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Threat Assessment: Ryuk Ransomware

Unit 42 assesses Ryuk ransomware amid a CISA/FBI/HHS alert on threats to U.S. healthcare, including the UHS attack that disrupted hospital operations.

A joint CISA, FBI, and HHS alert on October 28, 2020 warned of an imminent threat to U.S. healthcare from operators deploying Trickbot and Ryuk ransomware. Universal Health Services reported a Ryuk attack that disrupted all U.S. UHS sites for weeks, with similar incidents at hospitals in Oregon and New York. Ryuk typically arrives after Trickbot or BazaLoader infections delivered via malicious email, and operators enumerate networks with PowerShell and WMI before encryption. The Trickbot Anchor_DNS module performs DNS tunneling for C2, using connectivity checks to benign domains like ipinfo.io and checkip.amazonaws.com.

Palo Alto Unit 42 · Aug 17, 2026Ransomware in the wild

Threat Brief: 3CXDesktopApp Supply Chain Attack (Updated)

Trojanized 3CXDesktopApp installers for Windows and macOS loaded RC4-encrypted shellcode delivering a backdoor to hundreds of thousands of 3CX users.

Threat actors compromised the 3CXDesktopApp build process, adding malicious libraries (ffmpeg.dll, d3dcompiler_47.dll) to installers downloaded from the developer's website. The Windows MSI loader decrypts embedded shellcode with RC4, sleeps for a random 1-4 weeks, then beacons to C2 hidden in icon files on GitHub. Unit 42 fingerprinted 247,277 IPs across 199 countries using 3CX applications and blocked shellcode execution at 127 Cortex XDR customers between March 9-30, 2023.

Palo Alto Unit 42 · Aug 17, 2026Threat actor in the wild1