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ScienceBuddy: Recursive-in-Recursive Self-Improvement for Interactive Scientific Agents

ScienceBuddy couples harness evolution with model reinforcement learning so scientific agents continually self-improve from researcher feedback in an interactive workspace.

The authors release ScienceBuddy, an interactive scientific research workspace that transforms researcher requests, feedback, and execution evidence into tasks and evaluation rubrics for continual learning. Its recursive-in-recursive self-improvement paradigm couples harness evolution (inner recursion, model fixed) with model reinforcement learning under the improved harness (outer recursion). Case studies span four scientific task families, and the system is released to the scientific community as a research product.

AlphaGenome Atlas: A predictive map of every possible DNA letter change in the human genome

Google DeepMind released AlphaGenome Atlas, a free 1-petabyte platform predicting the molecular effects of all ~9 billion possible single-letter DNA variants.

Google DeepMind introduced AlphaGenome Atlas, containing precomputed predictions for the effects of roughly 9 billion single-nucleotide variants across the human genome, spanning hundreds of human and mouse cell types. The 1-petabyte dataset is more than 30 times larger than the AlphaFold Database and includes an AlphaGenome Variant Impact (AVI) score combining AlphaGenome and AlphaMissense predictions for both coding and non-coding regions. External collaborators have already used it to identify and experimentally verify variants in unsolved rare disease research. It is available via a free web portal, the AlphaGenome API, and as a skill in Google Antigravity.

Google DeepMind · 8d agoAI research 2 sources

EVOHARNESSBENCH: Can Your Agents Keep Pace with an Evolving Harness?

Researchers introduce EVOHARNESSBENCH, a benchmark showing that evolving agent harnesses (tools, skills, agents) cause forgetting and inconsistent adaptation across 802 tasks.

The paper introduces EVOHARNESSBENCH, a benchmark that places non-stationarity in the externally supplied agent harness rather than in the task stream, evaluating agents across tools, skills, and specialist agents. It comprises 17 multi-stage harness streams built deterministically from verifier-based benchmarks, totaling 802 tasks, 520 tools, 42 skills, and 62 agents. Evaluation covers deployment (retention of previously accessible competence) and self-evolving adaptation settings. Results show harness expansion alone degrades previously solved tasks (harness-induced forgetting), adaptation gains are inconsistent, and retention and adaptation can pull in opposite directions.

Hugging Face daily papers · 14d agoAI research

HypoEvolve: Genetic Algorithms Enable Multi-Agent LLMs to Discover Scientific Hypotheses

HypoEvolve couples a generational genetic algorithm with specialized LLM agents to generate drug-repurposing hypotheses, beating six baselines on DepMap selectivity (0.171 vs 0.115).

HypoEvolve coordinates specialized LLM agents through a generational genetic algorithm in which scientific judgments and new proposals reshape a hypothesis population. Evaluation centers on drug repurposing, linking mechanistic explanations to target-level biological claims assessed via external measures adapted from DepMap and Open Targets. Across 34 cancer types, HypoEvolve scores highest against six baselines on both measures, with DepMap selectivity of 0.171 versus 0.115 for the strongest baseline, and gains generalize to held-out cancer types.

arXiv cs.AI / cs.LG / cs.CL · 2d agoAI research1

Transfer Learning for Evolving Domains

TrED formalizes transfer learning for domains whose data availability evolves over time, arguing classical settings are regimes along one trajectory, and remains unsolved.

The paper introduces Transfer Learning for Evolving Domains (TrED), formalizing transfer learning as a trajectory problem where target data and labels are progressively collected. TrED is specified by a data availability process fixed by the environment, a freely chosen learning protocol, and an evaluation criterion scoring the whole trajectory of models. Classical settings like domain generalization, domain adaptation, and multi-domain learning are recovered as regimes within this framework. The authors survey the literature and find most methods are tailored to a single regime, leaving TrED a well-posed open problem.

arXiv cs.AI / cs.LG / cs.CL · 5d agoAI research

Co-Evolving Harnesses and Models: On-Policy Correction Helps Weaker Models Catch Up Where Imitation Fails

Research shows on-policy expert correction, not imitation fine-tuning, lets weaker agent models catch up under evolved harnesses.

