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Google DeepMind Releases AlphaGenome Atlas With Precomputed Molecular Effect Predictions and AVI Scores for 9 Billion Human DNA Variants

Google DeepMind launched AlphaGenome Atlas, precomputing molecular effect predictions and AVI impact scores for ~9 billion human single-nucleotide variants in a 1-petabyte catalogue.

Google DeepMind released AlphaGenome Atlas, a 1-petabyte catalogue of precomputed molecular effect predictions for roughly 9 billion possible single-nucleotide variants in the human genome. It introduces the AlphaGenome Variant Impact (AVI) score, combining AlphaGenome regulatory predictions with AlphaMissense, plus per-variant feature attributions and over 2,500 recurrent DNA sequence motifs. DeepMind reports best-in-class AVI performance on variant pathogenicity and rare disease benchmarks. Early users at the Broad Institute, University of Exeter, and Stowers Institute demonstrated rare-disease variant reprioritization and 22% more non-coding associations across 54,000+ UK Biobank genomes.

MarkTechPost · 7d agoAI research1

Inside NVIDIA’s cuDNN Graph API: Fusion, Autotuning, and Plan Reuse with cuDNN Frontend

MarkTechPost tutorial walks through NVIDIA's cuDNN Frontend graph API, covering kernel fusion, autotuning, plan reuse, and CUDA graph capture on Colab GPUs.

The tutorial explains how to express GPU computations as operation graphs via the cuDNN Frontend graph API, running the five-step build pipeline of validate, build operation graph, create execution plans, check support, and build plans. It progresses from a single fused convolution with bias and ReLU to autotuning across engine configs, FP8-style epilogues, attention, plan serialization, dynamic shapes, and CUDA graph capture. Each kernel is benchmarked against a PyTorch reference on a single Colab GPU to verify correctness and measure cost. The piece also covers practical setup issues like making libcudnn.so visible to the frontend's dynamic loader.

MarkTechPost · 1h agoAI tools & infra

Google Releases Gemini 3.8 Live and 3.8 Live Extended Thinking for Production Grade Voice Agents

Google launches Gemini 3.8 Live and Extended Thinking speech-to-speech models for production voice agents, topping speech-to-speech benchmarks.

Google released Gemini 3.8 Live and Gemini 3.8 Live Extended Thinking, native speech-to-speech models for real-time voice agents, available hosted via the Gemini Live API and AI Studio. Extended Thinking ranks #1 on Artificial Analysis' Speech-to-Speech Quality Index with 82.6, scores 68.6% on τ-Voice, 35.1% on Sierra's τ-Voice-banking, and 97.7% on Big Bench Audio. The models support asynchronous function calling, near-real-time visual context, alphanumeric precision, and 97 languages, priced at $0.005/min audio input and $0.018/min audio output. All generated audio carries Google DeepMind's imperceptible SynthID watermark.

MarkTechPost · 2h agoModel release 3 sources

Hierarchical NeRF with JAX3D for Volumetric Rendering, Novel-View Synthesis, and 3D Reconstruction

MarkTechPost tutorial implements a hierarchical NeRF in JAX using jax3d volume-rendering primitives for novel-view synthesis and 3D reconstruction.

The tutorial builds an end-to-end hierarchical Neural Radiance Field using JAX, Flax, Optax, and jax3d's volume-rendering functions (sample_along_rays, volume_rendering, sample_piecewise_constant_pdf). It implements positional encoding, skip connections, separate coarse and fine networks, and view-direction conditioning with hierarchical importance sampling. Training uses JAX JIT compilation, Adam optimization, exponential learning-rate decay, and gradient clipping. Evaluation covers PSNR, depth and opacity visualization, 360-degree rendering, and marching-cubes geometry extraction.

