Search: “BIND”

Google's AI genome system evaluates every possible one-base change

Google's AlphaGenome AI system predicts functional effects of non-coding DNA variants in humans and mice.

Google's AlphaGenome AI system evaluates genomic sequences to predict gene expression, transcription factor binding, chromatin accessibility, splice site usage, and related genomic features. The system is currently limited to human and mouse sequences and a limited set of well-studied cell types, but its predictions generally match or exceed specialized software tools. Researchers can use it to assess whether non-coding variants are likely significant and generate hypotheses about their function.

Ars Technica · AI·Sep 9, 16:34 UTC · 7d agoAI research

IBIB: A Protocol for Measuring Enterprise AI Systems by Serving Route, Not Model Identifier

IB2 protocol scores enterprise AI systems by serving route with reliability-inclusive scoring; serving-arm choice moved one score from 77.38 to 82.54.

The protocol has three parts: a gold-blind capability-binding preflight verifying a route can execute the evaluation contract, a reliability-inclusive first-pass scoring rule, and structurally score-blind adjudication. Its reference instantiation uses 128 locked tasks and 987 assertions over document, spreadsheet, chart, tool, and database work, released as procedure and schemas rather than an exposed corpus. Across eleven systems, two complete runs on identical weights later failed distinct binding-gate predicates, four of seven suites saturate within a six-system band driven by governed database work and multi-tab joins, and excluding failed responses from denominators changes the point ordering. Serving-arm choice shifted one declared revision and precision from 77.38 to 82.54, though arms differed in access mode, harness generation, and the tool-call parser.

arXiv cs.AI / cs.LG / cs.CL·Sep 9, 17:31 UTC · 7d agoAI research1

Long-Lived Characters, Local Inference: Incremental Memory Maintenance for Game NPCs

Researchers present incremental KV-cache memory maintenance for long-lived game NPCs running locally on a quantized Qwen hybrid model.

The paper studies incremental memory maintenance for long-lived game NPCs deployed locally with a quantized Qwen hybrid recurrent-attention language model. The runtime removes superseded attention KV entries, computes replacement records at the true sequence tail, and preserves the continuing recurrent state and unchanged KV. Experiments across eight scripted maintenance rounds show true-tail updates preserve current-state and historical bindings, while slot-preserving alternatives repeat a double-subtraction error.

arXiv cs.AI / cs.LG / cs.CL·Sep 16, 17:09 UTC · 19h agoAI research

Reward AI Releases OM-1: A Robot Policy Trained on Human Demonstrations Only, With No Teleoperation or On-Robot Data

Reward AI released OM-1, a general-purpose manipulation policy trained solely on human demonstrations from a sensorized glove, with no teleoperation or robot data.

Reward AI announced OM-1 (Omnibody Model 1), a general-purpose robot manipulation policy trained only on human demonstrations captured via Omnibody Hand, a 7-DoF wearable glove with tactile, proximity, and in-hand camera sensing. The system uses electromagnetic hand-pose tracking, cutting mean overshoot error to 9.5 mm versus 24.9 mm for visual-inertial at 67 cm/s (a 60% reduction), and reportedly learns brand-new tasks from under 30 minutes of human data. A separate RL-trained control layer runs on its own clock so policy inference latency never stalls motion, and the policy spans industrial arms, legged humanoids, and wheeled mobile manipulators. No weights, code, dataset, API, paper, or benchmark comparisons have been released, so claims are demonstration-backed only.

MarkTechPost·Sep 14, 21:08 UTC · 2d agoAI research

Target leakage, not model class, explains reported accuracy in survey-based cardiovascular screening: a leakage-tiered audit of glass-box and tabular foundation models

Audits of 10 classifiers on BRFSS show target leakage, not model class, drives the reported 0.89 AUROC in survey-based cardiovascular screening.

