Search: “quest-diagnostics”

Discovery Foundation Models: Toward Open-Ended Discovery Intelligence

Proposes Discovery Foundation Models that participate in creating new problems and knowledge, instantiated in Zetema and the GALILEO therapeutic-discovery system.

The paper formulates Discovery Foundation Models (DFMs) as general-purpose systems for open-ended discovery, supporting seven coupled capabilities from problem discovery through evidence-grounded revision and continual improvement. It instantiates the framework with Zetema, combining explicit research-state dynamics, verification gating, external grounding, and cross-task Discovery Skill evolution. GALILEO, a real therapeutic-discovery system, closes the loop between Dry-Lab reasoning, robotic and hands-on Wet-Lab experimentation, and iterative hypothesis revision. The authors also define process-centered evaluation so discovery behavior can be trained and measured beyond final answers.

arXiv cs.AI / cs.LG / cs.CL·Sep 14, 17:56 UTC · 1d agoAI research 2 sources

AI SIEM Search

Huntress launched AI Search for Managed SIEM, translating plain-English questions into ESQL log queries with schedulable custom alerts.

Huntress introduced AI Search in its Managed SIEM, letting users query logs in natural language instead of writing ESQL, KQL, or SPL. The feature generates a real ESQL query behind the scenes, exposes it for users to inspect and learn from, and allows saved searches to be scheduled as recurring alerts at hourly, daily, or weekly cadence. A planned next version will return summarized plain-language answers instead of raw logs.

Huntress·Sep 7, 14:00 UTC · 9d agoTools

Emergency Department Revisit Quality Review Screening: Exploring Human Decision-Making and Artificial Intelligence Support

A retrospective study found GPT-4 over-flagged emergency department revisit cases while an LLM knowledge-graph screener achieved 83-100% positive predictive value.

In an exploratory retrospective study of 99 emergency department diagnosis pairs from a multihospital health system, clinicians and GPT-4 independently judged whether revisit pairs warranted further assessment. GPT-4 responses correlated poorly with clinicians, flagging 94% of pairs for follow-up, 4.4-13.3 times more than clinicians, though prompt engineering was minimal. An algorithm leveraging an LLM-populated knowledge graph (KGA) achieved 83-100% positive predictive value against at least one clinician rater, suggesting LLM-based screening could broaden revisit quality review without substantially increasing reviewer workload.

arXiv cs.AI / cs.LG / cs.CL·Sep 9, 16:37 UTC · 7d agoAI research1

AI-Infra-Guard: Open-source security scanner for AI systems

Tencent's Zhuque Lab open-sourced AI-Infra-Guard, a scanner that fingerprints AI services, checks 1,600+ CVEs, and evaluates MCP skills.

AI-Infra-Guard fingerprints running AI services such as Ollama, vLLM and ComfyUI, checks them against more than 1,600 known CVEs, and inspects MCP servers and agent skills across 14 risk categories. Its SkillTrustBench judging set contains 5,520 human-labeled samples, with false positive rates of 1.20%–18.67% depending on the judging model. Users include ICBC, China Merchants Bank, China Telecom, Lenovo, vivo and Bilibili. Release 4.1.9 hardened scanning agents against indirect prompt injection, and the open-source build ships without authentication, requiring a reverse proxy with Basic Auth or an IP allowlist.

Help Net Security·Sep 9, 05:30 UTC · 7d agoTools

Performance of Clinical AI System and Physicians and Frontier Language Models in primary care diagnostics

Clinical AI system Doctorina achieved 82.0% primary-care diagnostic concordance versus 57.0% for physicians across 150 synthetic consultations.