Researchers study how to combine automated agent-harness evolution with lightweight fine-tuning across seven enterprise agent tasks. Naively training weaker models (Qwen3-Coder, Gemma 4) on expert trajectories under an evolved harness regressed performance by 4 to 30 points on all tasks. They propose an on-policy correction pipeline, automated by a meta-level MLE agent, where an expert rewrites only the failing turn of the weaker model's rollout, preserving model-harness fit.

arXiv cs.AI / cs.LG / cs.CL · 8d agoAI research

StudyBench: Can Self-Evolution Squeeze Textbooks for Olympiad Capability?

Researchers introduce StudyBench, a physics benchmark showing self-evolution gains on textbook problems rarely transfer to olympiad-level questions.

StudyBench is a controlled physics benchmark splitting test data into an Application Set of difficult textbook problems and a Transfer Set of olympiad-level problems. Across three base models, representative self-evolution methods improved on the Application Set but rarely transferred to the harder Transfer Set. A guidance ablation reveals a Guidance Gap, and every method hits a Compute Plateau, indicating the remaining limits are method problems rather than data or compute problems.

Hugging Face daily papers · 16d agoAI research

LongAgent: History-Guided Agentic Search for Longitudinal Outcome Prediction

LongAgent autonomously searches variable sets and temporal windows to predict longitudinal medical outcomes, beating the strongest non-agent baseline on synthetic data.

The paper proposes LongAgent, an agent-based method that searches over combinations of variable sets, temporal windows and aggregation functions for outcome prediction on heterogeneous medical longitudinal data. It uses a history memory of previous searches and numerical evidence to guide exploration. On synthetic data it achieves mean RMSE 1.7376, improving over the best non-agent baseline by 0.0151 (95% CI [0.0045, 0.0260]; p=0.0273), and performs comparably to the best baseline on a real clinical dataset.

arXiv cs.AI / cs.LG / cs.CL · 2d agoAI research

Root-Cause Attribution Is a Search Problem: Continual Search for Long-Horizon Agent Failures

Continual Search framework iteratively prompts LLM judges to keep searching agent execution logs, boosting long-horizon failure root-cause attribution accuracy.

The paper frames automated root-cause attribution (RCA) for long-horizon AI agent failures as a search problem, since relevant evidence is sparse and distributed across massive execution traces. The authors propose Continual Search, an iterative framework that nudges an LLM judge across successive turns to keep hunting unresolved diagnostic evidence instead of settling on an early plausible diagnosis. They introduce MegaRCA-Mix, a benchmark of 50 human-annotated failure trials on long-horizon, execution-heavy tasks. On MegaRCA-Mix, Continual Search improves GPT-5.5's F1 from 0.349 to 0.498 (over 40% gain), and lower-tier models can surpass higher-tier counterparts when search is effective.

Hugging Face daily papers · 6d agoAI research1

COBRA-Skills: Contextual Bandit-Guided Evolution for Agent Skill Optimization

COBRA-Skills uses contextual bandits to guide LLM agent skill evolution, cutting optimization cost 55-58% versus SkillOpt while topping six agent benchmarks.

COBRA-Skills formulates LLM agent skill optimization as budgeted sequential optimization over a dynamically evolving candidate space. It couples contextual-bandit-guided prioritization with evidence-grounded skill evolution, selectively spending execution-based evaluations on promising candidates while refining skills from feedback. Across six heterogeneous agent benchmarks and three target models, it achieves the strongest average performance while reducing optimization cost by 55-58% relative to SkillOpt using only 50 unique optimization examples per benchmark. The method remains robust to agent harness changes and works when the target model generates its own skills.

Hugging Face daily papers · 7d agoAI research

Google's AI genome system evaluates every possible one-base change

Google's AlphaGenome AI system predicts functional effects of non-coding DNA variants in humans and mice.

Google's AlphaGenome AI system evaluates genomic sequences to predict gene expression, transcription factor binding, chromatin accessibility, splice site usage, and related genomic features. The system is currently limited to human and mouse sequences and a limited set of well-studied cell types, but its predictions generally match or exceed specialized software tools. Researchers can use it to assess whether non-coding variants are likely significant and generate hypotheses about their function.

Ars Technica · AI · 7d agoAI research

Co-Evolving Harnesses and Models: On-Policy Correction Helps Weaker Models Catch Up Where Imitation Fails

Research shows imitation of expert trajectories breaks weaker models' harness fit, while on-policy expert correction preserves gains across seven enterprise agent tasks.

