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ScienceBuddy: Recursive-in-Recursive Self-Improvement for Interactive Scientific Agents

ScienceBuddy couples harness evolution with model reinforcement learning so scientific agents continually self-improve from researcher feedback in an interactive workspace.

The authors release ScienceBuddy, an interactive scientific research workspace that transforms researcher requests, feedback, and execution evidence into tasks and evaluation rubrics for continual learning. Its recursive-in-recursive self-improvement paradigm couples harness evolution (inner recursion, model fixed) with model reinforcement learning under the improved harness (outer recursion). Case studies span four scientific task families, and the system is released to the scientific community as a research product.

HypoEvolve: Genetic Algorithms Enable Multi-Agent LLMs to Discover Scientific Hypotheses

HypoEvolve couples a generational genetic algorithm with specialized LLM agents to generate drug-repurposing hypotheses, beating six baselines on DepMap selectivity (0.171 vs 0.115).

HypoEvolve coordinates specialized LLM agents through a generational genetic algorithm in which scientific judgments and new proposals reshape a hypothesis population. Evaluation centers on drug repurposing, linking mechanistic explanations to target-level biological claims assessed via external measures adapted from DepMap and Open Targets. Across 34 cancer types, HypoEvolve scores highest against six baselines on both measures, with DepMap selectivity of 0.171 versus 0.115 for the strongest baseline, and gains generalize to held-out cancer types.

arXiv cs.AI / cs.LG / cs.CL · 1d agoAI research1

Google's AI genome system evaluates every possible one-base change

Google's AlphaGenome AI system predicts functional effects of non-coding DNA variants in humans and mice.

Google's AlphaGenome AI system evaluates genomic sequences to predict gene expression, transcription factor binding, chromatin accessibility, splice site usage, and related genomic features. The system is currently limited to human and mouse sequences and a limited set of well-studied cell types, but its predictions generally match or exceed specialized software tools. Researchers can use it to assess whether non-coding variants are likely significant and generate hypotheses about their function.

Ars Technica · AI · 6d agoAI research 2 sources

LLM-Driven Algorithm Design for Quantum Circuit Synthesis based on Binary Decision Diagrams

QuantumEvo uses an LLM to evolve BDD variable-ordering heuristics, achieving a 70.9% tie-or-win rate on quantum circuit cost versus baseline methods.

The QuantumEvo framework uses an LLM as a heuristic generator for quantum-cost-aware BDD variable ordering in reversible circuit synthesis, searching over heuristics initialized from multiple families and selecting them by downstream quantum circuit cost. The discovered heuristic HGA-QE modifies the sifting step inside a genetic algorithm and achieves a 70.9% tie-or-win rate against the per-function best baseline, with strict wins on 13.5% of functions. Advantages are clearer on benchmark suites not used for heuristic discovery.

arXiv cs.AI / cs.LG / cs.CL · 11d agoAI research1

ModularRSI: Modular and Generalizable Recursive Harness Self-Improvementnew

Researchers propose ModularRSI, a modular benchmark-disjoint recursive self-improvement framework that evolves agent harnesses across five modules, improving TB2.0 and SWE-Bench Verified results.

ModularRSI targets generalizable recursive self-improvement (RSI) for agent harnesses by contrasting successful and failed trajectories for the same task and aggregating evidence across tasks to find recurring behavioral deficiencies. It decomposes the evolvable harness into five modules—Agent Loop, Tool Use, Observation Management, Context Management, and Task Completion Detection—each evolved independently within a restricted scope, then integrated with conflict resolution. Using 2,000 executable evolution tasks disjoint from evaluation benchmarks, it shows consistent gains on TB2.0 and SWE-Bench Verified and transfers across different foundation models.

Hugging Face daily papers · 2d agoAI research

From Concept to Context Engine: How Wiz Built AI-Powered Data Discovery

Wiz details the multi-agent pipeline and feedback loops that evolved its bucket scanner into AI-powered data discovery.

Wiz published an engineering write-up on building its AI-powered data discovery capability, tracing the evolution from a bucket scanner to a context engine. The post explains the multi-agent pipeline and feedback loops behind the system. The article is a vendor engineering deep-dive with no disclosed vulnerabilities, incidents, or exploitation activity.

Wiz Blog · 19d agoTools1

Guiding Worker Self-Selection in Crowdsourcing Contests: An LLM-Augmented Algorithmic Approach

Researchers introduce GRAF, a greedy framework for crowdsourcing contest self-selection, and LLMScore, an LLM-driven method that auto-designs its scoring algorithm.