The study compared Doctorina, eight physicians, and four standalone frontier language models on 150 synthetic Polish-language primary-care consultations. Doctorina achieved 82.0% Top-1 diagnostic concordance versus 57.0% for physicians (25.0-point difference, 95% CI 17.7-32.7) and 97.3% versus 85.0% primary-or-reference-differential concordance. Normalized workup and treatment scores were 89.4 versus 66.9 and 83.7 versus 61.2. Kimi K3 ranked next on diagnosis, while Claude Opus 5 led the closely spaced management estimates among Opus, Doctorina and Kimi.

arXiv cs.AI / cs.LG / cs.CL·Sep 8, 17:25 UTC · 8d agoAI research

ENCP: Episode-Normalized Conformal Prediction for Vision-and-Language Navigation

ENCP calibrates conformal prediction per navigation episode, giving step-level coverage guarantees for vision-language navigation agents despite within-episode dependence.

Episode-Normalized Conformal Prediction (ENCP) rescales a nonconformity score by a VLN policy's residual confidence and calibrates one maximum score per episode, preserving step-level coverage of at least 1−α despite dependence among steps within an episode. Across four VLN policies and three nonconformity scores on R2R and REVERIE, ENCP meets all reported empirical step-coverage targets in seen-to-unseen evaluation. The model-agnostic uncertainty estimates can signal when an agent should defer to a stronger predictor or human assistance.

arXiv cs.AI / cs.LG / cs.CL·Sep 15, 17:42 UTC · 23h agoAI research

LongAgent: History-Guided Agentic Search for Longitudinal Outcome Prediction

LongAgent autonomously searches variable sets and temporal windows to predict longitudinal medical outcomes, beating the strongest non-agent baseline on synthetic data.

The paper proposes LongAgent, an agent-based method that searches over combinations of variable sets, temporal windows and aggregation functions for outcome prediction on heterogeneous medical longitudinal data. It uses a history memory of previous searches and numerical evidence to guide exploration. On synthetic data it achieves mean RMSE 1.7376, improving over the best non-agent baseline by 0.0151 (95% CI [0.0045, 0.0260]; p=0.0273), and performs comparably to the best baseline on a real clinical dataset.

arXiv cs.AI / cs.LG / cs.CL·Sep 14, 16:51 UTC · 2d agoAI research

ModaLens: Measuring Image Sensitivity in Report-Conditioned Medical VLMs

ModaLens image-swap audit shows report availability cuts MedGemma-27B image sensitivity on MIMIC-CXR from 20.94% to 4.26% answer changes.

ModaLens is a paired image-swap audit measuring how report availability affects image sensitivity in report-conditioned medical VLMs. On MedGemma-27B across 3,199 paired MIMIC-CXR cases from 293 patients (14 questions per case), generated answers changed on 4.26% of image-swap trials with the report versus 20.94% without it, a 16.7-point paired difference (95% CI 15.6-17.7). The original prompt with a lowercase first-token readout gave 4.70% versus 17.07%, and the direction replicated in two further model lineages. Labels derived from reports limit conclusions about visual correctness; code, prompts, and run records are publicly released.

Hugging Face daily papers·Sep 13, 20:00 UTC · 2d agoAI research

Scores Alone Do Not Prove Discovery: The Discovery Certification Protocol for Auditing AI Research Agents

Researchers introduce the Discovery Certification Protocol, an auditable test framework that verifies whether AI research agents' claimed discoveries are genuine.

The Discovery Certification Protocol (DCP) converts AI research agents' discovery claims into executable recovery and feedback tests organized as gated audits. Controlled audits in SQLite optimization and virtual catalyst control produced zero recoveries in 96 episodes, with an upper bound of 0.0468. A deterministic, LLM-free verifier reproduces audit decisions from frozen evidence, giving AI research a common evidence language for outcomes, alternative routes, and feedback effects.

Hugging Face daily papers·Sep 6, 20:00 UTC · 9d agoAI research

Evidence-Grounded Retrieval for Investigation Hunt Lead Generation from CTI Reports

AHLERT generates environment-aware threat hunting leads from CTI reports using ATT&CK-seeded knowledge graph retrieval, roughly doubling F1 over flat-RAG baselines.