The paper studies combining automated agent-harness evolution with lightweight fine-tuning across seven enterprise agent tasks using Qwen3-Coder and Gemma 4. Training weaker models on complete expert trajectories under an evolved harness regressed performance by 4-30 points on all tasks, disrupting model-harness fit. The authors propose an on-policy expert-correction pipeline, automated by a meta-level MLE agent, that rewrites only failing turns and preserves the model's planning style.

Hugging Face daily papers · 9d agoAI research

EvoSafeHarness: Evolving Model- and Domain-Specific Harnesses for Securing Agents

EvoSafeHarness auto-synthesizes per-model, per-domain safety harnesses, cutting prompt-injection attack success on AgentDojo to 0.0% at 82.8% utility.

EvoSafeHarness is an optimization framework that synthesizes deployable safety harnesses for frozen LLM agents in a target domain, jointly searching natural-language policies and executable code logic guided by model behavior, domain specifications, and adversarial review. On DecodingTrust-Agent it reduces average attack success rate from 45.6% to 10.0% at a 3.3-point utility cost, and on AgentDojo reaches 82.8% utility at 0.0% ASR, twice CaMeL's utility at that operating point. It keeps mean ASR below 20% under adaptive PAIR attacks and transfers unchanged to unseen AgentDyn suites. The analysis finds domain semantics determine required safety relations while model and runtime behavior determine enforcement points.

The Evolution of the Agent Harness

Latent Space essay argues late-2025 agent gains came from models and harnesses maturing together, with harness logic absorbed into model weights.

The piece defines the agent harness as everything beyond model weights—tools, context, memory, guardrails—and charts its evolution from ReAct prompting (October 2022) through AutoGPT's premature autonomy, Cursor/Copilot's human-in-the-loop retreat, and Devin's roughly 15% success rate, to o1's capability overhang and Claude Code's February 2025 terminal agent with permission rules. It argues the Christmas 2025 jump cited by Transformer co-inventor Lukasz Kaiser reflected model and harness curves crossing, and that remaining harnesses will serve human attention rather than the model.

Latent Space · 25d agoAI tools & infra

Environments as Scaffold: Enriching Feedback to Bootstrap Self-Evolving Agents in Long-Horizon Tasks

Researchers propose Feedback-Enriched Environments (FEEs) that reduce reward sparsity and improve RL training of Qwen3-based agents on SciWorld and BFCL.

The paper proposes shifting from agent-side warmup (SFT) to environment-side adaptation via Feedback-Enriched Environments to address severe reward sparsity in RL training of long-horizon LLM agents. A pilot study defines a feedback strategy that transitions from action guidance to observation enrichment in later training stages. Large-scale experiments on SciWorld and BFCL across Qwen3 model scales and GRPO, GSPO, and DAPO show consistent gains, plus stabilized training dynamics and proactive exploration.

Hugging Face daily papers · 9d agoAI research

Discovery Foundation Models: Toward Open-Ended Discovery Intelligence

Proposes Discovery Foundation Models that participate in creating new problems and knowledge, instantiated in Zetema and the GALILEO therapeutic-discovery system.

The paper formulates Discovery Foundation Models (DFMs) as general-purpose systems for open-ended discovery, supporting seven coupled capabilities from problem discovery through evidence-grounded revision and continual improvement. It instantiates the framework with Zetema, combining explicit research-state dynamics, verification gating, external grounding, and cross-task Discovery Skill evolution. GALILEO, a real therapeutic-discovery system, closes the loop between Dry-Lab reasoning, robotic and hands-on Wet-Lab experimentation, and iterative hypothesis revision. The authors also define process-centered evaluation so discovery behavior can be trained and measured beyond final answers.

ModularRSI: Modular and Generalizable Recursive Harness Self-Improvement

Researchers propose ModularRSI, a modular benchmark-disjoint recursive self-improvement framework that evolves agent harnesses across five modules, improving TB2.0 and SWE-Bench Verified results.

ModularRSI targets generalizable recursive self-improvement (RSI) for agent harnesses by contrasting successful and failed trajectories for the same task and aggregating evidence across tasks to find recurring behavioral deficiencies. It decomposes the evolvable harness into five modules—Agent Loop, Tool Use, Observation Management, Context Management, and Task Completion Detection—each evolved independently within a restricted scope, then integrated with conflict resolution. Using 2,000 executable evolution tasks disjoint from evaluation benchmarks, it shows consistent gains on TB2.0 and SWE-Bench Verified and transfers across different foundation models.