MarkTechPost · 2d agoAI research

DeepSeek AI Released DeepSeek-V4.1-Flash with 1M Context, FP4 KV Cache, and Cross-Layer Attention Reuse

DeepSeek released open-weight V4.1-Flash, a 552B MoE model with 1M context and FP4 KV cache, beating Opus-5 and GPT-5.6 Sol on agent benchmarks.

DeepSeek-V4.1-Flash is a multimodal Mixture-of-Experts model with a 552B-parameter backbone plus 196B Engram parameters, activating 8B parameters at prefill and 16B at decode, with a 1M-token context window. It introduces a causal encoder-decoder design, Compressed Sparse Attention 2, and FP4 (E2M1) KV cache quantization, cutting global KV cache to 890 bytes per token, about 1/4 of V4-Flash and 437x smaller than V1. Pre-training covered 45T multimodal tokens; the MIT-licensed weights ship on Hugging Face with vLLM and SGLang support. It scores 90.6 on Terminal-Bench 2.1 and 74.2 on DeepSWE v1.1, ahead of Opus-5 and GPT-5.6 Sol.

MarkTechPost · 5d agoModel release1

LandingAI Releases Agentic Document Extraction Gen2 with DPT-3 Pro and DPT-3 Verity

LandingAI shipped Agentic Document Extraction Gen2 with DPT-3 Pro and DPT-3 Verity parsing models, adding usage-based billing, block-tree outputs, and word-level grounding.

LandingAI has generally released Agentic Document Extraction Gen2, rebuilt around two parsing models: DPT-3 Verity for deterministic transcription of digital documents with per-word bounding boxes and confidence scores, and DPT-3 Pro for layout-aware parsing of scans, handwriting, non-Latin scripts, and LaTeX math. Billing changes from a flat 3 credits per page to a page-plus-output-character model (Pro: 1 credit/page plus 0.5 credits per 1,000 output characters on priority; Verity: 0.3 plus 0.2), with an asynchronous standard tier at 0.5x price and vendor-claimed 25-80% cost reductions. Parse v2 returns a document-page-block tree with semantic IDs, normalized bounding boxes, and line- or word-level atomic grounding, replacing flat chunks; Gen1 client code will not run against Gen2 endpoints. Deployment options include US/EU cloud, VPCs on AWS, Azure, and Google Cloud, Snowflake, and air-gapped on-premises environments, with automated model routing planned for fall 2026.

MarkTechPost · 5d agoAI tools & infra

NVIDIA Announces CUDA Rust with cuda-oxide (SIMT) and cutile-rs (Tile) for Compile-Time-Safe GPU Kernels

NVIDIA launches CUDA Rust via open-source cuda-oxide (SIMT) and cutile-rs (Tile), bringing compile-time-safe Rust GPU kernels.

NVIDIA announced CUDA Rust, making Rust a first-class language for GPU kernels through two NVlabs open-source projects: cuda-oxide for the SIMT model and cutile-rs for the Tile model. Both use Rust's ownership and borrow checker to catch buffer aliasing bugs at compile time. cutile-rs is published on crates.io, runs on stable Rust 1.89+ with CUDA 13.3, and is already used in Hugging Face's Grout inference engine and mistral.rs; cuda-oxide is early alpha requiring nightly Rust, CUDA 12.x, and compute capability 8.0+. cuda-oxide compiles Rust MIR through the community Pliron IR framework and LLVM to PTX, while cutile-rs JIT-compiles kernels via CUDA Tile IR.

MarkTechPost · 7d agoAI tools & infra1

Reducto Releases r-1: A Single Pass Document Parsing Model That Cuts Errors 20% at 1 Cent Per Page

Reducto launched r-1, a single-pass document parsing model claiming 20% error reduction over its legacy agentic pipeline, priced at 1 cent per page.

Reducto announced r-1, the first model in a new parsing family that replaces multi-stage agentic OCR with one full-page pass handling text, tables, figures, layout, formatting, and grounding with page-relative bounding boxes. The company reports a 20% error reduction measured against its own legacy agentic pipelines, plus vendor-run wins over Amazon Textract and Azure Document Intelligence on complex documents. Pricing is a flat 1 cent per page versus 3-6 cents for legacy models; r-1 is available in preview via the V3 Parse API with no open weights.

