Cisco confirms active exploitation of ISE and ISE
Vulnerabilities mentionedAll →
| CVE | Vulnerability | CVSS | EPSS | Flags | Affected | Exposure | Published |
|---|---|---|---|---|---|---|---|
| CVE-2025-20281 +1 in the same advisory: …20282 | Unauthenticated Root RCE via API Injection in Cisco ISE and ISE-PIC CVE-2025-20281 is an injection flaw (CWE-74) in a specific API of Cisco Identity Services Engine (ISE) and Cisco ISE Passive Identity Connector (ISE-PIC), caused by insufficient validation of user-supplied input. An unauthenticated, remote attacker can trigger it by sending a crafted request to that API; no valid credentials or user interaction are required. A successful exploit yields arbitrary code execution on the underlying operating system with root privileges, giving the attacker full control of the affected device (scope-changing per the CVSS 10.0 score). Any organization running affected ISE or ISE-PIC releases is exposed, particularly where the vulnerable API is reachable from untrusted networks. The flaw is confirmed under active exploitation: CISA added it to the Known Exploited Vulnerabilities catalog on 2025-07-28, EPSS assigns a 97.1% probability of exploitation within 30 days, and ZDI has published a writeup of the unauthenticated root RCE. Do: Upgrade Cisco ISE and ISE-PIC to the patched releases specified in Cisco's PSIRT advisory, and check whether the vulnerable API/admin interface is reachable from untrusted networks, restricting access until patching is complete. As a KEV entry added 2025-07-28, U.S. federal agencies must apply vendor mitigations per BOD 22-01 guidance or discontinue use of the product; given EPSS of 97.1% and confirmed active exploitation, prioritize internet-facing ISE instances and review API/web-server logs for signs of exploitation. | 10.0 | 97% | KEV PoC |
| largeroughly tens of thousands of enterprise/government deployments worldwide (estimate), with an unknown subset exposing the vulnerable API to untrusted networks | |
| CVE-2025-20337 | Unauthenticated Injection Flaw Allows Root RCE in Cisco ISE and ISE-PIC CVE-2025-20337 is a critical (CVSS 3.1: 10.0) injection vulnerability (CWE-74) in a specific API of Cisco Identity Services Engine (ISE) and Cisco ISE Passive Identity Connector (ISE-PIC), caused by insufficient validation of user-supplied input. An unauthenticated, remote attacker can trigger it by submitting a crafted request to the affected API, with no valid credentials required. Successful exploitation allows arbitrary code execution on the underlying operating system with root privileges, giving the attacker full control of the affected device, consistent with the changed-scope, high-impact CVSS score. Any organization running Cisco ISE or ISE-PIC is potentially affected; CISA added the flaw to the Known Exploited Vulnerabilities catalog on 2025-07-28, and press reports indicate active exploitation, including zero-day use per Amazon threat intelligence coverage. EPSS assigns a 67% probability of exploitation within 30 days (99th percentile), and no public proof-of-concept is known. Do: Upgrade Cisco ISE and ISE-PIC to the fixed releases identified in Cisco's security advisory (fixed version details are not included in this data set), and check management/API logs for unauthenticated crafted API requests indicating exploitation. As an interim mitigation, restrict network access to the affected API and the ISE administration interface. Organizations covered by BOD 22-01 must apply vendor mitigations per Cisco's instructions or discontinue use of the product by the KEV remediation deadline. | 10.0 | 68% | KEV |
| moderatelikely on the order of tens of thousands of enterprise deployments worldwide (deployment-pattern estimate; no public install or scan counts) |
Full article504 words · extracted from securityaffairs.com · click to collapse

Cisco warns of active exploits targeting Identity Services Engine (ISE) and ISE-PIC flaws, first observed in July 2025.
Cisco confirmed attempted exploitation in the wild of recently disclosed ISE and ISE-PIC flaws (CVE-2025-20281, CVE-2025-20282, CVE-2025-20337), updating its advisory after detecting attacks in July 2025.
“Multiple vulnerabilities in Cisco Identity Services Engine (ISE) and Cisco ISE Passive Identity Connector (ISE-PIC) could allow an unauthenticated, remote attacker to issue commands on the underlying operating system as the root user.” reads the advisory. “In July 2025, the Cisco PSIRT became aware of attempted exploitation of some of these vulnerabilities in the wild. Cisco continues to strongly recommend that customers upgrade to a fixed software release to remediate these vulnerabilities.”
In June, Cisco addressed the critical vulnerabilities CVE-2025-20281 and CVE-2025-20282 in Identity Services Engine (ISE) and ISE Passive Identity Connector (ISE-PIC) that could allow remote, unauthenticated attackers to execute arbitrary code with root privileges.
“Multiple vulnerabilities in Cisco Identity Services Engine (ISE) and Cisco ISE Passive Identity Connector (ISE-PIC) could allow an unauthenticated, remote attacker to issue commands on the underlying operating system as the root user.” reads the advisory.
CVE-2025-20281 (CVSS score of 10) affects Cisco ISE/ISE-PIC 3.3+, while CVE-2025-20282 (CVSS score of 10) impacts only version 3.4. Versions outside these ranges are not impacted.
CVE-2025-20281 is a critical flaw in Cisco ISE/ISE-PIC allowing unauthenticated remote attackers to execute code as root via a vulnerable API.
“This vulnerability is due to insufficient validation of user-supplied input. An attacker could exploit this vulnerability by submitting a crafted API request.” continues the advisory. “A successful exploit could allow the attacker to obtain root privileges on an affected device.”
The second flaw, tracked as CVE-2025-20282, is a critical issue in Cisco ISE/ISE-PIC allowing unauthenticated remote attackers to upload and execute files as root via an internal API.
“This vulnerability is due a lack of file validation checks that would prevent uploaded files from being placed in privileged directories on an affected system. An attacker could exploit this vulnerability by uploading a crafted file to the affected device.” reads the advisory. “A successful exploit could allow the attacker to store malicious files on the affected system and then execute arbitrary code or obtain root privileges on the system.”
Last week, Cisco addressed the critical vulnerability CVE-2025-20337 (CVSS score of 10) in Identity Services Engine (ISE) and Cisco Identity Services Engine Passive Identity Connector (ISE-PIC). An attacker could trigger the vulnerability to execute arbitrary code on the underlying operating system with root privileges.
“Multiple vulnerabilities in Cisco Identity Services Engine (ISE) and Cisco ISE Passive Identity Connector (ISE-PIC) could allow an unauthenticated, remote attacker to issue commands on the underlying operating system as the root user.” reads the report published by the IT giant.
The vulnerability CVE-2025-20337 is similar to CVE-2025-20281.
Cisco did not share details about the attacks exploiting the flaws and the threat actors behind them.
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