The paper studies self-selection in Tullock contests (SSTC), where workers choose contests and then compete within them. GRAF is a greedy polynomial-time framework that orders workers by a score vector with zero worker regret and platform optimality guarantees in special cases. LLMScore is an LLM-driven evolutionary framework that produces human-readable, inspectable scoring code, jointly optimizing platform utility and worker satisfaction. Across 1,000 synthetic instances in four settings, GRAF with LLMScore achieves high-quality, often near-optimal outcomes with low worker regret, transferring from small training instances to larger, structurally different settings.

arXiv cs.AI / cs.LG / cs.CL · 8d agoAI research1

EVOHARNESSBENCH: Can Your Agents Keep Pace with an Evolving Harness?

Researchers introduce EVOHARNESSBENCH, a benchmark showing that evolving agent harnesses (tools, skills, agents) cause forgetting and inconsistent adaptation across 802 tasks.

The paper introduces EVOHARNESSBENCH, a benchmark that places non-stationarity in the externally supplied agent harness rather than in the task stream, evaluating agents across tools, skills, and specialist agents. It comprises 17 multi-stage harness streams built deterministically from verifier-based benchmarks, totaling 802 tasks, 520 tools, 42 skills, and 62 agents. Evaluation covers deployment (retention of previously accessible competence) and self-evolving adaptation settings. Results show harness expansion alone degrades previously solved tasks (harness-induced forgetting), adaptation gains are inconsistent, and retention and adaptation can pull in opposite directions.

Hugging Face daily papers · 13d agoAI research

AgenticGen: Reward-Guided Agentic Video Generation for Advertising

AgenticGen applies DPO and GRPO reward-guided reasoning to ad video generation, improving TikTok CTR 2.72%, CVR 2.63%, and Advv 9.61%.

AgenticGen decomposes advertising video generation into two trainable reasoning stages, strategy selection and draft generation, supervised by online business feedback. It learns a performance-based reward from accumulated online feedback plus a rubric-based reward aligned with human quality standards, then optimizes policies with DPO followed by GRPO using process and outcome rewards. Online A/B experiments in the TikTok advertising system show CTR up 2.72%, CVR up 2.63%, and Advv up 9.61% over an SFT baseline.

Hugging Face daily papers · 16d agoAI research

Dream-RSI: Recursive Self-Improvement through Evolving Worlds

Dream-RSI refines exploration policies by dreaming in replay simulators built from discovery history, cutting discovery costs across coding tasks.

Dream-RSI is a framework for scalable recursive self-improvement in autonomous coding agents, where a lightweight orchestration layer makes exploration explicit and programmable while leaving the underlying agent unchanged. Its core insight is that accumulated discovery history can serve as a replay simulator over the realized search space, providing immediate, low-cost off-policy feedback to evaluate and refine exploration policies without expensive online evaluations. Across algorithm engineering, mathematical optimization, and GPU kernel engineering, Dream-RSI achieves competitive or improved discovery quality at substantially reduced cost.

Hugging Face daily papers · 2d agoAI research

MIT creates method to force AI to comply with safety rules

MIT researchers published HardFlow, a method enforcing hard safety constraints on flow-matching generative models' final outputs without retraining.

MIT researchers led by Zeyang Li and Navid Azizan developed HardFlow, a trajectory-optimization method that enforces strict, non-negotiable constraints on flow-matching generative models by checking rule satisfaction only at the final generation step. Published in IEEE TPAMI, it outperformed six rival projection and guidance methods on four simulated benchmarks including D3IL robotic manipulation, Maze2D, physical process control, and image editing. All results are simulation-only, with no independent reproduction yet reported.

Entropy-Regularized Rank-Masked Policy Optimization for Test-Time Reinforcement Learning in Code Generation

Researchers propose ERPO, enabling test-time reinforcement learning for code generation via probe-executed consensus rewards, rank masking, and entropy regularization.