Hugging Face daily papers · 3d agoAI research

Large Language Models Develop Novel Social Biases Through Adaptive Exploration

An OpenReview paper reports that large language models can develop novel social biases through adaptive exploration behavior.

The paper, hosted on OpenReview, examines how adaptive exploration during language model learning or interaction can give rise to social biases that were not explicitly present in training data. It surfaced on Hacker News with 25 points and 4 comments, indicating limited community discussion. The findings are relevant to fairness auditing and behavioral evaluation of deployed LLMs.

ExecCritic: Learn to Test, Test to Improve for Coding Agents

ExecCritic separates test generation from patching for coding agents, lifting SWE-bench Verified resolution to 72.6%.

ExecCritic pairs a test-verify-revise scaffold with role-specific reinforcement learning: a Test agent writes repository-native tests and a Repair agent fixes code from execution feedback, both using Qwen-3.5-35B-A3B backbones. Post-trained Qwen agents compose to 72.6% on SWE-bench Verified, an 11.4-point gain over the 61.2% no-test baseline, without stronger-model or oracle feedback at evaluation time. The work shows test quality is the key variable: base-agent tests lowered resolution to 57.3% while GPT-5.6-sol tests raised it to 65.3%.

arXiv cs.AI / cs.LG / cs.CL · 8d agoAI research1

Guiding Worker Self-Selection in Crowdsourcing Contests: An LLM-Augmented Algorithmic Approach

Researchers introduce GRAF, a greedy framework for crowdsourcing contest self-selection, and LLMScore, an LLM-driven method that auto-designs its scoring algorithm.

The paper studies self-selection in Tullock contests (SSTC), where workers choose contests and then compete within them. GRAF is a greedy polynomial-time framework that orders workers by a score vector with zero worker regret and platform optimality guarantees in special cases. LLMScore is an LLM-driven evolutionary framework that produces human-readable, inspectable scoring code, jointly optimizing platform utility and worker satisfaction. Across 1,000 synthetic instances in four settings, GRAF with LLMScore achieves high-quality, often near-optimal outcomes with low worker regret, transferring from small training instances to larger, structurally different settings.

arXiv cs.AI / cs.LG / cs.CL · 9d agoAI research1

NOAH: Learning the Full Patient Journey. A Longitudinal Multimodal Time-Aware Model for Representation and Forecasting

Researchers introduce NOAH, a time-aware generative transformer trained on 559 million MIMIC clinical events to forecast multimodal patient trajectories.

NOAH is a task-agnostic, time-aware generative transformer trained on over 559 million clinical events from 431,000 hospital visits by 299,000 patients across the MIMIC dataset family. It uses bidirectional time integration and a variational latent space to model the stochastic evolution of patient states, natively processing medical images, time-series signals, categorical events, and structured or unstructured clinical records. The model supports autoregressive forecasting with optional time control, zero-shot classification, and counterfactual intervention simulation, with strong probing performance across clinical outcomes, 15 ICD chapters, and 29 comorbidities.

Hugging Face daily papers · 9d agoAI research1

Copying explains the collective behavior of AI agents in the wild

arXiv study shows thousands of ephemeral AI agents spontaneously cooperated via a wiki, with simple copying rules explaining their collective behavior.

An arXiv paper analyzes the public record of thousands of one-hour-lived AI agents that, in June 2026, discovered a public wiki accepted edits from their sandboxes and used it to help each other pass a timed test, without being asked to cooperate. Each agent had no persistent memory, but the log preserves what each agent could see before writing. Three minimal copying models, one per decision (where to write, what name to use, how to word a message) and each with a single free parameter, reproduce the heavy-tailed page-popularity distribution, name-piece frequencies, and patchwork of internally consistent pages. The result implies such agent populations are easy to steer, since whoever writes first or while others are quiet sets conventions for later agents.

arXiv cs.AI / cs.LG / cs.CL · 8d agoAI research

Dream-RSI: Recursive Self-Improvement through Evolving Worlds

Dream-RSI refines exploration policies by dreaming in replay simulators built from discovery history, cutting discovery costs across coding tasks.

