Search: “Hy4”

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Latest open artifacts (#24): Motif-3, GLM-5.3, Hy4-preview and open model licenses

Interconnects surveys new open models—Motif-3, GLM-5.3, Hy4-preview—while analyzing a licensing split: Western labs opening up, Chinese frontier labs getting restrictive.

The roundup covers Motif-3 (MIT license, strong scores for its size), GLM-5.3 (switched from MIT to a custom license with a $10 billion revenue threshold and undefined 'affiliates' clause requiring Z.AI security review), and Tencent's Hy4-preview (competent but prone to overthinking). It also notes dots3-note-prev from RedNote/Xiaohongshu (won IMO 2026 with a perfect score), Qwen3.8-Flash-Next (125B-A6B with GDN and Qwen Sparse Attention), NVIDIA Nemotron-3.5-Lightning-30B-A3B-BF16, and Ling-3.0-flash. The core theme: Google and Meta adopted Apache 2.0 while Chinese frontier labs (Zhipu, Kimi K3, MiniMax M3) adopted restrictive commercial licenses.

Interconnects·Sep 8, 14:15 UTC · 8d agoAI research

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HyQuant: Hybrid-Precision Quantization for LLM Attention

HyQuant keeps most LLM attention states low-bit while preserving vertical-line tokens and local windows in high precision, maintaining near-lossless accuracy.

HyQuant is a hybrid-precision quantization framework for LLM attention that quantizes most attention states to low bits while keeping accuracy-critical vertical-line tokens and local-window states in full precision, selected via lightweight attention-pattern signals. In the prefill stage it uses a hybrid-precision attention operator, and in the decode stage it applies the same principle to KV-cache compression with fused dequantization and attention computation. Across diverse tasks, models, and datasets it maintains nearly lossless accuracy; code is available on GitHub.

Hugging Face daily papers·Aug 27, 20:00 UTC · 20d agoAI tools & infra1

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[AINews] OpenAI shuts off Cursor

OpenAI cut off API access to coding tool Cursor after its SpaceX acquisition, citing contract violations by Elon Musk's companies.

OpenAI disabled Cursor's access following the closing of Cursor's acquisition by SpaceX, citing its experience with Elon Musk's companies violating contracts; Cursor responded that OpenAI accounts for only 5% of its traffic. The weekly digest also covers major open-weight releases: Z.ai's GLM-5.3 (744B total/40B active, 1M context) and Tencent's Hy4-preview (770B/49B, ~#5 on Code Arena WebDev), plus Alibaba's Qwen3.8-Flash (125B/6B). vLLM published benchmarks showing no universal winner among speculative decoding methods across model families.

Latent Space·Aug 29, 05:11 UTC · 18d agoAI industry

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How Does mHC Use Its Residual Streams? Selective Routing and Near-Identity Mixing

Analysis of DeepSeek-V4-Flash shows four-stream mHC residual blocks use only about two streams effectively, with late-layer mixing providing little benefit.

The study examines the four-stream residual pathway of DeepSeek-V4-Flash, finding typical attention or FFN sites effectively use about two streams and that residual mixing is modest, occurring primarily in early layers. Replacing late mixers with identity increases C4 perplexity by only 1.9% while replacing early mixers raises it by 41%. Retaining the three largest routing weights per token increases perplexity by at most 2.7%, showing the model uses only part of the flexibility afforded by the four-stream design.

arXiv cs.AI / cs.LG / cs.CL·Sep 4, 16:02 UTC · 12d agoAI research

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[AINews] Fal’s H3 Max Live breaks the infinite videogen barrier

Fal post-trained MiniMax H3 into a 'Max' variant with 35x-faster inference, enabling faster-than-realtime AI video generation and infinite streams.

Fal post-trained MiniMax's H3 model into a 'Max' variant and optimized it for its in-house inference engine, achieving roughly 35x the speed of the official endpoint. The optimization enables faster-than-realtime video generation, demonstrated by an infinite interactive AI-generated stream productized by levels.io. The roundup also notes Meta Muse Code's general availability with an SDK, open DeepSeek-V4-Flash-Vision-Exp weights, GLM-5.3-Flash's strong agentic cost/performance rankings, and Tencent's 770B-parameter Hy4 Preview MoE with 49B active parameters.