The paper introduces probe-driven test-time reinforcement learning (TTRL) for code generation, where output-free probe inputs are constructed from problem statements and candidate programs are executed on them to compute a Probe Consensus Reward (PCR). Because PCR can be gamed through spurious consensus, the authors propose Entropy-Regularized Rank-Masked Policy Optimization (ERPO), which turns low-PCR outcomes into conservative negative updates via rank masking and constrains policy drift with an entropy ceiling. On coding benchmarks, ERPO substantially improves pass@1 and pass@k in both in-domain adaptation and zero-shot transfer.

arXiv cs.AI / cs.LG / cs.CL · 7d agoAI research1

AI Is Learning to Write Genetic Code

AI models generated viable bacteriophage genomes, with 16 designs successfully replicating and some outperforming the original virus at attacking E. coli.

Two AI models generated complete genome designs for bacteriophages modeled on ΦX174, a virus known to infect E. coli. Researchers produced about 700,000 candidate designs, selected 285 promising ones, and synthesized DNA inserted into E. coli, yielding 16 viable viruses. Some of the newly generated viruses proved more effective at attacking E. coli than the original bacteriophage.

Schneier on Security · 25d agoAI research

COBRA-Skills: Contextual Bandit-Guided Evolution for Agent Skill Optimization

COBRA-Skills uses contextual bandits to guide LLM agent skill evolution, cutting optimization cost 55-58% versus SkillOpt while topping six agent benchmarks.

COBRA-Skills formulates LLM agent skill optimization as budgeted sequential optimization over a dynamically evolving candidate space. It couples contextual-bandit-guided prioritization with evidence-grounded skill evolution, selectively spending execution-based evaluations on promising candidates while refining skills from feedback. Across six heterogeneous agent benchmarks and three target models, it achieves the strongest average performance while reducing optimization cost by 55-58% relative to SkillOpt using only 50 unique optimization examples per benchmark. The method remains robust to agent harness changes and works when the target model generates its own skills.

Hugging Face daily papers · 6d agoAI research

AgentGrad: Intervention-guided Prompt Optimization for Multi Agent Systems

AgentGrad introduces intervention-guided prompt optimization for LLM multi-agent systems, achieving state-of-the-art results with 2.5x faster optimization.

AgentGrad is a prompt optimization framework for LLM-based multi-agent systems that addresses limitations in textual gradient extraction and aggregation. It uses sequential intervention to identify the agent whose prompt modification resolves a given failure, then applies agent-level supervision and semantic gradient clustering to build generalized gradients. Experiments report state-of-the-art performance across five MAS benchmarks and a 2.5x average reduction in wall-clock optimization time versus the next-fastest baseline.

Hugging Face daily papers · 8d agoAI research

StudyBench: Can Self-Evolution Squeeze Textbooks for Olympiad Capability?

Researchers introduce StudyBench, a physics benchmark showing self-evolution gains on textbook problems rarely transfer to olympiad-level questions.

StudyBench is a controlled physics benchmark splitting test data into an Application Set of difficult textbook problems and a Transfer Set of olympiad-level problems. Across three base models, representative self-evolution methods improved on the Application Set but rarely transferred to the harder Transfer Set. A guidance ablation reveals a Guidance Gap, and every method hits a Compute Plateau, indicating the remaining limits are method problems rather than data or compute problems.

Hugging Face daily papers · 15d agoAI research

Transfer Learning for Evolving Domains

TrED formalizes transfer learning for domains whose data availability evolves over time, arguing classical settings are regimes along one trajectory, and remains unsolved.

The paper introduces Transfer Learning for Evolving Domains (TrED), formalizing transfer learning as a trajectory problem where target data and labels are progressively collected. TrED is specified by a data availability process fixed by the environment, a freely chosen learning protocol, and an evaluation criterion scoring the whole trajectory of models. Classical settings like domain generalization, domain adaptation, and multi-domain learning are recovered as regimes within this framework. The authors survey the literature and find most methods are tailored to a single regime, leaving TrED a well-posed open problem.

arXiv cs.AI / cs.LG / cs.CL · 4d agoAI research

Graph Machine: Towards Better Pretraining via Edges

Researchers propose Graph Machine, an O(n)-state sparse architecture that replaces 75% of Qwen3-0.6B dense layers with only slight loss change.

The paper introduces the Graph Machine (GM), an architecture that maintains an O(n)-sized state accessed through sparse, dynamic routing via pointer-like edges updated differentiably by a referral mechanism resembling pointer chasing. The authors replaced 75% of dense Transformer layers in Qwen3-0.6B with GM sparse layers and pretrained from scratch on 15.7B tokens. Retrieving 2 of 4,096 tokens per KV head in each sparse layer degrades loss only slightly, while retrieving 4 marginally improves loss over the dense baseline.

