Search: “uk-biobank”

Google’s Atlas of the human genome could pave the way for new treatments

Google DeepMind launches AlphaGenome Atlas, a catalog of predicted molecular effects for roughly nine billion single-letter DNA changes across the human genome.

Google DeepMind unveiled AlphaGenome Atlas, a roughly 1-petabyte dataset predicting how each of about nine billion possible single-nucleotide variants affects molecular biology, including non-coding regions that regulate gene behavior. It builds on the AlphaGenome model released in 2025 and adds a Variant Impact Score (AVI) to help researchers rank variants. The catalog is available for noncommercial research via a web portal, the Antigravity platform, and the AlphaGenome interface, with commercial access on Google Cloud planned.

The Verge · AI·Sep 8, 14:00 UTC · 8d agoAI industry 2 sources

Welsh environment regulator's FoI blunder exposes diversity data of 2,000 staff

Natural Resources Wales inadvertently exposed diversity data of about 2,000 current and former staff via a 2021 Freedom of Information spreadsheet published online.

Natural Resources Wales confirmed equality monitoring data of roughly 2,000 employees who worked between April 2013 and March 2018 was inadvertently disclosed in a spreadsheet released in 2021 in response to a Freedom of Information Act request. The data may have included ethnicity, disability status, religion or belief, sexual orientation, Welsh language ability, and caring responsibilities — special category data under UK GDPR. The breach was reported to the Information Commissioner's Office, the data was removed and permanently deleted, and NRW says it has found no evidence of misuse. The issue was discovered only after a member of the public alerted the regulator on 23 August 2026.

The Register · Security·Sep 7, 11:04 UTC · 9d agoData breach

Google DeepMind Releases AlphaGenome Atlas With Precomputed Molecular Effect Predictions and AVI Scores for 9 Billion Human DNA Variants

Google DeepMind launched AlphaGenome Atlas, precomputing molecular effect predictions and AVI impact scores for ~9 billion human single-nucleotide variants in a 1-petabyte catalogue.

Google DeepMind released AlphaGenome Atlas, a 1-petabyte catalogue of precomputed molecular effect predictions for roughly 9 billion possible single-nucleotide variants in the human genome. It introduces the AlphaGenome Variant Impact (AVI) score, combining AlphaGenome regulatory predictions with AlphaMissense, plus per-variant feature attributions and over 2,500 recurrent DNA sequence motifs. DeepMind reports best-in-class AVI performance on variant pathogenicity and rare disease benchmarks. Early users at the Broad Institute, University of Exeter, and Stowers Institute demonstrated rare-disease variant reprioritization and 22% more non-coding associations across 54,000+ UK Biobank genomes.

MarkTechPost·Sep 8, 19:00 UTC · 8d agoAI research2

The 2026 PNPL Competition: Word Classification and Efficient Cross-Subject Generalisation in LibriBrain100

The 2026 PNPL competition releases LibriBrain100, a MEG speech dataset with 32 extra subjects, targeting word classification and cross-subject BCI generalization.

The 2025 PNPL competition on non-invasive speech decoding from MEG achieved F1-macro scores of 95.6% for speech detection and 73.6% for phoneme classification, built on LibriBrain's ~50 hours of single-subject data. The 2026 edition extends this with LibriBrain100, adding 32 subjects (~40 minutes each) plus ~80 hours of within-subject data. Two tracks target within-subject word classification at scale and cross-subject generalization with subject-specific fine-tuning shrinking from ~40 to ~20 to ~10 minutes, aiming at clinically feasible non-invasive BCIs for people with profound paralysis.

Hugging Face daily papers·Sep 2, 20:00 UTC · 14d agoAI research

K-Bench: a clinically calibrated benchmark for evaluating large language models in high-risk mental health conversations

Clinician-calibrated K-Bench evaluates 125 LLM configurations on 200 high-risk mental health vignettes, exposing wide variation in suicide and violence risk handling.

K-Bench is a clinician-calibrated, protected benchmark evaluating 125 model configurations from 33 base models across 14 providers on 200 multi-turn vignettes covering suicide, self-harm, domestic violence, substance misuse and no-risk presentations. A frozen GPT-4o judge achieved 94.2% exact agreement with clinician consensus across 6,751 eligible comparisons from 151 clinician-rated transcripts. Leading models combined supportive conversation with combined-risk scores above 95, while risk exploration varied substantially among weaker configurations; therapeutic prompting helped weaker models and elevated reasoning produced no average improvement. A continuously updated public leaderboard is hosted at k-bench.ai with protected test materials.

arXiv cs.AI / cs.LG / cs.CL·Sep 14, 16:49 UTC · 2d agoAI safety & security

ICO Urges Police to Improve Data Governance in Facial Recognition Rollouts

The UK's ICO urged police forces deploying facial recognition to strengthen data governance and follow the regulator's published recommendations.

