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DataGrout helps enterprises control AI usage, governance and LLM costs

SelectHub launched DataGrout, an LLM cost and governance platform combining dynamic context pruning, symbolic inference and MCP gating, claiming about 60% token reduction.

SelectHub launched DataGrout, an LLM inference optimization and AI governance platform combining dynamic context pruning, a symbolic inference layer, and an MCP gateway with per-call token and cost monitoring. Early tests claim roughly 60% token reduction on data-intensive ERP and CRM integration tasks without accuracy loss. The platform connects via its Conduit SDK, MCP or JSON-RPC, offers its own MCP servers for SaaS apps such as Salesforce, SAP and ServiceNow, and supports bring-your-own-key LLM access or gateways like Amazon Bedrock and Kong.

Help Net Security · Aug 13, 2026AI tools & infra1

New infosec products of the week: August 14, 2026

Vendors A10 Networks, ScienceLogic, Searchlight Cyber, and DataGrout/SelectHub released new security and AI operations products this week.

A weekly product roundup covering four releases: ScienceLogic Skylar AI 2.5 with expanded secure deployment options, Searchlight Cyber's Preemptive Threat Exposure Management platform combining exposure visibility with threat intelligence, the general availability of the A10 AI Gateway for routing and governing enterprise AI traffic, and DataGrout's LLM inference optimization and AI governance platform.

Help Net Security · Aug 14, 2026Tools

Multi-Grid Post-Training for Long-Form Multi-Shot Video Generation

MovieGrid arranges long videos on spatial grids during post-training, generating 6.05x more shots than temporal packing with state-of-the-art cross-shot consistency.

MovieGrid is a multi-grid post-training paradigm that decomposes long videos into temporally ordered chunks arranged on a spatial grid for joint modeling, enabling cross-chunk information exchange. The authors build the Multi-Grid Long Video (MGLV) dataset from 1,000 long-form videos, producing 54K grid videos paired with character-aware story prompts. Under the same token budget, MovieGrid generates 6.05x more shots than Temporal Packing in a 1,616-frame video. It achieves state-of-the-art intra-shot consistency of 0.9131 versus 0.8086 for HoloCine and inter-shot consistency of 0.5914 versus 0.5384 for StoryMem.

Hugging Face daily papers · 10d agoAI research

New infosec products of the month: August 2026

August 2026 roundup of security product releases from ServiceNow, Tanium, Snyk, F5, A10, Searchlight Cyber, Intezer, NETSCOUT, Tufin, and Abnormal AI.

Help Net Security's monthly product roundup covers roughly a dozen vendors. Highlights include Snyk's general availability of Evo Continuous Offensive Security with AI-powered pentesting and AI agent red teaming, Searchlight Cyber's PTEM platform combining exposure visibility with attacker intelligence, and A10 and F5 AI gateways to govern enterprise LLM and agent usage. Other updates include Abnormal AI email DLP and phishing training, NETSCOUT outbound DDoS mitigation for service providers, Intezer's native Workflows automation, and Tufin's AI-powered Segmentation Intelligence.

Help Net Security · 19d agoTools

DataFlex-RL: An Evaluation Platform for RLVR Data Policies

DataFlex-RL benchmark of 13 RLVR data policies on Qwen2.5-7B finds none reproducibly beats uniform sampling under matched GRPO training.

DataFlex-RL is an evaluation platform comparing rollout-selection, reweighting, and mixture data policies for RLVR under a common GRPO recipe. Across 13 configurations and 12 matched seeds with Qwen2.5-7B-Base on 12 math, logic, and science benchmarks, uniform GRPO improved domain-balanced accuracy by 7.76 points, but no alternative policy achieved a statistically significant improvement. A corrected 12-seed Llama-3.1-8B-Base extension found no consistent winner, and math-heavy evaluation summaries were negatively correlated (-0.33) with domain-balanced summaries.

Hugging Face daily papers · 11d agoAI research

datasette-mcp 0.2

Simon Willison released datasette-mcp 0.2, changing MCP SQL results to object arrays for better small-model usability.

Datasette-mcp 0.2 changes the execute_sql 'rows' output from an array of arrays to an array of objects, helping weaker models avoid losing track of positional column mappings. The plugin now depends on mcp>=2.1.1. This is the first non-alpha release, and the author reports using it extensively.

Simon Willison · 14d agoAI tools & infra

Datamimic – don't let your coding agent invent its own test worldnew

Datamimic is an open-source test data generation tool aimed at keeping coding agents from inventing their own test fixtures.

