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How a researcher uses Codex and ChatGPT to search for new antimicrobial molecules

OpenAI profiles César de la Fuente's lab using ChatGPT and Codex alongside deep-learning models to accelerate antimicrobial molecule discovery.

OpenAI published a case study on bioengineer César de la Fuente's lab, which uses ChatGPT and Codex for hypothesis brainstorming, code writing, dataset processing, and bridging knowledge gaps across biology, chemistry, and computer science. The lab's deep-learning models scan genome and protein databases for antimicrobial peptide candidates, potentially cutting initial searches from years to hours. Bacterial antimicrobial resistance was associated with about five million deaths in 2021, a toll projected to roughly double by 2050.

OpenAI News · 6d agoAI industry1

The Surprising Effectiveness of Approximate Value Iteration in Self-Play

Minimal approximate value iteration self-play learns more accurate value functions than AlphaZero in Connect Four and Hex while cutting training and inference costs.

The paper trains a minimal self-play implementation of Approximate Value Iteration (AVI) without MCTS and uses ground-truth oracles for exact evaluation in Connect Four, 7x7 Hex, and synthetic games. AVI learns more accurate value functions than AlphaZero, and its one-step-lookahead greedy policies remain competitive with MCTS-based policies at substantially lower training and inference cost. Preliminary experiments on Othello and 9x9 Go show AVI trains stably on larger games, suggesting simpler approaches have become increasingly practical with modern deep-learning tools.

arXiv cs.AI / cs.LG / cs.CL · 8d agoAI research