Hugging Face daily papers · 14d agoAI research

Biology-in-the-loop: Amortized Adaptive Hit Discovery in CRISPR Screens

Researchers release AssayBench-Loop, a 1,389-screen CRISPR benchmark, and AssayLoop, a framework that learns adaptive hit discovery policies.

The paper introduces AssayBench-Loop, a large-scale benchmark of 1,389 CRISPR screens across five phenotype categories for adaptive hit discovery under budget constraints. It also introduces AssayLoop, which combines AssayFormer, a transformer-based amortized acquisition policy trained across historical screens, with LLM-derived biological priors via an adaptive handoff. On temporally held-out screens, AssayLoop achieves 5.67-fold enrichment over random selection and recovers 27.7% of hits after assaying roughly 5% of the candidate library, outperforming existing adaptive-design methods and standalone LLMs.

arXiv cs.AI / cs.LG / cs.CL · 5d agoAI research1

Building AI to accelerate science and improve lives

Google highlights AI-for-science advances: AlphaGenome Atlas mapping 9 billion genetic variants, WeatherNext 3 weather model, and global health AI tools.

Google detailed AI advances across science and health, including AlphaGenome Atlas, which mapped all 9 billion possible single-letter genetic changes in the human genome and was made openly available. WeatherNext 3 delivers 50% more accurate precipitation forecasts a day or more ahead and is already in products. AlphaFold is used by 4 million researchers in 190 countries, TB chest X-ray screening has processed 25,000+ scans across six nations, and the diabetic retinopathy model has supported 1.15 million screenings. Google also released its AI & Economy ATLAS global usage insights.

Google · AI · 18h agoAI industry

RSIAgent: Autonomous Exploration for Recursive Self-improvement in New Environments

RSIAgent, a training-free multi-agent framework, builds reusable environment memory enabling Kimi-K3 and GLM-5.3 to beat GPT-6.

RSIAgent is a training-free framework for recursive self-improvement through autonomous memory construction, coordinating curriculum, actor, and verifier agents. It uses broad-then-deep exploration to capture environment structures, hidden constraints, and causal dependencies, and freezes the resulting memory for direct reuse without parameter updates. On OSWorld-v2 and Agent's Last Exam it substantially improves strong open-source models, enabling Kimi-K3 and GLM-5.3 to outperform frontier closed-source models including GPT-6.

Hugging Face daily papers · 2d agoAI research2

Procedural Graphs: Self-Evolving Execution Structures for LLM Agents

Researchers introduce Procedural Graphs, self-evolving (procedure, relation, procedure) structures guiding LLM agent tool use and planning.

Procedural Graphs organize procedural knowledge into (procedure, relation, procedure) triplets to guide LLM agent actions, addressing drift such as lost objectives, out-of-order tool calls, and repeated unproductive steps. At each decision step the framework localizes the active node and a guidance model translates the surrounding subgraph into step-level situational guidance. An LLM refiner edits graph topology by contrasting failed with successful trajectories, and across datasets, task types and LLMs the approach outperforms memory-based baselines and matches or surpasses hand-designed graphs.

arXiv cs.AI / cs.LG / cs.CL · 7d agoAI research1

Beyond Solver Verdicts: Generative Reward Models for Autoformalization

Researchers introduce Generative Verification (GenV), a generative reward model achieving 0.961 AUROC in detecting unfaithful autoformalization that preserves solver verdicts.

The paper formalizes Verdict-Preserving-Unfaithfulness (VPU), a failure mode in neurosymbolic autoformalization where an incorrect encoding executes successfully and matches the expected solver verdict, and proves verdict-only verification is bounded to chance-level detection. The proposed Generative Verification (GenV) distills an offline Z3-equivalence oracle into a reference-free, continuous reference-equivalence score within the language model's vocabulary space. The oracle-mined verifier (GenV+HN) achieves 0.961 AUROC, generalizes zero-shot across unseen translators and formal styles, and yields an 11.3-point downstream accuracy gain in agentic test-time compute allocation. Mechanistic analysis with decision-projected logit lenses and sparse autoencoders shows the generative readout extracts precise spatial error coordinates without explicit localization training.

Hugging Face daily papers · 6d agoAI research1

Train Smarter, Not Harder: Switching Signal-Guided Training in Active Learning

HybridAL is an active-learning training schedule that switches from retraining to fine-tuning on stabilization signals, saving up to 49% time.

