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NVIDIA Details BioNeMo Inference Runtime (BioIR): 2.90x Higher Boltz-2 Folding Throughput and 58.5K Residues per GPU-Hour on 8xH100
NVIDIA released BioNeMo Inference Runtime (BioIR), an open-source PyTorch-compatible library delivering 2.90x higher Boltz-2 protein-folding throughput on 8xH100 GPUs.
NVIDIA detailed BioIR, a Python library that accelerates Boltz-2, OpenFold2, and OpenFold3 structure-prediction inference on NVIDIA GPUs while preserving standard PyTorch workflows. On a matched benchmark of 1,000 human dimers on 8xH100 80GB GPUs, BioIR delivered 58.5K folded residues per GPU-hour versus 20.2K for a torch.compile baseline, a 2.90x throughput gain. BioIR already powered the AlphaFold Database expansion, generating about 31 million candidate complexes across 4,777 proteomes, with 1.81 million released as high-confidence predictions. Extrapolated to 1 million targets, estimated folding energy drops from 35 MWh to 11 MWh at 8-GPU TDP equivalents.
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ToolHive: The open-source way to run any MCP server securely
Stacklok's open-source ToolHive runs Model Context Protocol servers in isolated containers with per-request identity enforcement, audit logging and a signed registry.
ToolHive, shipped under Apache 2.0, containersizes MCP servers locally via Docker or Podman or in clusters through a Kubernetes operator, applying permissions, network filtering, and secrets management. The platform includes a Registry Server implementing the official MCP Registry API with signing and provenance verification, a Virtual MCP Server gateway with OIDC/OAuth single sign-on and OpenTelemetry traces, and a desktop Portal for one-click installs. The browser-based cloud UI is retired, so the desktop app and CLI are the supported rollout paths.
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Linux Foundation takes on TRACE, a hardware-backed runtime evidence specification for AI agents
The Linux Foundation adopts TRACE, an OPAQUE-contributed spec giving AI agents hardware-attested, cryptographically verifiable runtime and compliance evidence.
The Linux Foundation accepted the TRACE (Trust, Runtime Attestation and Compliance Evidence) specification contributed by OPAQUE, developed with AMD, Intel, Microsoft, and the Technology Innovation Institute. TRACE binds runtime environment, software, policies, data classifications, and tool usage into a portable, cryptographically verifiable artifact, composing existing standards such as RATS, EAT, SLSA, SCITT, SPIFFE, and EAR. It recorded nearly 135,000 PyPI downloads within 10 weeks of its June 2026 introduction, and its technical workstream will be hosted by the Coalition for Secure AI.
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