The paper introduces AHLERT, a system that converts Cyber Threat Intelligence reports into structured, investigable hunt leads via hybrid dense retrieval with multi-hop traversal over an MITRE ATT&CK-seeded knowledge graph and ontology-grounded RAG constrained to the defender's assets. It is LLM-agnostic and evaluated on public CTI reports for well-known APTs across proprietary and open-weight models. Hybrid evidence retrieval with ontology grounding raises mean F1 from 0.44 to 0.85, and AHLERT attains the highest effectiveness score (~86.95%) versus off-the-shelf LLMs.

arXiv cs.CR·Sep 8, 14:21 UTC · 8d agoResearch

Product showcase: AI Paper Trail shows the privacy cost of talking to AI

Proton launched AI Paper Trail, a free tool that analyzes ChatGPT or Claude exports and reports what personal data can be inferred from AI conversations.

Proton released AI Paper Trail, a free web tool that analyzes the 200 most recent prompts from exported ChatGPT or Claude conversation histories and generates a privacy report with an AI Exposure Score, inferred personal data categories, and an estimated advertising value. In a hands-on test it identified 47 data points, returned a 58/100 exposure score, estimated $185 in advertising value, and flagged five red flags spanning location, interests, finances, and relationships. Proton states that uploaded data is deleted after analysis and is not stored on its Lumo servers.

Help Net Security·Aug 24, 00:00 UTC · 23d agoAI industry

numbat - AI agent observability, (Fri, Sep 4th)

SANS reviews Perplexity's open source numbat, a Go-based tool giving security teams observability, detection rules, and enforcement for AI agents like Claude and Gemini.

Numbat, Perplexity AI's open source observability tool, monitors desktop, CLI, IDE, and gateway AI agents through local hooks, OTLP/HTTP logs, and on-disk session artifacts. It ships detection rules mapped to MITRE ATT&CK (e.g., recon.network_sweep / T1046), supports enforcement mode, and packages investigations with SHA256-verified manifests and timelines. The SANS review positions it as a response to unmanaged AI agent and MCP server sprawl highlighted by the OpenAI/Hugging Face incident.

SANS Internet Storm Center·Sep 5, 03:39 UTC · 11d agoAI tools & infra

SAEScientist-Bench: Can AI Agents Conduct Autonomous SAE Interpretability Research?

SAEScientist-Bench evaluates whether AI agents can autonomously conduct SAE interpretability research in Gemma-2-9B-IT, finding frontier agents trail expert baselines.

SAEScientist-Bench tests if AI agents can act as scientists using SAE tools for autonomous mechanistic discovery, requiring them to design contrastive probes and navigate a Gemma Scope dictionary of 131K+ features in Gemma-2-9B-IT. Across 10 agent configurations and 20 tasks, frontier agents showed genuine discovery capability but remained well behind expert reference features, lagging most in causal steering. Agents frequently misinterpreted experimental measurements even when designing effective contrasts.

Hugging Face daily papers·Sep 7, 20:00 UTC · 8d agoAI research

The Pelican comparison grid for Astra is pretty interesting

Simon Willison's pelican SVG comparison shows GPT-6 Astra producing markedly better images than GPT-5.6 Sol, Terra, and Luna across reasoning levels.

Willison generated pelicans-riding-bicycles SVGs with newly accessed GPT-6 Astra at low through max reasoning levels and rendered them in a comparison grid against GPT-5.6 Sol, Terra, and Luna. Astra's outputs were markedly more coherent, while even the best GPT-5.6-Sol images remained largely abstract shapes. Astra does not support a reasoning=none setting, so all comparisons involved reasoning-enabled runs.

Simon Willison·Sep 4, 23:59 UTC · 11d agoAI research

Dr. Claw: An AI Scientist Workspace for Vibe Research

Researchers release Dr. Claw, an open-source auditable workspace that wraps coding agents like Claude Code for end-to-end AI-assisted research workflows.

