Search: “Zhuque Lab”

Discovery Foundation Models: Toward Open-Ended Discovery Intelligence

Paper defines Discovery Foundation Models with seven coupled capabilities for open-ended discovery, demonstrated via Zetema and GALILEO systems.

The paper formulates Discovery Foundation Models (DFMs) as general-purpose model systems for open-ended discovery, supporting seven coupled capabilities spanning problem discovery, formulation, representation construction, hypothesis formation, intervention, evidence-grounded revision, and continual improvement. It instantiates the framework with Zetema, which couples explicit research-state dynamics, verification and experimental gating, and cross-task Discovery Skill evolution. The framework is grounded with GALILEO, a real therapeutic-discovery system combining dry-lab reasoning with robotic wet-lab experimentation in a closed physical discovery loop; code is released on GitHub.

Hugging Face daily papers·updated Sep 14, 17:56 UTC · 2d ago·first Sep 13, 20:00 UTC · 3d agoAI research 2 sources

How hackers used Claude for missiles, drone swarms, and surveillance, while Chinese labs mined it for training data

Anthropic's threat report details eight months of Claude misuse: AI-assisted espionage against 20+ organizations, self-rewriting malware, and Chinese labs distilling Claude via fraudulent accounts.

Anthropic's threat intelligence report covering December 2025 through August 2026 documents Claude misuse across seven categories including cyber operations, surveillance, fraud, and unauthorized model distillation. A Russian-speaking espionage actor tracked as GTG-20006 used AI agents to rewrite and recompile malware evading antivirus detection, targeting more than 20 organizations in Ukraine and Europe and stealing a drone vision system SDK. Alibaba's Qwen lab ran the largest distillation campaign, with over 151 million exchanges between May and July 2026 peaking near 3 million per day to train Qwen 3.5, 3.6, and 3.7. DeepSeek, Moonshot AI, Xiaomi, and Zhipu also relayed customer or replayed traffic to Claude, including PLA-linked users analyzing CCTV footage and users with credentials tied to the Russian Ministry of Defense.

The Decoder·updated 13:01 UTC · 8h ago·first Sep 11, 13:50 UTC · 5d agoAI safety & security in the wild 18 sources2

AI-Infra-Guard: Open-source security scanner for AI systems

Tencent's Zhuque Lab open-sourced AI-Infra-Guard, a scanner that fingerprints AI services, checks 1,600+ CVEs, and evaluates MCP skills.

AI-Infra-Guard fingerprints running AI services such as Ollama, vLLM and ComfyUI, checks them against more than 1,600 known CVEs, and inspects MCP servers and agent skills across 14 risk categories. Its SkillTrustBench judging set contains 5,520 human-labeled samples, with false positive rates of 1.20%–18.67% depending on the judging model. Users include ICBC, China Merchants Bank, China Telecom, Lenovo, vivo and Bilibili. Release 4.1.9 hardened scanning agents against indirect prompt injection, and the open-source build ships without authentication, requiring a reverse proxy with Basic Auth or an IP allowlist.

Help Net Security·Sep 9, 05:30 UTC · 7d agoTools

Anthropic Says Seven China-Based AI Labs Ran Industrial-Scale Claude Distillation Attacks

Anthropic disrupted industrial-scale unauthorized Claude distillation by seven China-based AI labs, including Alibaba, DeepSeek, Moonshot, and Z.ai.

Anthropic identified and disrupted six illicit distillation campaigns since February 2026 run by seven China-based labs: Alibaba, Moonshot, DeepSeek, Z.ai (Zhipu), MiniMax, Xiaomi, and SenseTime. The largest, GTG-16005, involved 151 million exchanges targeting Claude Opus 4.6/4.7 chain-of-thought transcripts, peaking at roughly 3 million exchanges per day from more than 3,500 fraudulent accounts. Labs used proxy/relay services with fictitious identities, fake or stolen credit cards, harvested API keys, and purchased conversation transcripts from third-party resellers. Anthropic is countering by banning reseller accounts, summarizing internal reasoning before responding, and introducing preserved thinking in Fable 5.1, which encrypts reasoning and prevents context edits before it.

The Hacker News·Sep 11, 16:15 UTC · 5d agoAI safety & security 9 sources

18-Year-Old Linux SCTP Flaw Could Let Local Users Gain Root and Escape Containers

The Hacker News·Aug 7, 11:10 UTC · Aug 7, 2026Exploit / PoC in the wildCVE-2026-64564

Evaluating Verified Autonomy in Quantum Engineering

Quantum-Harbor lab and QIQCBench (49 tasks) expose wide performance gaps across 17 frontier agentic systems in verified quantum engineering.