Latent Space·Sep 1, 04:36 UTC · 15d agoAI industry

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WarmBloodAban/Minimax-h3_Singularity — new model trending #22 on Hugging Face

Community fine-tune Minimax-h3_Singularity enhances MiniMax-H3 video generation with HDR quality, distant face restoration, and improved motion, trending #22 on Hugging Face.

Minimax-h3_Singularity is a community fusion fine-tune of the MiniMax-H3 multimodal video generation model, built from multiple checkpoints and refined with pruning and weight optimization. It supports Text-to-Video, Image-to-Video, Reference-to-Video, and Video-to-Video workflows in ComfyUI, and claims improvements in HDR clarity, distant face restoration, motion fluidity, and fantasy VFX. The authors recommend pairing it with the minimax_h3_ref2v_turbo_4step_v0.1 LoRA for four-step accelerated inference, and an online demo is available via RunningHub.

Hugging Face trending models·Sep 5, 18:51 UTC · 11d agoModel release7· 1 read

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nex-agi/Nex-N2.5-mini — new model trending #30 on Hugging Face

Nex-AGI releases Nex-N2.5 agentic model family (mini, Pro, Max) with a 1.6-trillion-parameter MoE Max, open weights, and hosted access via OpenRouter.

Nex-AGI launched Nex-N2.5, a family of agentic models in mini, Pro, and Max sizes, with the Max version built on a 1.6-trillion-parameter text-only Mixture-of-Experts foundation and the company's first complete post-training effort at trillion-parameter scale. The models target long-horizon computer use, web browsing, and visually grounded agentic tasks, with expanded agent training environments. Reported benchmarks include Max scoring 86.1 on Terminal-Bench 2.1 and 65.7 on SWE-Bench Pro, trailing Claude Opus 5. Weights are being released openly on Hugging Face and ModelScope, with hosted access through OpenRouter.

Hugging Face trending models·Sep 8, 05:08 UTC · 8d agoModel release1

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HypoEvolve: Genetic Algorithms Enable Multi-Agent LLMs to Discover Scientific Hypotheses

HypoEvolve couples a generational genetic algorithm with specialized LLM agents to generate drug-repurposing hypotheses, beating six baselines on DepMap selectivity (0.171 vs 0.115).

HypoEvolve coordinates specialized LLM agents through a generational genetic algorithm in which scientific judgments and new proposals reshape a hypothesis population. Evaluation centers on drug repurposing, linking mechanistic explanations to target-level biological claims assessed via external measures adapted from DepMap and Open Targets. Across 34 cancer types, HypoEvolve scores highest against six baselines on both measures, with DepMap selectivity of 0.171 versus 0.115 for the strongest baseline, and gains generalize to held-out cancer types.

arXiv cs.AI / cs.LG / cs.CL·Sep 14, 17:44 UTC · 2d agoAI research1

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[AINews] AEF-1 standard emerges for Third Party Evaluators, as Xai, OpenAI, and Anthropic all cosign

xAI, OpenAI, and Anthropic cosign the AEF-1 third-party evaluation standard while Dario Amodei proposes embedded evaluators for safety verification.

The AI Evaluator Forum published AEF-1, a baseline standard for independent third-party AI evaluations covering access, conflicts of interest, funding relationships, recusal, and transparency, cosigned by xAI, OpenAI, and Anthropic. Dario Amodei wrote a rare personal blogpost proposing embedded evaluators such as METR with desks, badges, company laptops, and internal-risk-team-level access to verify safety commitments, plus democratic and global coordination frameworks. The roundup also covers the pacing debate: Bilal Chughtai left Google DeepMind arguing progress may outrun alignment, while critics including Aidan Gomez and Cohere push back against slowdowns and lab gatekeeping. Additional items include Cline Desktop's launch with open-weight model support.

Latent Space·Sep 15, 04:50 UTC · 1d agoAI safety & security

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Molecular Déjà Vu: Digit-Level Retrieval of Published Values in Frontier Language Models

Audit of 22 frontier models finds widespread verbatim retrieval of published molecular property values, with higher reasoning increasing recall of memorized numbers.

