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AlphaGenome Atlas: A predictive map of every possible DNA letter change in the human genome

Google DeepMind released AlphaGenome Atlas, a free 1-petabyte platform predicting the molecular effects of all ~9 billion possible single-letter DNA variants.

Google DeepMind introduced AlphaGenome Atlas, containing precomputed predictions for the effects of roughly 9 billion single-nucleotide variants across the human genome, spanning hundreds of human and mouse cell types. The 1-petabyte dataset is more than 30 times larger than the AlphaFold Database and includes an AlphaGenome Variant Impact (AVI) score combining AlphaGenome and AlphaMissense predictions for both coding and non-coding regions. External collaborators have already used it to identify and experimentally verify variants in unsolved rare disease research. It is available via a free web portal, the AlphaGenome API, and as a skill in Google Antigravity.

Google DeepMind · 8d agoAI research 2 sources

Education Under Attack: The Pattern Behind Recent University Breaches

Huntress finds four recent university breaches share one root cause, security misconfigurations, and outlines fixes for higher education.

Huntress analyzed four university breaches from 2026 and identified misconfiguration as the common root cause behind the incidents. The report describes the recurring attack pattern targeting higher education and offers remediation guidance to close the gap. Specific victim institutions, threat actor attribution, and breach volumes are not named in the announcement.

Huntress · Aug 13, 2026Threat actor in the wild

Building a Production Greek-English Speech Recognizer

Engineering report details Sophea, a production Greek-English ASR reaching 4.26% WER on public English sets via ROVER ensemble and data-pipeline calibration.

Across 23 training iterations, two architectures, and nine production gates, no single data composition passed all gates; a three-model ROVER ensemble reached 9 of 9 gates and cut overlapping-speech WER from 53.35% to 37.87%. Calibrating an audio-quality filter against in-domain anchors reduced discarded scored Greek audio from 98.7% to 10.6%, and a pre-registered ablation traced a hallucination defect to one training-data package. The sophea/asr-k1 preview arbiter lists 4.26% average WER on eight public English test sets and 25.88% WER on live Greek noisy traffic; no weights or training data are released.

Hugging Face daily papers · 5d agoAI research

Google DeepMind Releases AlphaGenome Atlas With Precomputed Molecular Effect Predictions and AVI Scores for 9 Billion Human DNA Variants

Google DeepMind launched AlphaGenome Atlas, precomputing molecular effect predictions and AVI impact scores for ~9 billion human single-nucleotide variants in a 1-petabyte catalogue.

Google DeepMind released AlphaGenome Atlas, a 1-petabyte catalogue of precomputed molecular effect predictions for roughly 9 billion possible single-nucleotide variants in the human genome. It introduces the AlphaGenome Variant Impact (AVI) score, combining AlphaGenome regulatory predictions with AlphaMissense, plus per-variant feature attributions and over 2,500 recurrent DNA sequence motifs. DeepMind reports best-in-class AVI performance on variant pathogenicity and rare disease benchmarks. Early users at the Broad Institute, University of Exeter, and Stowers Institute demonstrated rare-disease variant reprioritization and 22% more non-coding associations across 54,000+ UK Biobank genomes.

MarkTechPost · 7d agoAI research2

I wrote an AI textbook — how long until AI can do it better?

AI researcher Nathan Lambert argues LLMs remain weak at long-form technical writing, questioning whether models can autonomously organize scientific knowledge for breakthroughs.

Nathan Lambert describes writing a post-training textbook, Reinforcement Learning from Human Feedback, and finds today's LLMs weak at organizing long-form technical content despite becoming superhuman at coding and math. He notes GPT 5.5 Pro found deep typos across a 200-300 page manuscript while Claude models proved more useful as editors. He argues that compressing knowledge through writing is a prerequisite for autonomous scientific insight and tempers expectations for near-term AI-driven open science.