Researchers built Quantum-Harbor, a virtual laboratory providing a controlled execution environment where scientific AI agents interacting with quantum systems can have both actions and conclusions directly verified. QIQCBench contributes 49 expert-authored tasks spanning calibration and control, error correction and compilation, and sensing and networking. Across 17 frontier agentic systems, verified performance varied widely, exposing a substantial gap between demonstrated capability and reliable autonomous operation.

arXiv cs.AI / cs.LG / cs.CL·Sep 15, 16:46 UTC · 1d agoAI research1

Week in review: Linux rootkit deployed on F5 BIG-IP APM devices, Cisco FMC bugs exploited

Weekly roundup: Cisco FMC and N-able N-central zero-days exploited in the wild, MikroTik RouterOS hijacks, Microsoft Patch Tuesday ships two exploited zero-days.

State-sponsored and financially-motivated attackers are actively exploiting CVE-2026-20079, a critical authentication bypass in Cisco Secure Firewall Management Center (FMC), alongside CVE-2026-20316. N-able issued an emergency hotfix for CVE-2026-86218, a critical pre-auth RCE in the N-central RMM platform exploited in the wild. CERT Polska disclosed six RouterOS vulnerabilities being chained to hijack internet-exposed MikroTik devices. Microsoft's September 2026 Patch Tuesday shipped a record patch count including two zero-days, while roughly 67,000 Trezor customers faced phishing after a shipping-partner breach and researchers privately disclosed a zero-click WeChat worm to Tencent.

Help Net Security·Sep 13, 08:00 UTC · 3d agoExploit / PoC in the wildCVE-2026-20079CVE-2026-20316CVE-2026-862182· 1 read

GLM-5.3: How Chinese labs keep stride with the frontier

Z.ai released GLM-5.3, a ~750B-parameter model with frontier agentic coding scores, with open weights on Hugging Face planned in two weeks.

Z.ai announced GLM-5.3, initially available only in its coding plan, with API access and open Hugging Face weights promised within two weeks. The roughly 750B-parameter model, one-third the size of Moonshot AI's Kimi K3, surpasses Kimi K3 on many benchmarks and beats Claude Fable 5 or GPT-5.6-Sol on some, placing it at the frontier of agentic coding benchmarks. GLM-5.3 reuses the GLM-5.2 base model with substantially extended post-training based on more RL environments, more diverse tasks and more compute. The post also analyzes how Chinese labs keep pace with the frontier, arguing release speed matters more than distillation.

Interconnects·Aug 14, 21:23 UTC · Aug 14, 2026Model release

ISTA-DASLab/Qwen3.8-27B-GSQ-RCO-GGUF — new model trending #3 on Hugging Face

ISTA-DASLab releases GSQ-RCO non-uniform GGUF quantizations of Qwen3.8-27B down to 2.5 bpw, with task-lossless IQ3_S matching BF16 benchmark scores.

ISTA-DASLab released GGUF quantizations of Qwen3.8-27B produced with GSQ (Gumbel-Softmax Quantization) and RCO (Riemannian Constrained Optimization), non-uniform methods that allocate per-tensor precision via gradient-based search under a total size budget. Four checkpoints range from 2.50 bpw (8.4 GB) to 3.50 bpw (11.8 GB), plus a BF16 vision projector (mmproj) enabling multimodal use. The recommended IQ3_S build is task-lossless, matching the BF16 base exactly on AIME25 (100.00) and LiveCodeBench v6 (85.71) at roughly one fifth of the BF16 size. Optional -mtp variants add a Multi-Token Prediction head for speculative decoding in llama.cpp.

Hugging Face trending models·Aug 28, 18:38 UTC · 19d agoModel release1

Y Combinator’s Garry Tan wants U.S. open-weight AI labs to ‘distill’ frontier models, too

Y Combinator CEO Garry Tan urges US open-weight labs to distill frontier models and regulators to stay out, countering Anthropic's crackdown calls.

Y Combinator CEO Garry Tan told CNBC he would "do nothing" about Chinese labs distilling frontier models and floated an "American distillation regime" letting US open-weight labs do the same to American frontier labs. Anthropic this week released its second report alleging Chinese labs conduct "illicit distillation attacks" using hidden identities, fraud, and stolen credentials, and CEO Dario Amodei has called for US regulators to crack down. Tan argued closed labs cannot dictate what customers do with API outputs, noting frontier labs trained on copyrighted material without permission, and called a single monolithic proprietary provider the true AI doomer scenario.