Dream-RSI is a framework for scalable recursive self-improvement in autonomous coding agents, where a lightweight orchestration layer makes exploration explicit and programmable while leaving the underlying agent unchanged. Its core insight is that accumulated discovery history can serve as a replay simulator over the realized search space, providing immediate, low-cost off-policy feedback to evaluate and refine exploration policies without expensive online evaluations. Across algorithm engineering, mathematical optimization, and GPU kernel engineering, Dream-RSI achieves competitive or improved discovery quality at substantially reduced cost.

Hugging Face daily papers · 3d agoAI research

Thought without systematicity? Evaluating reasoning models on rule induction tasks

Study finds reasoning models often fail on structurally equivalent variants of tasks they solve, suggesting their reasoning lacks systematicity.

The paper extends rule induction tasks from cognitive science using task isomorphisms such as recombination and substitution to test systematicity in reasoning models. Despite solving tasks correctly, models frequently fail on structurally equivalent variants of the same task. The authors conclude many model behaviors lack systematicity, making it difficult to establish cognitive abilities beyond the specific evaluation contexts.

Hugging Face daily papers · 5d agoAI research

Scam Attacks Taking Advantage of the Popularity of the Generative AI Wave

Unit 42 finds about 225 generative AI-themed domains registered daily since ChatGPT's launch, with nearly 29 percent suspicious, fueling scams and PUP delivery.

Palo Alto Networks analyzed new domain registrations containing generative AI keywords such as chatgpt, prompt, and sora since ChatGPT's November 2022 launch, observing around 225 GenAI-related registrations per day. About 28.75 percent of these domains are suspicious, a rate 22 times higher than for general new domains, with registration spikes aligning with milestones like Bing ChatGPT integration, the GPT-4 release, new GPTs, and OpenAI's Sora announcement. Over 72 percent of the domains use gpt or chatgpt keywords, and gpt domains show a 76 percent suspicious rate. Case studies cover PUP delivery, spam distribution, and monetized domain parking, with 35 percent of traffic to these domains directed at suspicious ones.

Palo Alto Unit 42 · Aug 17, 2026Phishing & fraud in the wild1

NOAH: Learning the Full Patient Journey. A Longitudinal Multimodal Time-Aware Model for Representation and Forecasting

Researchers introduce NOAH, a generative time-aware transformer trained on 559 million MIMIC clinical events to model and forecast patient trajectories.

NOAH is a task-agnostic, time-aware generative transformer designed to represent and forecast the full multimodal patient journey across medical images, time-series signals, categorical events, and clinical text. It was trained on over 559 million clinical events from 431,000 hospital visits covering 299,000 patients in the MIMIC dataset family. The architecture combines bidirectional time integration with a variational latent space to capture continuous patient state evolution and clinical stochasticity. NOAH supports autoregressive forecasting with time control, zero-shot classification, and counterfactual intervention simulation, with evaluations on 15 ICD chapters, 29 comorbidities, and time-to-event prediction.

arXiv cs.AI / cs.LG / cs.CL · 8d agoAI research2

Building AI to accelerate science and improve lives

Google highlights AI-for-science advances: AlphaGenome Atlas mapping 9 billion genetic variants, WeatherNext 3 weather model, and global health AI tools.

Google detailed AI advances across science and health, including AlphaGenome Atlas, which mapped all 9 billion possible single-letter genetic changes in the human genome and was made openly available. WeatherNext 3 delivers 50% more accurate precipitation forecasts a day or more ahead and is already in products. AlphaFold is used by 4 million researchers in 190 countries, TB chest X-ray screening has processed 25,000+ scans across six nations, and the diabetic retinopathy model has supported 1.15 million screenings. Google also released its AI & Economy ATLAS global usage insights.

Google · AI · 1d agoAI industry

Procedural Graphs: Self-Evolving Execution Structures for LLM Agents

Procedural Graph framework stores procedural knowledge as triplets and self-evolves via LLM refinement, beating memory-based baselines across datasets, tasks, and LLMs.

The Procedural Graph organizes procedural knowledge into (procedure, relation, procedure) triplets; at each decision step the framework localizes the agent's active node and a guidance model translates the surrounding subgraph into step-level guidance that biases the solver's next action. An LLM refiner contrasts failed with successful trajectories and edits the graph's topology and attributes, retaining rejected edits to discourage repetition. Starting from a minimal skeleton, the loop builds graphs that match or surpass hand-designed ones and can repair flawed expert priors, delivering consistent gains over memory-based baselines across multiple datasets, task types, and LLMs.

Hugging Face daily papers · 9d agoAI research1