Researchers find that choosing between retraining from scratch and fine-tuning is an exploitable decision variable in active learning: retraining helps in early rounds while fine-tuning is safer once the model trajectory stabilizes. HybridAL monitors an online stabilization signal using spectral exponent change and accuracy change, switching from retraining to fine-tuning after sustained stabilization. Across three encoder backbones and six text-classification tasks with five seeds each, HybridAL keeps endpoint macro-F1 non-inferior within a 0.010 margin, saves up to 49% of retraining time, and improves the time-calibration trade-off measured by negative log-likelihood.

Hugging Face daily papers · 10d agoAI research

Co-Evolving Harnesses and Models: On-Policy Correction Helps Weaker Models Catch Up Where Imitation Fails

Research shows on-policy expert correction, not imitation fine-tuning, lets weaker agent models catch up under evolved harnesses.

Researchers study how to combine automated agent-harness evolution with lightweight fine-tuning across seven enterprise agent tasks. Naively training weaker models (Qwen3-Coder, Gemma 4) on expert trajectories under an evolved harness regressed performance by 4 to 30 points on all tasks. They propose an on-policy correction pipeline, automated by a meta-level MLE agent, where an expert rewrites only the failing turn of the weaker model's rollout, preserving model-harness fit.

arXiv cs.AI / cs.LG / cs.CL · 7d agoAI research

AlphaGenome Atlas: A predictive map of every possible DNA letter change in the human genome

Google DeepMind released AlphaGenome Atlas, a free 1-petabyte platform predicting the molecular effects of all ~9 billion possible single-letter DNA variants.

Google DeepMind introduced AlphaGenome Atlas, containing precomputed predictions for the effects of roughly 9 billion single-nucleotide variants across the human genome, spanning hundreds of human and mouse cell types. The 1-petabyte dataset is more than 30 times larger than the AlphaFold Database and includes an AlphaGenome Variant Impact (AVI) score combining AlphaGenome and AlphaMissense predictions for both coding and non-coding regions. External collaborators have already used it to identify and experimentally verify variants in unsolved rare disease research. It is available via a free web portal, the AlphaGenome API, and as a skill in Google Antigravity.

Google DeepMind · 7d agoAI research 2 sources

On the Navier–Stokes Millennium Prize Problem

OpenAI announced an AI-generated solution to the Navier-Stokes Millennium Prize Problem, including a writeup and a formal Lean proof.

OpenAI shared what it describes as an AI-generated solution to the Navier-Stokes Millennium Prize Problem, one of the Clay Mathematics Institute's seven Millennium Prize Problems concerning fluid dynamics. The announcement includes a writeup and a machine-checkable formal proof in the Lean theorem prover. Details on the model, methodology and independent verification were not provided in the announcement text.

OpenAI News · 8d agoAI research

Procedural Graphs: Self-Evolving Execution Structures for LLM Agents

Procedural Graph framework stores procedural knowledge as triplets and self-evolves via LLM refinement, beating memory-based baselines across datasets, tasks, and LLMs.

The Procedural Graph organizes procedural knowledge into (procedure, relation, procedure) triplets; at each decision step the framework localizes the agent's active node and a guidance model translates the surrounding subgraph into step-level guidance that biases the solver's next action. An LLM refiner contrasts failed with successful trajectories and edits the graph's topology and attributes, retaining rejected edits to discourage repetition. Starting from a minimal skeleton, the loop builds graphs that match or surpass hand-designed ones and can repair flawed expert priors, delivering consistent gains over memory-based baselines across multiple datasets, task types, and LLMs.

Hugging Face daily papers · 8d agoAI research1

An Open Recipe for IMO Gold: Training Nemotron for Olympiad Mathematics

Open post-training pipeline turns Nemotron 3 Ultra checkpoints into an IMO 2026 gold-medal system, scoring 30/42 without formal provers or external tools.

Starting from Nemotron 3 Ultra, researchers trained two specialist checkpoints using supervised fine-tuning and reinforcement learning for natural-language olympiad proof generation. Three checkpoints power an iterative generate-verify-refine search plus a separate high-compute selection stage, operating entirely in natural language with no formal prover, external tools, or internet access. The system scored 30 of 42 points at IMO 2026, reaching the gold-medal threshold. The release includes the post-trained checkpoints, training data, training and inference code, submitted solutions, and Nemotron-IMO-Bench with 200 novel olympiad-level problems.

Hugging Face daily papers · 7d agoModel release