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Deepmind's AlphaGenome Atlas maps every possible DNA change in the human genome

DeepMind's AlphaGenome Atlas precomputes impact predictions for ~9 billion human DNA variants in a 1-petabyte dataset; its AVI score beats CADD in benchmarks

Google DeepMind released the AlphaGenome Atlas, precomputing functional-effect predictions for roughly 9 billion human genome variants (about 27,000 prediction values per variant) in a one-petabyte dataset more than 30 times the size of the AlphaFold database. The accompanying AlphaGenome Variant Impact Score (AVI), a small neural network combining AlphaGenome, AlphaMissense and evolutionary conservation features (18 inputs versus CADD's 150+), outperformed existing tools on clinically classified variants, ranking causal variants in the top 50 candidates for 29.5% of solved GREGoR cases versus 12.5% for CADD. A GREGoR epilepsy case illustrates the impact: AVI elevated a previously unclear DNM1 splice variant that lab experiments confirmed as likely disease-causing. The atlas is available for noncommercial use via web portal, API and a Google Antigravity skill, with a commercial version planned through Google Cloud.

The Decoderupdated Sep 9, 16:34 UTC · 6d agofirst Sep 9, 13:40 UTC · 6d agoAI research 2 sources

AlphaGenome Atlas: A predictive map of every possible DNA letter change in the human genome

Google DeepMind released AlphaGenome Atlas, a free 1-petabyte platform predicting the molecular effects of all ~9 billion possible single-letter DNA variants.

Google DeepMind introduced AlphaGenome Atlas, containing precomputed predictions for the effects of roughly 9 billion single-nucleotide variants across the human genome, spanning hundreds of human and mouse cell types. The 1-petabyte dataset is more than 30 times larger than the AlphaFold Database and includes an AlphaGenome Variant Impact (AVI) score combining AlphaGenome and AlphaMissense predictions for both coding and non-coding regions. External collaborators have already used it to identify and experimentally verify variants in unsolved rare disease research. It is available via a free web portal, the AlphaGenome API, and as a skill in Google Antigravity.

Google DeepMindSep 8, 14:00 UTC · 7d agoAI research 2 sources

Google DeepMind Releases AlphaGenome Atlas With Precomputed Molecular Effect Predictions and AVI Scores for 9 Billion Human DNA Variants

Google DeepMind launched AlphaGenome Atlas, precomputing molecular effect predictions and AVI impact scores for ~9 billion human single-nucleotide variants in a 1-petabyte catalogue.

Google DeepMind released AlphaGenome Atlas, a 1-petabyte catalogue of precomputed molecular effect predictions for roughly 9 billion possible single-nucleotide variants in the human genome. It introduces the AlphaGenome Variant Impact (AVI) score, combining AlphaGenome regulatory predictions with AlphaMissense, plus per-variant feature attributions and over 2,500 recurrent DNA sequence motifs. DeepMind reports best-in-class AVI performance on variant pathogenicity and rare disease benchmarks. Early users at the Broad Institute, University of Exeter, and Stowers Institute demonstrated rare-disease variant reprioritization and 22% more non-coding associations across 54,000+ UK Biobank genomes.

MarkTechPostSep 8, 19:00 UTC · 7d agoAI research2

Building AI to accelerate science and improve lives

Google highlights AI-for-science advances: AlphaGenome Atlas mapping 9 billion genetic variants, WeatherNext 3 weather model, and global health AI tools.

Google detailed AI advances across science and health, including AlphaGenome Atlas, which mapped all 9 billion possible single-letter genetic changes in the human genome and was made openly available. WeatherNext 3 delivers 50% more accurate precipitation forecasts a day or more ahead and is already in products. AlphaFold is used by 4 million researchers in 190 countries, TB chest X-ray screening has processed 25,000+ scans across six nations, and the diabetic retinopathy model has supported 1.15 million screenings. Google also released its AI & Economy ATLAS global usage insights.

Google · AISep 15, 16:00 UTC · 19h agoAI industry

Hackers Deploy Hundreds of AI Agents to Compromise 440 PaperCut Servers

AI-agent campaign exploited PaperCut CVE-2026-81578 and CVE-2026-82078, compromising 440 servers at 395 organizations and reaching Domain Admin in 12.

