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HypoEvolve: Genetic Algorithms Enable Multi-Agent LLMs to Discover Scientific Hypotheses

HypoEvolve uses a generational genetic algorithm coordinating specialized LLM agents to generate scientific hypotheses, outperforming six baselines on cancer drug repurposing.

HypoEvolve is a framework that coordinates specialized LLM agents through a generational genetic algorithm to produce, revise, and retain scientific hypotheses with explicit collaboration roles. It evaluates drug repurposing hypotheses against external evidence from DepMap and Open Targets across 34 cancer types. It achieves the highest scores against six baselines, reaching DepMap selectivity of 0.171 versus 0.115 for the strongest baseline, and gains over single-pass generation generalize to held-out cancer types.

Hugging Face daily papersupdated · 2d agofirst · 3d agoAI research 2 sources

GPT-6 Astra appears to show a "step change" in spatial reasoning based on early benchmarks

Early StationeryBench robotics results show OpenAI's GPT-6 Astra far ahead of Ai2's MolmoAct2 at dual-arm manipulation, completing 7 of 100 tasks versus zero.

A new robotics benchmark called StationeryBench tested OpenAI's GPT-6 Astra against Ai2's MolmoAct2 on five desk-object tasks using identical dual-arm YAM robots over 200 trials. Astra fully completed 7 of 100 tasks with a median progress score of 46 out of 100, while MolmoAct2 completed zero with a median score of 12. Cornell and Google DeepMind researcher Yoav Artzi called the result a 'step change in spatial reasoning' and noted Astra approaches human-level accuracy on the unpublished REMAP benchmark. He speculated OpenAI trained the model on large amounts of 3D data such as Blender scenes, and OpenAI reportedly plans consumer robots.

The Decoder · 4d agoAI industry1

Breaking the Vision-Action Shortcut: Latent Interface Training for Generalizable Robotics Foundation Models

Latent Interface Training improves robot foundation model generalization by constraining visual conditioning, boosting LIBERO-Plus success up to 10.7 points.

The paper identifies vision-action shortcuts where robot policies exploit task-irrelevant visual cues that fail under distribution shift. Latent Interface Training (LIT) first trains an action expert conditioned on language, robot state, and terminal SE(3) end-effector poses without images, then constrains visual input through a pose-supervised latent interface. Across four VLA and world-action architectures (Pi0.5, MolmoAct2, FAST-WAM, ImageWAM), LIT improves LIBERO-Plus success by 3.87-10.70 percentage points. Real-world tests show 13.30-16.70 percentage-point gains under unseen cameras, lighting, and distractors.

Hugging Face daily papers · 6d agoAI research

Domain-Specific Hallucination Detection in Large Language Models

A multi-signal pipeline detects LLM hallucinations, reaching F1 0.915 on HaluEval and cutting Qwen2.5-0.5B hallucination rates from 85.5% to 37.7% via DPO.

The paper presents a hallucination detection pipeline combining fine-tuned DeBERTa-v3 classification, Monte Carlo Dropout uncertainty, and temperature-scaled calibration. It achieves F1 0.915 and AUROC 0.977 on general-domain HaluEval tasks, with MC Dropout inference raising accuracy to 93.2%. Applying DPO to a Qwen2.5-0.5B generator reduces its hallucination rate from 85.5% to 37.7%, while cross-domain evaluation shows poor general-domain transfer to SciFact (F1 0.52) and PubMedBERT fine-tuning as the strongest adaptation (F1 0.63).

arXiv cs.AI / cs.LG / cs.CL · 6d agoAI research1

IFM/K2-Horizon-MoVA-36B-A4B — new model trending #15 on Hugging Face

IFM released K2-Horizon-MoVA-36B-A4B, an open-weights 36B-parameter MoE model with 4B active parameters and native 512K context.

IFM released the final checkpoint of K2-Horizon-MoVA-36B-A4B, a sparse Mixture-of-Experts model using Mixture-of-Values (MoVA) attention with 36B total and 4B active parameters. The model supports native 524,288-token context and reportedly outscores open-weight dense and MoE models up to 15x its size on agentic and reasoning benchmarks, while competing against closed frontier models. Intermediate checkpoints, training data, the training recipe, and training code are slated for public release.