An arXiv audit tests 22 frontier LLMs across 12 molecular regression benchmarks for verbatim retrieval of published values. More than 50% of the LLMs show verbatim retrieval on five datasets, and identical experiments are flagged 89% more often at a high reasoning level than at the lowest one. Suppressing retrieval moves model prediction errors closer together in relative terms, suggesting predictive capability is not determined solely by memorized values.

arXiv cs.AI / cs.LG / cs.CL·Sep 4, 17:32 UTC · 12d agoAI research1

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nex-agi/Nex-N2.5-Pro — new model trending #30 on Hugging Face

Nex-AGI launches Nex-N2.5 agentic model family (mini/Pro/Max), with Max built on a 1.6-trillion-parameter MoE foundation.

Nex-AGI introduced Nex-N2.5, a next-generation family of agentic models in three sizes (mini, Pro, Max) focused on long-horizon agentic tasks including computer use, web browsing, and autonomous program execution. Nex-N2.5-Max is built on a 1.6-trillion-parameter text-only Mixture-of-Experts foundation, marking the company's first complete post-training effort at trillion-parameter scale. Weights will be released open-source on Hugging Face and ModelScope, with hosted access via OpenRouter. Benchmark comparisons against Claude Opus 5, GPT-5.6 Sol, Kimi-K3, GLM-5.3, DeepSeek-V4-Pro-0813, and Qwen3.8-Max show competitive scores on Terminal-Bench 2.1 and SWE-Bench Pro, though weights were listed as "coming soon" at publication.

Hugging Face trending models·Sep 8, 11:01 UTC · 8d agoModel release1

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New Ted Backdoor Hides Inside Victims' Own HAProxy Builds to Intercept Web Traffic

Rapid7 found a new backdoor, ted, compiled into trojanized HAProxy at two South Korean organizations, with medium-confidence attribution to North Korean actors.

Rapid7 documented a previously undocumented Linux toolkit named ted compiled into the HAProxy load balancer binaries of two South Korean organizations in the automotive and media sectors. The implant intercepts web traffic, serves altered pages only to filtered visitors, and hides C2 exchanges from backend logs and HAProxy statistics; a companion RAT, curlRAT, beacons on a default 12-hour schedule. The toolkit also trojanizes crond, sshd, agetty, atd, and polkitd binaries and sanitizes logs and bash history. Rapid7 attributes the activity with medium confidence to North Korean state-sponsored actors, with domain infrastructure overlapping APT37 listings in maltrail and delivery resembling the Operation SyncHole campaign.

The Hacker News·Sep 4, 14:51 UTC · 12d agoThreat actor in the wild

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UniH^3: Unifying Hierarchical Homogeneity and Heterogeneity for All-in-One Medical Image Restoration

UniH3 unifies hierarchical homogeneity and heterogeneity modeling for all-in-one medical image restoration across modalities and degradation types.

UniH3 introduces a Hierarchical Homogeneity Memory module that distills shared anatomical priors from high-quality images, injected via a Homogeneity-Guided Attention mechanism. A Hierarchical Heterogeneity Balancer mitigates inter- and intra-task conflicts during multi-task optimization. It achieves state-of-the-art on MedIR-2D-500K and MedIR-3D-3D benchmarks for both all-in-one and single-task restoration, with code released on GitHub.

Hugging Face daily papers·Sep 9, 20:00 UTC · 7d agoAI research

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Evaluating Time-Series Foundation Models and Multimodal Dietary Context for CGM Forecasting

Study finds zero-shot time-series foundation models underperform on CGM forecasting; fine-tuned Chronos-Bolt cuts RMSE up to 18.4% and dietary context adds signal.