Interconnects · Aug 12, 2026AI research

Deepmind's AlphaGenome Atlas maps every possible DNA change in the human genome

DeepMind's AlphaGenome Atlas precomputes impact predictions for ~9 billion human DNA variants in a 1-petabyte dataset; its AVI score beats CADD in benchmarks

Google DeepMind released the AlphaGenome Atlas, precomputing functional-effect predictions for roughly 9 billion human genome variants (about 27,000 prediction values per variant) in a one-petabyte dataset more than 30 times the size of the AlphaFold database. The accompanying AlphaGenome Variant Impact Score (AVI), a small neural network combining AlphaGenome, AlphaMissense and evolutionary conservation features (18 inputs versus CADD's 150+), outperformed existing tools on clinically classified variants, ranking causal variants in the top 50 candidates for 29.5% of solved GREGoR cases versus 12.5% for CADD. A GREGoR epilepsy case illustrates the impact: AVI elevated a previously unclear DNM1 splice variant that lab experiments confirmed as likely disease-causing. The atlas is available for noncommercial use via web portal, API and a Google Antigravity skill, with a commercial version planned through Google Cloud.

The Decoder · 7d agoAI research

Two-year university study finds banning AI from classrooms leaves students worse off

A two-year university study found students banned from using ChatGPT performed worst, while formal prompt-engineering training advantages faded as everyday AI familiarity grew.

Researcher Schrepel ran a classroom experiment in 2024 (66 students) and 2025 (164 participants) comparing a no-AI group, unguided ChatGPT users, and trained students revising EU AI Act provisions. The no-AI group finished last both years, hitting 'idea exhaustion' after 10-15 minutes, while the trained group's advantage nearly vanished by 2025 as everyday chatbot familiarity rose. Schrepel now argues blanket AI bans harm outcomes and universities should rethink bans and pure literature-review theses.

The Decoder · 3d agoAI industry

Quoting Laurie Voss

Laurie Voss argues AI collapses code-writing and review costs, leaving product discovery and precise definition as the core of software engineering.

Simon Willison quotes Laurie Voss's essay "We are all Product Engineers now," which argues that AI is collapsing the cost of writing code and will likewise collapse the cost of reviewing, fixing, and operating it. Voss contends the remaining work is finding out what people want, defining it precisely, and making software pleasant to use. He expects the amount of software to grow without limit because demand has no ceiling, making product-definition skills the whole job. No specific models, tools, or incidents are named; this is career and industry commentary.

Simon Willison · 2d agoAI industry

Thinking of ACE? We Can Do It with Fewer Tokens

IBM Research's ALTK-EVOLVE-SLDD blog post claims ACE-style LLM analysis using substantially fewer tokens.

IBM Research published a Hugging Face blog post titled 'Thinking of ACE? We Can Do It with Fewer Tokens' describing ALTK-EVOLVE-SLDD. The method targets reproducing ACE (attribution-based confidence estimation) capabilities in LLMs while consuming far fewer tokens. No article text was available, so details beyond the title are limited.

Hugging Face Blog · Aug 11, 2026AI research

How a researcher uses Codex and ChatGPT to search for new antimicrobial molecules

OpenAI profiles César de la Fuente's lab using ChatGPT and Codex alongside deep-learning models to accelerate antimicrobial molecule discovery.

OpenAI published a case study on bioengineer César de la Fuente's lab, which uses ChatGPT and Codex for hypothesis brainstorming, code writing, dataset processing, and bridging knowledge gaps across biology, chemistry, and computer science. The lab's deep-learning models scan genome and protein databases for antimicrobial peptide candidates, potentially cutting initial searches from years to hours. Bacterial antimicrobial resistance was associated with about five million deaths in 2021, a toll projected to roughly double by 2050.

OpenAI News · 6d agoAI industry1

Who Should Grade My Work? Student Perspectives on Transparent AI-Assisted Writing Assessment in Higher Education

A Saudi university study finds students value ChatGPT writing feedback but treat human instructors as the final grading authority.

Thirteen male undergraduate computing students at a Saudi public university completed handwritten writing tasks that were scored by ChatGPT using a rubric-based prompt, then reflected after being told the score and feedback were AI-generated. Inductive thematic analysis identified four themes: perceived feedback usefulness, awareness of AI's contextual and pedagogical limitations, conditional trust, and reflection on the instructor's institutional role. Participants accepted GenAI feedback for surface-level revision but consistently positioned human instructors as the authority over grading decisions, distinguishing feedback utility from evaluative authority.

arXiv cs.AI / cs.LG / cs.CL · 11d agoAI research

Unsolved Problem by Fields Medalist Breached by Two High School Students

Two high school students used Claude Opus 5 and GPT-5.6 Sol to help solve an open Lorentzian polynomials problem, posting a 75-page arXiv proof.