Hugging Face trending models · 15d agoModel release

Linux Detection Engineering - Local Privilege Escalation

Elastic details a layered detection framework for Linux local privilege escalation, covering 2026's copy-on-write bug wave and LLM-assisted discovery.

Elastic Security Labs describes how most Linux local privilege escalations share a common host flow — an unprivileged process launched from a writable path becoming root — and proposes layered detections combining general outcome-based rules with per-technique rules in Elastic Defend and Auditd. It tracks 13 recent LPE disclosures, seven of which share a copy-on-write/zero-copy bug class, including Copy Fail, DirtyFrag, Fragnesia, DirtyDecrypt, DirtyClone, pedit COW, and RefluXFS. Qualys attributes RefluXFS to an LLM-assisted research effort with Anthropic using Claude Mythos Preview, and another bug is credited to an LLM-assisted workflow. Detection and endpoint rules are published in Elastic's detection-rules and protections-artifacts repositories.

Elastic Security Labs · 6d agoResearch1

harshatheg/Qwen-2.5-1B-RLCD — new model trending #30 on Hugging Face

A community MLX inference engine evaluates constrained JSON schema fields in parallel on Apple Silicon, reporting 5.6-7.0x latency speedups with guaranteed schema validity.

The repository harshatheg/Qwen-2.5-1B-RLCD appeared at #30 on Hugging Face trending, but its content describes Parallel Constrained Decoding, an MLX-based inference engine for structured extraction and classification on Apple Silicon Macs. Benchmarked with mlx-community/Qwen2.5-1.5B-Instruct-4bit on an M4 Max, it reports 5.6x-7.0x latency reductions (e.g., 1,900 ms to 270 ms for a 28-field support triage task) with 100% syntactic validity and calibrated field-level probabilities. The engine prefills a single KV-cache, broadcasts it across all schema fields, and slices logits to valid candidate tokens for enum fields with up to 255 choices.

Hugging Face trending models · 1d agoAI tools & infra1

Harnessing LLMs for Automating BOLA Detection

Unit 42's BOLABuster methodology uses LLMs to automate detection of broken object-level authorization vulnerabilities, uncovering flaws in Grafana, Harbor, and Easy!Appointments.

Palo Alto Unit 42 details BOLABuster, a methodology combining large language models with heuristics to automate detection of broken object-level authorization (BOLA) flaws, which traditional fuzzing and static analysis struggle to find. The approach uses LLM reasoning to understand application logic, map endpoint dependency relationships, and generate and interpret test cases. It found CVE-2024-1313 in Grafana, CVE-2024-22278 in Harbor, and 15 CVEs in Easy!Appointments. The team is continuing to hunt for BOLAs in open-source and internal projects.

BreezeBlue/Breeze-TTS-2 — new model trending #19 on Hugging Face

BreezeBlue open-weights Breeze TTS 2, a bilingual text-to-speech model it ranks #1 among open-weight models on the Artificial Analysis TTS leaderboard.

BreezeBlue released open weights and Apache 2.0-licensed PyTorch inference code for Breeze TTS 2 on 2026-08-25. The text-to-speech model supports English and Chinese, voice cloning, reference-free voice design, voice direction, and inline vocal events like (laugh) and (sigh). Reported performance includes #1 open-weight ranking on the Artificial Analysis Elo leaderboard, under 40 ms time-to-first-audio, a 0.32 real-time factor on an NVIDIA H100, and about 7.7 GiB GPU memory for eager inference.

Hugging Face trending models · 22d agoModel release

InceptionRAG: Stealthy Poisoning Attack Against Retrieval-Augmented Generation

InceptionRAG fragments malicious payloads into dormant passages that trigger LLMs to self-deduce misinformation via multi-hop reasoning, bypassing existing RAG poisoning defenses.