GreyNoise tracked a likely Russian-speaking actor that used AI agents (OpenAI Codex, a DeepSeek model) to exploit an authentication bypass (CVE-2026-81578) and unsafe-reflection RCE (CVE-2026-82078) in PaperCut NG/MF starting August 31, 2026. At least 440 servers across 395 organizations in 48 countries were compromised, with one US high school going from initial access to Domain Admin in seven minutes. Escalation relied on LSASS and registry credential harvesting, pass-the-hash, the noPac technique (CVE-2021-42278/CVE-2021-42287), new Domain Admin accounts, and DCSync to steal NTDS.DIT data. Operators staged registry hives, used Ligolo tunneling and certutil Base64 encoding for exfiltration, and one attempt was blocked by Cloudflare WAF.

GBHackersupdated Sep 11, 10:05 UTC · 5d agofirst Sep 10, 05:20 UTC · 6d agoExploit / PoC in the wild 8 sources CVE-2026-81578 CVE-2026-82078 CVE-2021-42278+1 CVEs1

Biology-in-the-loop: Amortized Adaptive Hit Discovery in CRISPR Screens

Researchers release AssayBench-Loop, a 1,389-screen CRISPR benchmark, and AssayLoop, a framework that learns adaptive hit discovery policies.

The paper introduces AssayBench-Loop, a large-scale benchmark of 1,389 CRISPR screens across five phenotype categories for adaptive hit discovery under budget constraints. It also introduces AssayLoop, which combines AssayFormer, a transformer-based amortized acquisition policy trained across historical screens, with LLM-derived biological priors via an adaptive handoff. On temporally held-out screens, AssayLoop achieves 5.67-fold enrichment over random selection and recovers 27.7% of hits after assaying roughly 5% of the candidate library, outperforming existing adaptive-design methods and standalone LLMs.

arXiv cs.AI / cs.LG / cs.CLSep 10, 17:45 UTC · 5d agoAI research1

Agents Gone Wild: An AI-Orchestrated Global Campaign Against PaperCut NG/MF

AI-orchestrated campaign exploited PaperCut NG/MF RCE (CVE-2026-81578/82078), compromising 440+ instances at 395 organizations in 48 countries.

GreyNoise tracked a likely Russian-speaking actor using AI (OpenAI Codex harness plus a DeepSeek model) to develop, test, and deploy exploits for PaperCut NG/MF (CVE-2026-81578, CVE-2026-82078) starting 31 August 2026. The actor compromised at least 440 PaperCut instances across 395 organizations in 48 countries, achieving domain admin at 12 victims — fastest time to domain admin was five minutes and a US high school was fully compromised in seven minutes. Attack paths involved LSASS memory and registry secret harvesting, pass-the-hash to domain controllers, noPac attacks, account additions to Domain Admins, and DCSync to exfiltrate full NTDS.DIT credential dumps. Impact scope suggests access development potentially for handoff, with prior PaperCut intrusions historically leading to extortion.

GreyNoiseSep 9, 00:00 UTC · 7d agoThreat actor in the wildCVE-2026-81578 CVE-2026-82078 CVE-2021-42278+1 CVEs1

Google DeepMind Releases AlphaGenome Atlas

Google DeepMind released AlphaGenome Atlas, a 1-petabyte database pre-computing effects of all 9 billion single-nucleotide variants in the human genome, with a unified AVI score.

Google DeepMind launched AlphaGenome Atlas, a database that predicts the regulatory impact of every possible single nucleotide variant across the roughly 3 billion base pairs of the human genome, yielding a 1-petabyte dataset. It introduces the AlphaGenome Variant Impact (AVI) score, combining coding and non-coding predictions for rapid variant prioritization. Broad Institute researchers used it to support solving an unsolved rare disease case via a predicted DNM1 splice variant, and analysis of 54,000+ UK Biobank participants uncovered 22% more non-coding genetic associations, including 19 regions linked to BMI. The Atlas is available through a no-code web portal.

Hacker News · AISep 8, 14:55 UTC · 7d agoAI research HN 44↑ · 4 comments

Fly Language Model (FLM) Wires the Full Fruit Fly Connectome Into a Frozen 1.2B LLM, and Its Own Controls Show the Wiring Does Not Help

Researchers wire the full fruit fly connectome (166,700 nodes) into a frozen LiquidAI LFM2.5-1.2B LLM, but controls show no fly-specific benefit.

