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AlphaGenome Atlas: A predictive map of every possible DNA letter change in the human genome

Google DeepMind released AlphaGenome Atlas, a free 1-petabyte platform predicting the molecular effects of all ~9 billion possible single-letter DNA variants.

Google DeepMind introduced AlphaGenome Atlas, containing precomputed predictions for the effects of roughly 9 billion single-nucleotide variants across the human genome, spanning hundreds of human and mouse cell types. The 1-petabyte dataset is more than 30 times larger than the AlphaFold Database and includes an AlphaGenome Variant Impact (AVI) score combining AlphaGenome and AlphaMissense predictions for both coding and non-coding regions. External collaborators have already used it to identify and experimentally verify variants in unsolved rare disease research. It is available via a free web portal, the AlphaGenome API, and as a skill in Google Antigravity.

Google DeepMind · 8d agoAI research 2 sources

Type Diversity Enables Transformers to Generalise Compositionally

Researchers show lexical-versus-structural compositional generalization gaps in Transformers stem from type diversity imbalance in datasets, not architectural limits.

The paper argues that Transformers' difficulty with structural compositional generalization is an artifact of low structural type diversity in prior benchmark datasets rather than an architectural limitation. Using Grammatical Framework, the authors create linguistically diverse variants of COGS and SLOG. They find type diversity correlates with compositional generalization equally in lexical and structural test cases, contradicting previous claims that compound divergence explains task difficulty.

arXiv cs.AI / cs.LG / cs.CL · 4d agoAI research

Anthropic Adds Plugin Evals to Claude Code: 6 Grader Types, a No-Plugin Baseline, and a CI Gate for Skills

Anthropic ships a plugin evals workflow for Claude Code with six grader types, a no-plugin baseline arm, and a CI gate via threshold and cost flags.

Anthropic published a plugin evals workflow for Claude Code, exposed via the "claude plugin eval" command on v2.1.269+. Six grader types exist: regex, tool_used, tool_order, and file_exists are free transcript checks, while llm and baseline invoke a billed judge model. Every case runs with and without the plugin, and the delta (Δ) isolates the plugin's contribution; a Δ near zero with a failing tool_used:Skill grader indicates the skill never triggers. CI gating uses --threshold 0.8, --max-cost-usd, --trust-plugin, and --no-publish flags, with results written to a report.html under evals/results/.

MarkTechPost · 4d agoAI tools & infra2

Google DeepMind Releases AlphaGenome Atlas With Precomputed Molecular Effect Predictions and AVI Scores for 9 Billion Human DNA Variants

Google DeepMind launched AlphaGenome Atlas, precomputing molecular effect predictions and AVI impact scores for ~9 billion human single-nucleotide variants in a 1-petabyte catalogue.

Google DeepMind released AlphaGenome Atlas, a 1-petabyte catalogue of precomputed molecular effect predictions for roughly 9 billion possible single-nucleotide variants in the human genome. It introduces the AlphaGenome Variant Impact (AVI) score, combining AlphaGenome regulatory predictions with AlphaMissense, plus per-variant feature attributions and over 2,500 recurrent DNA sequence motifs. DeepMind reports best-in-class AVI performance on variant pathogenicity and rare disease benchmarks. Early users at the Broad Institute, University of Exeter, and Stowers Institute demonstrated rare-disease variant reprioritization and 22% more non-coding associations across 54,000+ UK Biobank genomes.

MarkTechPost · 7d agoAI research2

Characterizing Language Generation in the Limit: Finite Witnesses and a Separation-Width Hierarch

New work characterizes language generation in the limit via finite witnesses, proves a full separation-width hierarchy, and formalizes all results in Lean.