A Hacker News discussion (40 points) highlights Datamimic, an open-source rapiddweller GitHub project for generating realistic synthetic test data. The tool targets AI coding agents, aiming to prevent them from fabricating their own inconsistent test worlds. Only the repository link was shared, so details are limited.

ThinkPrior: Zero-Rollout Difficulty Priors for Cold-Start Prompt Selection in RLVR

ThinkPrior builds zero-rollout difficulty priors via an offline verifier-anchored pass, halving silent groups in RLVR and cutting wasted rollouts on Qwen2.5-Math-7B.

In GRPO-based RLVR, groups where all rollouts are correct or all are wrong yield zero advantages and consume about 39% of a run's rollouts under uniform sampling. ThinkPrior initializes a Beta posterior from an external anchor pass's verifier-scored pass rate, selecting prompts by expected learnability before any target-policy rollout, without changing the loss or optimizer. On Qwen2.5-Math-7B across sixteen seeds it more than halves early silent groups and cuts wasted rollouts through step 30 by nearly a fifth, with no detected final-accuracy difference. The ThinkPrior+DAPO composition reduces generated rollouts by 10.6% at an equal 3,840-rollout update budget.

arXiv cs.AI / cs.LG / cs.CL · 7d agoAI research1

DriveZero: End-to-End Driving Beyond Human Demonstrations

DriveZero pairs a frozen vision-foundation-model perception stack with a PPO-trained closed-loop RL teacher to beat replay experts on nuPlan.

DriveZero is an end-to-end camera-only autonomous-driving planner that separates perception and action. Its DriveVFM perception backbone consolidates frozen vision foundation models (DINOv3, SigLIP2, SAM, Depth Anything V2) from raw images without task annotations, while DriveRL trains a privileged PPO teacher policy through closed-loop rollouts in interactive worlds built from real driving logs. The planner distills this teacher, achieving a 93.57 mean nuPlan score across Val14, Test14-hard and Test14-random splits and beating the Log-Replay expert on all three. It also sets state of the art on NAVSIMv1, NAVSIMv2 and closed-loop HUGSIM without human trajectory supervision.

Hugging Face daily papers · 11d agoAI research

Feyospace-v1: How the Cyber Mercury Seven Trained Frontier Cyber Models

A seven-person independent team trained open-weight agentic cyber models via a data-centric post-training framework, ranking 10th on CyberGym and first at comparable scale.

The paper presents Feyospace-v1, a data-centric post-training framework combining five systems: Choulea (hidden reasoning analysis), SkyReal (teacher-sampling cost reduction), Hongzwang (bypassing teacher API restrictions), PSBreakup (restoring capabilities weakened by model merging), and Kreator (converting expert interventions into trainable reasoning). The data engine builds resettable coding, vulnerability, CTF, kernel-history, full-exploit, firmware, and device-backed environments, retaining only execution-verified and evidence-audited trajectories, yielding 164,269 trajectories for long-context supervised fine-tuning. Three checkpoints improve over their starting models by an average of 23.76% on the full CyberGym suite and 10.49% across pooled CTF suites. As of September 1, 2026, Feyospace-s1 achieves a 63.24% verified success rate, ranks 10th on the official CyberGym leaderboard, and all three checkpoints rank 1st among models at comparable parameter scales.

Hugging Face daily papers · 8d agoAI research

Difficulty-Adaptive Tree-Structured Policy Optimization for Expanding Reasoning Coverage in RLVR

Researchers propose DATPO, a difficulty-adaptive tree-structured RLVR training method that expands reasoning coverage (pass@k) and improves test-time scaling on math benchmarks.

The paper identifies three rollout design principles for RLVR: difficulty-adaptive rollout expands pass@k, tree-based rollout beats parallel sampling, and sentence-entropy-guided forking overcomes token-level branching localization. DATPO combines difficulty-adaptive tree search with a sibling-diversity advantage term to promote semantic diversity during training. On mathematical reasoning benchmarks, DATPO outperforms baselines in pass@k, directly translating to superior test-time scaling performance.

Hugging Face daily papers · 8d agoAI research

Implementation of Machine Learning Workflows with NVIDIA cuML, RAPIDS, GPU Benchmarking, Explainability, Clustering, and Model Inference

Hands-on tutorial implements NVIDIA cuML and RAPIDS to GPU-accelerate scikit-learn-style ML workflows with benchmarking, clustering, and inference.

