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Google DeepMind Releases AlphaGenome Atlas With Precomputed Molecular Effect Predictions and AVI Scores for 9 Billion Human DNA Variants

Google DeepMind launched AlphaGenome Atlas, precomputing molecular effect predictions and AVI impact scores for ~9 billion human single-nucleotide variants in a 1-petabyte catalogue.

Google DeepMind released AlphaGenome Atlas, a 1-petabyte catalogue of precomputed molecular effect predictions for roughly 9 billion possible single-nucleotide variants in the human genome. It introduces the AlphaGenome Variant Impact (AVI) score, combining AlphaGenome regulatory predictions with AlphaMissense, plus per-variant feature attributions and over 2,500 recurrent DNA sequence motifs. DeepMind reports best-in-class AVI performance on variant pathogenicity and rare disease benchmarks. Early users at the Broad Institute, University of Exeter, and Stowers Institute demonstrated rare-disease variant reprioritization and 22% more non-coding associations across 54,000+ UK Biobank genomes.

MarkTechPost · 8d agoAI research2

New insights from Google’s AI & Economy ATLAS

Google launches an interactive AI & Economy ATLAS experience; new research shows nearly half of surveyed scientists use AI daily.

Google introduced new interactive, open-access data visualizations for its AI & Economy ATLAS project tracking global AI adoption patterns. Research from Google, Google DeepMind, and MIT FutureTech analyzed 2,600 specialized AI models and surveyed over 600 U.S. and U.K. scientists, finding nearly half use AI daily and report saving almost seven hours per week. The study also found validation bottlenecks and a growing backlog of untested hypotheses limiting research productivity gains.

Google · AI · 1d agoAI industry

Google DeepMind Releases AlphaGenome Atlas

Google DeepMind released AlphaGenome Atlas, a 1-petabyte database pre-computing effects of all 9 billion single-nucleotide variants in the human genome, with a unified AVI score.

Google DeepMind launched AlphaGenome Atlas, a database that predicts the regulatory impact of every possible single nucleotide variant across the roughly 3 billion base pairs of the human genome, yielding a 1-petabyte dataset. It introduces the AlphaGenome Variant Impact (AVI) score, combining coding and non-coding predictions for rapid variant prioritization. Broad Institute researchers used it to support solving an unsolved rare disease case via a predicted DNM1 splice variant, and analysis of 54,000+ UK Biobank participants uncovered 22% more non-coding genetic associations, including 19 regions linked to BMI. The Atlas is available through a no-code web portal.

Hacker News · AI · 8d agoAI researchHN 44↑ · 4 comments

Deepmind's AlphaGenome Atlas maps every possible DNA change in the human genome

DeepMind's AlphaGenome Atlas precomputes impact predictions for ~9 billion human DNA variants in a 1-petabyte dataset; its AVI score beats CADD in benchmarks

Google DeepMind released the AlphaGenome Atlas, precomputing functional-effect predictions for roughly 9 billion human genome variants (about 27,000 prediction values per variant) in a one-petabyte dataset more than 30 times the size of the AlphaFold database. The accompanying AlphaGenome Variant Impact Score (AVI), a small neural network combining AlphaGenome, AlphaMissense and evolutionary conservation features (18 inputs versus CADD's 150+), outperformed existing tools on clinically classified variants, ranking causal variants in the top 50 candidates for 29.5% of solved GREGoR cases versus 12.5% for CADD. A GREGoR epilepsy case illustrates the impact: AVI elevated a previously unclear DNM1 splice variant that lab experiments confirmed as likely disease-causing. The atlas is available for noncommercial use via web portal, API and a Google Antigravity skill, with a commercial version planned through Google Cloud.

The Decoder · 7d agoAI research

Google’s Atlas of the human genome could pave the way for new treatments

Google DeepMind launches AlphaGenome Atlas, a catalog of predicted molecular effects for roughly nine billion single-letter DNA changes across the human genome.

Google DeepMind unveiled AlphaGenome Atlas, a roughly 1-petabyte dataset predicting how each of about nine billion possible single-nucleotide variants affects molecular biology, including non-coding regions that regulate gene behavior. It builds on the AlphaGenome model released in 2025 and adds a Variant Impact Score (AVI) to help researchers rank variants. The catalog is available for noncommercial research via a web portal, the Antigravity platform, and the AlphaGenome interface, with commercial access on Google Cloud planned.

The Verge · AI · 8d agoAI industry 2 sources

Atlas: Efficient Verifiable Semantic Search

Atlas delivers zero-knowledge proofs for HNSW semantic search, verifying RAG retrieval in under a second on SIFT1M and 2.0 seconds at 100M vectors.

