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Towards a Deterministic Math Solver for Clinical Language Models

Paper shows handing arithmetic to a deterministic Python solver beats direct model calculation at 32B but not reliably at 7B on MedCalc-Bench.

Researchers test a Program-Solve interface where clinical LLMs write case-specific Python executed by a restricted local solver instead of doing arithmetic directly. On MedCalc-Bench Verified (1,100 cases, 55 calculators), Qwen2.5-32B-AWQ scored 90.53% with solver handoff versus 83.47% with direct arithmetic (+7.05 points), while Qwen2.5-7B gained an unreliable +3.29 points with a confidence interval spanning zero. The authors audited the benchmark against clinical guidelines and flagged 16 of 55 calculators for version, use, or coefficient concerns.

Hugging Face daily papers · 7d agoAI research

Google DeepMind Releases AlphaGenome Atlas

Google DeepMind released AlphaGenome Atlas, a 1-petabyte database pre-computing effects of all 9 billion single-nucleotide variants in the human genome, with a unified AVI score.

Google DeepMind launched AlphaGenome Atlas, a database that predicts the regulatory impact of every possible single nucleotide variant across the roughly 3 billion base pairs of the human genome, yielding a 1-petabyte dataset. It introduces the AlphaGenome Variant Impact (AVI) score, combining coding and non-coding predictions for rapid variant prioritization. Broad Institute researchers used it to support solving an unsolved rare disease case via a predicted DNM1 splice variant, and analysis of 54,000+ UK Biobank participants uncovered 22% more non-coding genetic associations, including 19 regions linked to BMI. The Atlas is available through a no-code web portal.

AlphaGenome Atlas: A predictive map of every possible DNA letter change in the human genome

Google DeepMind released AlphaGenome Atlas, a free 1-petabyte platform predicting the molecular effects of all ~9 billion possible single-letter DNA variants.

Google DeepMind introduced AlphaGenome Atlas, containing precomputed predictions for the effects of roughly 9 billion single-nucleotide variants across the human genome, spanning hundreds of human and mouse cell types. The 1-petabyte dataset is more than 30 times larger than the AlphaFold Database and includes an AlphaGenome Variant Impact (AVI) score combining AlphaGenome and AlphaMissense predictions for both coding and non-coding regions. External collaborators have already used it to identify and experimentally verify variants in unsolved rare disease research. It is available via a free web portal, the AlphaGenome API, and as a skill in Google Antigravity.

Google DeepMind · 8d agoAI research 2 sources