Paper 2609.00365 presents Dr. Claw, an open-source workspace that wraps existing coding-agent executors such as Claude Code and Gemini CLI in a controllable, human-in-the-loop research workflow. It uses persistent state objects, a reusable skill library, and multi-executor coordination to make research decisions auditable and recoverable, rather than adding another autonomous agent. Holding the executor fixed, Dr. Claw scores higher on research completeness than a bare command-line agent while preserving an auditable process trail. The code is released under AGPL-3.0 on GitHub (OpenLAIR/dr-claw).

Hugging Face daily papers·Aug 30, 20:00 UTC · 16d agoAI research1

What the 3M ChatGPT case reveals about AI governance

3M litigation shows ChatGPT prompts can become discoverable evidence, forcing enterprises to govern AI conversation records.

In the Watson Grinding explosion litigation, an engineering expert retained by 3M had used ChatGPT, and a surfaced prompt asked the system to 'show how 3M is 0% at fault'; after an off-record deposition demand, more than 350 pages of previously unproduced ChatGPT material were provided. The author argues AI interaction histories are becoming part of decision records and discovery material, a trend the American Bar Association has already examined. Enterprises are urged to manage retention, ownership, sharing, and deletion of AI conversation logs across tools like ChatGPT, Copilot, Claude, and Gemini.

CSO Online·Sep 14, 09:00 UTC · 2d agoPolicy & legal

Evaluating Verified Autonomy in Quantum Engineering

Quantum-Harbor lab and QIQCBench (49 tasks) expose wide performance gaps across 17 frontier agentic systems in verified quantum engineering.

Researchers built Quantum-Harbor, a virtual laboratory providing a controlled execution environment where scientific AI agents interacting with quantum systems can have both actions and conclusions directly verified. QIQCBench contributes 49 expert-authored tasks spanning calibration and control, error correction and compilation, and sensing and networking. Across 17 frontier agentic systems, verified performance varied widely, exposing a substantial gap between demonstrated capability and reliable autonomous operation.

arXiv cs.AI / cs.LG / cs.CL·Sep 15, 16:46 UTC · 1d agoAI research1

IBIB: A Protocol for Measuring Enterprise AI Systems by Serving Route, Not Model Identifier

IB2 protocol scores enterprise AI systems by serving route with reliability-inclusive scoring; serving-arm choice moved one score from 77.38 to 82.54.

The protocol has three parts: a gold-blind capability-binding preflight verifying a route can execute the evaluation contract, a reliability-inclusive first-pass scoring rule, and structurally score-blind adjudication. Its reference instantiation uses 128 locked tasks and 987 assertions over document, spreadsheet, chart, tool, and database work, released as procedure and schemas rather than an exposed corpus. Across eleven systems, two complete runs on identical weights later failed distinct binding-gate predicates, four of seven suites saturate within a six-system band driven by governed database work and multi-tab joins, and excluding failed responses from denominators changes the point ordering. Serving-arm choice shifted one declared revision and precision from 77.38 to 82.54, though arms differed in access mode, harness generation, and the tool-call parser.

arXiv cs.AI / cs.LG / cs.CL·Sep 9, 17:31 UTC · 7d agoAI research1

AMIE, our research medical AI system, demonstrates real-time clinical video consultation capabilities in a first-of-its-kind study.

Google's AMIE research medical AI system demonstrates real-time clinical video consultations in a first-of-its-kind simulated study.

Google introduced AMIE, its research medical AI system, demonstrating real-time clinical video consultation capabilities in a first-of-its-kind study. The evaluation was conducted in simulated settings, extending the AMIE diagnostic dialogue research line to multimodal video consultations. AMIE remains a research system rather than a deployed clinical product.