The paper fully characterizes when language generation in the limit is possible for arbitrary families over a countable universe: each target must admit a finite positive witness such that targets activated by any finite sample share an infinite common intersection. It defines positive separation width and proves every level of the resulting hierarchy occurs, with countable families admitting singleton witnesses and unions of families with infinite common cores requiring unbounded finite witnesses. The characterization, a universal normalization, and a diagonal capture lemma are machine-checked in the Lean proof assistant, with the development maintained on GitHub.

arXiv cs.AI / cs.LG / cs.CL · 6d agoAI research1

Deepmind's AlphaGenome Atlas maps every possible DNA change in the human genome

DeepMind's AlphaGenome Atlas precomputes impact predictions for ~9 billion human DNA variants in a 1-petabyte dataset; its AVI score beats CADD in benchmarks

Google DeepMind released the AlphaGenome Atlas, precomputing functional-effect predictions for roughly 9 billion human genome variants (about 27,000 prediction values per variant) in a one-petabyte dataset more than 30 times the size of the AlphaFold database. The accompanying AlphaGenome Variant Impact Score (AVI), a small neural network combining AlphaGenome, AlphaMissense and evolutionary conservation features (18 inputs versus CADD's 150+), outperformed existing tools on clinically classified variants, ranking causal variants in the top 50 candidates for 29.5% of solved GREGoR cases versus 12.5% for CADD. A GREGoR epilepsy case illustrates the impact: AVI elevated a previously unclear DNM1 splice variant that lab experiments confirmed as likely disease-causing. The atlas is available for noncommercial use via web portal, API and a Google Antigravity skill, with a commercial version planned through Google Cloud.

The Decoder · 7d agoAI research

An Empirical Analysis of ReDoS Vulnerabilities and ReDoS Detection Tools

Study of NVD data finds ReDoS vulnerabilities growing more prevalent and more likely to be exploited, while five detection tools disagree substantially.

The study compares five publicly available ReDoS detection tools and one regex correction tool across three datasets. An empirical analysis of all ReDoS vulnerabilities reported to the NVD finds they are becoming more prevalent and are much more likely to be exploited than non-ReDoS weaknesses. The detection tools exhibited substantial disagreement on whether a given regex is vulnerable.

arXiv cs.CR · 6d agoResearch

Google DeepMind Releases AlphaGenome Atlas

Google DeepMind released AlphaGenome Atlas, a 1-petabyte database pre-computing effects of all 9 billion single-nucleotide variants in the human genome, with a unified AVI score.

Google DeepMind launched AlphaGenome Atlas, a database that predicts the regulatory impact of every possible single nucleotide variant across the roughly 3 billion base pairs of the human genome, yielding a 1-petabyte dataset. It introduces the AlphaGenome Variant Impact (AVI) score, combining coding and non-coding predictions for rapid variant prioritization. Broad Institute researchers used it to support solving an unsolved rare disease case via a predicted DNM1 splice variant, and analysis of 54,000+ UK Biobank participants uncovered 22% more non-coding genetic associations, including 19 regions linked to BMI. The Atlas is available through a no-code web portal.

Large Language Models Develop Novel Social Biases Through Adaptive Exploration

An OpenReview paper reports that large language models can develop novel social biases through adaptive exploration behavior.

The paper, hosted on OpenReview, examines how adaptive exploration during language model learning or interaction can give rise to social biases that were not explicitly present in training data. It surfaced on Hacker News with 25 points and 4 comments, indicating limited community discussion. The findings are relevant to fairness auditing and behavioral evaluation of deployed LLMs.

The Frontier AEO Tracker: What Astra Chooses (and every other frontier model, and what you can do about it)

Latent Space launches an AEO tracker scoring 7 frontier models' product recommendations across 161 categories, revealing generational bias flips.

Latent Space built a tracker measuring Answer Engine Optimization by running 6 prompt variations across 7 frontier models with search enabled over 161 product categories, scoring first choices, alternatives, mentions, and anti-recommendations. It found 28 categories with a universally dominant primary choice and observed soft biases, such as models favoring their own lab's coding agents. Analysis of Anthropic's Sol→Astra and Opus→Fable generations showed newer models consulting fewer sources and being less likely to change answers when questions are paraphrased.