MarkTechPost · 7d agoModel release

IFM Releases K2 Horizon: Six Apache 2.0 Models From 0.9B to 375B

MBZUAI's IFM released K2 Horizon, six Apache 2.0 models (0.9B-375B) with open training data, code, and checkpoints, claiming the largest fully open-source launch.

The Institute of Foundation Models (IFM), launched by MBZUAI, released K2 Horizon: six Apache 2.0 models (0.9B, 3.7B, 7B, 32B, 36B-A4B, 375B-A23B) shipping with the ~20-trillion-token pretraining corpus, intermediate checkpoints, training code, and logs, which IFM calls the largest fully open-source launch in AI history. The 375B-A23B scores 70.2 on Terminal-Bench 2.1 and 87.3 on GPQA Diamond; the 7B model posts 70.6 on SWE-bench Verified. New techniques include MoVA, which extends MoE routing into attention (36B total, ~4B active), and Uno, a LoRA adapter giving roughly 3x lossless decoding speedup. IFM's own reward-hacking audit re-scored 375B-A23B from 70.2% to 66.9% after flagging 24 of 712 Terminal-Bench trials.

MarkTechPost · 8d agoModel release

H Company Releases NeoMME: A Family of 260M and 800M Single-Tower Multimodal Encoders That Drop the Vision Tower and Causal Decoder

H Company released NeoMME, 260M/800M single-tower multimodal encoders matching 3.75B ColQwen2.5 on ViDoRe v3 while being 14.4x smaller, under Apache 2.0.

H Company released NeoMME, a family of 262,937,906- and 793,715,032-parameter bidirectional encoders that process text and raw 32x32 image patches in a single tower, pretrained via masked diffusion and released under Apache 2.0 with day-zero Hugging Face Transformers support. NeoMME-Retriever-260M reaches 0.523 nDCG@10 on ViDoRe v3, matching 3.75B-parameter ColQwen2.5 while being 14.4x smaller; the 800M model scores 0.556. Hierarchical token pooling with int8 and binary quantization shrinks late-interaction indexes from roughly 1.5 MB to 6 kB per page while retaining 95.19% of nDCG@10; text-only BEIR retrieval remains a weak spot.

MarkTechPost · 9d agoAI research

Meta FAIR Introduces AI Research Preference Models (RPMs): Ranking ML Experiments Before Spending GPU Hours

Meta FAIR, Oxford and UCL introduce Research Preference Models that rank unexecuted ML experiments, lifting AIRS-Bench scores from 0.684 to 0.729 and cutting compute ~1.6×.

Researchers from Meta FAIR, Oxford, and UCL introduce Research Preference Models (RPMs), which use frozen pretrained LLMs (Qwen3.6-27B backbone, no fine-tuning) to rank unexecuted experiment candidates and execute only the winner of a pairwise knockout tournament. Two variants shipped: an inference-only LLM-as-a-judge and an agentic variant that runs small pilot experiments in an H200 sandbox. On AIRS-Bench (20 tasks, 24 hours on one H200, 10 seeds), scores rise from 0.684 (random) to 0.711 and 0.729 versus a 0.748 validation oracle, and both variants reach the baseline's 24-hour score in roughly 15 hours. The team reports new SOTA on WinoGrande (94.1% with Agentic RPM) and SVAMP (95.7% with inference-only).

MarkTechPost · 9d agoAI research

UC Berkeley Researchers Release CUA-Lite, an Open Platform Unifying Sandboxes, Data, Evaluation and RL for Computer-Use Agents

UC Berkeley's CUA-Lite is an open platform unifying computer-use agent sandboxes, datasets, evaluation and RL; Lite.OSWorld cuts OSWorld memory 4.1 GB to 0.9 GB.

