Search: “NextGen Healthcare”

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Google’s Atlas of the human genome could pave the way for new treatments

Google DeepMind launches AlphaGenome Atlas, a catalog of predicted molecular effects for roughly nine billion single-letter DNA changes across the human genome.

Google DeepMind unveiled AlphaGenome Atlas, a roughly 1-petabyte dataset predicting how each of about nine billion possible single-nucleotide variants affects molecular biology, including non-coding regions that regulate gene behavior. It builds on the AlphaGenome model released in 2025 and adds a Variant Impact Score (AVI) to help researchers rank variants. The catalog is available for noncommercial research via a web portal, the Antigravity platform, and the AlphaGenome interface, with commercial access on Google Cloud planned.

The Verge · AISep 8, 14:00 UTC · 8d agoAI industry 2 sources

NextGen Healthcare Mirth Connect

CISA warns NextGen Healthcare Mirth Connect <=4.7.1 has SQL injection and XXE flaws enabling credential theft, file writes, and DoS.

CISA released advisory ICSMA-26-253-01 covering three vulnerabilities in NextGen Healthcare Mirth Connect versions 4.7.1 and earlier: SQL injection CVE-2026-82583 (CVSS 8.3), XXE CVE-2026-78224 (CVSS 8.2), and XXE CVE-2026-82578 (CVSS 7.5). Exploitation could expose stored credentials for connected systems, enable arbitrary file writes, and cause denial-of-service conditions. No public exploitation has been reported; the product is deployed worldwide in the Healthcare and Public Health sector.

CISA Advisoriesupdated Sep 11, 13:08 UTC · 5d agofirst Sep 10, 12:00 UTC · 6d agoAdvisory 2 sources CVE-2026-82583 CVE-2026-78224 CVE-2026-82578

NOAH: Learning the Full Patient Journey. A Longitudinal Multimodal Time-Aware Model for Representation and Forecasting

Researchers introduce NOAH, a time-aware generative transformer trained on 559 million MIMIC clinical events to forecast multimodal patient trajectories.

NOAH is a task-agnostic, time-aware generative transformer trained on over 559 million clinical events from 431,000 hospital visits by 299,000 patients across the MIMIC dataset family. It uses bidirectional time integration and a variational latent space to model the stochastic evolution of patient states, natively processing medical images, time-series signals, categorical events, and structured or unstructured clinical records. The model supports autoregressive forecasting with optional time control, zero-shot classification, and counterfactual intervention simulation, with strong probing performance across clinical outcomes, 15 ICD chapters, and 29 comorbidities.

Hugging Face daily papersSep 7, 20:00 UTC · 8d agoAI research1

NOAH: Learning the Full Patient Journey. A Longitudinal Multimodal Time-Aware Model for Representation and Forecasting

Researchers introduce NOAH, a generative time-aware transformer trained on 559 million MIMIC clinical events to model and forecast patient trajectories.

NOAH is a task-agnostic, time-aware generative transformer designed to represent and forecast the full multimodal patient journey across medical images, time-series signals, categorical events, and clinical text. It was trained on over 559 million clinical events from 431,000 hospital visits covering 299,000 patients in the MIMIC dataset family. The architecture combines bidirectional time integration with a variational latent space to capture continuous patient state evolution and clinical stochasticity. NOAH supports autoregressive forecasting with time control, zero-shot classification, and counterfactual intervention simulation, with evaluations on 15 ICD chapters, 29 comorbidities, and time-to-event prediction.

arXiv cs.AI / cs.LG / cs.CLSep 8, 17:56 UTC · 8d agoAI research2

Healthcare organizations can now connect EHR and additional industry data to ChatGPT

OpenAI announced ChatGPT integrations allowing healthcare organizations to connect EHR and industry data so clinicians can access patient context and research securely.

OpenAI said healthcare organizations can now connect electronic health records and other industry data sources to ChatGPT. The feature is aimed at letting clinicians securely access patient context and medical research within the assistant. The announcement was published on OpenAI's news site without disclosure of a new model release.

OpenAI NewsSep 1, 12:00 UTC · 15d agoAI industry

AMIE, our research medical AI system, demonstrates real-time clinical video consultation capabilities in a first-of-its-kind study.