Atlas lets a search provider prove that a query was answered correctly against a committed HNSW index without revealing the index, addressing provider deviations like truncation or bias. It combines offline preprocessing, a fixed-size-state restructuring of HNSW with a correctness proof, and timestep-tagged batching of per-step arguments. The system proves queries in under a second on SIFT1M and 2.0 seconds at 100 million vectors while preserving plaintext HNSW recall, and proven retrieval maintains end-to-end RAG answer quality at lower cost than prior verifiable retrieval systems.

arXiv cs.CR · 6d agoResearch1

Building AI to accelerate science and improve lives

Google highlights AI-for-science advances: AlphaGenome Atlas mapping 9 billion genetic variants, WeatherNext 3 weather model, and global health AI tools.

Google detailed AI advances across science and health, including AlphaGenome Atlas, which mapped all 9 billion possible single-letter genetic changes in the human genome and was made openly available. WeatherNext 3 delivers 50% more accurate precipitation forecasts a day or more ahead and is already in products. AlphaFold is used by 4 million researchers in 190 countries, TB chest X-ray screening has processed 25,000+ scans across six nations, and the diabetic retinopathy model has supported 1.15 million screenings. Google also released its AI & Economy ATLAS global usage insights.

Google · AI · 1d agoAI industry

UltraViolet Cyber Equinox measures detection coverage against MITRE frameworks

UltraViolet Cyber launches Equinox, an AI-automated platform mapping SIEM and EDR detection coverage against MITRE ATT&CK and ATLAS frameworks.

UltraViolet Cyber announced Equinox, a detection engineering platform from its TIDE team that maps existing detections and log sources against MITRE ATT&CK and MITRE ATLAS. It performs coverage analysis in under 30 minutes and recommends vendor or custom detections to fill gaps, with engineers reviewing and backtesting each recommendation. In one customer trial, mapped technique coverage rose from 59 of 222 techniques (26.6%) to 136 of 222 (61.3%) without increasing alert volume.

Help Net Security · 1d agoTools2

The AI graveyard: a running list of projects and startups that didn’t make it

TechCrunch compiles a running list of failed AI products and startups, including Relay, OpenAI's Sora, Humane AI Pin, Notion Mail, and Microsoft's Recall.

TechCrunch's 'AI graveyard' tracks notable AI products and startups that shut down or underperformed, citing S&P Global data that about 42% of AI initiatives are abandoned. Examples include the Relay automation startup, OpenAI's Sora video platform (shut March 2026), ChatGPT Atlas browser (discontinued August 9), Notion Mail (shutting September 22), and Apple's delayed Siri AI that contributed to a $250 million settlement. Hardware failures include the Humane AI Pin ($230 million raised, assets sold to HP for $116 million) and the Rabbit R1, which sold 100,000 units but received poor reviews. Microsoft's Recall feature remains controversial after a researcher demonstrated a tool extracting its captured data.

TechCrunch · AI · 1d agoAI industry1

Sequoia doubles down on Cymphony as AI agents create new enterprise security risks

Cymphony emerges with $30M from Sequoia and SMBC to give security teams unified visibility into AI agent and non-human identities.

Cymphony, a New York- and Tel Aviv-based startup, raised a $25 million Series A co-led by Sequoia and SMBC Fin Atlas Beyond Fund, valuing it above $100 million. Its platform builds a "workforce graph" unifying identity, data, and activity signals for employees, AI agents, and other non-human identities. The company says it found roughly 85,000 files exposed to AI tools at one US public company and reached seven-figure ARR in its first year of sales with customers including KKR and Syngenta. Sequoia previously led its undisclosed seed round, betting on Israeli Talpiot program alumni founders.

TechCrunch · Security · 7d agoIndustry

Chrome is now shipping updates every 2 weeks as AI changes the security landscape

Google switches Chrome to two-week release cycles starting with Chrome 153, shrinking the N-day patch gap as AI-driven threats accelerate.

Chrome officially moved from a four-week to a two-week release schedule with Tuesday's launch of Chrome 153 on desktop, iOS, and Android. Google ties the change to its evolving security strategy, saying faster releases shrink the N-day patch gap as AI tools and community bug reports increase patch volume. Mozilla, Microsoft, and Brave have already adopted the two-week cadence, and Google is also racing AI-native browsers like Brave, Dia, Opera Neon, and Perplexity's Comet while experimenting with AI features in Chrome.

TechCrunch · Security · 8d agoIndustry

Reflectiz Launches Agentic Pentesting for Websites: Up to 10x Coverage vs Conventional Pentests

Reflectiz launched a multi-agent AI penetration testing platform for websites, claiming up to 10x more coverage than conventional pentests.

Reflectiz, a continuous web exposure management vendor, launched a multi-agent penetration testing platform for websites under a new Offensive Hub. Four specialized agents crawl the site like a real user, fingerprint the stack, run attacks, and independently validate findings to remove false positives. The company claims up to 10x more coverage than conventional pentesting by starting from its pre-existing live model of each site. Findings integrate via REST API, CI/CD triggers and Slack, and the Atlas remediation agent guides fixes.