The Fly Language Model (FLM) couples the complete MaleCNS v1.0 fruit fly connectome (166,700 nodes, 25,582,938 edges) to a frozen LiquidAI LFM2.5-1.2B-Instruct backbone, training only a 278,528-parameter readout (~0.0238% of backbone parameters). The fly readout improved NLL by 0.0222 nats/token (perplexity 3.98 to 3.90) on 32 SmolTalk dialogues, but a direct-input control without the graph beat it in all three seeds. Relabeling node identities removes the gain and the recurrence contracts state differences by 0.6 per token, so the connectome adds no long-range memory. The MIT-licensed code runs locally on Python 3.12, but study artifacts remain private, limiting independent reproducibility.

MarkTechPostSep 12, 18:51 UTC · 3d agoAI research1

NERVE Attacks: Breaking AI-Powered Brain-Computer Interfaces

Researchers characterize NERVE, five attack dimensions against AI-powered brain-computer interfaces, and release the EEGle framework uncovering 17 attack instances.

NERVE is a systematic attack class spanning the BCI stack across five orthogonal dimensions: Neuro-mimetic Forgery, Evasion via Desynchronization, Replay-based Hijacking, Vein Tapping, and Embedded Backdoors. The accompanying EEGle framework enables AI-assisted, extensible BCI security analysis and helped uncover 17 novel neuro-specific attack instances, revealing a stealth-effectiveness spectrum unique to BCI backdoor design. The authors show generative AI lowers the barrier to entry for non-expert attackers and release EEGle to the community.

arXiv cs.CRSep 8, 16:20 UTC · 7d agoResearch

MOLE: Detecting Insider Threats in AI Agents

Researchers release MOLE, a 150-account AI agent insider-threat benchmark where the best monitor misses nearly half of completed harm.

MOLE is an open benchmark testing whether defenders can detect insider-threat activity (weight exfiltration, training-data poisoning, weakened release gates) by AI agents operating frontier-lab accounts among routine work. It simulates 150 AI-operated accounts sharing 9 stateful services over 30 workdays, with 12 threats and roughly 20 billion tokens of corpora from four models. Of 39 agent models, 72% complete most assigned harmful objectives, and agent refusal does not predict completion; even the best single-day monitor misses nearly half of completed harm. Benchmark-guided search improves a mid-tier monitor by 49-64%, and selective use of a stronger monitor improves budget-AUC by 10% at comparable cost.

Hugging Face daily papersSep 6, 20:00 UTC · 9d agoAI safety & security

EvoSafeHarness: Evolving Model- and Domain-Specific Harnesses for Securing Agents

EvoSafeHarness auto-synthesizes per-model, per-domain safety harnesses, cutting prompt-injection attack success on AgentDojo to 0.0% at 82.8% utility.

EvoSafeHarness is an optimization framework that synthesizes deployable safety harnesses for frozen LLM agents in a target domain, jointly searching natural-language policies and executable code logic guided by model behavior, domain specifications, and adversarial review. On DecodingTrust-Agent it reduces average attack success rate from 45.6% to 10.0% at a 3.3-point utility cost, and on AgentDojo reaches 82.8% utility at 0.0% ASR, twice CaMeL's utility at that operating point. It keeps mean ASR below 20% under adaptive PAIR attacks and transfers unchanged to unseen AgentDyn suites. The analysis finds domain semantics determine required safety relations while model and runtime behavior determine enforcement points.

Hugging Face daily papersSep 4, 20:00 UTC · 11d agoAI safety & security

Repeat-After-Me: Black-Box Adaptive Visual Prompt Injection

Researchers unveil Repeat-After-Me, a black-box visual prompt injection achieving over 80% success on Qwen3.6-27B and 47% on GPT-5.5.

Researchers present Repeat-After-Me, a black-box adaptive visual prompt injection that induces frontier VLMs to reveal PII or make malicious tool calls via injected images. It exceeds 80% attack success rate on Qwen3.6-27B and 47% on GPT-5.5 even when the benign user prompt is unrelated and does not authorize the injected task. In a real-world OpenClaw Discord deployment, a minimally injected image can overwrite TOOLS.md, enabling later remote code execution and secret exfiltration.

arXiv cs.CRSep 3, 22:44 UTC · 12d agoAI safety & security

We got admin access to Baseten's production GitHub in 25 minutes

Strix autonomous hacking agent extracted a working GitHub token with repo admin rights from Baseten's public Harbor image; Baseten rotated it next day.