TechCrunch · AI·Sep 11, 20:59 UTC · 5d agoAI industry

Latest open artifacts (#24): Motif-3, GLM-5.3, Hy4-preview and open model licenses

Interconnects surveys new open models—Motif-3, GLM-5.3, Hy4-preview—while analyzing a licensing split: Western labs opening up, Chinese frontier labs getting restrictive.

The roundup covers Motif-3 (MIT license, strong scores for its size), GLM-5.3 (switched from MIT to a custom license with a $10 billion revenue threshold and undefined 'affiliates' clause requiring Z.AI security review), and Tencent's Hy4-preview (competent but prone to overthinking). It also notes dots3-note-prev from RedNote/Xiaohongshu (won IMO 2026 with a perfect score), Qwen3.8-Flash-Next (125B-A6B with GDN and Qwen Sparse Attention), NVIDIA Nemotron-3.5-Lightning-30B-A3B-BF16, and Ling-3.0-flash. The core theme: Google and Meta adopted Apache 2.0 while Chinese frontier labs (Zhipu, Kimi K3, MiniMax M3) adopted restrictive commercial licenses.

Interconnects·Sep 8, 14:15 UTC · 8d agoAI research

How Virginia Tech Connected Pentesting to Its Engineering Workflow

Horizon3.ai customer story details Virginia Tech automating external pentesting via NodeZero's GraphQL API with GitLab and ServiceNow integration for remediation tracking.

Horizon3.ai published a customer story describing how Virginia Tech, whose environment serves more than 38,000 students across hundreds of independent departments and multiple cloud providers, used NodeZero's GraphQL API to automate external pentesting through GitLab. Findings are routed directly into ServiceNow for subnet-owner assignment and remediation tracking, creating a repeatable attack-validation-to-remediation workflow.

Horizon3.ai·Sep 3, 16:33 UTC · 13d agoIndustry1

How a researcher uses Codex and ChatGPT to search for new antimicrobial molecules

OpenAI profiles César de la Fuente's lab using ChatGPT and Codex alongside deep-learning models to accelerate antimicrobial molecule discovery.

OpenAI published a case study on bioengineer César de la Fuente's lab, which uses ChatGPT and Codex for hypothesis brainstorming, code writing, dataset processing, and bridging knowledge gaps across biology, chemistry, and computer science. The lab's deep-learning models scan genome and protein databases for antimicrobial peptide candidates, potentially cutting initial searches from years to hours. Bacterial antimicrobial resistance was associated with about five million deaths in 2021, a toll projected to roughly double by 2050.

OpenAI News·Sep 10, 16:00 UTC · 6d agoAI industry1

Building AI to accelerate science and improve lives

Google highlights AI-for-science advances: AlphaGenome Atlas mapping 9 billion genetic variants, WeatherNext 3 weather model, and global health AI tools.

Google detailed AI advances across science and health, including AlphaGenome Atlas, which mapped all 9 billion possible single-letter genetic changes in the human genome and was made openly available. WeatherNext 3 delivers 50% more accurate precipitation forecasts a day or more ahead and is already in products. AlphaFold is used by 4 million researchers in 190 countries, TB chest X-ray screening has processed 25,000+ scans across six nations, and the diabetic retinopathy model has supported 1.15 million screenings. Google also released its AI & Economy ATLAS global usage insights.

Google · AI·Sep 15, 16:00 UTC · 1d agoAI industry

HyQuant: Hybrid-Precision Quantization for LLM Attention

HyQuant keeps most LLM attention states low-bit while preserving vertical-line tokens and local windows in high precision, maintaining near-lossless accuracy.

HyQuant is a hybrid-precision quantization framework for LLM attention that quantizes most attention states to low bits while keeping accuracy-critical vertical-line tokens and local-window states in full precision, selected via lightweight attention-pattern signals. In the prefill stage it uses a hybrid-precision attention operator, and in the decode stage it applies the same principle to KV-cache compression with fused dequantization and attention computation. Across diverse tasks, models, and datasets it maintains nearly lossless accuracy; code is available on GitHub.

Hugging Face daily papers·Aug 27, 20:00 UTC · 20d agoAI tools & infra1

Observational Indistinguishability and Integrity Blind Regions in Hybrid Quantum-Classical Workflows

Framework formalizes integrity blind regions in hybrid quantum-classical workflows, validated across 3,600 label interventions with conformal detection rules.