CSO Online · 8d agoTools

Reflectiz Launches Agentic Pentesting for Websites: Up to 10x Coverage vs Conventional Pentests

Reflectiz launched a multi-agent AI penetration testing platform for websites, claiming up to 10x more coverage than conventional pentests by leveraging existing site context.

Reflectiz, a web exposure management vendor, announced an agentic penetration testing product within a new Offensive Hub. The platform uses specialized AI agents for crawling, stack fingerprinting, attack execution, and independent validation, claiming to cover the OWASP Top 10 and reduce false positives. Findings integrate with existing workflows via REST API, CI/CD triggers, and Slack, and an AI remediation agent named Atlas guides fixes. The announcement is a vendor press release with a planned September 15 webinar demo.

GBHackers · 8d agoTools 2 sources

IFM Releases K2 Horizon: Six Apache 2.0 Models From 0.9B to 375B

MBZUAI's IFM released K2 Horizon, six Apache 2.0 models (0.9B-375B) with open training data, code, and checkpoints, claiming the largest fully open-source launch.

The Institute of Foundation Models (IFM), launched by MBZUAI, released K2 Horizon: six Apache 2.0 models (0.9B, 3.7B, 7B, 32B, 36B-A4B, 375B-A23B) shipping with the ~20-trillion-token pretraining corpus, intermediate checkpoints, training code, and logs, which IFM calls the largest fully open-source launch in AI history. The 375B-A23B scores 70.2 on Terminal-Bench 2.1 and 87.3 on GPQA Diamond; the 7B model posts 70.6 on SWE-bench Verified. New techniques include MoVA, which extends MoE routing into attention (36B total, ~4B active), and Uno, a LoRA adapter giving roughly 3x lossless decoding speedup. IFM's own reward-hacking audit re-scored 375B-A23B from 70.2% to 66.9% after flagging 24 of 712 Terminal-Bench trials.

MarkTechPost · 9d agoModel release1

What 90 days and a small budget can buy in AI agent security

Versa Field CISO details hidden costs of self-hosting open-weight models and a 90-day AI agent security plan of inventory, blast-radius reduction and testing.

In a Help Net Security interview, Prasad Tharippala, Field CISO at Versa, argues running open-weight models in-house improves control but shifts hardening, patching, access control, monitoring and incident response onto the buyer, with underestimated costs in GPU infrastructure, licensing review, EU AI Act compliance and scarce AI/ML security skills. On red-teaming AI agents, he recommends testing prompt injection, indirect injection, excessive permissions, data leakage, memory and RAG poisoning, malicious tool outputs, cross-agent trust abuse and infrastructure attack paths, mapped to OWASP agentic guidance and MITRE ATLAS. He highlights the handoff between chained agents as a major risk zone and stresses exercising human approval, shutdown and rollback controls under test conditions. For teams with 90 days and small budgets, he ranks inventory, blast radius reduction and ongoing testing as the priority order.

Help Net Security · 19d agoAI safety & security

[AINews] 10% worse, 100x cheaper, 10000x faster: Why Simulation is taking over

Latent Space argues AI training pipeline stages—rewards, data, teachers, curricula, environments—are flipping from human-made to model-made simulation.

Latent Space's AINews essay traces how each component of AI training has turned synthetic since 2022: reward models (InstructGPT, RLAIF), synthetic pretraining data (Microsoft Phi, NVIDIA Nemotron-4 340B), model teachers (Alpaca, DeepSeek-R1 distillation), and self-generated curricula (Self-Rewarding Language Models, SPIN). In 2026 it highlights Karpathy's autoresearch loop—700 experiments yielding 20 kept improvements, cutting GPT-2 training time from 2.02 to 1.80 hours—and Z.ai's GLM-5.3 fully synthetic RL environment, judging, and verification stack. It frames these shifts as 'simulation': 10% worse but 100x cheaper and 10,000x faster than human equivalents.

Latent Space · 25d agoAI industry

NETSCOUT expands Adaptive DDoS Protection with outbound attack mitigation

NETSCOUT extended Adaptive DDoS Protection to detect and mitigate outbound DDoS traffic at source, targeting IoT botnet attacks like Turbo-Mirai.

NETSCOUT announced an extension of its Adaptive DDoS Protection (ADP) for service providers to automatically detect and mitigate outbound DDoS traffic from compromised subscriber devices such as broadband routers and IoT devices. The capability addresses Turbo-Mirai-class botnets capable of multi-terabit attacks and integrates with Arbor Sightline, Arbor Threat Mitigation System, the ATLAS Intelligence Feed, and ASERT analysts. Source-side mitigation aims to reduce outages, transit costs, peering damage, and abuse complaints at ISPs.

Help Net Security · 29d agoTools