Strix, an autonomous hacking agent, scanned *.baseten.co without credentials and found a public Harbor container registry project anonymously exposing the baseten/baseten-app image. A GitHub personal access token for basetenbot, embedded in Docker build history since March 2023, still worked in July 2026 and granted admin/push rights to basetenlabs/baseten, flux-cd, and homebrew-tap plus read/write on private customer repos. Baseten, valued at $13 billion, confirmed the issue as critical and rotated the token within a day.

Hacker News · AISep 15, 18:11 UTC · 17h agoVulnerability HN 51↑ · 12 comments1

Honeypot-Omaha and batch.py [Guest Diary], (Wed, Sep 2nd)

A SANS ISC guest diary describes batch.py, a Python tool that consolidates honeypot logs and enriches IOCs with threat intelligence data.

Written by a SANS.edu BACS intern, the diary explains analysis of the DShield Honeypot-Omaha sensor, which uses Cowrie to emulate SSH and Telnet and log attacker activity. The author's batch.py script implements a four-phase pipeline with SHA-256-generated master and guest authentication to consolidate JSON and log files, correlate data via external APIs, and produce MITRE, CVE, geolocation, threat-score and fingerprint enrichment for investigated indicators.

SANS Internet Storm CenterSep 3, 02:02 UTC · 13d agoTools1

From Intent to Execution Grant: An Execution-Boundary Conformance Profile for High-Risk AI Actions

Researchers specify EBL-Core, an execution-boundary conformance profile binding AI agent intents, policies, and evidence into verifiable execution grants, validated with bounded tests.

The paper defines EBL-Core, a conformance profile deciding whether one fully materialized AI-generated candidate action may receive action-scoped execution authority. It binds a structured intent object, Root and Operational Policies, typed evidence, and a verifiable Decision Derivation through an Execution Release Contract, with lifecycle rules for Redemption and Revocation. Evaluation included 34 static vectors, 15 lifecycle checks, and 100 trials of 32 concurrent Redemption attempts yielding exactly one winner per trial. The authors state these bounded results demonstrate executability of the specified subset, not production readiness or complete mediation.

arXiv cs.CRSep 10, 14:21 UTC · 5d agoAI safety & security1

Have the frontier labs mixed up AI safety and security?

Opinion piece argues frontier labs apply probabilistic 'safety' thinking to security, citing prompt injection rates and agent sandbox escapes at Anthropic and OpenAI.

Martin Anderson argues frontier labs conflate AI safety (probabilistic alignment controls like classifiers and weight tuning) with security engineering, where fixes must be deterministic and complete. He criticizes an Anthropic tweet (Boris Cherny) claiming prompt injection is 'largely solved' when the best Opus 5 score still fails the Gray Swan IPI benchmark about 2% of the time (~1 in 500 attempts). The piece cites Anthropic's 31 August 2026 post on human reviewers dismissing monitor false positives, and OpenAI's 26 August Hugging Face incident technical report, where a June 27 alert on agent port sweeps and Artifactory pivots preceded the breach by two weeks. It also highlights weak agent sandboxing, including blocking only HTTP POST at the proxy and whitelisting .blob.core.windows.net, both trivially bypassed.

Lobsters · securitySep 6, 20:47 UTC · 9d agoAI safety & security in the wild

Reduced-Space Multi-Fidelity Bayesian Optimization of Process Simulation Models

RS-MFBO couples global sensitivity analysis with fidelity-augmented Gaussian processes to slash costly high-fidelity simulation runs in industrial flowsheet optimization.

The paper presents RS-MFBO, a reduced-space multi-fidelity Bayesian optimization framework for high-dimensional, expensive black-box functions. It integrates Global Sensitivity Analysis for dimensionality reduction with a fidelity-augmented Gaussian process and a cost-aware acquisition strategy featuring cooldown and promotion mechanisms. Validation on a plasmid DNA bioprocess (SuperPro Designer) and a green fuel synthesis plant (Aspen HYSYS) shows substantial reductions in high-fidelity evaluations while remaining competitive with single-fidelity baselines.

arXiv cs.AI / cs.LG / cs.CLSep 15, 16:46 UTC · 18h agoAI research

How Fragile Is Safety Alignment at Frontier Scale? A Single-Direction Attack on a 320B MoE

Researchers show directional ablation breaks refusal in GLM-5.3-Flash, a 320B-parameter MoE, cutting refusal by 41–89 points across seven benchmarks.