The tutorial demonstrates NVIDIA cuML as a GPU-accelerated machine learning framework, using cuml.accel to speed up unmodified scikit-learn scripts with zero code changes and the native cuML API for CuPy/cuDF interoperability. It benchmarks CPU versus GPU implementations of PCA, K-Means, nearest-neighbor search, logistic regression, random forests, and DBSCAN on datasets up to 200,000 samples with 64 features. It also builds GPU pipelines with UMAP, t-SNE, and HDBSCAN, validates GPU-generated SHAP explanations, uses the FIL library for forest inference, and covers model serialization and GPU/CPU portability.

MarkTechPost · 3d agoAI tools & infra

27.5KB language-agnostic WebGPU syntax highlighter

A developer released gpu-lexer, a 27.5KB language-agnostic syntax highlighter that uses a tiny WebGPU model to label code tokens in the browser.

gpu-lexer splits source into words, whitespace, and symbols, then a small WebGPU model uses local and whole-file context to assign nine token classes, working on languages never seen in training. On held-out files, 12.57% of token labels differ from Shiki, though this measures agreement with Shiki rather than objective correctness. In benchmarks against Shiki 4.4.3, Prism.js, Highlight.js, Sugar High, and Starry Night, it highlighted 10 concatenated copies of three.min.js (5.56M characters) about 10x faster on an Apple M4 Pro in Chrome 152. The author frames it as an experiment, not a grammar-equivalent highlighter.

CosmoH2G: A Hand-to-Gripper Transfer Dataset and Baseline Method for Object Manipulation with Complex Spatial Movements

Researchers release CosmoH2G, a 6,189-episode hand-to-gripper dataset with a two-stage method for complex spatial robot manipulation.

The paper introduces a scalable acquisition pipeline using a handheld gripper to collect paired hand-gripper demonstrations, producing 6,189 episodes across 1,254 unique objects with higher spatial complexity than existing benchmarks. A two-stage framework first predicts sparse gripper keyframes (initial and terminal), then generates the full continuous action sequence conditioned on them, while learning gripper orientation and post-optimizing translation via grasping heuristics and kinematic consistency. Simulation and real-robot experiments show stable, precise hand-to-gripper transfer of complex spatial manipulations, outperforming traditional baselines.

Hugging Face daily papers · 9d agoAI research

Fine-tuning a 350M Model for Better Structured Outputs in 100 GRPO Steps

Hugging Face guide fine-tunes a 350M-parameter model with 100 GRPO steps to improve structured output reliability.

A Hugging Face blog post demonstrates fine-tuning a 350M-parameter model using GRPO (Group Relative Policy Optimization) with TRL over 100 training steps. The stated goal is more reliable structured outputs from small language models. No article body was available, so details beyond the title are limited.

Hugging Face Blog · 13d agoAI tools & infra

Context Engineering Inside the Harness: 4 Mechanisms That Beat Context Overflow and Goal Loss on Long-Horizon Tasks

Survey of four harness mechanisms—context budgeting, compaction, todo-state, and memory—that keep long-horizon LLM agents on task across 200+ tool calls.

The article details how agent harnesses, not larger context windows, solve context overflow and goal loss on long-horizon tasks, citing Chroma's Context Rot report showing 18 LLMs (GPT-4.1, Claude 4, Gemini 2.5, Qwen3) degrade on long inputs. Concrete implementations include LangChain Deep Agents offloading tool responses over 20,000 tokens to the filesystem and truncating old tool calls at 85% window usage, and Claude Code capping auto memory at 25KB while re-reading the 5 most recently modified files after compaction. OpenAI's Responses API now offers server-side compaction via context_management with a standalone /responses/compact endpoint, which Codex uses for long-running coding tasks. Manus reports a roughly 100:1 input-to-output token ratio per ~50-tool-call task, motivating todo.md state recitation to prevent goal drift.

MarkTechPost · 3d agoAI research1

Characterizing Language Generation in the Limit: Finite Witnesses and a Separation-Width Hierarch

New work characterizes language generation in the limit via finite witnesses, proves a full separation-width hierarchy, and formalizes all results in Lean.