Google's AMIE research medical AI system demonstrates real-time clinical video consultations in a first-of-its-kind simulated study.

Google introduced AMIE, its research medical AI system, demonstrating real-time clinical video consultation capabilities in a first-of-its-kind study. The evaluation was conducted in simulated settings, extending the AMIE diagnostic dialogue research line to multimodal video consultations. AMIE remains a research system rather than a deployed clinical product.

Google · AIAug 11, 17:00 UTC · Aug 11, 2026AI research

Innovation in healthcare: A hacker's dream and CISO's nightmare?

Opinion piece argues AI could transform healthcare but warns the sector's surging cyber threats demand security-by-design and workforce awareness.

The commentary highlights AI's healthcare potential, citing Stanford's deep learning algorithm matching dermatologists at skin cancer detection and a UK review claiming full automation could save the NHS nearly £13bn annually. It notes healthcare experienced the largest year-over-year increase in cyber attacks, including targeting by state-sponsored groups such as Hidden Cobra. The piece urges organizations to build security in from the outset, hire cyber talent, address insider threats, and protect patient trust when rolling out AI.

Help Net SecurityAug 27, 06:52 UTC · 20d agoIndustry

Evaluating Time-Series Foundation Models and Multimodal Dietary Context for CGM Forecasting

Study finds zero-shot time-series foundation models underperform on CGM forecasting; fine-tuned Chronos-Bolt cuts RMSE up to 18.4% and dietary context adds signal.

The paper evaluates time-series foundation models for continuous glucose monitoring forecasting across eight public datasets covering Type 1 diabetes, Type 2 diabetes, and non-diabetes populations. Under a unified protocol, zero-shot foundation models did not consistently outperform baselines like Elastic Net and PatchTST, but lightweight fine-tuning did, with fine-tuned Chronos-Bolt reducing RMSE by 6.5%-18.4% in the T1D cohort and 8.6%-18.2% in the non-diabetes/T2D cohort. A residual-based fusion framework adding dietary context from CGMacros reduced overall RMSE by about 3% and postprandial RMSE by about 15% versus CGM-only baselines.

arXiv cs.AI / cs.LG / cs.CLSep 10, 17:43 UTC · 6d agoAI research

Performance of Clinical AI System and Physicians and Frontier Language Models in primary care diagnostics

Clinical AI system Doctorina achieved 82.0% primary-care diagnostic concordance versus 57.0% for physicians across 150 synthetic consultations.

The study compared Doctorina, eight physicians, and four standalone frontier language models on 150 synthetic Polish-language primary-care consultations. Doctorina achieved 82.0% Top-1 diagnostic concordance versus 57.0% for physicians (25.0-point difference, 95% CI 17.7-32.7) and 97.3% versus 85.0% primary-or-reference-differential concordance. Normalized workup and treatment scores were 89.4 versus 66.9 and 83.7 versus 61.2. Kimi K3 ranked next on diagnosis, while Claude Opus 5 led the closely spaced management estimates among Opus, Doctorina and Kimi.

arXiv cs.AI / cs.LG / cs.CLSep 8, 17:25 UTC · 8d agoAI research

Building AI to accelerate science and improve lives

Google highlights AI-for-science advances: AlphaGenome Atlas mapping 9 billion genetic variants, WeatherNext 3 weather model, and global health AI tools.

Google detailed AI advances across science and health, including AlphaGenome Atlas, which mapped all 9 billion possible single-letter genetic changes in the human genome and was made openly available. WeatherNext 3 delivers 50% more accurate precipitation forecasts a day or more ahead and is already in products. AlphaFold is used by 4 million researchers in 190 countries, TB chest X-ray screening has processed 25,000+ scans across six nations, and the diabetic retinopathy model has supported 1.15 million screenings. Google also released its AI & Economy ATLAS global usage insights.

Google · AISep 15, 16:00 UTC · 1d agoAI industry

Emergency Department Revisit Quality Review Screening: Exploring Human Decision-Making and Artificial Intelligence Support

A retrospective study found GPT-4 over-flagged emergency department revisit cases while an LLM knowledge-graph screener achieved 83-100% positive predictive value.