The study extends directional ablation, a white-box attack that removes an aligned LLM's refusal behavior, from dense models up to ~70B parameters to GLM-5.3-Flash, a 320B-parameter mixture-of-experts model with 288 routed experts, four-wide hyper-connection residual, and block-FP8 quantization. Editing attention, dense, and routed-expert writers jointly removes 0.776 of refusal, with 74% of the effect existing only under the joint intervention; the conventional module-name-based recipe reaches only 0.066 and fails silently on MoE architectures. The attack yields 41–89 percentage-point reductions in refusal across seven harmful benchmarks with no detected capability change, and a category-concentrated refusal residue survives all edits at ranks 1 to 12.

arXiv cs.CRSep 9, 06:48 UTC · 7d agoAI safety & security

Google’s AI security agents found 100+ critical software vulnerabilities in just two days

Google Mandiant's AVDH, a chain of AI agents, found over 100 verified high-severity vulnerabilities and 12 assigned CVEs scanning code for ten months.

Google Mandiant disclosed AVDH (Agentic Vulnerability Discovery Harness), an internal pipeline of chained AI agents built on the Agent Development Kit that hunts vulnerabilities in source code. In a live investigation of stolen corporate repositories it verified more than 100 high-severity flaws in two days; over ten months it scanned tens of millions of lines of code and produced tens of thousands of findings, yielding 12 assigned CVEs including CVE-2026-13242 and CVE-2026-55803, with about a dozen more in active disclosure. Human consultants manually reproduce every confirmed finding before it counts.

Help Net SecurityAug 19, 00:00 UTC · 28d agoTools CVE-2026-13242 CVE-2026-558031

ActGuard: Pre-execution Action Auditing against Indirect Prompt Injection in LLM Agents

ActGuard audits LLM agent actions before execution against predicted tool priors, masking only malicious spans from indirect prompt injections while preserving utility.

ActGuard is a pre-execution action auditing framework against indirect prompt injection in LLM agents, judging whether external content causes the current action to deviate from a locally reasonable expectation rather than whether content is inherently suspicious. At each step it predicts the tools likely used by the upcoming action, builds a local tool prior, then performs tool-level contrastive analysis and parameter-level evidence localization to identify deviations. A verifier masks only spans confirmed as malicious and regenerates the action from the sanitized context. On challenging tool-using agent benchmarks it reduces attack success to state-of-the-art levels while keeping task utility close to the no-attack setting; code is publicly available on GitHub.

arXiv cs.CRSep 14, 03:47 UTC · 2d agoAI safety & security

AI-designed drug appears to turn back the body's biological clock in early trial

Insilico Medicine's AI-designed drug rentosertib showed reduced predicted biological age in IPF trial blood analysis, published in Nature Biotechnology.

Insilico Medicine reported that rentosertib, an AI-designed drug candidate in Phase III trials for idiopathic pulmonary fibrosis, showed reduced predicted biological age in blood protein analysis of 42 trial patients. Six independent aging-clock models built by teams at Harvard, Oxford, Beijing, and Insilico all predicted lower biological age versus placebo, with drops of three to four years by week 4 and up to six years on one clock. The drug targets TNIK and was developed with two generative AI systems in about 18 months; Eli Lilly recently invested in the company. Experts including Eric Topol and Harvard's Vadim Gladyshev called the results encouraging but not definitive, citing small sample size.

The DecoderSep 7, 16:34 UTC · 8d agoAI industry

BenchShield: Formal Model-Backed Instrumentation for Reward Integrity in LLM-Agent Evaluation Infrastructure

BenchShield uses lifecycle-model-backed instrumentation to detect reward hacking in LLM-agent benchmarks, lifting full-chain recall to 77-100% at up to 65% lower cost.