The paper fully characterizes when language generation in the limit is possible for arbitrary families over a countable universe: each target must admit a finite positive witness such that targets activated by any finite sample share an infinite common intersection. It defines positive separation width and proves every level of the resulting hierarchy occurs, with countable families admitting singleton witnesses and unions of families with infinite common cores requiring unbounded finite witnesses. The characterization, a universal normalization, and a diagonal capture lemma are machine-checked in the Lean proof assistant, with the development maintained on GitHub.

arXiv cs.AI / cs.LG / cs.CL · 6d agoAI research1

Cadence: Error-Bounded Lossy Compression of Demand Time Series with a Time-Series Foundation Model

Cadence pairs Google's 330M-parameter TimesFM-3 foundation model with adaptive arithmetic coding, gaining 13-28% on 2026 demand series over classical predictors.

Cadence is an error-bounded lossy compressor for numeric time series combining the 330M-parameter Google TimesFM-3 foundation model with an adaptive arithmetic coder, guaranteeing a per-sample error bound. On 49 EIA-930 balancing-authority demand series from 2026 it gains 13.3% over the best of six classical predictors and 28.3% on 50 MTA ridership series, winning all 297 series-tolerance pairs with a 21.4% median gain. The paper also reports negative results, including that foundation models add negligible value for lossless coding and that PyTorch predictions are not bit-identical across batch sizes.

Hugging Face daily papers · 11d agoAI research1

Prior Labs Releases TabPFN-3.5: A Tabular Foundation Model That Beats the Winning Otto Kaggle Solution With Default Settings

Prior Labs releases TabPFN-3.5, a 220M-parameter open-weights tabular foundation model that beats the 2015 Otto Kaggle winning score with default settings.

Prior Labs released TabPFN-3.5, a tabular foundation model that predicts in a single forward pass without per-dataset training or tuning. The base model grew from 53M to 220M parameters with a single multitask checkpoint, learned Fourier features, and in-context ECDF rank encodings. It scores 0.375 on the 2015 Otto Kaggle private leaderboard versus the winning 0.382 and claims first place on seven tabular benchmarks including TabArena and BeyondArena. Open weights cover the base, Fast (84M), and Thinking variants, but production use requires the Prior Labs API or a commercial license.

MarkTechPost · 4h agoModel release

Target leakage, not model class, explains reported accuracy in survey-based cardiovascular screening: a leakage-tiered audit of glass-box and tabular foundation models

Audits of 10 classifiers on BRFSS show target leakage, not model class, drives the reported 0.89 AUROC in survey-based cardiovascular screening.

The study benchmarks ten model classes, including glass-box and tabular foundation models, for prevalent myocardial infarction on 442,067 respondents of the 2022 BRFSS across five feature tiers of decreasing leakage risk. Removing two post-diagnostic features costs every model 0.049-0.051 AUROC and collapses performance into a 0.0045-wide band, and the explainable boosting machine matches all alternatives within 0.005 while scoring roughly 104x faster than the strongest foundation model. Frozen models transport within 0.002 AUROC to 2023 data; the authors conclude evaluation practice and feature sets, not model capacity, are the binding constraint.

arXiv cs.AI / cs.LG / cs.CL · 5d agoAI research1

Inside NVIDIA’s cuDNN Graph API: Fusion, Autotuning, and Plan Reuse with cuDNN Frontend

MarkTechPost tutorial walks through NVIDIA's cuDNN Frontend graph API, covering kernel fusion, autotuning, plan reuse, and CUDA graph capture on Colab GPUs.

The tutorial explains how to express GPU computations as operation graphs via the cuDNN Frontend graph API, running the five-step build pipeline of validate, build operation graph, create execution plans, check support, and build plans. It progresses from a single fused convolution with bias and ReLU to autotuning across engine configs, FP8-style epilogues, attention, plan serialization, dynamic shapes, and CUDA graph capture. Each kernel is benchmarked against a PyTorch reference on a single Colab GPU to verify correctness and measure cost. The piece also covers practical setup issues like making libcudnn.so visible to the frontend's dynamic loader.

MarkTechPost · 13h agoAI tools & infra

Notes on gotchas while migrating 35kb preprompts from Opus to self-hosted Ollama

Opinion piece urges migrating 35KB preprompts from Anthropic/OpenAI to self-hosted Ollama, citing session privacy risks and safety filters blocking security research.

The author documents gotchas migrating 35KB preprompts from Claude Opus to self-hosted Ollama, motivated by fears that frontier providers train on user sessions, citing the OpenAI Navier-Stokes controversy. The piece argues inference providers cannot audit their own retention or training pipelines and that only self-hosted hardware offers verifiable privacy. It also criticizes frontier safety filters for refusing vulnerability research tasks and calls for models that support exploitability testing in CI/CD pipelines.

