cooldown and promotion mechanisms. Validation on a plasmid DNA bioprocess (SuperPro Designer) and a green fuel synthesis plant (Aspen HYSYS) shows substantial reductions in high-fidelity evaluations while remaining competitive with single-fidelity baselines.

arXiv cs.AI / cs.LG / cs.CL · 1d agoAI research

Testing race conditions with memory access tracing and stack-based delay injection

Google Project Zero released MAccConc, Linux kernel tooling that traces memory accesses to explore and test race condition interleavings.

A Google Project Zero researcher published MAccConc (Memory Access Concurrency), tooling for exploring possible interleavings of multithreaded test cases in the Linux kernel, available on GitHub. The tools use KCOV with ASAN outline-mode instrumentation to record per-access memory traces, enabling automatic testing of all A-B-A interleavings plus terminal and GUI explorers for manual analysis. The work targets confirming race condition candidates, building reliable regression tests, and enabling concurrency fuzzing, drawing on ideas from SKI and Ned Williamson's sockfuzzer.

Google Project Zero · 8d agoResearch1

HypoEvolve: Genetic Algorithms Enable Multi-Agent LLMs to Discover Scientific Hypotheses

HypoEvolve couples a generational genetic algorithm with specialized LLM agents to generate drug-repurposing hypotheses, beating six baselines on DepMap selectivity (0.171 vs 0.115).

HypoEvolve coordinates specialized LLM agents through a generational genetic algorithm in which scientific judgments and new proposals reshape a hypothesis population. Evaluation centers on drug repurposing, linking mechanistic explanations to target-level biological claims assessed via external measures adapted from DepMap and Open Targets. Across 34 cancer types, HypoEvolve scores highest against six baselines on both measures, with DepMap selectivity of 0.171 versus 0.115 for the strongest baseline, and gains generalize to held-out cancer types.

arXiv cs.AI / cs.LG / cs.CL · 2d agoAI research1

Quoting Calif Research

Calif Research demos WeWorm, an AI-built zero-click worm that spreads via WeChat calls on iOS and Android without user interaction.

Calif Research released a demo of WeWorm, described as the first zero-click worm to spread through WeChat calls across iOS and Android; victims need not answer the call and hear nothing even if they do. The team used AI to find the underlying bug and write a remote code execution exploit in about two days, then spent one more week building the worm. The researchers argue AI can now do most of the exploit-development work, with humans supplying judgment on targeting and safe testing.

Simon Willison · 6d agoAI safety & security

The 2026 PNPL Competition: Word Classification and Efficient Cross-Subject Generalisation in LibriBrain100

The 2026 PNPL competition releases LibriBrain100, a MEG speech dataset with 32 extra subjects, targeting word classification and cross-subject BCI generalization.

The 2025 PNPL competition on non-invasive speech decoding from MEG achieved F1-macro scores of 95.6% for speech detection and 73.6% for phoneme classification, built on LibriBrain's ~50 hours of single-subject data. The 2026 edition extends this with LibriBrain100, adding 32 subjects (~40 minutes each) plus ~80 hours of within-subject data. Two tracks target within-subject word classification at scale and cross-subject generalization with subject-specific fine-tuning shrinking from ~40 to ~20 to ~10 minutes, aiming at clinically feasible non-invasive BCIs for people with profound paralysis.

Hugging Face daily papers · 14d agoAI research

EVOHARNESSBENCH: Can Your Agents Keep Pace with an Evolving Harness?

Researchers introduce EVOHARNESSBENCH, a benchmark showing that evolving agent harnesses (tools, skills, agents) cause forgetting and inconsistent adaptation across 802 tasks.

The paper introduces EVOHARNESSBENCH, a benchmark that places non-stationarity in the externally supplied agent harness rather than in the task stream, evaluating agents across tools, skills, and specialist agents. It comprises 17 multi-stage harness streams built deterministically from verifier-based benchmarks, totaling 802 tasks, 520 tools, 42 skills, and 62 agents. Evaluation covers deployment (retention of previously accessible competence) and self-evolving adaptation settings. Results show harness expansion alone degrades previously solved tasks (harness-induced forgetting), adaptation gains are inconsistent, and retention and adaptation can pull in opposite directions.

Hugging Face daily papers · 14d agoAI research

Google DeepMind Releases AlphaGenome Atlas With Precomputed Molecular Effect Predictions and AVI Scores for 9 Billion Human DNA Variants

Google DeepMind launched AlphaGenome Atlas, precomputing molecular effect predictions and AVI impact scores for ~9 billion human single-nucleotide variants in a 1-petabyte catalogue.