UC Berkeley researchers released CUA-Lite, an open platform placing agents, environments, traces, and training for computer-use agents behind one action space, one LiteSample schema, and one command across desktop, browser, and mobile. Lite.OSWorld reproduces the OSWorld task suite and evaluators in plain Docker containers (0.9 GB RAM vs 4.1 GB, cold start 23.8s, ~4.6× more parallel instances), with scores matching the QEMU/KVM VM across 13 models. The platform claims 30k+ verifiable tasks, 15+ benchmarks, 10+ agents, and 20+ datasets on Hugging Face including Aguvis, OpenCUA, and ScaleCUA. A documented SFT run lifts Qwen3-VL-2B-Instruct mean episode return from 0.138 to 0.237 on the 332-task lite.osworld split.

MarkTechPost · 9d agoAI tools & infra1

Perplexity Details Its GPU Embedding Stack: How Ivy, Tulip and ROSE Serve pplx-embed

Perplexity details its GPU embedding serving stack (Ivy, Tulip, ROSE), which reuses LLM prefill/decode kernels, CUDA graphs, and LazyTensors to cut launch overhead.

Perplexity engineers published a deep dive on the serving infrastructure behind pplx-embed, used across Perplexity Search and its API platform. The stack comprises Ivy (Rust HTTP gateway), Tulip (gRPC scheduling and batching), and ROSE (Runtime-Optimized Serving Engine), which reuses LLM prefill and decode kernels rather than running a separate embedding engine. Optimizations include whole-model CUDA graphs with lazy capture and a LazyTensor abstraction that overlaps CPU batch preparation with in-flight GPU work. Benchmarks are reported against vLLM v0.22.0 in BF16, with FlashAttention 4 generally fastest but FlashInfer 3 winning on Qwen-based models at very long sequence lengths.

MarkTechPost · 9d agoAI tools & infra

GitHub Introduces Project HydraFusion: Runtime Multi-Model Orchestration That Builds a Workflow Per Coding Task in Copilot CLI

GitHub's Project HydraFusion research preview builds per-task multi-model workflows (Single, Cascade, Critique) in Copilot CLI, reporting +4.9 quality at 67% lower cost on TerminalBench 2.1.

Project HydraFusion is a research preview available on all GitHub Copilot plans inside Copilot CLI that treats model routing as workflow selection, choosing among Single, Cascade (draft plus quality gate), and Critique (cross-family reviewer) execution patterns per request. Against Claude Opus 5 baselines at medium reasoning, fixed HydraFusion policies cut estimated cost 67% while adding 4.9 quality points on TerminalBench 2.1, and cut cost 36% and 65% with slight quality dips on DeepSWE and CheckpointBench. Billing is per token at each underlying model's standard rate; there are no open weights or self-hosting options.

MarkTechPost · 10d agoAI tools & infra1

OpenBMB Releases MiniCPM5-2B: A 2.52B Dense Model Averaging 53.9 Across 34 Benchmarks and Built to Run On Device

OpenBMB released MiniCPM5-2B, a 2.52B-parameter Apache 2.0 on-device model averaging 53.9 across 34 benchmarks, ahead of Qwen3.5-4B.

OpenBMB released MiniCPM5-2B, a 2,516,756,480-parameter dense LlamaForCausalLM model with grouped-query attention and a 131,072-token context, under Apache 2.0, runnable via vLLM, SGLang, llama.cpp, and Ollama. It averages 53.9 across 34 benchmarks versus 51.1 for Qwen3.5-4B, with strong tool-use (97.1 on tau2-Bench Telecom) and code results (69.1 LiveCodeBench v6, 46.4 SWE-bench Verified). Training combined 400B tokens of deep-thinking SFT, critic-based JustRL II RL teachers, and on-policy distillation merging 16 RL experts; datasets and intermediate checkpoints were published alongside the weights.

MarkTechPost · 8d agoModel release