The paper evaluates time-series foundation models for continuous glucose monitoring forecasting across eight public datasets covering Type 1 diabetes, Type 2 diabetes, and non-diabetes populations. Under a unified protocol, zero-shot foundation models did not consistently outperform baselines like Elastic Net and PatchTST, but lightweight fine-tuning did, with fine-tuned Chronos-Bolt reducing RMSE by 6.5%-18.4% in the T1D cohort and 8.6%-18.2% in the non-diabetes/T2D cohort. A residual-based fusion framework adding dietary context from CGMacros reduced overall RMSE by about 3% and postprandial RMSE by about 15% versus CGM-only baselines.

arXiv cs.AI / cs.LG / cs.CL·Sep 10, 17:43 UTC · 6d agoAI research

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DynSHAP: Towards Explainable Dynamic Survival Analysis

DynSHAP extends SHAP explainability to dynamic survival analysis, treating time-feature pairs as Shapley players for longitudinal clinical predictions.

DynSHAP adapts marginal SHAP estimators to dynamic survival analysis by treating time-feature pairs as players in the Shapley game, handling longitudinal irregular inputs and functional survival outputs. Temporal DynSHAP learns linear feature dependencies over time and addresses them with conditional sampling. On synthetic data with ground-truth attributions it recovers temporally dependent features more accurately than marginal estimators, and it produces faithful attributions on two real-world clinical datasets across two DSA architectures.

arXiv cs.AI / cs.LG / cs.CL·Sep 11, 16:39 UTC · 5d agoAI research

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Google DeepMind Releases AlphaGenome Atlas With Precomputed Molecular Effect Predictions and AVI Scores for 9 Billion Human DNA Variants

Google DeepMind launched AlphaGenome Atlas, precomputing molecular effect predictions and AVI impact scores for ~9 billion human single-nucleotide variants in a 1-petabyte catalogue.

Google DeepMind released AlphaGenome Atlas, a 1-petabyte catalogue of precomputed molecular effect predictions for roughly 9 billion possible single-nucleotide variants in the human genome. It introduces the AlphaGenome Variant Impact (AVI) score, combining AlphaGenome regulatory predictions with AlphaMissense, plus per-variant feature attributions and over 2,500 recurrent DNA sequence motifs. DeepMind reports best-in-class AVI performance on variant pathogenicity and rare disease benchmarks. Early users at the Broad Institute, University of Exeter, and Stowers Institute demonstrated rare-disease variant reprioritization and 22% more non-coding associations across 54,000+ UK Biobank genomes.

MarkTechPost·Sep 8, 19:00 UTC · 8d agoAI research2

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LongAgent: History-Guided Agentic Search for Longitudinal Outcome Prediction

LongAgent autonomously searches variable sets and temporal windows to predict longitudinal medical outcomes, beating the strongest non-agent baseline on synthetic data.

The paper proposes LongAgent, an agent-based method that searches over combinations of variable sets, temporal windows and aggregation functions for outcome prediction on heterogeneous medical longitudinal data. It uses a history memory of previous searches and numerical evidence to guide exploration. On synthetic data it achieves mean RMSE 1.7376, improving over the best non-agent baseline by 0.0151 (95% CI [0.0045, 0.0260]; p=0.0273), and performs comparably to the best baseline on a real clinical dataset.

arXiv cs.AI / cs.LG / cs.CL·Sep 14, 16:51 UTC · 2d agoAI research

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Lightweight Vision Transformer Compression for On-Device Plant Disease Detection in Resource-Constrained Agricultural Field Conditions

A unified ViT compression pipeline (H-BAC pruning, quantization, distillation) cuts plant-disease models 54.5x to 6.01 MB while keeping 95.13% accuracy.

Researchers combined Hessian-Balanced Adaptive Block Pruning (H-BAC), guided by second-order sensitivity estimation, with quantization and attention-based knowledge distillation to compress Vision Transformers for on-device chilli plant disease detection in India. On a 3-class cross-village, cross-device out-of-distribution dataset, the integrated pipeline reduced model size from 327.42 MB to 6.01 MB (54.5x) at 95.13 +/- 2.32% accuracy, matching the 95.13% FP32 baseline. Ablations also show a directly trained 6.01 MB INT8 student reaches 94.87% accuracy, indicating where pruning and distillation add limited value.

arXiv cs.AI / cs.LG / cs.CL·Sep 4, 16:40 UTC · 12d agoAI research

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AlphaGenome Atlas: A predictive map of every possible DNA letter change in the human genome

Google DeepMind released AlphaGenome Atlas, a free 1-petabyte platform predicting the molecular effects of all ~9 billion possible single-letter DNA variants.