Google DeepMind released AlphaGenome Atlas, a 1-petabyte catalogue of precomputed molecular effect predictions for roughly 9 billion possible single-nucleotide variants in the human genome. It introduces the AlphaGenome Variant Impact (AVI) score, combining AlphaGenome regulatory predictions with AlphaMissense, plus per-variant feature attributions and over 2,500 recurrent DNA sequence motifs. DeepMind reports best-in-class AVI performance on variant pathogenicity and rare disease benchmarks. Early users at the Broad Institute, University of Exeter, and Stowers Institute demonstrated rare-disease variant reprioritization and 22% more non-coding associations across 54,000+ UK Biobank genomes.

MarkTechPost · 8d agoAI research2

Apple’s revamped Health app will calculate your ‘health age’ and readiness score

Apple redesigned its Health app with Apple Intelligence-powered Insights, readiness scores, Health Age, and a $119 Quest 50-biomarker lab panel.

Announced alongside the Apple Watch Series 12 and Ultra 4, the redesigned Apple Health app adds an Insights tab, a readiness score, and a 'Health Age' metric computed from VO2 max, sleep, and blood biomarkers. A partnership with Quest offers a 50-biomarker lab panel for $119. The app also adds movement assessments and a longevity tab, and rolls out later this year in U.S. English.

TechCrunch · AI · 7d agoAI industry

DianShi-RxnDB: A Large-Scale, Fine-Grained Organic Reaction Data Platform Built via a Fully Automated Pipeline for Researchers and AI Agents

Researchers release DianShi-RxnDB, a database of roughly 24 million organic reaction instances extracted automatically from USPTO and EPO patents since 1976.

DianShi-RxnDB is built by a fully automated pipeline integrating patent text, images, and reaction schemes, yielding about 24 million reaction instances, of which 14.8 million (61.7%) pass automated qualification checks. Manual evaluation of 1,300 sampled instances showed 92.95% field-level accuracy, and comparisons with Pistachio found advantages in deduplicated record counts and granularity. The platform offers a web research workbench and a Model Context Protocol (MCP) service enabling AI agents to perform composable structured retrieval.

Hugging Face daily papers · 11d agoAI research

Claude users found ways around safeguards for bioweapons research

Anthropic reports Claude users bypassed safeguards for bioweapons research and misused the model for fraud networks and dissident surveillance.

Anthropic's misuse report details users circumventing Claude safeguards to pursue bioweapons-related research, alongside incidents such as a network of fake dating apps used to defraud users and surveillance systems built to identify and monitor dissidents. The report also claims seven Chinese labs, including Moonshot AI and DeepSeek, used distillation to replicate capabilities of US frontier models. The findings land amid escalating AI safety debate following researcher Jacob Coxon's resignation from Anthropic and OpenAI's July disclosure that its models had autonomously hacked into Hugging Face.

Ars Technica · AI · 5d agoAI safety & security1

Nimbus Manticore Expands Toolset With TWOSTROKE

Group-IB found new infrastructure and TWOSTROKE-like malware used by IRGC-linked Nimbus Manticore, indicating expanded Middle East and Europe targeting.

Group-IB reported new Tortoiseshell infrastructure spanning Europe and the Middle East and two previously undocumented tools from IRGC-linked Nimbus Manticore (UNC1549): a reverse SSH tunneling utility connecting to 172.86.98.113 on port 443, and a C++ backdoor masquerading as wtsapi32.dll with three hard-coded C2 servers. The backdoor overlaps with TWOSTROKE and supports file transfer, execution, host information gathering, and persistence. Findings build on Kaspersky's report of the NightLedger backdoor and WebSocket tunnelers BridgeHead and ArcBridge, and suggest expanded targeting beyond the Middle East into Europe.

The Hacker News · 21d agoThreat actor in the wild

Evaluating Time-Series Foundation Models and Multimodal Dietary Context for CGM Forecasting

Study finds zero-shot time-series foundation models underperform on CGM forecasting; fine-tuned Chronos-Bolt cuts RMSE up to 18.4% and dietary context adds signal.

The paper evaluates time-series foundation models for continuous glucose monitoring forecasting across eight public datasets covering Type 1 diabetes, Type 2 diabetes, and non-diabetes populations. Under a unified protocol, zero-shot foundation models did not consistently outperform baselines like Elastic Net and PatchTST, but lightweight fine-tuning did, with fine-tuned Chronos-Bolt reducing RMSE by 6.5%-18.4% in the T1D cohort and 8.6%-18.2% in the non-diabetes/T2D cohort. A residual-based fusion framework adding dietary context from CGMacros reduced overall RMSE by about 3% and postprandial RMSE by about 15% versus CGM-only baselines.

arXiv cs.AI / cs.LG / cs.CL · 6d agoAI research

ApateWeb: An Evasive Large-Scale Scareware and PUP Delivery Campaign

Unit 42 uncovers ApateWeb, a campaign using over 130,000 domains and multilayered redirects to deliver scareware, adware and PUPs to millions of users.

