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Google DeepMind Releases AlphaGenome Atlas With Precomputed Molecular Effect Predictions and AVI Scores for 9 Billion Human DNA Variants
Google DeepMind launched AlphaGenome Atlas, precomputing molecular effect predictions and AVI impact scores for ~9 billion human single-nucleotide variants in a 1-petabyte catalogue.
Google DeepMind released AlphaGenome Atlas, a 1-petabyte catalogue of precomputed molecular effect predictions for roughly 9 billion possible single-nucleotide variants in the human genome. It introduces the AlphaGenome Variant Impact (AVI) score, combining AlphaGenome regulatory predictions with AlphaMissense, plus per-variant feature attributions and over 2,500 recurrent DNA sequence motifs. DeepMind reports best-in-class AVI performance on variant pathogenicity and rare disease benchmarks. Early users at the Broad Institute, University of Exeter, and Stowers Institute demonstrated rare-disease variant reprioritization and 22% more non-coding associations across 54,000+ UK Biobank genomes.
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Deepmind's AlphaGenome Atlas maps every possible DNA change in the human genome
DeepMind's AlphaGenome Atlas precomputes impact predictions for ~9 billion human DNA variants in a 1-petabyte dataset; its AVI score beats CADD in benchmarks
Google DeepMind released the AlphaGenome Atlas, precomputing functional-effect predictions for roughly 9 billion human genome variants (about 27,000 prediction values per variant) in a one-petabyte dataset more than 30 times the size of the AlphaFold database. The accompanying AlphaGenome Variant Impact Score (AVI), a small neural network combining AlphaGenome, AlphaMissense and evolutionary conservation features (18 inputs versus CADD's 150+), outperformed existing tools on clinically classified variants, ranking causal variants in the top 50 candidates for 29.5% of solved GREGoR cases versus 12.5% for CADD. A GREGoR epilepsy case illustrates the impact: AVI elevated a previously unclear DNM1 splice variant that lab experiments confirmed as likely disease-causing. The atlas is available for noncommercial use via web portal, API and a Google Antigravity skill, with a commercial version planned through Google Cloud.
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Google DeepMind Releases AlphaGenome Atlas
Google DeepMind released AlphaGenome Atlas, a 1-petabyte database pre-computing effects of all 9 billion single-nucleotide variants in the human genome, with a unified AVI score.
Google DeepMind launched AlphaGenome Atlas, a database that predicts the regulatory impact of every possible single nucleotide variant across the roughly 3 billion base pairs of the human genome, yielding a 1-petabyte dataset. It introduces the AlphaGenome Variant Impact (AVI) score, combining coding and non-coding predictions for rapid variant prioritization. Broad Institute researchers used it to support solving an unsolved rare disease case via a predicted DNM1 splice variant, and analysis of 54,000+ UK Biobank participants uncovered 22% more non-coding genetic associations, including 19 regions linked to BMI. The Atlas is available through a no-code web portal.
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The Surprising Effectiveness of Approximate Value Iteration in Self-Play
Minimal approximate value iteration self-play learns more accurate value functions than AlphaZero in Connect Four and Hex while cutting training and inference costs.
The paper trains a minimal self-play implementation of Approximate Value Iteration (AVI) without MCTS and uses ground-truth oracles for exact evaluation in Connect Four, 7x7 Hex, and synthetic games. AVI learns more accurate value functions than AlphaZero, and its one-step-lookahead greedy policies remain competitive with MCTS-based policies at substantially lower training and inference cost. Preliminary experiments on Othello and 9x9 Go show AVI trains stably on larger games, suggesting simpler approaches have become increasingly practical with modern deep-learning tools.
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Firefox, Chrome, Adobe, and VMware Updates Fix Multiple Critical Security Flaws
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Google’s Atlas of the human genome could pave the way for new treatments
Google DeepMind launches AlphaGenome Atlas, a catalog of predicted molecular effects for roughly nine billion single-letter DNA changes across the human genome.
Google DeepMind unveiled AlphaGenome Atlas, a roughly 1-petabyte dataset predicting how each of about nine billion possible single-nucleotide variants affects molecular biology, including non-coding regions that regulate gene behavior. It builds on the AlphaGenome model released in 2025 and adds a Variant Impact Score (AVI) to help researchers rank variants. The catalog is available for noncommercial research via a web portal, the Antigravity platform, and the AlphaGenome interface, with commercial access on Google Cloud planned.
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CISA Flags Actively Exploited Ray Flaw That Can Trigger Browser
CISA added actively exploited Ray flaw CVE-2025-62593 (CVSS 9.4) to its KEV catalog; the DNS rebinding RCE has powered crypto-mining and DDoS botnet campaigns.
CISA added CVE-2025-62593 (CVSS 9.4) to its Known Exploited Vulnerabilities catalog, citing active exploitation of a DNS rebinding-driven RCE flaw in the Ray distributed computing framework, fixed in version 2.52.0. The flaw stems from missing authentication on critical Ray endpoints and an insufficient User-Agent header guard, exploitable against developers running Ray in Firefox or Safari via malicious websites or ads. RondoDox botnet operators incorporated the PoC exploit before the November 26, 2025 disclosure, and unpatched GPU-equipped clusters were hijacked into self-replicating crypto-mining botnets in the ShadowRay 2.0 campaign. FCEB agencies must apply fixes by August 20, 2026.
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