Aayush Bathija and Prince Rohatgi of Oak Park High School, mentored by UCLA postdoc Daniel Soskin, published the 75-page paper 'Bounded Ratios for Lorentzian Polynomials' (arXiv 2609.05341), solving an open problem in Fields Medalist June Huh's Lorentzian polynomial theory. The main structural theorem extends bounded coefficient-ratio characterization from quadratic to arbitrary-degree polynomials via discrete convexity conditions. The students used Claude Opus 5 and GPT-5.6 Sol for exploration and proof ideas but independently verified all arguments; the result follows an open letter from 25 Fields Medalists voicing concerns about AI's impact on mathematical rigor.

At UBS, AI skills are now a condition for landing a job

UBS will require 2027 graduate and intern applicants in Global Banking to demonstrate AI skills, among the first major banks to do so.

Per the Financial Times, UBS will require candidates for 2027 graduate and internship roles in Global Banking and Markets to show how they use AI to improve outcomes and efficiency, with AI questions included in interviews. The requirement supplements, not replaces, traditional criteria, and Santander is similarly seeking advanced AI users for some trainee programs. Morgan Stanley analysts project more than 200,000 European banking jobs could disappear within five years as routine junior work is automated; UBS is also testing analyst avatars for client presentations.

The Decoder · 9d agoAI industry

The 2026 PNPL Competition: Word Classification and Efficient Cross-Subject Generalisation in LibriBrain100

The 2026 PNPL competition releases LibriBrain100, a MEG speech dataset with 32 extra subjects, targeting word classification and cross-subject BCI generalization.

The 2025 PNPL competition on non-invasive speech decoding from MEG achieved F1-macro scores of 95.6% for speech detection and 73.6% for phoneme classification, built on LibriBrain's ~50 hours of single-subject data. The 2026 edition extends this with LibriBrain100, adding 32 subjects (~40 minutes each) plus ~80 hours of within-subject data. Two tracks target within-subject word classification at scale and cross-subject generalization with subject-specific fine-tuning shrinking from ~40 to ~20 to ~10 minutes, aiming at clinically feasible non-invasive BCIs for people with profound paralysis.

Hugging Face daily papers · 13d agoAI research

🔬“We have foundation models for language, not for physics” — Anima Anandkumar, Bren Professor of Computing

Caltech professor Anima Anandkumar discusses Neural Operators and FourCastNet for physics modeling, arguing inductive biases beat pure token scaling.

Anima Anandkumar, Bren Professor at Caltech and co-founder of Accelerated Understanding, describes Fourier Neural Operators that learn in frequency and spherical-harmonic domains to model weather, fusion, and fluid or heat flow. Her team built FourCastNet 3, a global weather model competitive with physics-based simulations that runs on consumer-grade GPUs. She also introduced TorchLean, a framework for writing PyTorch-style networks inside the Lean proof assistant for formal verification, and was appointed to the United Nations Scientific Advisory Board. She argues physical domains resist scaling due to tiny datasets and context lengths in the hundreds of billions, so progress comes from built-in structure and physical priors.

Latent Space · 21d agoAI research1

NCP-ArchPreview Technical Report: Moving towards Latent Space Language Models through Next Concept Prediction

An 8.9B-parameter latent-space language model using next-concept prediction matches OLMo-3-7B pretraining loss with only 51.3% of the training tokens.

NCP-ArchPreview augments next-token prediction with Next Concept Prediction over a product-quantized concept vocabulary built from hidden states, trained jointly end-to-end. The 8.9B model was trained on 5.73T tokens from the Dolma-3 dataset, the largest latent-space language model demonstration to date. It consumes 51.3% of the tokens to reach OLMo-3-7B's final pretraining loss and outperforms it by 2.45 points on the downstream macro-average, including a 5.99-point GSM8K gain. The learned latent space also enables lightweight domain adaptation via a 17M-parameter VQ module and improves speculative drafting accepted length by 4.17%.

Hugging Face daily papers · 7d agoAI research1

Climate-ModernBERT: Revisiting Corpus Composition for Domain-Adaptive Continued Pretraining

Climate-ModernBERT domain-adapted encoders reach 76.3 average F1 across nine climate benchmarks, 2.8 points above vanilla ModernBERT-Base.