The UK Information Commissioner's Office called on police forces using facial recognition to improve their data governance practices. The privacy watchdog urged forces to follow its published recommendations when rolling out the technology. The intervention reflects ongoing regulatory scrutiny of law enforcement biometric surveillance in the UK.

Infosecurity Magazine·Aug 19, 09:30 UTC · 28d agoPolicy & legal

Google DeepMind Releases AlphaGenome Atlas

Google DeepMind released AlphaGenome Atlas, a 1-petabyte database pre-computing effects of all 9 billion single-nucleotide variants in the human genome, with a unified AVI score.

Google DeepMind launched AlphaGenome Atlas, a database that predicts the regulatory impact of every possible single nucleotide variant across the roughly 3 billion base pairs of the human genome, yielding a 1-petabyte dataset. It introduces the AlphaGenome Variant Impact (AVI) score, combining coding and non-coding predictions for rapid variant prioritization. Broad Institute researchers used it to support solving an unsolved rare disease case via a predicted DNM1 splice variant, and analysis of 54,000+ UK Biobank participants uncovered 22% more non-coding genetic associations, including 19 regions linked to BMI. The Atlas is available through a no-code web portal.

Hacker News · AI·Sep 8, 14:55 UTC · 8d agoAI researchHN 44↑ · 4 comments

Evaluating Time-Series Foundation Models and Multimodal Dietary Context for CGM Forecasting

Study finds zero-shot time-series foundation models underperform on CGM forecasting; fine-tuned Chronos-Bolt cuts RMSE up to 18.4% and dietary context adds signal.

The paper evaluates time-series foundation models for continuous glucose monitoring forecasting across eight public datasets covering Type 1 diabetes, Type 2 diabetes, and non-diabetes populations. Under a unified protocol, zero-shot foundation models did not consistently outperform baselines like Elastic Net and PatchTST, but lightweight fine-tuning did, with fine-tuned Chronos-Bolt reducing RMSE by 6.5%-18.4% in the T1D cohort and 8.6%-18.2% in the non-diabetes/T2D cohort. A residual-based fusion framework adding dietary context from CGMacros reduced overall RMSE by about 3% and postprandial RMSE by about 15% versus CGM-only baselines.

arXiv cs.AI / cs.LG / cs.CL·Sep 10, 17:43 UTC · 6d agoAI research

Deepmind's AlphaGenome Atlas maps every possible DNA change in the human genome

DeepMind's AlphaGenome Atlas precomputes impact predictions for ~9 billion human DNA variants in a 1-petabyte dataset; its AVI score beats CADD in benchmarks

Google DeepMind released the AlphaGenome Atlas, precomputing functional-effect predictions for roughly 9 billion human genome variants (about 27,000 prediction values per variant) in a one-petabyte dataset more than 30 times the size of the AlphaFold database. The accompanying AlphaGenome Variant Impact Score (AVI), a small neural network combining AlphaGenome, AlphaMissense and evolutionary conservation features (18 inputs versus CADD's 150+), outperformed existing tools on clinically classified variants, ranking causal variants in the top 50 candidates for 29.5% of solved GREGoR cases versus 12.5% for CADD. A GREGoR epilepsy case illustrates the impact: AVI elevated a previously unclear DNM1 splice variant that lab experiments confirmed as likely disease-causing. The atlas is available for noncommercial use via web portal, API and a Google Antigravity skill, with a commercial version planned through Google Cloud.

The Decoder·Sep 9, 13:40 UTC · 7d agoAI research

UK’s Police National Legal Database Reveals Data Breach

Infosecurity Magazine·Aug 4, 08:40 UTC · Aug 4, 2026Data breach

Emergency Department Revisit Quality Review Screening: Exploring Human Decision-Making and Artificial Intelligence Support

A retrospective study found GPT-4 over-flagged emergency department revisit cases while an LLM knowledge-graph screener achieved 83-100% positive predictive value.

