Search: “Cytosol”

AlphaGenome Atlas: A predictive map of every possible DNA letter change in the human genome

Google DeepMind released AlphaGenome Atlas, a free 1-petabyte platform predicting the molecular effects of all ~9 billion possible single-letter DNA variants.

Google DeepMind introduced AlphaGenome Atlas, containing precomputed predictions for the effects of roughly 9 billion single-nucleotide variants across the human genome, spanning hundreds of human and mouse cell types. The 1-petabyte dataset is more than 30 times larger than the AlphaFold Database and includes an AlphaGenome Variant Impact (AVI) score combining AlphaGenome and AlphaMissense predictions for both coding and non-coding regions. External collaborators have already used it to identify and experimentally verify variants in unsolved rare disease research. It is available via a free web portal, the AlphaGenome API, and as a skill in Google Antigravity.

Google DeepMind·Sep 8, 14:00 UTC · 8d agoAI research 2 sources

HypoEvolve: Genetic Algorithms Enable Multi-Agent LLMs to Discover Scientific Hypotheses

HypoEvolve couples a generational genetic algorithm with specialized LLM agents to generate drug-repurposing hypotheses, beating six baselines on DepMap selectivity (0.171 vs 0.115).

HypoEvolve coordinates specialized LLM agents through a generational genetic algorithm in which scientific judgments and new proposals reshape a hypothesis population. Evaluation centers on drug repurposing, linking mechanistic explanations to target-level biological claims assessed via external measures adapted from DepMap and Open Targets. Across 34 cancer types, HypoEvolve scores highest against six baselines on both measures, with DepMap selectivity of 0.171 versus 0.115 for the strongest baseline, and gains generalize to held-out cancer types.

arXiv cs.AI / cs.LG / cs.CL·Sep 14, 17:44 UTC · 2d agoAI research1

Molecular Déjà Vu: Digit-Level Retrieval of Published Values in Frontier Language Models

Audit of 22 frontier models finds widespread verbatim retrieval of published molecular property values, with higher reasoning increasing recall of memorized numbers.

An arXiv audit tests 22 frontier LLMs across 12 molecular regression benchmarks for verbatim retrieval of published values. More than 50% of the LLMs show verbatim retrieval on five datasets, and identical experiments are flagged 89% more often at a high reasoning level than at the lowest one. Suppressing retrieval moves model prediction errors closer together in relative terms, suggesting predictive capability is not determined solely by memorized values.

arXiv cs.AI / cs.LG / cs.CL·Sep 4, 17:32 UTC · 12d agoAI research1

Biology-in-the-loop: Amortized Adaptive Hit Discovery in CRISPR Screens

Researchers release AssayBench-Loop, a 1,389-screen CRISPR benchmark, and AssayLoop, a framework that learns adaptive hit discovery policies.

The paper introduces AssayBench-Loop, a large-scale benchmark of 1,389 CRISPR screens across five phenotype categories for adaptive hit discovery under budget constraints. It also introduces AssayLoop, which combines AssayFormer, a transformer-based amortized acquisition policy trained across historical screens, with LLM-derived biological priors via an adaptive handoff. On temporally held-out screens, AssayLoop achieves 5.67-fold enrichment over random selection and recovers 27.7% of hits after assaying roughly 5% of the candidate library, outperforming existing adaptive-design methods and standalone LLMs.

arXiv cs.AI / cs.LG / cs.CL·Sep 10, 17:45 UTC · 6d agoAI research1

Google's AI genome system evaluates every possible one-base change

Google's AlphaGenome AI system predicts functional effects of non-coding DNA variants in humans and mice.

Google's AlphaGenome AI system evaluates genomic sequences to predict gene expression, transcription factor binding, chromatin accessibility, splice site usage, and related genomic features. The system is currently limited to human and mouse sequences and a limited set of well-studied cell types, but its predictions generally match or exceed specialized software tools. Researchers can use it to assess whether non-coding variants are likely significant and generate hypotheses about their function.

Ars Technica · AI·Sep 9, 16:34 UTC · 7d agoAI research

The 2026 PNPL Competition: Word Classification and Efficient Cross-Subject Generalisation in LibriBrain100

The 2026 PNPL competition releases LibriBrain100, a MEG speech dataset with 32 extra subjects, targeting word classification and cross-subject BCI generalization.