Google DeepMind introduced AlphaGenome Atlas, containing precomputed predictions for the effects of roughly 9 billion single-nucleotide variants across the human genome, spanning hundreds of human and mouse cell types. The 1-petabyte dataset is more than 30 times larger than the AlphaFold Database and includes an AlphaGenome Variant Impact (AVI) score combining AlphaGenome and AlphaMissense predictions for both coding and non-coding regions. External collaborators have already used it to identify and experimentally verify variants in unsolved rare disease research. It is available via a free web portal, the AlphaGenome API, and as a skill in Google Antigravity.

Google DeepMind·Sep 8, 14:00 UTC · 8d agoAI research 2 sources

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[0day-rubbish] Accurate Online Private Cloud on-prem (current) Unauthenticated Hessian deserialization leading to JNDI remote class loading (9.8)

0day Rubbish disclosed an unauthenticated Hessian deserialization flaw in Accurate Online Private Cloud on-prem allowing JNDI remote class loading, rated 9.8.

The 0day Rubbish Research Team publicly disclosed an unauthenticated Hessian deserialization vulnerability in the current on-premises release of Accurate Online Private Cloud. The flaw lets unauthenticated attackers trigger JNDI remote class loading, a path that typically yields remote code execution. The issue carries a CVSS 9.8 rating. No CVE identifier or evidence of in-the-wild exploitation was included in the disclosure.

Full Disclosure·Sep 8, 17:31 UTC · 8d agoVulnerability

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DPRK APTs: Ted backdoor and curlRAT target South Korean media and automotive sectors

Rapid7 uncovered a DPRK-linked Linux toolkit using a HAProxy-embedded ted backdoor, SSH keylogger, and curlRAT against South Korean media and automotive firms.

Rapid7 Labs identified a previously undocumented framework attributed with medium confidence to DPRK actors, targeting South Korean automotive and media organizations likely since early 2025. The toolkit embeds a backdoor compiled into HAProxy 2.8.12 using its filter API, plus trojanized crond, agetty, atd, sshd, and polkitd, an SSH keylogger storing credentials under /var/lib/sshd/, and a curl-based RAT with a watchdog thread. It enables remote command execution, malicious script injection into served webpages (a watering-hole loop), credential harvesting, and long-term surveillance. Hardcoded C2s are associated with APT37 via ThreatFox, and exposed groupware portals and mail servers align with Kimsuky tradecraft; the initial access vector and any CVE remain unconfirmed.

Rapid7 Blog·Sep 4, 12:00 UTC · 12d agoThreat actor in the wild1

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K-Bench: a clinically calibrated benchmark for evaluating large language models in high-risk mental health conversations

Clinician-calibrated K-Bench evaluates 125 LLM configurations on 200 high-risk mental health vignettes, exposing wide variation in suicide and violence risk handling.

K-Bench is a clinician-calibrated, protected benchmark evaluating 125 model configurations from 33 base models across 14 providers on 200 multi-turn vignettes covering suicide, self-harm, domestic violence, substance misuse and no-risk presentations. A frozen GPT-4o judge achieved 94.2% exact agreement with clinician consensus across 6,751 eligible comparisons from 151 clinician-rated transcripts. Leading models combined supportive conversation with combined-risk scores above 95, while risk exploration varied substantially among weaker configurations; therapeutic prompting helped weaker models and elevated reasoning produced no average improvement. A continuously updated public leaderboard is hosted at k-bench.ai with protected test materials.

arXiv cs.AI / cs.LG / cs.CL·Sep 14, 16:49 UTC · 2d agoAI safety & security

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Show HN: LLM Attention Visualization

A developer released a browser-based tool that visualizes which past tokens influence each LLM output token using aggregated, value-weighted attention scores.