Researchers introduce InceptionRAG, a stealthy corpus poisoning attack against retrieval-augmented generation that splits a malicious payload into a chain of individually harmless dormant passages. When retrieved together, the passages induce LLMs to self-deduce target misinformation through multi-hop reasoning, achieving over 80% attack success rate across three datasets and three LLMs under rigorous adversarial constraints. A zeroth-order suffix optimization (ZOSO) method automates authoritative suffix generation in black-box settings. The authors also propose HODOR, a document isolation defense that decouples adversarial logical dependencies.

arXiv cs.CR · 2d agoResearch1

OpenBMB Releases MiniCPM5-2B: A 2.52B Dense Model Averaging 53.9 Across 34 Benchmarks and Built to Run On Device

OpenBMB released MiniCPM5-2B, a 2.52B-parameter Apache 2.0 on-device model averaging 53.9 across 34 benchmarks, ahead of Qwen3.5-4B.

OpenBMB released MiniCPM5-2B, a 2,516,756,480-parameter dense LlamaForCausalLM model with grouped-query attention and a 131,072-token context, under Apache 2.0, runnable via vLLM, SGLang, llama.cpp, and Ollama. It averages 53.9 across 34 benchmarks versus 51.1 for Qwen3.5-4B, with strong tool-use (97.1 on tau2-Bench Telecom) and code results (69.1 LiveCodeBench v6, 46.4 SWE-bench Verified). Training combined 400B tokens of deep-thinking SFT, critic-based JustRL II RL teachers, and on-policy distillation merging 16 RL experts; datasets and intermediate checkpoints were published alongside the weights.

MarkTechPost · 9d agoModel release

Kaininja: Extending Native 3D Generators to the Part Level

KaiNinja extends TRELLIS.2 native 3D generation to part-level assets via a dual-volume O-Voxel representation, cutting whole-object Chamfer distance by 40%.

KaiNinja extends the TRELLIS.2 native 3D generator to produce part-level assets instead of one fused mesh, enabling downstream editing, rigging, and simulation. A dual-volume form of the O-Voxel representation solves the problem that a single volume cannot represent interfaces where two parts touch. The model needs no segmentation network, is partly trained on LLM-agent-authored part data, lowers whole-object Chamfer distance by 40%, and raises strict part F-score by 16% versus other part-generation pipelines.

Hugging Face daily papers · 3d agoAI research

Identifying a BOLA Vulnerability in Harbor, a Cloud

Unit 42 found a BOLA flaw, CVE-2024-22278 (CVSS 6.4), letting Maintainers improperly alter Harbor project metadata; fixed in versions 2.9.5, 2.10.3, and 2.11.0.

Unit 42 researchers identified a broken object-level authorization flaw, CVE-2024-22278, in Harbor, a CNCF-graduated cloud-native container registry with 1.8 million downloads. The flaw (CVSS 6.4) lets users with the Maintainer role create, update, and delete project metadata, actions reserved for ProjectAdmin, risking data exposure, integrity compromise, and circumvention of vulnerability scanning. Harbor patched the issue in versions 2.9.5, 2.10.3, and 2.11.0. The finding came from Unit 42's automated BOLA detection tool built on generative AI.

Palo Alto Unit 42 · Aug 17, 2026VulnerabilityCVE-2024-22278

MicroHasTEE: Bare-Metal Haskell for Type-Level Peripheral Ownership on Armv8-M

MicroHasTEE expresses TrustZone secure and non-secure firmware as one typed Haskell program, catching peripheral-ownership inconsistencies at compile time.

MicroHasTEE is a multiparty Haskell framework that models both TrustZone firmware images as participants in a single typed program, using type-level capability ledgers to track peripheral acquisition, configuration, transfer, and finalization. MicroHs compiles the shared program twice to produce separate bare-metal Secure and Non-secure firmware images. The framework rejects inconsistent resource use, post-configuration attribution changes, wrong-domain callbacks, and calls to unregistered Secure services. A door-lock case study on an STM32U5 Nucleo board produced images of 232.7 KiB and 228.4 KiB of flash with roughly 220 KiB of SRAM per domain.

arXiv cs.CR · 6d agoResearch1

NOAH: Learning the Full Patient Journey. A Longitudinal Multimodal Time-Aware Model for Representation and Forecasting

Researchers introduce NOAH, a time-aware generative transformer trained on 559 million MIMIC clinical events to forecast multimodal patient trajectories.