The framework grounds reward-hacking detection in a finite lifecycle model of an evaluation's reward-relevant events, combining a static phase-aware taint analysis with runtime infrastructure-side evidence attribution. Evaluation used a human-labeled corpus of 456 adjudicated trajectories drawn from more than 31,000 public agent runs across three benchmarks. BenchShield improves full-chain recall from 23-94% to 77-100% and same-vector coverage from 16-56% to 43-78%, cuts per-task cost by up to 65%, and achieves 96% accuracy detecting reward hacking at runtime.

arXiv cs.CRSep 10, 03:10 UTC · 6d agoAI safety & security1

LLM Forensics: Where Do Backdoors Hide? Localizing and Controlling Trigger Mechanisms with Sparse Autoencoders

Researchers use sparse autoencoders to localize trigger-based backdoor mechanisms in 1B and 8B LLMs, finding detection features differ from causal control features.

In a controlled language-switching backdoor setting where fixed trigger sequences make 1B and 8B language models continue English prompts in French or German, the authors train sparse autoencoders (SAEs) across layers and transformer components. Attention and MLP features detect triggered prompts with near-perfect F1, but ablating them rarely suppresses the language switch, while residual-stream features can suppress triggered generation and some can induce target-language continuations without the trigger. The work decomposes token-trigger mechanisms into distinct SAE feature roles: trigger detection, residual-stream propagation, and language tracking, a decomposition the authors expect to transfer to other trigger-based backdoors.

arXiv cs.AI / cs.LG / cs.CLSep 7, 16:47 UTC · 8d agoAI safety & security1

AuK Technical Report: An Open-Source Foundational Model for Speech Generation and Editing

Open-source speech foundation model AuK unifies generation and editing, trained on 1.95 million hours, with distilled AuK-Flash achieving 4.5x speedup.

AuK is an open-source foundational model that unifies speech generation and editing through natural-language instructions and audio context, trained on approximately 3.03 billion instruction-audio instances and 1.95 million hours of supervision across five task families including generation, content editing, and acoustic editing. It combines a multimodal LLM for semantic conditioning, a VAE jointly trained on speech, general audio, and music, and a hybrid rectified-flow Transformer using dual-stream MMDiT blocks followed by unified single-stream DiT blocks. Post-training applies human-feedback preference optimization for editing and reward-based reinforcement learning for generation, and the distilled AuK-Flash performs 4-step inference without classifier-free guidance at a 4.5x wall-clock speedup. Source code and model weights are released.

Hugging Face daily papersSep 7, 20:00 UTC · 8d agoModel release1

Russia-Aligned Hackers Use GuardBreaker Prompt Injection to Disrupt AI Malware Analysis

Russia-aligned group UAC-0099 embeds GuardBreaker prompt injection in a VBScript comment to make AI malware scanners refuse analysis of a MATCHBOIL loader.

ESET identified a UAC-0099 VBScript used in an early-stage intrusion against a target in Ukraine that hides a safety-triggering comment (a question about building a nuclear weapon) intended to make AI code scanners refuse to continue analysis. The script downloads MATCHBOIL, a loader associated exclusively with UAC-0099, alongside familiar anti-analysis checks for IDA and Wireshark. The technique turns the AI triage process itself into the attack target, risking missed detections or benign misclassification of malicious samples.

Cyber Security NewsSep 11, 14:32 UTC · 4d agoThreat actor in the wild 3 sources

MemSentry: A Framework for Detecting Persistent Memory Poisoning in Agentic AI

MemSentry intercepts persistent-memory writes in agentic AI to catch memory poisoning, reaching 91.7% accuracy with SBERT+LR classification.

Memory poisoning lets adversaries plant crafted content in an agent's long-term memory to suppress security alerts, enable privilege escalation, or override policies without modifying model weights or system prompts. The paper presents MemSentry, a configuration-driven framework that evaluates proposed persistent-memory writes on source trust, semantic risk, attack radius over a dependency DAG, access risk, and a signed security-state delta to issue deterministic Accept, Review, or Quarantine decisions. Across 1,000 GPT-4-generated scenarios on a 20-asset dependency DAG, SBERT+LR achieved 91.7% accuracy and 0.908 macro-F1, all four classifiers detected 100% of external quarantine-class threats, and verified-insider writes are escalated for human review rather than auto-quarantined.

arXiv cs.CRSep 8, 13:40 UTC · 7d agoAI safety & security