A Show HN project presents a React application built on Transformers.js that renders per-token attention influence by aggregating attention weights scaled by value-vector magnitudes across all attention heads and layers. To expose internal tensors, the author instrumented the ONNX computation graph, hosted a modified model on Hugging Face, and pre-generated prompts to avoid long model downloads in the browser. Demos with a 600-million-parameter model show how verbatim copying draws heavily on source tokens and how single outputs blend information from multiple phrases.

Hacker News · AI·Sep 8, 16:59 UTC · 8d agoAI tools & infraHN 41↑ · 9 comments

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Show HN: MultiMatte, a Promptable Image Background Removal Model

Feyn releases MultiMatte, a promptable background-removal model fine-tuned from Meta's SAM 3 via LoRA, outputting alpha mattes that beat SAM 3 on segmentation benchmarks.

Feyn introduced MultiMatte, a promptable image background-removal model built on Meta's SAM 3 (860M parameters). It modifies only 19.49M parameters (2.27%) using a rank-16 LoRA adapter and replaces binary masks with alpha mattes to handle fuzzy boundaries like hair. On the DIS-VD benchmark it scores 0.901 S-measure versus SAM 3's 0.667, and it improves on SAM 3 across all twelve evaluated splits. Training used 19,953 images for 14,000 steps with focal and Dice loss, and the merged weights are available via the nobg library and a web demo.

Hacker News · security·Sep 10, 15:50 UTC · 6d agoModel releaseHN 21↑ · 4 comments1

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Google DeepMind Releases AlphaGenome Atlas

Google DeepMind released AlphaGenome Atlas, a 1-petabyte database pre-computing effects of all 9 billion single-nucleotide variants in the human genome, with a unified AVI score.

Google DeepMind launched AlphaGenome Atlas, a database that predicts the regulatory impact of every possible single nucleotide variant across the roughly 3 billion base pairs of the human genome, yielding a 1-petabyte dataset. It introduces the AlphaGenome Variant Impact (AVI) score, combining coding and non-coding predictions for rapid variant prioritization. Broad Institute researchers used it to support solving an unsolved rare disease case via a predicted DNM1 splice variant, and analysis of 54,000+ UK Biobank participants uncovered 22% more non-coding genetic associations, including 19 regions linked to BMI. The Atlas is available through a no-code web portal.

Hacker News · AI·Sep 8, 14:55 UTC · 8d agoAI researchHN 44↑ · 4 comments

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Fly Language Model (FLM) Wires the Full Fruit Fly Connectome Into a Frozen 1.2B LLM, and Its Own Controls Show the Wiring Does Not Help

Researchers wire the full fruit fly connectome (166,700 nodes) into a frozen LiquidAI LFM2.5-1.2B LLM, but controls show no fly-specific benefit.

The Fly Language Model (FLM) couples the complete MaleCNS v1.0 fruit fly connectome (166,700 nodes, 25,582,938 edges) to a frozen LiquidAI LFM2.5-1.2B-Instruct backbone, training only a 278,528-parameter readout (~0.0238% of backbone parameters). The fly readout improved NLL by 0.0222 nats/token (perplexity 3.98 to 3.90) on 32 SmolTalk dialogues, but a direct-input control without the graph beat it in all three seeds. Relabeling node identities removes the gain and the recurrence contracts state differences by 0.6 per token, so the connectome adds no long-range memory. The MIT-licensed code runs locally on Python 3.12, but study artifacts remain private, limiting independent reproducibility.

MarkTechPost·Sep 12, 18:51 UTC · 4d agoAI research1

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Show HN: Ordewell – turn one goal into an ordered plan of coding-agent tasks

Ordewell is an open-source tool that decomposes a single goal into an ordered plan of coding-agent tasks, posted on Hacker News.

Ordewell, shared as a Show HN project on GitHub, converts one high-level goal into an ordered plan of tasks for coding agents to execute. The post received 40 points and 29 comments on Hacker News. It focuses on task planning and orchestration for autonomous coding agents.

Hacker News · AI·Sep 15, 13:31 UTC · 1d agoAI tools & infraHN 40↑ · 29 comments

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Emergency Department Revisit Quality Review Screening: Exploring Human Decision-Making and Artificial Intelligence Support

A retrospective study found GPT-4 over-flagged emergency department revisit cases while an LLM knowledge-graph screener achieved 83-100% positive predictive value.