In an exploratory retrospective study of 99 emergency department diagnosis pairs from a multihospital health system, clinicians and GPT-4 independently judged whether revisit pairs warranted further assessment. GPT-4 responses correlated poorly with clinicians, flagging 94% of pairs for follow-up, 4.4-13.3 times more than clinicians, though prompt engineering was minimal. An algorithm leveraging an LLM-populated knowledge graph (KGA) achieved 83-100% positive predictive value against at least one clinician rater, suggesting LLM-based screening could broaden revisit quality review without substantially increasing reviewer workload.

arXiv cs.AI / cs.LG / cs.CLSep 9, 16:37 UTC · 7d agoAI research1

LongAgent: History-Guided Agentic Search for Longitudinal Outcome Prediction

LongAgent autonomously searches variable sets and temporal windows to predict longitudinal medical outcomes, beating the strongest non-agent baseline on synthetic data.

The paper proposes LongAgent, an agent-based method that searches over combinations of variable sets, temporal windows and aggregation functions for outcome prediction on heterogeneous medical longitudinal data. It uses a history memory of previous searches and numerical evidence to guide exploration. On synthetic data it achieves mean RMSE 1.7376, improving over the best non-agent baseline by 0.0151 (95% CI [0.0045, 0.0260]; p=0.0273), and performs comparably to the best baseline on a real clinical dataset.

arXiv cs.AI / cs.LG / cs.CLSep 14, 16:51 UTC · 2d agoAI research

The 2026 PNPL Competition: Word Classification and Efficient Cross-Subject Generalisation in LibriBrain100

The 2026 PNPL competition releases LibriBrain100, a MEG speech dataset with 32 extra subjects, targeting word classification and cross-subject BCI generalization.

The 2025 PNPL competition on non-invasive speech decoding from MEG achieved F1-macro scores of 95.6% for speech detection and 73.6% for phoneme classification, built on LibriBrain's ~50 hours of single-subject data. The 2026 edition extends this with LibriBrain100, adding 32 subjects (~40 minutes each) plus ~80 hours of within-subject data. Two tracks target within-subject word classification at scale and cross-subject generalization with subject-specific fine-tuning shrinking from ~40 to ~20 to ~10 minutes, aiming at clinically feasible non-invasive BCIs for people with profound paralysis.

Hugging Face daily papersSep 2, 20:00 UTC · 13d agoAI research

Supporting Thailand’s next generation of AI startups

OpenAI and Thailand's MHESI launched an eight-week accelerator for ten health, wellness, and education AI startups.

OpenAI announced a program with Thailand's Ministry of Higher Education, Science, Research and Innovation (MHESI) to support the country's next generation of AI startups. The eight-week accelerator will help ten startups in health, wellness, and education turn AI prototypes into trusted products.

OpenAI NewsAug 28, 02:00 UTC · 19d agoAI industry

NCP-ArchPreview Technical Report: Moving towards Latent Space Language Models through Next Concept Prediction

An 8.9B-parameter latent-space language model using next-concept prediction matches OLMo-3-7B pretraining loss with only 51.3% of the training tokens.

NCP-ArchPreview augments next-token prediction with Next Concept Prediction over a product-quantized concept vocabulary built from hidden states, trained jointly end-to-end. The 8.9B model was trained on 5.73T tokens from the Dolma-3 dataset, the largest latent-space language model demonstration to date. It consumes 51.3% of the tokens to reach OLMo-3-7B's final pretraining loss and outperforms it by 2.45 points on the downstream macro-average, including a 5.99-point GSM8K gain. The learned latent space also enables lightweight domain adaptation via a 17M-parameter VQ module and improves speculative drafting accepted length by 4.17%.

Hugging Face daily papersSep 8, 20:00 UTC · 7d agoAI research1

Change Healthcare Cyber

Change Healthcare's ransomware attack disrupted US healthcare payments and exposed data of roughly 190 million people.

Infosecurity Magazine covers the cyberattack on Change Healthcare, the UnitedHealth Group subsidiary hit by ALPHV/BlackCat ransomware. The attack disrupted US pharmacy and payment processing services and led to the exposure of data belonging to about 190 million individuals. It ranks among the largest healthcare sector cyber incidents on record.