Latent Space · 8d agoAI research

Can Edge-Deployable Vision-Language Models Identify Species?

Evaluation of 2-8B VLMs (Qwen3-VL, Gemma3) against BioCLIP on camera-trap species ID shows all models degrade sharply on field imagery.

The study tests whether edge-deployable 2-8B vision-language models carry genuine taxonomic knowledge, comparing Qwen3-VL 2B/4B/8B and Gemma3 4B against the 300M specialist BioCLIP on a 96-species task across clean iNaturalist photos and six LILA.science camera-trap collections. All models degrade 9.6-26.6 percentage points on field imagery, and BioCLIP outperforms every VLM by 33.2-59.2 points on an expanded 200-image sample, suggesting specialized data rather than scale drives the gap. Under open-set prompting, 5.9-9.6% of responses are syntactically valid but taxonomically nonexistent species names, with fabrication rankings replicating across evaluation sets.

arXiv cs.AI / cs.LG / cs.CL · 5d agoAI research1

Thought without systematicity? Evaluating reasoning models on rule induction tasks

Study finds reasoning models often fail on structurally equivalent variants of tasks they solve, suggesting their reasoning lacks systematicity.

The paper extends rule induction tasks from cognitive science using task isomorphisms such as recombination and substitution to test systematicity in reasoning models. Despite solving tasks correctly, models frequently fail on structurally equivalent variants of the same task. The authors conclude many model behaviors lack systematicity, making it difficult to establish cognitive abilities beyond the specific evaluation contexts.

Hugging Face daily papers · 4d agoAI research

Technical Manual for a Toolkit for Measuring Contextual Individuation in Transformer Language Models

An open methodology toolkit measures whether transformer language models contextualize fixed word forms across domains using bridge forms and layer-wise silhouette analysis.

The manual documents an open toolkit built around 'bridge forms' - identical written words recurring across two or more subject domains with a different sense in each - to test whether transformer language models individuate word occurrences by context beyond the embedding layer. It covers declarative specification of bridge forms, Wikipedia corpus acquisition, occurrence localization, layer-wise representation extraction, domain-pairwise silhouette measurement, and visualization, justifying each choice against failure modes such as sense contamination and subword-tokenization misalignment. It is a methodological and implementation reference and reports no empirical results.

arXiv cs.AI / cs.LG / cs.CL · 11d agoAI research

Update modules/auxiliary/scanner/http/elasticsearch_tika_xfa_xxe.rb

Rapid7 updated a Metasploit auxiliary scanner module that detects XML external entity injection in Elasticsearch via Apache Tika.

A commit in the Metasploit Framework updated modules/auxiliary/scanner/http/elasticsearch_tika_xfa_xxe.rb, an auxiliary scanner module. The module targets XML external entity (XXE) injection in Elasticsearch through Apache Tika, and was co-authored by jheysel-r7. The terse commit message contains no additional details, CVE references, or exploitation notes.

Metasploit Framework commits · 7d agoTools

Google's AI genome system evaluates every possible one-base change

Google's AlphaGenome AI system predicts functional effects of non-coding DNA variants in humans and mice.

Google's AlphaGenome AI system evaluates genomic sequences to predict gene expression, transcription factor binding, chromatin accessibility, splice site usage, and related genomic features. The system is currently limited to human and mouse sequences and a limited set of well-studied cell types, but its predictions generally match or exceed specialized software tools. Researchers can use it to assess whether non-coding variants are likely significant and generate hypotheses about their function.

Ars Technica · AI · 6d agoAI research

Climate-ModernBERT: Revisiting Corpus Composition for Domain-Adaptive Continued Pretraining

Climate-ModernBERT domain-adapted encoders reach 76.3 average F1 across nine climate benchmarks, 2.8 points above vanilla ModernBERT-Base.