Miles v0.1: Production-Level Post-Training

Radix Ark open-sources Miles v0.1, a full-stack RL post-training framework demonstrated with asynchronous agentic RL on GLM-5.2 744B-A40B across 64 GB300 GPUs.

Miles v0.1 is a full-stack, open-source system for frontier-scale reinforcement-learning post-training, built on slime with rollout engines on SGLang and trainers supporting NVIDIA Megatron-LM and PyTorch FSDP backends plus three weight-synchronization transports. It supports full-parameter RL, LoRA RL, on-policy distillation, supervised fine-tuning, true-on-policy rollout-training alignment, and extends to diffusion models. The end-to-end case study ran fully asynchronous agentic RL on GLM-5.2 744B-A40B for terminal-use coding tasks on 64 NVIDIA GB300 GPUs with a median step time of 263 seconds over the first 30 measured steps. The code is open-sourced on GitHub.

Hugging Face daily papers · 8d agoAI tools & infra

Augustinian BabyLM: What Ostensive Definition Can and Cannot Teach a Small Language Model

Study shows visually grounded token embeddings in a small masked LM persist through training and improve object-property knowledge, but escape standard BabyLM benchmarks.

The paper implements ostensive definition for a small DeBERTa masked language model trained on 10M words, seeding visually grounded tokens with embeddings derived from labeled image regions before training. Visual initialization leaves a persistent, seed-replicated advantage on object-property knowledge (COMPS) and a corpus-tailored Visual-Property Swap benchmark covering color, material, size, and shape, but has no effect on most BabyLM grammar benchmarks. Synthetic grounding of previously unseeded words causally transfers the advantage to exactly those words.

arXiv cs.AI / cs.LG / cs.CL · 5d agoAI research

Mythos Vulnerability Firehose Hits a Human Bottleneck

Analysis of Project Glasswing findings shows only a fraction of discovered vulnerabilities have reached disclosure and even fewer are fixed.

Dark Reading reports that an analysis of Project Glasswing findings shows only a fraction of the vulnerabilities discovered by the program have reached disclosure, and an even smaller number have been fixed. The article examines how the volume of findings from the discovery program is bottlenecked by limited human triage and remediation capacity. The piece highlights growing tension between high-volume vulnerability discovery and the industry's ability to process, disclose and patch reports.

Dark Reading · 6d agoResearch

Evaluating Time-Series Foundation Models and Multimodal Dietary Context for CGM Forecasting

Study finds zero-shot time-series foundation models underperform on CGM forecasting; fine-tuned Chronos-Bolt cuts RMSE up to 18.4% and dietary context adds signal.

The paper evaluates time-series foundation models for continuous glucose monitoring forecasting across eight public datasets covering Type 1 diabetes, Type 2 diabetes, and non-diabetes populations. Under a unified protocol, zero-shot foundation models did not consistently outperform baselines like Elastic Net and PatchTST, but lightweight fine-tuning did, with fine-tuned Chronos-Bolt reducing RMSE by 6.5%-18.4% in the T1D cohort and 8.6%-18.2% in the non-diabetes/T2D cohort. A residual-based fusion framework adding dietary context from CGMacros reduced overall RMSE by about 3% and postprandial RMSE by about 15% versus CGM-only baselines.

arXiv cs.AI / cs.LG / cs.CL · 5d agoAI research

Axis Robotics Releases AXIS: A Browser-Based Data Engine With 207 Robot Manipulation Tasks and 50,129 Trajectories

Axis Robotics and academic partners released AXIS, a browser-based teleoperation system yielding 207 manipulation tasks and 50,129 trajectories that lifts pi0.5 to 88.8 on LIBERO-Plus.

A team from Axis Robotics, UC Berkeley, Georgia Tech, and NTU introduced AXIS, a browser-based data engine where contributors teleoperate a simulated Franka Research 3 in a MuJoCo WebAssembly frontend while GPU backends handle task generation, training, and evaluation. The released snapshot holds 207 tasks, 50,129 episodes, and 60K+ task or scene variants from more than 70,000 community contributors. Continual pretraining of pi0.5 on AXIS data raises LIBERO-Plus performance from 83.9 to 88.8, versus 57.5 for a volume-matched RoboCasa365 control; the 2.36 TB dataset is gated for non-commercial academic use.