Infosecurity MagazineAug 19, 00:00 UTC · 28d agoRansomware in the wild

CareMirror: Bringing Caregiver Wellbeing into the Dementia Care Ecosystem

Interview study with 14 dementia caregivers probes CareMirror wellbeing ecosystem, revealing demands for control over clinical sharing and AI boundaries.

CareMirror is an envisioned caregiver wellbeing ecosystem with interconnected caregiver- and clinician-facing interfaces for longitudinal reflection, personalized support, and caregiver-controlled sharing. Semi-structured interviews with 14 family caregivers used the system as a design probe. Caregivers valued wellbeing attention and clinical visibility but found repeated reflection burdensome and worried automatic clinical sharing would inhibit candid disclosure, expecting AI to support rather than replace caregiver and clinician judgment.

arXiv cs.AI / cs.LG / cs.CLSep 15, 16:43 UTC · 1d agoAI research

OmniMed-FL: A Robust Multimodal Federated Learning Framework for Clinical Diagnosis

OmniMed-FL benchmarks multimodal federated learning for chest radiograph diagnosis across 3-20 clients, with FedProx leading under severe non-IID skew.

OmniMed-FL studies multimodal federated learning combining chest radiographs and clinical notes for five-class condition classification under HIPAA/GDDR-compliant decentralized training. It benchmarks eight fusion strategies, imputation rules, and federated baselines under Dirichlet non-IID partitioning across 3-20 hospital clients. With 5 clients and severe skew (alpha=0.1), FedProx scored 0.737 macro-F1 versus 0.662 for FedAvg and 0.297 for local-only training. Multimodal fusion beat unimodal inputs (0.956 vs 0.934 text, 0.664 images) on the synthetic corpus.

arXiv cs.AI / cs.LG / cs.CLSep 9, 15:56 UTC · 7d agoAI research1

Google DeepMind Releases AlphaGenome Atlas With Precomputed Molecular Effect Predictions and AVI Scores for 9 Billion Human DNA Variants

Google DeepMind launched AlphaGenome Atlas, precomputing molecular effect predictions and AVI impact scores for ~9 billion human single-nucleotide variants in a 1-petabyte catalogue.

Google DeepMind released AlphaGenome Atlas, a 1-petabyte catalogue of precomputed molecular effect predictions for roughly 9 billion possible single-nucleotide variants in the human genome. It introduces the AlphaGenome Variant Impact (AVI) score, combining AlphaGenome regulatory predictions with AlphaMissense, plus per-variant feature attributions and over 2,500 recurrent DNA sequence motifs. DeepMind reports best-in-class AVI performance on variant pathogenicity and rare disease benchmarks. Early users at the Broad Institute, University of Exeter, and Stowers Institute demonstrated rare-disease variant reprioritization and 22% more non-coding associations across 54,000+ UK Biobank genomes.

MarkTechPostSep 8, 19:00 UTC · 8d agoAI research2

Google DeepMind Releases AlphaGenome Atlas

Google DeepMind released AlphaGenome Atlas, a 1-petabyte database pre-computing effects of all 9 billion single-nucleotide variants in the human genome, with a unified AVI score.

Google DeepMind launched AlphaGenome Atlas, a database that predicts the regulatory impact of every possible single nucleotide variant across the roughly 3 billion base pairs of the human genome, yielding a 1-petabyte dataset. It introduces the AlphaGenome Variant Impact (AVI) score, combining coding and non-coding predictions for rapid variant prioritization. Broad Institute researchers used it to support solving an unsolved rare disease case via a predicted DNM1 splice variant, and analysis of 54,000+ UK Biobank participants uncovered 22% more non-coding genetic associations, including 19 regions linked to BMI. The Atlas is available through a no-code web portal.

Hacker News · AISep 8, 14:55 UTC · 8d agoAI research HN 44↑ · 4 comments

Google's AI genome system evaluates every possible one-base change

Google's AlphaGenome AI system predicts functional effects of non-coding DNA variants in humans and mice.