The authors continue pretraining ModernBERT-Base on three climate corpora - academic text, climate-filtered web data, and synthetic documents - and compare joint mixtures against parameter-space merging of specialized checkpoints. The best model achieves 76.3 average F1 across nine climate NLP benchmarks, a 2.8-point improvement over the vanilla baseline. Academic climate corpora provide the strongest adaptation signal, and parameter-space merging outperforms joint multi-source training while preserving complementary corpus information; all variants are released.

arXiv cs.AI / cs.LG / cs.CL · 8d agoAI research

Molecular Déjà Vu: Digit-Level Retrieval of Published Values in Frontier Language Models

Audit of 22 frontier models finds widespread verbatim retrieval of published molecular property values, with higher reasoning increasing recall of memorized numbers.

An arXiv audit tests 22 frontier LLMs across 12 molecular regression benchmarks for verbatim retrieval of published values. More than 50% of the LLMs show verbatim retrieval on five datasets, and identical experiments are flagged 89% more often at a high reasoning level than at the lowest one. Suppressing retrieval moves model prediction errors closer together in relative terms, suggesting predictive capability is not determined solely by memorized values.

arXiv cs.AI / cs.LG / cs.CL · 11d agoAI research1

Anchoring Clinical Events in Time: UID-Preserving Multimodal Reconstruction and Source-Grounded Adjudication

UID-preserving multimodal framework plus GAVEL LLM judge improves clinical timeline reconstruction, boosting event recovery 43% over prior matching.

The paper introduces a UID-preserving framework linking each narrative clinical event to its source span through text-only estimation, structured-evidence retrieval, timestamped source-row grounding, and joint revision. GAVEL, an LLM judge, compares UID-aligned timelines against narrative and structured records. Across six open-weight models and 40 mixed-critical-care summaries, GLM 5.2 multimodal revision improved temporal agreement without reducing event recovery and performed competitively with clinician annotations, while DeepSeek V3.2 did not benefit from multimodality. The pipeline achieves 43% increased event recovery with occurrence-level provenance.

arXiv cs.AI / cs.LG / cs.CL · 4d agoAI research1

Better answers, broader thinking: What students gain from ChatGPT and critical-thinking training

OpenAI published a randomized study of over 1,000 students examining ChatGPT's effects on critical thinking and performance.

OpenAI released results from a randomized study of more than 1,000 students using ChatGPT on a real-world university assignment. The research examined effects on critical thinking, originality, and student performance. Findings inform ongoing debates about AI's role in education and learning outcomes.

OpenAI News · 20d agoAI research

How law firm Gilbert + Tobin governs and scales AI with OpenAI

OpenAI details how law firm Gilbert + Tobin scales ChatGPT Enterprise and Codex firm-wide under CEO-led governance with human accountability.

OpenAI published a customer story describing Gilbert + Tobin's adoption of ChatGPT Enterprise and Codex across the law firm. The firm pairs executive-level commitment with formal governance and human accountability to expand AI use in legal workflows. The piece is a promotional case study, with no new product capabilities or research announced.

OpenAI News · 15d agoAI industry1

NOAH: Learning the Full Patient Journey. A Longitudinal Multimodal Time-Aware Model for Representation and Forecasting

Researchers introduce NOAH, a time-aware generative transformer trained on 559 million MIMIC clinical events to forecast multimodal patient trajectories.

NOAH is a task-agnostic, time-aware generative transformer trained on over 559 million clinical events from 431,000 hospital visits by 299,000 patients across the MIMIC dataset family. It uses bidirectional time integration and a variational latent space to model the stochastic evolution of patient states, natively processing medical images, time-series signals, categorical events, and structured or unstructured clinical records. The model supports autoregressive forecasting with optional time control, zero-shot classification, and counterfactual intervention simulation, with strong probing performance across clinical outcomes, 15 ICD chapters, and 29 comorbidities.

Hugging Face daily papers · 8d agoAI research1

“Zlibrary my beloved”: Anthropic staff chats extolling piracy cited in Sony suit

Sony's copyright lawsuit against Anthropic now cites internal staff chats praising Z-Library piracy as evidence in the AI training-data dispute.