Unit 42 discovered ApateWeb, a large-scale campaign using a network of more than 130,000 domains to deliver scareware, potentially unwanted programs, adware including a rogue browser and browser extensions, and scam pages. The campaign uses a three-layer structure with deceptive emails as the entry point, centralized victim tracking via UUIDs, intermediate adware or anti-bot redirections, and evasion tactics such as cloaking, bot detection error pages, and wildcard DNS abuse. Activity spiked since August 2022, with several hundred attacker-controlled sites remaining in Tranco's top 1 million rankings and millions of monthly hits; Unit 42 blocked an estimated 3.5 million sessions across 74,711 devices in November 2023.

Palo Alto Unit 42 · Aug 17, 2026Phishing & fraud in the wild

We got admin access to Baseten's production GitHub in 25 minutes

Strix autonomous hacking agent extracted a working GitHub token with repo admin rights from Baseten's public Harbor image; Baseten rotated it next day.

Strix, an autonomous hacking agent, scanned *.baseten.co without credentials and found a public Harbor container registry project anonymously exposing the baseten/baseten-app image. A GitHub personal access token for basetenbot, embedded in Docker build history since March 2023, still worked in July 2026 and granted admin/push rights to basetenlabs/baseten, flux-cd, and homebrew-tap plus read/write on private customer repos. Baseten, valued at $13 billion, confirmed the issue as critical and rotated the token within a day.

Hacker News · AI · 1d agoVulnerabilityHN 51↑ · 12 comments1

Deepmind's AlphaGenome Atlas maps every possible DNA change in the human genome

DeepMind's AlphaGenome Atlas precomputes impact predictions for ~9 billion human DNA variants in a 1-petabyte dataset; its AVI score beats CADD in benchmarks

Google DeepMind released the AlphaGenome Atlas, precomputing functional-effect predictions for roughly 9 billion human genome variants (about 27,000 prediction values per variant) in a one-petabyte dataset more than 30 times the size of the AlphaFold database. The accompanying AlphaGenome Variant Impact Score (AVI), a small neural network combining AlphaGenome, AlphaMissense and evolutionary conservation features (18 inputs versus CADD's 150+), outperformed existing tools on clinically classified variants, ranking causal variants in the top 50 candidates for 29.5% of solved GREGoR cases versus 12.5% for CADD. A GREGoR epilepsy case illustrates the impact: AVI elevated a previously unclear DNM1 splice variant that lab experiments confirmed as likely disease-causing. The atlas is available for noncommercial use via web portal, API and a Google Antigravity skill, with a commercial version planned through Google Cloud.

The Decoder · 7d agoAI research

Researchers Use Claude to Port Pre-Auth RCE Exploit From One PLC Model to Another

Forescout used Anthropic's Claude to port a working pre-auth RCE exploit for CVE-2021-31886 between WAGO PLCs, executing ARM shellcode on live hardware.

Forescout Vedere Labs used Claude interactively to port an RCE exploit for CVE-2021-31886, a CVSS 9.8 stack buffer overflow in the Nucleus FTP server's USER command, from a WAGO 750-852 to a WAGO 750-831 PLC, running attacker-supplied ARM shellcode. The final RCE stage cost $535.74 in API usage over 8 hours 32 minutes, and a follow-up attempt to build a C2 implant permanently bricked the device. CERT@VDE lists many Nucleus V1-based WAGO models as vulnerable with no updates available; Siemens plans no Nucleus NET remediation. The work follows a joint NSA/CISA/FBI/DOE/EPA advisory warning of AI-generated exploitation scripts targeting internet-exposed Siemens S7 PLCs.

The Hacker News · 14d agoResearchCVE-2021-318862

BleachBit 6.0.4 fixes secure wiping that skipped clusters on Windows

BleachBit 6.0.4 fixes Windows secure-wipe bugs that skipped fragmented-file clusters, adds HSTS tracker deletion, early macOS support, and broad hardening.

The open-source cleaner BleachBit released version 6.0.4, fixing Windows shredding bugs where fragmented files were wiped incompletely because noncontiguous clusters were skipped, leaving potentially sensitive data on disk. The release adds deletion of dynamic HSTS tracking data in six Chromium-based browsers and Zen, early macOS support including a Safari cleaner and full CLI, plus hardening such as absolute paths for ipconfig/taskkill, symlink and reparse-point handling, DTD-free XML parsing, and PATH/environment sanitization when running as root.

Help Net Security · 7d agoTools

[Control Systems] National Instruments security advisory (AV26-856)

Canada's Cyber Centre relayed National Instruments advisories for memory corruption, out-of-bounds read, and out-of-bounds write flaws in LabVIEW versions.

The Canadian Centre for Cyber Security published control systems advisory AV26-856 covering National Instruments LabVIEW. Affected versions include releases before 23.0.0, 23.3.10, 24.3.7, 25.3.5, and 26.3.1. The flaws include memory corruption, an integer conversion out-of-bounds read, and an integer overflow out-of-bounds write. Users and administrators are urged to review the links and apply NI security updates.

Canadian Centre for Cyber Security · 19d agoAdvisory