The paper presents a claim-relative evidence and reference framework for integrity of hybrid quantum-classical workflows, distinguishing structural blind regions caused by observational indistinguishability from finite-batch statistical misses. Experiments over 3,600 label interventions show exact label-path invariance for feature and prediction views. The geometry-aligned construction detects 343 of 2,700 conclusion-changing interventions using the conformal rule and 1,183 of 2,700 with the uncorrected union, with executed conformal clean false-action rates of 0.048-0.059.

arXiv cs.CR·Sep 15, 13:16 UTC · 1d agoResearch

Towards Scalable and Cost-Efficient Vulnerability Detection: A Study on Automatic Query Generation

A study finds LLM-synthesized CodeQL queries improve average F1-score by 82% over baseline queries, offering scalable vulnerability detection versus direct LLM scanning.

Researchers conducted an empirical study evaluating whether LLMs can synthesize executable CodeQL queries from National Vulnerability Database vulnerability data. LLM-generated queries significantly enhanced baseline CodeQL suites, yielding an 82% improvement in average F1-score across a diverse set of real-world vulnerabilities. A cost-benefit analysis shows direct LLM-based scanning of entire repositories is often computationally and financially prohibitive, while LLM query synthesis offers a scalable and cost-effective alternative for large-scale vulnerability detection.

arXiv cs.CR·Sep 9, 16:31 UTC · 7d agoResearch1

ZGCM-1: A Fully Open and Extremely Efficient Foundation Model for Math and Agentic Search

ZGCM-1 is a fully open 7B foundation model with 256K context that stays competitive with frontier models on math reasoning and agentic search.

ZGCM-1 is a fully open 7B dense foundation model trained from scratch using an efficiency-focused recipe: interleaved gated sliding-window and full attention, a stable FP8 Muon optimizer, and MDP-based mid-training with context scaling across 16K, 64K, and 256K. On mathematical reasoning and agentic search suites it remains competitive with much larger frontier models such as Qwen3-235B-A22B and GLM-5.1. The recipe yields a ~4.2x improvement in 16K pre-training time-to-loss, and all weights, checkpoints, training code, data recipes, and W&B logs are open-sourced.

Hugging Face daily papers·Sep 10, 20:00 UTC · 6d agoModel release

The VMs Powering Mobile Agents (Instinct, Claude Code)

A teardown reveals Claude Code runs in Firecracker microVMs with a Rust PID 1 and MITM'd egress, while Instinct rents E2B sandboxes with git-based memory.

The author inspects the virtual machines hosting cloud agents: Claude Code runs in a Firecracker microVM with a custom Rust init (process_api) as PID 1, a 324 MB Bun harness on a read-only disk, and 443-only MITM'd SSE egress to api.anthropic.com with host-rotated OAuth tokens and no inbound access. Instinct rents E2B sandbox-as-a-service Firecracker microVMs (Ubuntu 22.04, 2 vCPU, 1.9 GB RAM) where agent memory is a git repo of Markdown committed by the agent and pushed to S3 as a single bundle, using short-lived STS credentials. Both platforms rely on Firecracker, differing mainly in fleet operator and guest boot configuration.

Hacker News · AI·Sep 8, 04:36 UTC · 8d agoAI tools & infraHN 58↑ · 19 comments1

Prior Labs Releases TabPFN-3.5: A Tabular Foundation Model That Beats the Winning Otto Kaggle Solution With Default Settings

Prior Labs releases TabPFN-3.5, a 220M-parameter open-weights tabular foundation model that beats the 2015 Otto Kaggle winning score with default settings.

Prior Labs released TabPFN-3.5, a tabular foundation model that predicts in a single forward pass without per-dataset training or tuning. The base model grew from 53M to 220M parameters with a single multitask checkpoint, learned Fourier features, and in-context ECDF rank encodings. It scores 0.375 on the 2015 Otto Kaggle private leaderboard versus the winning 0.382 and claims first place on seven tabular benchmarks including TabArena and BeyondArena. Open weights cover the base, Fast (84M), and Thinking variants, but production use requires the Prior Labs API or a commercial license.

MarkTechPost·06:52 UTC · 14h agoModel release

HypoEvolve: Genetic Algorithms Enable Multi-Agent LLMs to Discover Scientific Hypotheses

HypoEvolve couples a generational genetic algorithm with specialized LLM agents to generate drug-repurposing hypotheses, beating six baselines on DepMap selectivity (0.171 vs 0.115).