Sony's lawsuit against Anthropic cites internal staff chats in which employees extolled pirating books from Z-Library, according to Ars Technica. The suit forms part of the broader copyright dispute over torrented works used to train AI models. The article also notes AI-generated songs reaching the top of music charts, raising stakes for songwriters in the case.

Ars Technica · AI · 15d agoAI policy

CARDEA: Auditable Reasoning Grounded in Spatial Evidence for End-to-End Coronary Angiography Interpretation

CARDEA, a vision-language model trained only on public data, matches cardiologists on coronary angiography complexity assessment while exposing auditable bounding-box evidence.

CARDEA is a unified large vision-language model serving as the inference core of an end-to-end coronary angiography pipeline from multi-view videos to study-level diagnosis. It was trained on public datasets through visual alignment, self-distilled Chain-of-Box cold start, and reinforcement learning with verifiable rewards encouraging bounding-box reasoning. It reached 0.91 accuracy on dominance classification under domain shift and 0.90 on complexity assessment, comparable to two interventional cardiologists. RLVR raised zero-shot report generation vessel-severity macro-F1 from 0.513 to 0.686, while supervised imitation alone did not.

Hugging Face daily papers · 9d agoAI research

Towards a Deterministic Math Solver for Clinical Language Models

Paper shows handing arithmetic to a deterministic Python solver beats direct model calculation at 32B but not reliably at 7B on MedCalc-Bench.

Researchers test a Program-Solve interface where clinical LLMs write case-specific Python executed by a restricted local solver instead of doing arithmetic directly. On MedCalc-Bench Verified (1,100 cases, 55 calculators), Qwen2.5-32B-AWQ scored 90.53% with solver handoff versus 83.47% with direct arithmetic (+7.05 points), while Qwen2.5-7B gained an unreliable +3.29 points with a confidence interval spanning zero. The authors audited the benchmark against clinical guidelines and flagged 16 of 55 calculators for version, use, or coefficient concerns.

Hugging Face daily papers · 7d agoAI research

UCQ Leak, Israeli GlobalProtect Access, Digital Nirvana Dump, 32baar, and Ghorer Bazar

SOCRadar flags underground posts selling an alleged Universidad Cuauhtémoc database, Israeli GlobalProtect VPN access, and Digital Nirvana data dumps.

SOCRadar's Dark Web Team identified several new underground posts, including an alleged database leak from Universidad Cuauhtémoc (UCQ), a Mexican university. Additional listings include access to an Israeli organization's Palo Alto GlobalProtect VPN, a data dump attributed to Digital Nirvana, and marketplace posts tied to 32baar and Ghorer Bazar. The leaks are alleged and unverified at this stage.

SOCRadar · 2d agoData breach

SenseNova-U1.5: Towards Native Unified Visual Intelligence

SenseTime releases SenseNova-U1.5, an 8B-MoT encoder-free multimodal model unifying visual understanding, reasoning, and generation with native 4K resolution.

SenseNova-U1.5 is an 8B mixture-of-transformers multimodal model with an encoder-free, VAE-free architecture that understands, reasons about, and generates visual content at native resolutions up to 4K. Post-training optimizes specialized experts for visual aesthetics, bilingual text rendering, infographic generation, and image editing, consolidated through multi-expert on-policy distillation. Evaluations report gains in image fidelity, text rendering, multi-reference editing, and instruction following. The team plans to open-source training code including supervised fine-tuning, reinforcement learning, and on-policy distillation.

Hugging Face daily papers · 6d agoModel release

Quoting Boris Cherny

Anthropic's Boris Cherny says AI-generated production code needs a higher quality bar enforced with tests, fuzzers, and automated reviews.

In remarks quoted by Simon Willison, Anthropic's Boris Cherny argued that production code written by Claude should meet a higher quality bar than human-written code. He described guardrails at Anthropic including lint rules, extensive tests, Claude-driven end-to-end tests, daily Claude-powered fuzzers, and automated code and security reviews. He warned that without such controls AI-generated code can become hard to maintain.

Simon Willison · 4d agoAI tools & infra1

Meta FAIR Introduces AI Research Preference Models (RPMs): Ranking ML Experiments Before Spending GPU Hours

Meta FAIR, Oxford and UCL introduce Research Preference Models that rank unexecuted ML experiments, lifting AIRS-Bench scores from 0.684 to 0.729 and cutting compute ~1.6×.