Google's AlphaGenome AI system evaluates genomic sequences to predict gene expression, transcription factor binding, chromatin accessibility, splice site usage, and related genomic features. The system is currently limited to human and mouse sequences and a limited set of well-studied cell types, but its predictions generally match or exceed specialized software tools. Researchers can use it to assess whether non-coding variants are likely significant and generate hypotheses about their function.

Ars Technica · AISep 9, 16:34 UTC · 7d agoAI research

AgenticGen: Reward-Guided Agentic Video Generation for Advertising

AgenticGen applies DPO and GRPO reward-guided reasoning to ad video generation, improving TikTok CTR 2.72%, CVR 2.63%, and Advv 9.61%.

AgenticGen decomposes advertising video generation into two trainable reasoning stages, strategy selection and draft generation, supervised by online business feedback. It learns a performance-based reward from accumulated online feedback plus a rubric-based reward aligned with human quality standards, then optimizes policies with DPO followed by GRPO using process and outcome rewards. Online A/B experiments in the TikTok advertising system show CTR up 2.72%, CVR up 2.63%, and Advv up 9.61% over an SFT baseline.

Hugging Face daily papersAug 30, 20:00 UTC · 16d agoAI research

DynSHAP: Towards Explainable Dynamic Survival Analysis

DynSHAP extends SHAP explainability to dynamic survival analysis, treating time-feature pairs as Shapley players for longitudinal clinical predictions.

DynSHAP adapts marginal SHAP estimators to dynamic survival analysis by treating time-feature pairs as players in the Shapley game, handling longitudinal irregular inputs and functional survival outputs. Temporal DynSHAP learns linear feature dependencies over time and addresses them with conditional sampling. On synthetic data with ground-truth attributions it recovers temporally dependent features more accurately than marginal estimators, and it produces faithful attributions on two real-world clinical datasets across two DSA architectures.

arXiv cs.AI / cs.LG / cs.CLSep 11, 16:39 UTC · 5d agoAI research

HypoEvolve: Genetic Algorithms Enable Multi-Agent LLMs to Discover Scientific Hypotheses

HypoEvolve couples a generational genetic algorithm with specialized LLM agents to generate drug-repurposing hypotheses, beating six baselines on DepMap selectivity (0.171 vs 0.115).

HypoEvolve coordinates specialized LLM agents through a generational genetic algorithm in which scientific judgments and new proposals reshape a hypothesis population. Evaluation centers on drug repurposing, linking mechanistic explanations to target-level biological claims assessed via external measures adapted from DepMap and Open Targets. Across 34 cancer types, HypoEvolve scores highest against six baselines on both measures, with DepMap selectivity of 0.171 versus 0.115 for the strongest baseline, and gains generalize to held-out cancer types.

arXiv cs.AI / cs.LG / cs.CLSep 14, 17:44 UTC · 2d agoAI research1

Deepmind's AlphaGenome Atlas maps every possible DNA change in the human genome

DeepMind's AlphaGenome Atlas precomputes impact predictions for ~9 billion human DNA variants in a 1-petabyte dataset; its AVI score beats CADD in benchmarks

Google DeepMind released the AlphaGenome Atlas, precomputing functional-effect predictions for roughly 9 billion human genome variants (about 27,000 prediction values per variant) in a one-petabyte dataset more than 30 times the size of the AlphaFold database. The accompanying AlphaGenome Variant Impact Score (AVI), a small neural network combining AlphaGenome, AlphaMissense and evolutionary conservation features (18 inputs versus CADD's 150+), outperformed existing tools on clinically classified variants, ranking causal variants in the top 50 candidates for 29.5% of solved GREGoR cases versus 12.5% for CADD. A GREGoR epilepsy case illustrates the impact: AVI elevated a previously unclear DNM1 splice variant that lab experiments confirmed as likely disease-causing. The atlas is available for noncommercial use via web portal, API and a Google Antigravity skill, with a commercial version planned through Google Cloud.

The DecoderSep 9, 13:40 UTC · 7d agoAI research

Japan’s Health Ministry to Strengthen Cybersecurity Measures at Hospitals

Japan's Health Ministry requested ¥13.7 billion for fiscal 2027 to strengthen hospital cybersecurity with network protections and dedicated specialists amid rising attacks.