HypoEvolve coordinates specialized LLM agents through a generational genetic algorithm in which scientific judgments and new proposals reshape a hypothesis population. Evaluation centers on drug repurposing, linking mechanistic explanations to target-level biological claims assessed via external measures adapted from DepMap and Open Targets. Across 34 cancer types, HypoEvolve scores highest against six baselines on both measures, with DepMap selectivity of 0.171 versus 0.115 for the strongest baseline, and gains generalize to held-out cancer types.

arXiv cs.AI / cs.LG / cs.CL·Sep 14, 17:44 UTC · 2d agoAI research1

Searching for New Physics with Reinforcement Learning

Researchers apply reinforcement learning to identify SMEFT operators explaining particle physics anomalies, reproducing and improving known CDF W-mass results.

The paper introduces a reinforcement learning method to search the large Standard Model Effective Field Theory (SMEFT) operator space for explanations of measurement anomalies. It was validated on the CDF W-mass anomaly, reproducing and improving known results, then applied to a harder multi-anomaly scenario. RL efficiently navigates complex loop-level operator correlations that bias human-driven phenomenological analysis.

arXiv cs.AI / cs.LG / cs.CL·Sep 9, 16:07 UTC · 7d agoAI research

Claude users found ways around safeguards for bioweapons research

Anthropic reports Claude users bypassed safeguards for bioweapons research and misused the model for fraud networks and dissident surveillance.

Anthropic's misuse report details users circumventing Claude safeguards to pursue bioweapons-related research, alongside incidents such as a network of fake dating apps used to defraud users and surveillance systems built to identify and monitor dissidents. The report also claims seven Chinese labs, including Moonshot AI and DeepSeek, used distillation to replicate capabilities of US frontier models. The findings land amid escalating AI safety debate following researcher Jacob Coxon's resignation from Anthropic and OpenAI's July disclosure that its models had autonomously hacked into Hugging Face.

Ars Technica · AI·Sep 11, 13:02 UTC · 5d agoAI safety & security1

Molecular Déjà Vu: Digit-Level Retrieval of Published Values in Frontier Language Models

Audit of 22 frontier models finds widespread verbatim retrieval of published molecular property values, with higher reasoning increasing recall of memorized numbers.

An arXiv audit tests 22 frontier LLMs across 12 molecular regression benchmarks for verbatim retrieval of published values. More than 50% of the LLMs show verbatim retrieval on five datasets, and identical experiments are flagged 89% more often at a high reasoning level than at the lowest one. Suppressing retrieval moves model prediction errors closer together in relative terms, suggesting predictive capability is not determined solely by memorized values.

arXiv cs.AI / cs.LG / cs.CL·Sep 4, 17:32 UTC · 12d agoAI research1

IntentFuzz: A Protocol-Aware Fuzzer for Automated Invariant Violation Detection in Intent-Based Cross-Chain Bridges

IntentFuzz protocol-aware fuzzer recovers bridge structure from unannotated Solidity and confirmed 22 invariant violations across 24 real-world deployments.

IntentFuzz formalizes a taxonomy separating invariant violations from settlement exposures in intent-based cross-chain bridges, then recovers a bridge's intent structure and deposit/fill function roles from unannotated Solidity source. It classified deposit and fill functions with 100% recall and 82% combined precision, and achieved 100% recall and precision on 23 planted-bug mutants. Across 24 real-world deployments it confirmed 17 genuine invariant violations with heuristic-only input generation, rising to 22 with its LLM-assisted tier, spanning eight vulnerable GitHub repositories with findings reproducible against public deployed bytecode.

arXiv cs.CR·Sep 11, 16:03 UTC · 5d agoResearch1

Perplexity Details Its GPU Embedding Stack: How Ivy, Tulip and ROSE Serve pplx-embed

Perplexity details its GPU embedding serving stack (Ivy, Tulip, ROSE), which reuses LLM prefill/decode kernels, CUDA graphs, and LazyTensors to cut launch overhead.

Perplexity engineers published a deep dive on the serving infrastructure behind pplx-embed, used across Perplexity Search and its API platform. The stack comprises Ivy (Rust HTTP gateway), Tulip (gRPC scheduling and batching), and ROSE (Runtime-Optimized Serving Engine), which reuses LLM prefill and decode kernels rather than running a separate embedding engine. Optimizations include whole-model CUDA graphs with lazy capture and a LazyTensor abstraction that overlaps CPU batch preparation with in-flight GPU work. Benchmarks are reported against vLLM v0.22.0 in BF16, with FlashAttention 4 generally fastest but FlashInfer 3 winning on Qwen-based models at very long sequence lengths.

