Why AlphaFold Didn't Solve Protein Folding — Pushmeet Kohli, Google DeepMind & Sal Candido, Biohub
DeepMind and Biohub researchers say AlphaFold did not solve protein folding and biology needs better data, not just scale.
In a Latent Space panel, Google DeepMind’s Pushmeet Kohli and Biohub’s Sal Candido said AlphaFold did not solve protein folding. They argued that dynamics, disorder, and whole-cell behavior remain open, and that scaling compute without the right biological data will not yield predictive models of living systems. The discussion covered scaling laws, handcrafted versus general architectures, protein language models, cryo-EM data, and the need for large breakthroughs in drug discovery.
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