HypoEvolve: Genetic Algorithms Enable Multi-Agent LLMs to Discover Scientific Hypotheses
HypoEvolve uses a generational genetic algorithm coordinating specialized LLM agents to generate scientific hypotheses, outperforming six baselines on cancer drug repurposing.
HypoEvolve is a framework that coordinates specialized LLM agents through a generational genetic algorithm to produce, revise, and retain scientific hypotheses with explicit collaboration roles. It evaluates drug repurposing hypotheses against external evidence from DepMap and Open Targets across 34 cancer types. It achieves the highest scores against six baselines, reaching DepMap selectivity of 0.171 versus 0.115 for the strongest baseline, and gains over single-pass generation generalize to held-out cancer types.