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AI-designed drug appears to turn back the body's biological clock in early trial
Insilico Medicine's AI-designed drug rentosertib showed reduced predicted biological age in IPF trial blood analysis, published in Nature Biotechnology.
Insilico Medicine reported that rentosertib, an AI-designed drug candidate in Phase III trials for idiopathic pulmonary fibrosis, showed reduced predicted biological age in blood protein analysis of 42 trial patients. Six independent aging-clock models built by teams at Harvard, Oxford, Beijing, and Insilico all predicted lower biological age versus placebo, with drops of three to four years by week 4 and up to six years on one clock. The drug targets TNIK and was developed with two generative AI systems in about 18 months; Eli Lilly recently invested in the company. Experts including Eric Topol and Harvard's Vadim Gladyshev called the results encouraging but not definitive, citing small sample size.
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The 12 Best Antivirus (Endpoint Protection) Software for Business, Compared and Priced
GBHackers compares 12 business antivirus products on detection, EDR depth, pricing, and platform coverage, ranking CrowdStrike and Bitdefender joint top at 8.8.
The roundup scores 12 enterprise endpoint protection vendors across detection, EDR depth, management, pricing transparency, and platform coverage. CrowdStrike and Bitdefender tie at 8.8, with Microsoft Defender for Endpoint scoring 8.5 and noted as effectively free for Microsoft 365 E5 licensees. The piece also flags that Kaspersky cannot legally be sold in the US and that Panda and Webroot now sit under WatchGuard and OpenText respectively.
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Do AI Coding Assistants Check Before They Install? A Pre-Registered Demand-Side Audit of Trust Signals in the Research Software Supply Chain
Pre-registered audit finds AI coding assistants verified provenance signals in only 9 of 1,920 trials before installing research software packages.
The study tested whether AI coding assistants check machine-readable trust signals such as SBOMs, signed releases, and provenance attestations before installing six open-source research software projects spanning HPC and quantum computing. Three models under two operating modes produced 1,920 registered trials scored from container logs. Provenance signals were opened in only 9 of 1,920 trials (0.5%) and zero of 384 control trials, with no trial running a verification command. The authors conclude publishing signals is insufficient and verification must be built into the program running the assistant.
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12 Best CNAPP Platforms Compared (2026): Features & Pricing
Independent comparison of 12 CNAPP platforms finds identical estates draw quotes 2-3x apart; Microsoft Defender for Cloud is the only fully published per-resource option.
A vendor-independent buyer's guide compares twelve CNAPP platforms including Prisma Cloud, CrowdStrike Falcon Cloud Security, Wiz, Uptycs, Aqua, Zscaler, and Microsoft Defender for Cloud on pricing mechanics, procurement leverage, and capability-per-dollar. It finds quotes swing 2-3x on identical estates because vendors define 'workload' differently. Microsoft Defender for Cloud is highlighted as the only major with fully published per-resource rates.
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11 Best CSPM Tools Compared (2026): Features & Pricing
CSPM comparison ranks Wiz first for agentless attack-path analysis; notes Ermetic absorbed into Tenable and Lacework into Fortinet FortiCNAPP.
An editorial comparison of eleven CSPM tools ranks Wiz as the agentless attack-path momentum leader, Prisma Cloud as the breadth benchmark, and Orca as the agentless SideScanning pioneer. It highlights consolidation: Ermetic now powers Tenable Cloud Security and Lacework became Fortinet's FortiCNAPP. The guide recommends starting with free tiers from Defender for Cloud, Prowler, and native cloud tools before buying.
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12 Best Patch Management Software Compared (2026): Features & Pricing
GBHackers ranks NinjaOne, ManageEngine, and Automox atop twelve patch management tools for 2026, emphasizing third-party application coverage.
GBHackers scored twelve patch management platforms on coverage, automation, visibility, deployment, and value, with NinjaOne ranked highest at 4.55. Action1 is highlighted for its genuinely usable free tier, ManageEngine for third-party catalog breadth, and Automox for cloud-native cross-OS automation. The piece notes that unpatched known vulnerabilities remain a top initial-access vector, citing CISA's Known Exploited Vulnerabilities catalog.
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The 12 Best Antivirus Software for Mac, Compared and Priced
GBHackers ranks 12 Mac antivirus products, naming Bitdefender best overall and noting Gen Digital owns Norton, Avast, and Avira.
GBHackers scored twelve Mac antivirus products, ranking Bitdefender first at 8.8/10, followed by Intego, Malwarebytes, and ESET. The piece highlights that Gen Digital owns Norton, Avast, and Avira following the NortonLifeLock-Avast merger, so three of the twelve options share one corporate owner. It advises comparing year-two renewal prices rather than discounted first-year pricing and notes macOS already ships XProtect, Gatekeeper, and automatic malware removal. The 2026 Mac threat model described is infostealers harvesting passwords, cookies, and wallets via cracked software, fake installers, and malicious search ads.
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