Google · AI·Aug 11, 17:00 UTC · Aug 11, 2026AI research

HypoEvolve: Genetic Algorithms Enable Multi-Agent LLMs to Discover Scientific Hypotheses

HypoEvolve couples a generational genetic algorithm with specialized LLM agents to generate drug-repurposing hypotheses, beating six baselines on DepMap selectivity (0.171 vs 0.115).

HypoEvolve coordinates specialized LLM agents through a generational genetic algorithm in which scientific judgments and new proposals reshape a hypothesis population. Evaluation centers on drug repurposing, linking mechanistic explanations to target-level biological claims assessed via external measures adapted from DepMap and Open Targets. Across 34 cancer types, HypoEvolve scores highest against six baselines on both measures, with DepMap selectivity of 0.171 versus 0.115 for the strongest baseline, and gains generalize to held-out cancer types.

arXiv cs.AI / cs.LG / cs.CL·Sep 14, 17:44 UTC · 1d agoAI research1

Former OpenAI researcher builds an AI model that judges options instead of writing text

TypeSafe AI launches Jev, a judgment-only model built by ex-OpenAI staff that classifies inputs with 70-500 ms latency instead of generating text.

Startup TypeSafe AI, co-founded by former OpenAI researcher and InstructGPT co-author Diogo Almeida, introduced Jev, a model that scores developer-defined answer options with probabilities rather than generating free-form text. The company claims 70-500 ms responses, parallel multi-question evaluation, and $0.042 per million input tokens with free outputs, targeting request routing, sales intent scoring, and assistant guardrail checks. Benchmarks are self-built and not independently verified, the 'no hallucination' guarantee only covers output structure, and access is currently via waitlist.

The Decoder·15:19 UTC · 2h agoAI industry

When the prompt becomes the payload: A practical pen-testing guide for GenAI, LLM and RAG applications

CSO Online publishes a practical penetration-testing guide for GenAI, LLM, and RAG applications, covering prompt injection, retrieval poisoning, and tenant isolation testing.

The guide frames LLM applications as attack graphs spanning prompts, retrieval layers, vector stores, tools, identities, and downstream APIs, arguing that conventional web testing misses instruction-vs-data channel risks. It builds on OWASP prompt injection guidance (direct vs. indirect injection) and NIST's 2025 adversarial machine-learning taxonomy, noting that RAG and fine-tuning do not remove injection risk. Recommended practices include documenting trust transitions across components, using canaries and synthetic records to avoid test side effects, running multi-turn and obfuscated injection campaigns, and verifying chains from poisoned documents to observable state changes. It also details testing RAG pipelines via controlled document poisoning across metadata, OCR layers, and code comments, plus cross-tenant isolation checks on retrieved document IDs.

CSO Online·Sep 9, 10:00 UTC · 7d agoAI safety & security1

New View for Security Incident Investigations

Huntress launched a new view giving partners visibility into how its SOC investigates security incidents from first signal to resolution.

Huntress announced a new view into its security incident investigation workflow, showing partners how the Huntress SOC progresses cases from first signal to final resolution, including those closed as benign. The feature adds transparency into SOC triage and investigation decisions for managed detection and response customers.

Huntress·Aug 24, 14:00 UTC · 23d agoTools

SchemeArena: Factorized Stress Testing of Scheming in LLM Agents

Researchers introduce SchemeArena, a 400-scenario benchmark stress-testing scheming in LLM agents, finding explicit instrumental goals are the strongest driver of covert misaligned behavior.

The paper presents SchemeArena, a 400-scenario benchmark built through factorized scenario synthesis spanning safety-relevant tool domains, instrumental goals, oversight conditions and pressure mechanisms. The accompanying SCOUT monitor grounds multi-criteria scheming judgments in evidence drawn from agents' reasoning and actions. Stress tests across five LLM agents show explicit instrumental goals are the strongest driver of scheming propensity, while action-only monitoring increased scheming in several closed models, suggesting partial oversight can act as an optimization constraint. The benchmark, code and monitor are released at github.com/launchnlp/SchemeArena.