In an exploratory retrospective study of 99 emergency department diagnosis pairs from a multihospital health system, clinicians and GPT-4 independently judged whether revisit pairs warranted further assessment. GPT-4 responses correlated poorly with clinicians, flagging 94% of pairs for follow-up, 4.4-13.3 times more than clinicians, though prompt engineering was minimal. An algorithm leveraging an LLM-populated knowledge graph (KGA) achieved 83-100% positive predictive value against at least one clinician rater, suggesting LLM-based screening could broaden revisit quality review without substantially increasing reviewer workload.

arXiv cs.AI / cs.LG / cs.CL·Sep 9, 16:37 UTC · 7d agoAI research1

NVIDIA Details BioNeMo Inference Runtime (BioIR): 2.90x Higher Boltz-2 Folding Throughput and 58.5K Residues per GPU-Hour on 8xH100

NVIDIA released BioNeMo Inference Runtime (BioIR), an open-source PyTorch-compatible library delivering 2.90x higher Boltz-2 protein-folding throughput on 8xH100 GPUs.

NVIDIA detailed BioIR, a Python library that accelerates Boltz-2, OpenFold2, and OpenFold3 structure-prediction inference on NVIDIA GPUs while preserving standard PyTorch workflows. On a matched benchmark of 1,000 human dimers on 8xH100 80GB GPUs, BioIR delivered 58.5K folded residues per GPU-hour versus 20.2K for a torch.compile baseline, a 2.90x throughput gain. BioIR already powered the AlphaFold Database expansion, generating about 31 million candidate complexes across 4,777 proteomes, with 1.81 million released as high-confidence predictions. Extrapolated to 1 million targets, estimated folding energy drops from 35 MWh to 11 MWh at 8-GPU TDP equivalents.

MarkTechPost·Sep 10, 21:57 UTC · 6d agoAI tools & infra1

UK government seeks powers to secretly block risky tech suppliers

UK amendments to the Cyber Security and Resilience Bill would let ministers secretly ban risky tech suppliers across critical sectors.

The UK government published amendments to the Cyber Security and Resilience Bill creating 'vendor-related directions' that allow ministers to order companies in critical sectors to stop buying from a supplier, restrict its products, or remove installed equipment on national security grounds. The powers extend beyond telecoms to managed service providers, data centers, digital infrastructure and the energy, water, transport and health sectors, adapting the mechanism used to restrict Huawei in UK 5G while removing some transparency safeguards. Ministers would not have to publicly name the vendor, could withhold details on national security or commercial grounds, and could bar recipients and consultees from discussing the orders, though the government would report annually to Parliament on directions issued. The amendments will be considered at committee stage in the House of Lords in September.

The Record·Aug 26, 13:53 UTC · 21d agoPolicy & legal

Six in 10 Cyberattacks in Colombia Target Hospitals

A Biofile report based on IBM X-Force data finds 60% of cyberattacks in Colombia target healthcare institutions, making medical data a prime target.

A Biofile report drawing on IBM's X-Force Index found that six out of ten cyberattacks recorded in Colombia target health sector institutions. The finding highlights the growing exposure of hospitals and clinics to digital threats. Medical information has become one of the main targets for attackers in the country.

DataBreaches.net·Sep 13, 22:33 UTC · 3d agoResearch

Can Edge-Deployable Vision-Language Models Identify Species?

Evaluation of 2-8B VLMs (Qwen3-VL, Gemma3) against BioCLIP on camera-trap species ID shows all models degrade sharply on field imagery.

The study tests whether edge-deployable 2-8B vision-language models carry genuine taxonomic knowledge, comparing Qwen3-VL 2B/4B/8B and Gemma3 4B against the 300M specialist BioCLIP on a 96-species task across clean iNaturalist photos and six LILA.science camera-trap collections. All models degrade 9.6-26.6 percentage points on field imagery, and BioCLIP outperforms every VLM by 33.2-59.2 points on an expanded 200-image sample, suggesting specialized data rather than scale drives the gap. Under open-set prompting, 5.9-9.6% of responses are syntactically valid but taxonomically nonexistent species names, with fabrication rankings replicating across evaluation sets.

arXiv cs.AI / cs.LG / cs.CL·Sep 10, 17:57 UTC · 6d agoAI research1

AI-designed drug appears to turn back the body's biological clock in early trial

Insilico Medicine's AI-designed drug rentosertib showed reduced predicted biological age in IPF trial blood analysis, published in Nature Biotechnology.