Japan's Health, Labor and Welfare Ministry included ¥13.7 billion in its fiscal 2027 budget request to strengthen cybersecurity at hospitals. The measures aim to protect hospital networks and deploy cybersecurity specialists, responding to a surge in cyberattacks on medical institutions. The plan was reported by The Yomiuri Shimbun.

DataBreaches.netSep 7, 12:41 UTC · 9d agoPolicy & legal

AI-designed drug appears to turn back the body's biological clock in early trial

Insilico Medicine's AI-designed drug rentosertib showed reduced predicted biological age in IPF trial blood analysis, published in Nature Biotechnology.

Insilico Medicine reported that rentosertib, an AI-designed drug candidate in Phase III trials for idiopathic pulmonary fibrosis, showed reduced predicted biological age in blood protein analysis of 42 trial patients. Six independent aging-clock models built by teams at Harvard, Oxford, Beijing, and Insilico all predicted lower biological age versus placebo, with drops of three to four years by week 4 and up to six years on one clock. The drug targets TNIK and was developed with two generative AI systems in about 18 months; Eli Lilly recently invested in the company. Experts including Eric Topol and Harvard's Vadim Gladyshev called the results encouraging but not definitive, citing small sample size.

The DecoderSep 7, 16:34 UTC · 9d agoAI industry

LandingAI Releases Agentic Document Extraction Gen2 with DPT-3 Pro and DPT-3 Verity

LandingAI shipped Agentic Document Extraction Gen2 with DPT-3 Pro and DPT-3 Verity parsing models, adding usage-based billing, block-tree outputs, and word-level grounding.

LandingAI has generally released Agentic Document Extraction Gen2, rebuilt around two parsing models: DPT-3 Verity for deterministic transcription of digital documents with per-word bounding boxes and confidence scores, and DPT-3 Pro for layout-aware parsing of scans, handwriting, non-Latin scripts, and LaTeX math. Billing changes from a flat 3 credits per page to a page-plus-output-character model (Pro: 1 credit/page plus 0.5 credits per 1,000 output characters on priority; Verity: 0.3 plus 0.2), with an asynchronous standard tier at 0.5x price and vendor-claimed 25-80% cost reductions. Parse v2 returns a document-page-block tree with semantic IDs, normalized bounding boxes, and line- or word-level atomic grounding, replacing flat chunks; Gen1 client code will not run against Gen2 endpoints. Deployment options include US/EU cloud, VPCs on AWS, Azure, and Google Cloud, Snowflake, and air-gapped on-premises environments, with automated model routing planned for fall 2026.

MarkTechPostSep 10, 02:13 UTC · 6d agoAI tools & infra

Large Language Models for HVAC Operations in Building Energy Systems: A Critical Review of Methods, Applications, and Deployment Readiness

Systematic review of 66 studies finds LLMs for HVAC operations are mostly research-stage, with no ready-now deployment and only four pilot-level studies.

A critical review of 66 peer-reviewed studies from 2023 to March 2026 examines LLMs for HVAC operations in building energy systems. Only four studies reach pilot-level evidence, none reports sustained operational deployment, and 63 of 66 are research-only. Conventional ML, MPC, and RL remain dominant for high-frequency control and short-horizon forecasting, and the evidence supports LLMs primarily as semantic and workflow layers rather than autonomous controllers.

arXiv cs.AI / cs.LG / cs.CLSep 4, 16:08 UTC · 12d agoAI research

France Establishes New Government-Focused Cyber Incident Response Unit

France created REACTIV, an ANSSI-led interministerial cyber incident response unit for state services, after the DGFiP breach exposed up to 678,000 taxpayers.

ANSSI announced REACTIV (Interministerial Response & Action against Data Breaches) on September 7, a dedicated incident response capability for French state services. It lets ANSSI require ministries to take urgent protective measures for citizens' data and lead centralized technical crisis communications during attacks on state services. The move follows the DGFiP tax authority attack that exposed data of 350,000 to 678,000 taxpayers, after which the Prime Minister ordered an extensive audit of ANSSI. Two suspects aged 16 and 18 from the ZeroBytes hacking group were arrested in late August.

Infosecurity MagazineSep 8, 14:30 UTC · 8d agoPolicy & legal