Researchers from Meta FAIR, Oxford, and UCL introduce Research Preference Models (RPMs), which use frozen pretrained LLMs (Qwen3.6-27B backbone, no fine-tuning) to rank unexecuted experiment candidates and execute only the winner of a pairwise knockout tournament. Two variants shipped: an inference-only LLM-as-a-judge and an agentic variant that runs small pilot experiments in an H200 sandbox. On AIRS-Bench (20 tasks, 24 hours on one H200, 10 seeds), scores rise from 0.684 (random) to 0.711 and 0.729 versus a 0.748 validation oracle, and both variants reach the baseline's 24-hour score in roughly 15 hours. The team reports new SOTA on WinoGrande (94.1% with Agentic RPM) and SVAMP (95.7% with inference-only).

MarkTechPost · 9d agoAI research

NOAH: Learning the Full Patient Journey. A Longitudinal Multimodal Time-Aware Model for Representation and Forecasting

Researchers introduce NOAH, a generative time-aware transformer trained on 559 million MIMIC clinical events to model and forecast patient trajectories.

NOAH is a task-agnostic, time-aware generative transformer designed to represent and forecast the full multimodal patient journey across medical images, time-series signals, categorical events, and clinical text. It was trained on over 559 million clinical events from 431,000 hospital visits covering 299,000 patients in the MIMIC dataset family. The architecture combines bidirectional time integration with a variational latent space to capture continuous patient state evolution and clinical stochasticity. NOAH supports autoregressive forecasting with time control, zero-shot classification, and counterfactual intervention simulation, with evaluations on 15 ICD chapters, 29 comorbidities, and time-to-event prediction.

arXiv cs.AI / cs.LG / cs.CL · 7d agoAI research2

ENEAS: Embedding-guided Neural Ensemble for Adaptive Segmentation

ENEAS adds text prompting and semantic verification to video segmentation to keep tracking targets through occlusion and reject lookalike distractors.

ENEAS is a unified text-promptable method for instance tracking and open-concept semantic discovery in video, designed to fix temporal hallucinations, spatial fragmentation, and semantic misclassification seen in SAM 3-class foundation models. It extends the geometrically robust SeC architecture with a text-prompting adapter and temporal memory, and uses a verification layer combining fast visual embedding matching with conditional VLM refinement for ambiguous candidates. It targets 3D reconstruction pipelines where a single misclassified distractor corrupts the asset. Code and models are open-sourced.

Hugging Face daily papers · 13d agoAI research

AuK Technical Report: An Open-Source Foundational Model for Speech Generation and Editing

Open-source speech foundation model AuK unifies generation and editing, trained on 1.95 million hours, with distilled AuK-Flash achieving 4.5x speedup.

AuK is an open-source foundational model that unifies speech generation and editing through natural-language instructions and audio context, trained on approximately 3.03 billion instruction-audio instances and 1.95 million hours of supervision across five task families including generation, content editing, and acoustic editing. It combines a multimodal LLM for semantic conditioning, a VAE jointly trained on speech, general audio, and music, and a hybrid rectified-flow Transformer using dual-stream MMDiT blocks followed by unified single-stream DiT blocks. Post-training applies human-feedback preference optimization for editing and reward-based reinforcement learning for generation, and the distilled AuK-Flash performs 4-step inference without classifier-free guidance at a 4.5x wall-clock speedup. Source code and model weights are released.

Hugging Face daily papers · 8d agoModel release1

An Open Recipe for IMO Gold: Training Nemotron for Olympiad Mathematics

Open post-training pipeline turns Nemotron 3 Ultra checkpoints into an IMO 2026 gold-medal system, scoring 30/42 without formal provers or external tools.

Starting from Nemotron 3 Ultra, researchers trained two specialist checkpoints using supervised fine-tuning and reinforcement learning for natural-language olympiad proof generation. Three checkpoints power an iterative generate-verify-refine search plus a separate high-compute selection stage, operating entirely in natural language with no formal prover, external tools, or internet access. The system scored 30 of 42 points at IMO 2026, reaching the gold-medal threshold. The release includes the post-trained checkpoints, training data, training and inference code, submitted solutions, and Nemotron-IMO-Bench with 200 novel olympiad-level problems.

Hugging Face daily papers · 7d agoModel release