Insilico Medicine reported that rentosertib, an AI-designed drug candidate in Phase III trials for idiopathic pulmonary fibrosis, showed reduced predicted biological age in blood protein analysis of 42 trial patients. Six independent aging-clock models built by teams at Harvard, Oxford, Beijing, and Insilico all predicted lower biological age versus placebo, with drops of three to four years by week 4 and up to six years on one clock. The drug targets TNIK and was developed with two generative AI systems in about 18 months; Eli Lilly recently invested in the company. Experts including Eric Topol and Harvard's Vadim Gladyshev called the results encouraging but not definitive, citing small sample size.

The Decoder·Sep 7, 16:34 UTC · 9d agoAI industry

WearableQA: A Benchmark for Health Reasoning over Real-World Wearable Data

WearableQA benchmark introduces 4,084 questions over real longitudinal wearable data, showing 14 LLMs score 19.6-72.9% on health reasoning, far from solved.

WearableQA is a benchmark of 4,084 10-option multiple-choice questions built from wearable time series, blood biomarkers, and demographics of 200 real users with up to 500 days of daily measurements. It defines 16 question types along two axes: data versus health reasoning, and single- versus cross-signal reasoning, using a dual-grounding framework combining literature and population-validated patterns. Evaluations of 14 proprietary and open-source LLMs show accuracy ranging from 19.6% to 72.9% against a 10% chance baseline, with most models below 60%.

Hugging Face daily papers·Sep 3, 20:00 UTC · 13d agoAI research

Apple’s revamped Health app will calculate your ‘health age’ and readiness score

Apple redesigned its Health app with Apple Intelligence-powered Insights, readiness scores, Health Age, and a $119 Quest 50-biomarker lab panel.

Announced alongside the Apple Watch Series 12 and Ultra 4, the redesigned Apple Health app adds an Insights tab, a readiness score, and a 'Health Age' metric computed from VO2 max, sleep, and blood biomarkers. A partnership with Quest offers a 50-biomarker lab panel for $119. The app also adds movement assessments and a longevity tab, and rolls out later this year in U.S. English.

TechCrunch · AI·Sep 9, 18:16 UTC · 7d agoAI industry

Medical device maker Boston Scientific says a cyberattack is causing a ‘global disruption’ to its operations

Boston Scientific says a cyberattack has caused global disruption to its operations, with no confirmation yet on device impact or data exfiltration.

Boston Scientific, a major medical device manufacturer, disclosed that a cyberattack is causing global disruption to its operations. The company has not confirmed whether medical devices are affected or whether any customer data was exfiltrated. The investigation appears to be ongoing, and healthcare-sector exposure raises patient-safety and supply-chain concerns.

TechCrunch · Security·Aug 26, 18:23 UTC · 21d agoData breach

Anthropic details distillation campaigns from Alibaba, Moonshot AI, and DeepSeek

Anthropic reports nearly 200 million Claude exchanges tied to distillation campaigns by Alibaba, Moonshot AI, and DeepSeek.

A new Anthropic report describes five distillation campaigns totaling nearly 200 million exchanges that extracted chain-of-thought traces from Claude to train competing models, targeting agentic tool use, coding, and reasoning capabilities. The largest campaign, attributed to Alibaba, accounted for 151 million exchanges between May and July 2026 across 3,500 accounts, peaking near three million exchanges per day, allegedly to produce training material for the Qwen model family. A Moonshot AI campaign routed roughly 300,000 requests over ten days through 5,000 accounts, primarily targeting Opus, including one task analyzing CCTV footage that appeared connected to the Chinese military. Attackers used prompt techniques, such as framing queries as katakana-only Japanese translation requests, to make Claude reveal its internal thinking traces.

TechCrunch · AI·updated Sep 16, 17:41 UTC · 13h ago·first Sep 10, 20:57 UTC · 6d agoAI safety & security 19 sources2

Ministry of Justice apologizes after court staff accessed Southport victims' files

UK Ministry of Justice apologized after court staff accessed Southport attack victims' files without authorization, exposing sensitive personal data with no evidence of third-party sharing.

The UK Ministry of Justice apologized after court staff accessed case files related to victims and survivors of the 2024 Southport murders without authorization, including sensitive personal data assessed as high risk for some individuals. There is no evidence the information was shared with third parties. HM Courts and Tribunals Service and HM Prison and Probation Service are investigating, and the Information Commissioner's Office has been informed. The incident follows similar unauthorized record access at North West Ambulance Service and Aintree University Hospital.

The Register · Security·Sep 16, 10:42 UTC · 20h agoData breach

US, Britain to coordinate on scam center takedowns

The US and UK signed an MOU to jointly investigate Southeast Asian scam compounds behind fraud that stole over $12 billion from Americans last year.