In an exploratory retrospective study of 99 emergency department diagnosis pairs from a multihospital health system, clinicians and GPT-4 independently judged whether revisit pairs warranted further assessment. GPT-4 responses correlated poorly with clinicians, flagging 94% of pairs for follow-up, 4.4-13.3 times more than clinicians, though prompt engineering was minimal. An algorithm leveraging an LLM-populated knowledge graph (KGA) achieved 83-100% positive predictive value against at least one clinician rater, suggesting LLM-based screening could broaden revisit quality review without substantially increasing reviewer workload.

arXiv cs.AI / cs.LG / cs.CL·Sep 9, 16:37 UTC · 7d agoAI research1

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Deepmind's AlphaGenome Atlas maps every possible DNA change in the human genome

DeepMind's AlphaGenome Atlas precomputes impact predictions for ~9 billion human DNA variants in a 1-petabyte dataset; its AVI score beats CADD in benchmarks

Google DeepMind released the AlphaGenome Atlas, precomputing functional-effect predictions for roughly 9 billion human genome variants (about 27,000 prediction values per variant) in a one-petabyte dataset more than 30 times the size of the AlphaFold database. The accompanying AlphaGenome Variant Impact Score (AVI), a small neural network combining AlphaGenome, AlphaMissense and evolutionary conservation features (18 inputs versus CADD's 150+), outperformed existing tools on clinically classified variants, ranking causal variants in the top 50 candidates for 29.5% of solved GREGoR cases versus 12.5% for CADD. A GREGoR epilepsy case illustrates the impact: AVI elevated a previously unclear DNM1 splice variant that lab experiments confirmed as likely disease-causing. The atlas is available for noncommercial use via web portal, API and a Google Antigravity skill, with a commercial version planned through Google Cloud.

The Decoder·Sep 9, 13:40 UTC · 7d agoAI research

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WearableQA: A Benchmark for Health Reasoning over Real-World Wearable Data

WearableQA benchmark introduces 4,084 questions over real longitudinal wearable data, showing 14 LLMs score 19.6-72.9% on health reasoning, far from solved.

WearableQA is a benchmark of 4,084 10-option multiple-choice questions built from wearable time series, blood biomarkers, and demographics of 200 real users with up to 500 days of daily measurements. It defines 16 question types along two axes: data versus health reasoning, and single- versus cross-signal reasoning, using a dual-grounding framework combining literature and population-validated patterns. Evaluations of 14 proprietary and open-source LLMs show accuracy ranging from 19.6% to 72.9% against a 10% chance baseline, with most models below 60%.

Hugging Face daily papers·Sep 3, 20:00 UTC · 13d agoAI research

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NOAH: Learning the Full Patient Journey. A Longitudinal Multimodal Time-Aware Model for Representation and Forecasting

Researchers introduce NOAH, a generative time-aware transformer trained on 559 million MIMIC clinical events to model and forecast patient trajectories.

NOAH is a task-agnostic, time-aware generative transformer designed to represent and forecast the full multimodal patient journey across medical images, time-series signals, categorical events, and clinical text. It was trained on over 559 million clinical events from 431,000 hospital visits covering 299,000 patients in the MIMIC dataset family. The architecture combines bidirectional time integration with a variational latent space to capture continuous patient state evolution and clinical stochasticity. NOAH supports autoregressive forecasting with time control, zero-shot classification, and counterfactual intervention simulation, with evaluations on 15 ICD chapters, 29 comorbidities, and time-to-event prediction.

arXiv cs.AI / cs.LG / cs.CL·Sep 8, 17:56 UTC · 8d agoAI research2

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JustFit: 200K-Token LLM Serving on a 24 GiB Laptop with Just-in-Time State Management

JustFit MLX runtime serves 200K-token contexts for Qwen3.8-27B on a 24 GiB MacBook via just-in-time state management.