The study benchmarks ten model classes, including glass-box and tabular foundation models, for prevalent myocardial infarction on 442,067 respondents of the 2022 BRFSS across five feature tiers of decreasing leakage risk. Removing two post-diagnostic features costs every model 0.049-0.051 AUROC and collapses performance into a 0.0045-wide band, and the explainable boosting machine matches all alternatives within 0.005 while scoring roughly 104x faster than the strongest foundation model. Frozen models transport within 0.002 AUROC to 2023 data; the authors conclude evaluation practice and feature sets, not model capacity, are the binding constraint.

arXiv cs.AI / cs.LG / cs.CL·Sep 10, 17:29 UTC · 6d agoAI research1

Deepmind's AlphaGenome Atlas maps every possible DNA change in the human genome

DeepMind's AlphaGenome Atlas precomputes impact predictions for ~9 billion human DNA variants in a 1-petabyte dataset; its AVI score beats CADD in benchmarks

Google DeepMind released the AlphaGenome Atlas, precomputing functional-effect predictions for roughly 9 billion human genome variants (about 27,000 prediction values per variant) in a one-petabyte dataset more than 30 times the size of the AlphaFold database. The accompanying AlphaGenome Variant Impact Score (AVI), a small neural network combining AlphaGenome, AlphaMissense and evolutionary conservation features (18 inputs versus CADD's 150+), outperformed existing tools on clinically classified variants, ranking causal variants in the top 50 candidates for 29.5% of solved GREGoR cases versus 12.5% for CADD. A GREGoR epilepsy case illustrates the impact: AVI elevated a previously unclear DNM1 splice variant that lab experiments confirmed as likely disease-causing. The atlas is available for noncommercial use via web portal, API and a Google Antigravity skill, with a commercial version planned through Google Cloud.

The Decoder·Sep 9, 13:40 UTC · 7d agoAI research

Google DeepMind Releases AlphaGenome Atlas With Precomputed Molecular Effect Predictions and AVI Scores for 9 Billion Human DNA Variants

Google DeepMind launched AlphaGenome Atlas, precomputing molecular effect predictions and AVI impact scores for ~9 billion human single-nucleotide variants in a 1-petabyte catalogue.

Google DeepMind released AlphaGenome Atlas, a 1-petabyte catalogue of precomputed molecular effect predictions for roughly 9 billion possible single-nucleotide variants in the human genome. It introduces the AlphaGenome Variant Impact (AVI) score, combining AlphaGenome regulatory predictions with AlphaMissense, plus per-variant feature attributions and over 2,500 recurrent DNA sequence motifs. DeepMind reports best-in-class AVI performance on variant pathogenicity and rare disease benchmarks. Early users at the Broad Institute, University of Exeter, and Stowers Institute demonstrated rare-disease variant reprioritization and 22% more non-coding associations across 54,000+ UK Biobank genomes.

MarkTechPost·Sep 8, 19:00 UTC · 8d agoAI research2

AlphaGenome Atlas: A predictive map of every possible DNA letter change in the human genome

Google DeepMind released AlphaGenome Atlas, a free 1-petabyte platform predicting the molecular effects of all ~9 billion possible single-letter DNA variants.

Google DeepMind introduced AlphaGenome Atlas, containing precomputed predictions for the effects of roughly 9 billion single-nucleotide variants across the human genome, spanning hundreds of human and mouse cell types. The 1-petabyte dataset is more than 30 times larger than the AlphaFold Database and includes an AlphaGenome Variant Impact (AVI) score combining AlphaGenome and AlphaMissense predictions for both coding and non-coding regions. External collaborators have already used it to identify and experimentally verify variants in unsolved rare disease research. It is available via a free web portal, the AlphaGenome API, and as a skill in Google Antigravity.

Google DeepMind·Sep 8, 14:00 UTC · 8d agoAI research 2 sources

VirtualBox 7.1: This is a major update, here's what's new

Help Net Security·Sep 12, 00:00 UTC · Sep 12, 2024AI research