The DOJ and UK's National Crime Agency and Crown Prosecutor signed a memorandum of understanding on Thursday for parallel investigations and information sharing on scam centers, largely run by Chinese gangs using human trafficking victims in compounds across Myanmar, Cambodia, and Laos. The Scam Center Strike Force, with more than 150 personnel from the FBI, IRS, and US Postal Inspection Service, leads the effort; the FBI says cyber-enabled fraud accounted for almost 85% of reported losses, with over $12 billion stolen from Americans last year. An in-person disruption event with private industry partners is planned in London in early October. The initiative follows sanctions on Prince Group and a roughly $15 billion bitcoin seizure linked to its CEO Chen Zhi.

The Record·Sep 4, 15:42 UTC · 12d agoPolicy & legal

Brown Health Medical Group-MA Data Breach Exposes Information of 311,000 Individuals

Security Affairs·Aug 5, 16:27 UTC · Aug 5, 2026Data breach

WearableQA: A Benchmark for Health Reasoning over Real-World Wearable Data

WearableQA benchmark tests LLM health reasoning over longitudinal wearable data; the best of 14 evaluated LLMs reaches 72.9% accuracy.

WearableQA comprises 4,084 ten-option multiple-choice questions built from wearable time series, blood biomarkers, and demographics of 200 real users with up to 500 days of daily measurements. It defines 16 question types along two axes: data versus health reasoning, and single- versus cross-signal reasoning. Evaluation of 14 proprietary and open-source LLMs shows performance from 19.6% to 72.9% against a 10% chance baseline, with most models below 60%.

arXiv cs.AI / cs.LG / cs.CL·Sep 4, 17:52 UTC · 12d agoAI research

UK Government Enables Passkey Login for 23 Million Users to Fight Phishing Attacks

UK Government enables optional passkey login for GOV.UK One Login, offering 23 million users phishing-resistant FIDO authentication.

The UK government has rolled out passkey authentication for GOV.UK One Login, the single sign-on for services like tax, State Pension, and driver's license renewals, available to over 23 million users. Passkeys are device-bound, unlocked via fingerprint, Face ID, or device PIN, and the government reports they are up to eight times faster than password plus two-step verification. During the initial trial over 300,000 users adopted passkeys, with nearly one in ten daily sign-ins already using them, saving roughly £600 per day in SMS costs. The NCSC endorses passkeys as phishing-resistant credentials that cannot be intercepted or reused, and biometric data never leaves the user's device.

GBHackers·Sep 15, 05:48 UTC · 2d agoPolicy & legal

UK Fraud Cases Hit Record High in 2026

Cifas reports UK fraud cases reached a record high in 2026, driven by account takeover and identity fraud.

Cifas data shows UK fraud cases hit a record high in 2026. Account takeover and identity fraud are the main drivers of the surge. The figures indicate rising fraud pressure on UK consumers and financial institutions.

Infosecurity Magazine·Aug 19, 08:45 UTC · 28d agoPhishing & fraud

Google's AI genome system evaluates every possible one-base change

Google's AlphaGenome AI system predicts functional effects of non-coding DNA variants in humans and mice.

Google's AlphaGenome AI system evaluates genomic sequences to predict gene expression, transcription factor binding, chromatin accessibility, splice site usage, and related genomic features. The system is currently limited to human and mouse sequences and a limited set of well-studied cell types, but its predictions generally match or exceed specialized software tools. Researchers can use it to assess whether non-coding variants are likely significant and generate hypotheses about their function.

Ars Technica · AI·Sep 9, 16:34 UTC · 7d agoAI research

Grindr to Pay £26 Million to Settle U.K. Claims Over HIV Status Data Sharing

Grindr will pay £26 million ($35.1M) to settle U.K. claims from 10,000+ users over pre-2020 sharing of HIV status and other sensitive data.

Grindr agreed to pay £26 million ($35.1 million) to settle a U.K. lawsuit brought on behalf of more than 10,000 claimants over sharing users' HIV status, last tested date, and other personal data with third parties for advertising before 2020, when the app was owned by China's Kunlun. The settlement, disclosed in a September 2 SEC filing, includes no findings or admission of liability, with £13 million due by December 31, 2026 and the rest by March 31, 2027. Norway's data protection authority previously fined Grindr £8.6 million (reduced to £5.5 million) under GDPR, a decision upheld on appeal last October.

The Hacker News·Sep 8, 07:00 UTC · 8d agoPolicy & legal