NOAH is a task-agnostic, time-aware generative transformer trained on over 559 million clinical events from 431,000 hospital visits by 299,000 patients across the MIMIC dataset family. It uses bidirectional time integration and a variational latent space to model the stochastic evolution of patient states, natively processing medical images, time-series signals, categorical events, and structured or unstructured clinical records. The model supports autoregressive forecasting with optional time control, zero-shot classification, and counterfactual intervention simulation, with strong probing performance across clinical outcomes, 15 ICD chapters, and 29 comorbidities.

Hugging Face daily papers · 9d agoAI research1

K-Bench: a clinically calibrated benchmark for evaluating large language models in high-risk mental health conversations

Clinician-calibrated K-Bench evaluates 125 LLM configurations on 200 high-risk mental health vignettes, exposing wide variation in suicide and violence risk handling.

K-Bench is a clinician-calibrated, protected benchmark evaluating 125 model configurations from 33 base models across 14 providers on 200 multi-turn vignettes covering suicide, self-harm, domestic violence, substance misuse and no-risk presentations. A frozen GPT-4o judge achieved 94.2% exact agreement with clinician consensus across 6,751 eligible comparisons from 151 clinician-rated transcripts. Leading models combined supportive conversation with combined-risk scores above 95, while risk exploration varied substantially among weaker configurations; therapeutic prompting helped weaker models and elevated reasoning produced no average improvement. A continuously updated public leaderboard is hosted at k-bench.ai with protected test materials.

Echo: Learning-based Matching Decompilation using Trusted Back Translation

Researchers introduce Echo, a matching decompiler using trusted back-translation that roughly doubles exact-match rates and outperforms GPT-5.6 and Codex on Mirai.

Echo performs matching decompilation by using compilation as trusted feedback for iterative search: a domain-specific model generates candidate code and compilation configurations, which are recompiled, compared at assembly level, and repaired via rule-based rewriting, neural refinement, and reasoning-based refinement. On function-level benchmarks, Echo produces 2.43x more exact matches than the strongest baseline and the highest structural similarity to ground truth. On the Mirai malware binary, it matches 2.75x and 7.4x as many functions as GPT-5.6 and Codex, respectively.

arXiv cs.CR · 23h agoResearch1

[AINews] Claude Fable/Mythos 5.1: new SOTA model, 75% cache price cut but 70% more output tokens

Anthropic launched Claude Fable 5.1 and Mythos 5.1, claiming new SOTA benchmarks, with 75% cache-read price cut and 1M-token context.

Anthropic released Claude Fable 5.1 and Mythos 5.1 as flagship models for coding and knowledge work, with a 1M-token context window and pricing of $10/$50 per million input/output tokens and cache reads cut 75% to $0.25. Artificial Analysis Intelligence Index scored Fable 5.1 at 66 versus 63 for Claude Opus 5, with HLE at 59.1% and Terminal-Bench v2.1 at 91.4%, though per-task cost rose ~20% due to 1.7x output token usage. Community analysis suggested Fable and Mythos may share underlying weights with different safety/routing behavior, and release notes highlighted Enterprise Frontier Safeguards and zero-data-retention support.

Latent Space · 15d agoModel release2

Augustinian BabyLM: What Ostensive Definition Can and Cannot Teach a Small Language Model

Study shows visually grounded token embeddings in a small masked LM persist through training and improve object-property knowledge, but escape standard BabyLM benchmarks.

The paper implements ostensive definition for a small DeBERTa masked language model trained on 10M words, seeding visually grounded tokens with embeddings derived from labeled image regions before training. Visual initialization leaves a persistent, seed-replicated advantage on object-property knowledge (COMPS) and a corpus-tailored Visual-Property Swap benchmark covering color, material, size, and shape, but has no effect on most BabyLM grammar benchmarks. Synthetic grounding of previously unseeded words causally transfers the advantage to exactly those words.

arXiv cs.AI / cs.LG / cs.CL · 6d agoAI research

llm-anthropic 0.28

llm-anthropic 0.28 released with Claude Fable 5.1 support, default reasoning traces and a new ClaudeRefusal exception.