MarkTechPost · 8d agoAI research

XHToken/Spark-X2.5-4B-GGUF — new model trending #30 on Hugging Face

XHToken released GGUF weights of Spark-X2.5-4B, a compact model with 1M-token context and 200+ language support, under Apache 2.0.

The Hugging Face repository provides BF16 GGUF conversions of Spark-X2.5-4B, a compact general-purpose language model for conversation, writing, translation, reasoning, coding, tool use, and agentic workflows. The model uses a hybrid attention architecture, supports a native context length up to 1M tokens, and covers more than 200 languages. Local inference is supported through Ollama and LM Studio via an XHToken llama.cpp fork, with a --think=false flag to disable thinking mode for faster responses. Released under Apache License 2.0; it was trending #30 on Hugging Face at publication.

Hugging Face trending models · 18d agoModel release

Attention Quantization for Tabular Foundation Models

FP8 quantization of attention queries, keys, and values speeds tabular foundation model inference up to 1.7x with no accuracy loss.

The paper develops an FP8 quantization strategy targeting attention calculations (queries, keys, values) in tabular foundation models, arguing attention matters more than weight or KV cache quantization given their differing size and serving patterns versus LLMs. Aligning quantization error between test rows and training rows proves crucial, since misalignment causes drastic accuracy drops. A Triton kernel using explicit FP8 matrix multiplication achieves up to 1.7x speedup over regular 16-bit kernels, with no relevant accuracy loss on TabPFN-v3 and TabICLv2 across TabArena and BeyondArena benchmarks.

arXiv cs.AI / cs.LG / cs.CL · 4d agoAI research1

Towards Scalable and Cost-Efficient Vulnerability Detection: A Study on Automatic Query Generation

A study finds LLM-synthesized CodeQL queries improve average F1-score by 82% over baseline queries, offering scalable vulnerability detection versus direct LLM scanning.

Researchers conducted an empirical study evaluating whether LLMs can synthesize executable CodeQL queries from National Vulnerability Database vulnerability data. LLM-generated queries significantly enhanced baseline CodeQL suites, yielding an 82% improvement in average F1-score across a diverse set of real-world vulnerabilities. A cost-benefit analysis shows direct LLM-based scanning of entire repositories is often computationally and financially prohibitive, while LLM query synthesis offers a scalable and cost-effective alternative for large-scale vulnerability detection.

arXiv cs.CR · 6d agoResearch1

ToolLoop: Closed-Loop Tool-Use Data Synthesis via Decomposed Generation and Dynamic Self-Feedback

ToolLoop introduces a closed-loop synthetic data framework whose 11K examples lift a 4B model to 86.40% on BFCL tool-use evaluation.

ToolLoop decomposes tool-use data synthesis into function-name sampling, backward derivation of user queries, and forward derivation of tool calls, with dynamic self-feedback at each stage. This shifts the paradigm from generate-then-filter to generate-verify-refine, reducing inefficient and imbalanced synthetic data. A 4B model trained on 11K synthetic examples reaches 86.40% accuracy on BFCL non-reasoning mode (86.07% in an Isolate variant excluding BFCL-overlapping functions) and 72.1% on ACEBench using only 18.3% of baseline training data.

arXiv cs.AI / cs.LG / cs.CL · 7d agoAI research1

NVIDIA Details BioNeMo Inference Runtime (BioIR): 2.90x Higher Boltz-2 Folding Throughput and 58.5K Residues per GPU-Hour on 8xH100

NVIDIA released BioNeMo Inference Runtime (BioIR), an open-source PyTorch-compatible library delivering 2.90x higher Boltz-2 protein-folding throughput on 8xH100 GPUs.

NVIDIA detailed BioIR, a Python library that accelerates Boltz-2, OpenFold2, and OpenFold3 structure-prediction inference on NVIDIA GPUs while preserving standard PyTorch workflows. On a matched benchmark of 1,000 human dimers on 8xH100 80GB GPUs, BioIR delivered 58.5K folded residues per GPU-hour versus 20.2K for a torch.compile baseline, a 2.90x throughput gain. BioIR already powered the AlphaFold Database expansion, generating about 31 million candidate complexes across 4,777 proteomes, with 1.81 million released as high-confidence predictions. Extrapolated to 1 million targets, estimated folding energy drops from 35 MWh to 11 MWh at 8-GPU TDP equivalents.

MarkTechPost · 5d agoAI tools & infra1