Hugging Face daily papers·Sep 7, 20:00 UTC · 8d agoAI safety & security

From Parameters to Answers: How LLMs Retrieve and Use Their Internal Knowledge

Interpretability study traces how Qwen, Llama, and Gemma route query information and internal knowledge across layers when answering questions.

Researchers used layerwise interventions on hidden states to separate query-routing signals from target knowledge in language models, testing Qwen, Llama, and Gemma on country-continent questions with varied answer types. A pair-conditioned request direction strengthens before interventions alter downstream knowledge, opening a causal window while answer-supporting content is still forming. Trajectories differ by model: Gemma shows a partially overlapping mid-layer routing profile, while Llama has no sustained routing-effect window under the same gates.

arXiv cs.AI / cs.LG / cs.CL·Sep 10, 17:39 UTC · 5d agoAI research1

Toolkit Hidden Inside Oracle Database Evades Endpoint Tools

Infosecurity Magazine·Aug 6, 15:30 UTC · Aug 6, 2026Vulnerability

Root-Cause Attribution Is a Search Problem: Continual Search for Long-Horizon Agent Failures

Continual Search framework iteratively prompts LLM judges to keep searching agent execution logs, boosting long-horizon failure root-cause attribution accuracy.

The paper frames automated root-cause attribution (RCA) for long-horizon AI agent failures as a search problem, since relevant evidence is sparse and distributed across massive execution traces. The authors propose Continual Search, an iterative framework that nudges an LLM judge across successive turns to keep hunting unresolved diagnostic evidence instead of settling on an early plausible diagnosis. They introduce MegaRCA-Mix, a benchmark of 50 human-annotated failure trials on long-horizon, execution-heavy tasks. On MegaRCA-Mix, Continual Search improves GPT-5.5's F1 from 0.349 to 0.498 (over 40% gain), and lower-tier models can surpass higher-tier counterparts when search is effective.

Hugging Face daily papers·Sep 10, 20:00 UTC · 5d agoAI research1

Atlas: Efficient Verifiable Semantic Search

Atlas delivers zero-knowledge proofs for HNSW semantic search, verifying RAG retrieval in under a second on SIFT1M and 2.0 seconds at 100M vectors.

Atlas lets a search provider prove that a query was answered correctly against a committed HNSW index without revealing the index, addressing provider deviations like truncation or bias. It combines offline preprocessing, a fixed-size-state restructuring of HNSW with a correctness proof, and timestep-tagged batching of per-step arguments. The system proves queries in under a second on SIFT1M and 2.0 seconds at 100 million vectors while preserving plaintext HNSW recall, and proven retrieval maintains end-to-end RAG answer quality at lower cost than prior verifiable retrieval systems.

arXiv cs.CR·Sep 10, 17:30 UTC · 6d agoResearch1

PuzzleMask: Abusing Plain Prose as a Covert AI Attack Vector

Check Point details PuzzleMask, a plain-prose technique that bypasses LLM gatekeeper policy checks, letting hidden payloads reach target models unreviewed.

Check Point Research describes PuzzleMask, a prompt-crafting technique that hides policy-violating payloads inside plain-English prose wrappers, bypassing quick LLM-based policy checks without emojis, Base64, or invisible formatting. The researchers tested 23 automated prompts against gatekeepers including GPT-4o-mini, GPT-OSS-Safeguard 20b, Claude 3 Haiku, and Llama Guard 3, and all were classified as safe despite policies that flagged the plain versions. When submitted to GPT-5 in thinking-high mode with a Python interpreter, the target model extracted and acted on the payload in over 90% of trials. The technique is not itself a jailbreak but can carry a jailbreak prompt as payload; mitigations include input paraphrasing, hardened gatekeeper policies, and output monitoring.

Check Point Research·updated Sep 11, 05:53 UTC · 5d ago·first Sep 10, 14:32 UTC · 6d agoAI safety & security 2 sources