Developer Simon Willison released version 0.28 of the llm-anthropic Python plugin, adding support for Claude Fable 5.1. Reasoning traces are now displayed by default for models that support them, and a new llm_anthropic.ClaudeRefusal exception is raised when Claude returns a refusal.

Simon Willison · 14d agoAI tools & infra2

llm 0.34

Version 0.34 of Simon Willison's llm CLI adds response-duration metrics to log output, plus bug fixes and faster log querying.

The open-source llm command-line tool for interacting with large language models released version 0.34. The headline change adds response duration in milliseconds and human-readable form to llm logs --usage Markdown output, plus a new duration_ms field in llm logs --short. The release includes several contributed bug fixes and a significant performance improvement to llm logs, alongside the related llm-openrouter 0.7.1 release.

Simon Willison · 14d agoAI tools & infra1

NOAH: Learning the Full Patient Journey. A Longitudinal Multimodal Time-Aware Model for Representation and Forecasting

Researchers introduce NOAH, a generative time-aware transformer trained on 559 million MIMIC clinical events to model and forecast patient trajectories.

NOAH is a task-agnostic, time-aware generative transformer designed to represent and forecast the full multimodal patient journey across medical images, time-series signals, categorical events, and clinical text. It was trained on over 559 million clinical events from 431,000 hospital visits covering 299,000 patients in the MIMIC dataset family. The architecture combines bidirectional time integration with a variational latent space to capture continuous patient state evolution and clinical stochasticity. NOAH supports autoregressive forecasting with time control, zero-shot classification, and counterfactual intervention simulation, with evaluations on 15 ICD chapters, 29 comorbidities, and time-to-event prediction.

arXiv cs.AI / cs.LG / cs.CL · 8d agoAI research2

Training a 3.8B LLM to 0.384 CORE for $998 – Hugo Vergnes

Independent developer Hugo Vergnes trained a 3.8B-parameter Llama-style model to 0.384 CORE on 65B tokens for $998 in 43 hours on rented B200s.

Hugo Vergnes trained little-lm, a 3.848B-parameter decoder-only LLM, on 65.3B tokens in 43 hours for $998 using rented NVIDIA B200s, scoring 0.384 on the CORE benchmark and beating nanochat d32 (0.310) at similar cost. The Llama-style architecture uses RMSNorm, RoPE, GQA with 24 query and 8 KV heads, relu-squared MLPs, QK-norm, and ResFormer-style value embeddings that account for 19% of parameters. Key wins included the Muon optimizer for matrix parameters, a trapezoidal learning-rate schedule with linear cooldown, FP8 training plus vocabulary padding for roughly 33% throughput gains, and the ClimMix dataset over FineWeb-Edu. The project, inspired by Karpathy's nanochat, was built as a config-driven YAML framework for small LLM training.

openbmb/MiniCPM5-2B — new model trending #4 on Hugging Face

OpenBMB released MiniCPM5-2B, a dense 2B open-weights Transformer claiming 2B-class open-source SOTA for on-device deployment.

OpenBMB released MiniCPM5-2B, the second model in the MiniCPM5 series following MiniCPM5-1B, and it is trending #4 on Hugging Face. The dense 2B Transformer targets on-device, local, and resource-constrained deployment and claims 2B-class open-source SOTA while remaining competitive with 4B-class models. Reported strengths include coding, mathematics, long-context understanding, tool use, and agentic tasks; a tech report (arXiv 2506.07900), GitHub repo, and online demo accompany the release.

Hugging Face trending models · 11d agoModel release

CERA-MoA: Co-Evolving Routing Mechanisms with Continually Learning LLM Agentsnew

CERA-MoA is a reinforcement learning framework where query routing and agent fine-tuning co-evolve, outperforming static Mixture-of-Agents routing baselines.

The paper (arXiv 2609.18779) introduces CERA-MoA, an iterative reinforcement learning framework in which a dynamic query router and independent agent policies co-evolve during post-training. A predictive familiarity estimator uses mid-layer hidden states to score agent competence without full rollouts, and cumulative-threshold adaptive routing activates a minimal tailored agent subset. Experiments across various domains show it outperforms state-of-the-art static-agent routing and fixed-workflow fine-tuning baselines.