The authors continue pretraining ModernBERT-Base on three climate corpora - academic text, climate-filtered web data, and synthetic documents - and compare joint mixtures against parameter-space merging of specialized checkpoints. The best model achieves 76.3 average F1 across nine climate NLP benchmarks, a 2.8-point improvement over the vanilla baseline. Academic climate corpora provide the strongest adaptation signal, and parameter-space merging outperforms joint multi-source training while preserving complementary corpus information; all variants are released.

arXiv cs.AI / cs.LG / cs.CL · 8d agoAI research

[AINews] Jev: a “System One Model” that only decides/classifies/routes/scores — >100x faster, >200x cheaper than small frontier LLMs

TypeSafe launches Jev, an RLCD-trained decision model claiming 20-200x faster, 40-400x cheaper classification than frontier LLMs, alongside Gemini 3.8 Live and Neon.

TypeSafe's Jev is a 'System One' decision model trained with RLCD, claiming 20-200x faster and 40-400x cheaper classification and routing than frontier LLMs with free output tokens and no hallucinated text. Google launched Gemini 3.8 Live and 3.8 Live Extended Thinking, supporting 97 languages and async tool calls, debuting #1 on Artificial Analysis' speech-to-speech index at 82.6. Periodic Labs' Neon is a ~1T-parameter XRD analysis model trained with RL on proprietary lab data using 1,300 H200s, lifting FrontierXRD success from 2.7% to 55.3% and beating GPT-6 Astra at lower inference cost.

Latent Space · 2h agoModel release

What Breaks Under Pruning in Smart Homes, and When? Evaluating LLM Degradation Across Architectures and Task Complexity

Pruning study across four LLM architectures finds dense models degrade sharply on smart-home tool calling while MoE models tolerate far more.

Researchers systematically study pruning-induced degradation in smart-home tool calling across four LLMs spanning dense Transformer, dense hybrid, and mixture-of-experts architectures, combining depth, width, hybrid, and expert pruning methods, and evaluate over 19,500 instances from three datasets after post-pruning supervised fine-tuning. Dense models show narrow safe pruning regions followed by sharp degradation, while MoE models tolerate substantially more pruning. Pruning degrades grounded specificity (operation, device, argument, value) before schema-level intent, and aggressive dense pruning can induce systematic over-refusal.

arXiv cs.AI / cs.LG / cs.CL · 20h agoAI research

Subgroup Packing for Batched PASTA Transciphering

Interleaved subgroup packing cuts PASTA homomorphic transciphering server cost by a median 1.60x at the expense of remaining noise capacity.

The paper studies how record word layout affects the cost of PASTA transciphering, where a server converts symmetrically encrypted records into homomorphic ciphertexts. A subgroup layout interleaves records so cyclic shifts preserve positions, reducing required displacements from 255 to 128 versus contiguous packing. In HElib across twelve paired corpora under six homomorphic keys, the median direct-to-subgroup server cost ratio is 1.60 including fresh generation, conversion, and two queries, but with less remaining noise capacity.

arXiv cs.CR · 5d agoResearch

XHToken/Spark-X2.5-4B-GGUF — new model trending #30 on Hugging Face

XHToken released GGUF weights of Spark-X2.5-4B, a compact model with 1M-token context and 200+ language support, under Apache 2.0.

The Hugging Face repository provides BF16 GGUF conversions of Spark-X2.5-4B, a compact general-purpose language model for conversation, writing, translation, reasoning, coding, tool use, and agentic workflows. The model uses a hybrid attention architecture, supports a native context length up to 1M tokens, and covers more than 200 languages. Local inference is supported through Ollama and LM Studio via an XHToken llama.cpp fork, with a --think=false flag to disable thinking mode for faster responses. Released under Apache License 2.0; it was trending #30 on Hugging Face at publication.