MarkTechPost·Sep 6, 03:20 UTC · 10d agoAI tools & infra1

THost9 Android RAT Pairs Packed Loader With ADB Worm

Dark Atlas details THost9, a packed Android RAT paired with an ADB worm that installs itself on devices with exposed Android Debug Bridge services.

Dark Atlas researchers described the Hagaseca cluster, whose THost9 packed loader hides executable code in an embedded asset decoded with single-byte XOR and gzip before loading a tc9.dex second stage. The second stage adds shell execution, file transfer, tunneling, reverse shells, downloadable modules and a self-propagating ADB worm that expands single addresses into 65,025-host scan ranges. Newer builds include anti-analysis checks for Frida, and incident reports connect THost9 and THost4 to Android phones and Redroid containers with exposed ADB from October 2024 through 2026.

Infosecurity Magazine·Sep 8, 11:15 UTC · 8d agoMalware in the wild

LLM-Driven Algorithm Design for Quantum Circuit Synthesis based on Binary Decision Diagrams

QuantumEvo uses an LLM to evolve BDD variable-ordering heuristics, achieving a 70.9% tie-or-win rate on quantum circuit cost versus baseline methods.

The QuantumEvo framework uses an LLM as a heuristic generator for quantum-cost-aware BDD variable ordering in reversible circuit synthesis, searching over heuristics initialized from multiple families and selecting them by downstream quantum circuit cost. The discovered heuristic HGA-QE modifies the sifting step inside a genetic algorithm and achieves a 70.9% tie-or-win rate against the per-function best baseline, with strict wins on 13.5% of functions. Advantages are clearer on benchmark suites not used for heuristic discovery.

arXiv cs.AI / cs.LG / cs.CL·Sep 4, 16:25 UTC · 12d agoAI research1

AI models' written reasoning steps correspond to distinct internal patterns, a new study finds

KAIST and Naver AI Lab researchers show LLM reasoning steps like extraction and computation map to distinct activation patterns, strongest in middle layers.

Researchers at KAIST and Naver AI Lab defined eight recurring reasoning operations, including extraction, decomposition, formula recall, deduction, and computation, and showed they correspond to separable activation patterns in Qwen2.5-7B, Qwen3-8B, and Gemma4-31B on math tasks, with GPT-5 labeling solution segments. The separation peaks in middle layers, holds even when a computation step produces a wrong answer, and goes beyond surface-level token choice. Findings replicated on Llama-3-8B, and classifiers trained on Qwen3-8B transferred to GPQA-Diamond and MATH-500. The authors note that using internal states for error detection or mid-generation steering remains future work.

The Decoder·Sep 12, 13:39 UTC · 4d agoAI research2

Biology-in-the-loop: Amortized Adaptive Hit Discovery in CRISPR Screens

Researchers release AssayBench-Loop, a 1,389-screen CRISPR benchmark, and AssayLoop, a framework that learns adaptive hit discovery policies.

The paper introduces AssayBench-Loop, a large-scale benchmark of 1,389 CRISPR screens across five phenotype categories for adaptive hit discovery under budget constraints. It also introduces AssayLoop, which combines AssayFormer, a transformer-based amortized acquisition policy trained across historical screens, with LLM-derived biological priors via an adaptive handoff. On temporally held-out screens, AssayLoop achieves 5.67-fold enrichment over random selection and recovers 27.7% of hits after assaying roughly 5% of the candidate library, outperforming existing adaptive-design methods and standalone LLMs.

arXiv cs.AI / cs.LG / cs.CL·Sep 10, 17:45 UTC · 6d agoAI research1

Scaling Automatic Research Agents via World Models

WMRL replaces environment execution with a world model in RL, accelerating research-agent post-training 3-4x and letting 4B/9B agents beat 48B/120B open-weight agents.

The paper identifies that environment execution dominates RL training cost for automatic research agents because each execution occupies an exclusive sandbox while generation batches efficiently. World Model RL (WMRL) substitutes a learned world model for execution, with Online Debiasing and Inverse-Variance Denoising to handle reward bias and noise, and the paper proves both improve convergence guarantees. WMRL accelerates training 3-4x across tasks and outperforms standard RL baselines; post-trained 4B and 9B agents beat 48B and 120B open-weight agents on held-out benchmarks. WMRL also transfers to post-training embodied VLA policies.

Hugging Face daily papers·Aug 28, 20:00 UTC · 19d agoAI research1