Hugging Face daily papers · 1d agoAI research

UniH^3: Unifying Hierarchical Homogeneity and Heterogeneity for All-in-One Medical Image Restoration

UniH3 unifies hierarchical homogeneity and heterogeneity modeling for all-in-one medical image restoration across modalities and degradation types.

UniH3 introduces a Hierarchical Homogeneity Memory module that distills shared anatomical priors from high-quality images, injected via a Homogeneity-Guided Attention mechanism. A Hierarchical Heterogeneity Balancer mitigates inter- and intra-task conflicts during multi-task optimization. It achieves state-of-the-art on MedIR-2D-500K and MedIR-3D-3D benchmarks for both all-in-one and single-task restoration, with code released on GitHub.

Hugging Face daily papers · 7d agoAI research

DynSHAP: Towards Explainable Dynamic Survival Analysis

DynSHAP extends SHAP explainability to dynamic survival analysis, treating time-feature pairs as Shapley players for longitudinal clinical predictions.

DynSHAP adapts marginal SHAP estimators to dynamic survival analysis by treating time-feature pairs as players in the Shapley game, handling longitudinal irregular inputs and functional survival outputs. Temporal DynSHAP learns linear feature dependencies over time and addresses them with conditional sampling. On synthetic data with ground-truth attributions it recovers temporally dependent features more accurately than marginal estimators, and it produces faithful attributions on two real-world clinical datasets across two DSA architectures.

arXiv cs.AI / cs.LG / cs.CL · 5d agoAI research

Measuring LLM Sycophancy under Sustained Multi-Turn Pressure

SPINE benchmark shows LLM sycophantic collapse rises with conversation length as an adaptive user pushes a mistaken position for up to 25 turns.

The SPINE benchmark uses an LLM proxy that persistently and adaptively defends a mistaken user position for up to 25 turns, testing four production LLM systems and three OLMo3-7B variants on 100 false-presupposition and 100 unethical-query items. Collapse rates increase with conversation length for every model, and short-horizon evaluation protocols underestimate sycophancy. Analysis of accessible reasoning traces shows the correct position often remains represented when the model concedes, indicating models choose to please users rather than lacking knowledge. Among tested tactics, emotional appeals are most associated with inducing sycophantic behavior.

llm-openrouter 0.7.1

Simon Willison released llm-openrouter 0.7.1, a performance fix for loading OpenRouter models in his LLM CLI plugin.

Version 0.7.1 of the llm-openrouter plugin addresses a performance problem when loading OpenRouter models in the LLM command-line tool. The fix was contributed by GitHub user waveplate. It is a minor maintenance release with no security implications noted.

Simon Willison · 14d agoAI tools & infra

Anchoring Clinical Events in Time: UID-Preserving Multimodal Reconstruction and Source-Grounded Adjudication

UID-preserving multimodal framework plus GAVEL LLM judge improves clinical timeline reconstruction, boosting event recovery 43% over prior matching.

The paper introduces a UID-preserving framework linking each narrative clinical event to its source span through text-only estimation, structured-evidence retrieval, timestamped source-row grounding, and joint revision. GAVEL, an LLM judge, compares UID-aligned timelines against narrative and structured records. Across six open-weight models and 40 mixed-critical-care summaries, GLM 5.2 multimodal revision improved temporal agreement without reducing event recovery and performed competitively with clinician annotations, while DeepSeek V3.2 did not benefit from multimodality. The pipeline achieves 43% increased event recovery with occurrence-level provenance.

arXiv cs.AI / cs.LG / cs.CL · 5d agoAI research1

Anthropic merges Claude Chat, Cowork, and more into a single product

Anthropic merged Claude Chat and Cowork into one product and launched Claude Docs and Slides for creating and exporting documents and presentations.

Anthropic is folding Claude Chat and Cowork into a single product where Claude automatically determines what a task needs, eliminating tab switching. It also introduced Claude Docs and Claude Slides for creating, editing, and exporting documents and presentations as PowerPoint or PDF, with Claude Design now integrated into conversations. The rollout starts with Pro and Max plans, followed by Team and Free tiers; enterprise admins receive at least 30 days' notice.

The Decoderupdated · 19h agofirst · 21h agoAI industry 5 sources1