Hugging Face trending models · 19d agoModel release

Flextype v1.0.0-alpha.3 Server-Side Request Forgery via fetch() in Query API

Flextype CMS v1.0.0-alpha.3 exposes an SSRF flaw in its /api/v1/query endpoint, letting authenticated users make the server send arbitrary HTTP requests.

Flextype CMS v1.0.0-alpha.3 contains a server-side request forgery vulnerability in the expression-processing functionality of the /api/v1/query endpoint. An authenticated remote attacker can supply an arbitrary URL to the exposed fetch() function, causing the server to issue outbound HTTP requests. The application does not sufficiently restrict destination hosts, enabling requests to attacker-controlled or internal targets.

Full Disclosure · 12d agoVulnerability 8 sources

Can your coding style predict whether your code is vulnerable?

University of Massachusetts Dartmouth researchers present VulStyle, a stylometry-based vulnerability detector that also exposes benchmark reliability problems.

VulStyle combines stylometric features with syntax-tree structure and source tokens, pre-trained on about 4.9 million functions across seven programming languages and fine-tuned on five vulnerability detection datasets. It beat token-only detectors on some benchmarks but its F1 drops sharply on DiverseVul, which the authors link to noisy labels inflating reported performance across popular datasets. The authors argue style-aware detection should be harder to evade but did not test this empirically, and they note that uniform LLM-generated code may strip away the individual developer style the model depends on.

Help Net Security · 23d agoResearch1

When the prompt becomes the payload: A practical pen-testing guide for GenAI, LLM and RAG applications

CSO Online publishes a practical penetration-testing guide for GenAI, LLM, and RAG applications, covering prompt injection, retrieval poisoning, and tenant isolation testing.

The guide frames LLM applications as attack graphs spanning prompts, retrieval layers, vector stores, tools, identities, and downstream APIs, arguing that conventional web testing misses instruction-vs-data channel risks. It builds on OWASP prompt injection guidance (direct vs. indirect injection) and NIST's 2025 adversarial machine-learning taxonomy, noting that RAG and fine-tuning do not remove injection risk. Recommended practices include documenting trust transitions across components, using canaries and synthetic records to avoid test side effects, running multi-turn and obfuscated injection campaigns, and verifying chains from poisoned documents to observable state changes. It also details testing RAG pipelines via controlled document poisoning across metadata, OCR layers, and code comments, plus cross-tenant isolation checks on retrieved document IDs.

CSO Online · 7d agoAI safety & security1

The 2026 PNPL Competition: Word Classification and Efficient Cross-Subject Generalisation in LibriBrain100

The 2026 PNPL competition releases LibriBrain100, a MEG speech dataset with 32 extra subjects, targeting word classification and cross-subject BCI generalization.

The 2025 PNPL competition on non-invasive speech decoding from MEG achieved F1-macro scores of 95.6% for speech detection and 73.6% for phoneme classification, built on LibriBrain's ~50 hours of single-subject data. The 2026 edition extends this with LibriBrain100, adding 32 subjects (~40 minutes each) plus ~80 hours of within-subject data. Two tracks target within-subject word classification at scale and cross-subject generalization with subject-specific fine-tuning shrinking from ~40 to ~20 to ~10 minutes, aiming at clinically feasible non-invasive BCIs for people with profound paralysis.

Hugging Face daily papers · 13d agoAI research

Evaluating Time-Series Foundation Models and Multimodal Dietary Context for CGM Forecasting

Study finds zero-shot time-series foundation models underperform on CGM forecasting; fine-tuned Chronos-Bolt cuts RMSE up to 18.4% and dietary context adds signal.