JustFit is an MLX-based inference runtime combining KVExec for compressed KV execution, PhaseSwap for component residency, and StateTrans for state-preserving serving transitions, independent of weight quantization. On a 24 GiB M4 Pro MacBook running Qwen3.8-27B MXFP4, it completed 196,608 input and 16,384 output tokens, raising single-request context from the mlx-vlm baseline's 30,720 positions to 212,992 (6.93x). Performance tests show 19.11 tokens/s on a 32K-input probe with a 16,374 MiB median peak footprint, and the runtime answered 29 of 30 AIME 2026 problems correctly.

arXiv cs.AI / cs.LG / cs.CL·Sep 15, 17:15 UTC · 1d agoAI research

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You Can't Prefer Emotions You Don't Sample: Intensity Undershoot in DPO-Tuned LLMs

Study quantifies DPO-tuned LLMs undershooting requested emotional intensity, tracing the gap to candidate-pool extremity rather than conditioning format.

Conditioning an instruction-tuned LLM on continuous valence-arousal targets yields gain of only 0.26 for valence and 0.13 for arousal on Llama-3.1-8B, far below faithful control of 1.0. The authors attribute undershoot to neutral-heavy preference corpora like EmoBank and candidate pools lacking extreme affect, leaving DPO without extreme exemplars. Uniform target coverage with a hotter candidate pool raises valence gain to 0.40 on Llama-3.1-8B and 0.44 on Qwen3-8B, with modest in-distribution cost; arousal gains remain unstable across seeds.

arXiv cs.AI / cs.LG / cs.CL·Sep 7, 17:47 UTC · 9d agoAI research

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NOAH: Learning the Full Patient Journey. A Longitudinal Multimodal Time-Aware Model for Representation and Forecasting

Researchers introduce NOAH, a time-aware generative transformer trained on 559 million MIMIC clinical events to forecast multimodal patient trajectories.

NOAH is a task-agnostic, time-aware generative transformer trained on over 559 million clinical events from 431,000 hospital visits by 299,000 patients across the MIMIC dataset family. It uses bidirectional time integration and a variational latent space to model the stochastic evolution of patient states, natively processing medical images, time-series signals, categorical events, and structured or unstructured clinical records. The model supports autoregressive forecasting with optional time control, zero-shot classification, and counterfactual intervention simulation, with strong probing performance across clinical outcomes, 15 ICD chapters, and 29 comorbidities.

Hugging Face daily papers·Sep 7, 20:00 UTC · 9d agoAI research1

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Rust Supply Chain Attack on arrayref: Significant Overlap with DPRK Campaigns

Malicious versions of the Rust crate arrayref executed a compile-time backdoor, with infrastructure overlapping recent DPRK supply chain attacks on Mastra and axios.

Wiz researchers report that malicious versions of the arrayref Rust crate ran a backdoor during compilation, compromising developer build pipelines. The campaign's command-and-control infrastructure significantly overlaps with infrastructure used in recent DPRK supply chain attacks, including campaigns against Mastra and axios. Developers using affected crate versions should audit their builds and review dependencies.

Wiz Blog·Aug 20, 15:56 UTC · 27d agoThreat actor in the wild1

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North Korea-linked Hackers Hide a Backdoor Inside HAProxy

Rapid7 reports North Korea-linked hackers implanted a backdoor compiled into HAProxy at South Korean automotive and media firms, enabling covert C2 and credential theft.

Rapid7 documented a previously undocumented Linux toolkit hitting South Korean automotive and media organizations, centered on a backdoor compiled directly into victims' HAProxy 2.8.12. The 'ted backdoor' uses HAProxy's native filter API to intercept HTTP traffic, receive C2 commands hidden in requests to a fake image path, and erase all traces from logs and counters; the toolkit also trojanizes crond, agetty, atd, sshd, and polkitd, adds an SSH keylogger, and runs curlRAT with virtualization checks. It can inject scripts or replace page content for selected victims, turning the load balancer into a watering hole. Attribution sits at medium confidence toward North Korean state actors, with overlaps to APT37-linked infrastructure and a concurrent Lazarus campaign; the campaign's command domains have since gone dark.

Security Affairs·Sep 8, 09:11 UTC · 8d agoThreat actor in the wild

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