The paper evaluates time-series foundation models for continuous glucose monitoring forecasting across eight public datasets covering Type 1 diabetes, Type 2 diabetes, and non-diabetes populations. Under a unified protocol, zero-shot foundation models did not consistently outperform baselines like Elastic Net and PatchTST, but lightweight fine-tuning did, with fine-tuned Chronos-Bolt reducing RMSE by 6.5%-18.4% in the T1D cohort and 8.6%-18.2% in the non-diabetes/T2D cohort. A residual-based fusion framework adding dietary context from CGMacros reduced overall RMSE by about 3% and postprandial RMSE by about 15% versus CGM-only baselines.

arXiv cs.AI / cs.LG / cs.CL · 5d agoAI research

Meta FAIR Introduces AI Research Preference Models (RPMs): Ranking ML Experiments Before Spending GPU Hours

Meta FAIR, Oxford and UCL introduce Research Preference Models that rank unexecuted ML experiments, lifting AIRS-Bench scores from 0.684 to 0.729 and cutting compute ~1.6×.

Researchers from Meta FAIR, Oxford, and UCL introduce Research Preference Models (RPMs), which use frozen pretrained LLMs (Qwen3.6-27B backbone, no fine-tuning) to rank unexecuted experiment candidates and execute only the winner of a pairwise knockout tournament. Two variants shipped: an inference-only LLM-as-a-judge and an agentic variant that runs small pilot experiments in an H200 sandbox. On AIRS-Bench (20 tasks, 24 hours on one H200, 10 seeds), scores rise from 0.684 (random) to 0.711 and 0.729 versus a 0.748 validation oracle, and both variants reach the baseline's 24-hour score in roughly 15 hours. The team reports new SOTA on WinoGrande (94.1% with Agentic RPM) and SVAMP (95.7% with inference-only).

MarkTechPost · 9d agoAI research

Diffs vs. Whole Files: An Empirical Comparison of Iterative Edit-Based and Direct Generation for Flutter/Dart Code Models

Empirical study finds direct whole-file generation beats iterative diff-based editing for Flutter/Dart code models on about 1,790 held-out tasks.

Researchers trained Rainbow-Pony-100M from scratch and fine-tuned Qwen2.5-Coder-0.5B in both direct-generation and diff-based regimes, then evaluated four resulting models on roughly 1,790 Flutter/Dart tasks. Direct generation outperformed diff-based generation on compilation pass rate, bits-per-byte, character-level similarity, and blinded LLM-judge ratings. Diff-based editing is competitive only on short, localized edits in refactoring and error-handling tasks, a property the authors call task locality.

Hugging Face daily papers · 11d agoAI research1

Does Syntax Matter? A Graph-Augmented Variational Topic Model for Computational Social Sciences

SCPTM graph-augmented variational topic model shows syntax aids topic diversity and descriptor quality but gains stem mainly from the variational encoder.

The Structural Contextual Probabilistic Topic Model represents corpora as heterogeneous document-word graphs with lexical and syntactic edges processed by a Graph Attention Network inside a VAE for mixed-membership topic distributions. Across four corpora, neural gains in document-topic alignment are attributable to the variational encoder rather than syntax, while graph-augmented variants improve topic diversity everywhere. Dependency paths add value on argumentative deliberative texts but are redundant in technical and institutional registers.

arXiv cs.AI / cs.LG / cs.CL · 8d agoAI research

Retrofitting Code Using LLMs to Support Exceptional Behavior

EXCODER combines static/dynamic analysis with LLMs to retrofit exception-handling code, achieving 85.92% pass@1 with Qwen 2.5 Coder 32B on Java benchmarks.

The paper introduces the task of retrofitting existing code with Exception Related Code (throw statements, guarding conditions, try/catch blocks) so that given Exceptional Behavior Tests pass. EXCODER performs context engineering by integrating static and dynamic program analysis output with LLMs; it was evaluated on a benchmark built from 304 methods across 75 GitHub Java projects. Combined with Qwen 2.5 Coder 32B, EXCODER achieves pass@1, 5, and 10 rates of 85.92%, 86.18%, and 86.51%, roughly 13 percentage points over baseline, and manual inspection reveals remaining limitations.

arXiv cs.AI / cs.LG / cs.CL · 6d agoAI research1