The 2025 PNPL competition on non-invasive speech decoding from MEG achieved F1-macro scores of 95.6% for speech detection and 73.6% for phoneme classification, built on LibriBrain's ~50 hours of single-subject data. The 2026 edition extends this with LibriBrain100, adding 32 subjects (~40 minutes each) plus ~80 hours of within-subject data. Two tracks target within-subject word classification at scale and cross-subject generalization with subject-specific fine-tuning shrinking from ~40 to ~20 to ~10 minutes, aiming at clinically feasible non-invasive BCIs for people with profound paralysis.

Hugging Face daily papers·Sep 2, 20:00 UTC · 13d agoAI research

Deepmind's AlphaGenome Atlas maps every possible DNA change in the human genome

DeepMind's AlphaGenome Atlas precomputes impact predictions for ~9 billion human DNA variants in a 1-petabyte dataset; its AVI score beats CADD in benchmarks

Google DeepMind released the AlphaGenome Atlas, precomputing functional-effect predictions for roughly 9 billion human genome variants (about 27,000 prediction values per variant) in a one-petabyte dataset more than 30 times the size of the AlphaFold database. The accompanying AlphaGenome Variant Impact Score (AVI), a small neural network combining AlphaGenome, AlphaMissense and evolutionary conservation features (18 inputs versus CADD's 150+), outperformed existing tools on clinically classified variants, ranking causal variants in the top 50 candidates for 29.5% of solved GREGoR cases versus 12.5% for CADD. A GREGoR epilepsy case illustrates the impact: AVI elevated a previously unclear DNM1 splice variant that lab experiments confirmed as likely disease-causing. The atlas is available for noncommercial use via web portal, API and a Google Antigravity skill, with a commercial version planned through Google Cloud.

The Decoder·Sep 9, 13:40 UTC · 7d agoAI research

Google DeepMind Releases AlphaGenome Atlas With Precomputed Molecular Effect Predictions and AVI Scores for 9 Billion Human DNA Variants

Google DeepMind launched AlphaGenome Atlas, precomputing molecular effect predictions and AVI impact scores for ~9 billion human single-nucleotide variants in a 1-petabyte catalogue.

Google DeepMind released AlphaGenome Atlas, a 1-petabyte catalogue of precomputed molecular effect predictions for roughly 9 billion possible single-nucleotide variants in the human genome. It introduces the AlphaGenome Variant Impact (AVI) score, combining AlphaGenome regulatory predictions with AlphaMissense, plus per-variant feature attributions and over 2,500 recurrent DNA sequence motifs. DeepMind reports best-in-class AVI performance on variant pathogenicity and rare disease benchmarks. Early users at the Broad Institute, University of Exeter, and Stowers Institute demonstrated rare-disease variant reprioritization and 22% more non-coding associations across 54,000+ UK Biobank genomes.

MarkTechPost·Sep 8, 19:00 UTC · 7d agoAI research2

'TerminalFix' Campaign Weaponizes PowerShell for Enterprise Attacks

A ClickFix-style campaign called TerminalFix weaponizes PowerShell and reverse tunnels to infiltrate enterprise networks in a multistage attack chain.

Dark Reading reports on the TerminalFix campaign, a sophisticated multistage attack targeting enterprises. It uses a ClickFix-style social engineering lure and heavily weaponizes PowerShell. The chain establishes reverse tunnels into victim organizations' networks, giving operators interactive access for follow-on activity.

Dark Reading·Aug 31, 20:25 UTC · 15d agoThreat actor in the wild

DianShi-RxnDB: A Large-Scale, Fine-Grained Organic Reaction Data Platform Built via a Fully Automated Pipeline for Researchers and AI Agents

Researchers release DianShi-RxnDB, a database of roughly 24 million organic reaction instances extracted automatically from USPTO and EPO patents since 1976.

DianShi-RxnDB is built by a fully automated pipeline integrating patent text, images, and reaction schemes, yielding about 24 million reaction instances, of which 14.8 million (61.7%) pass automated qualification checks. Manual evaluation of 1,300 sampled instances showed 92.95% field-level accuracy, and comparisons with Pistachio found advantages in deduplicated record counts and granularity. The platform offers a web research workbench and a Model Context Protocol (MCP) service enabling AI agents to perform composable structured retrieval.

Hugging Face daily papers·Sep 5, 20:00 UTC · 10d agoAI research

iceener/files-stdio-mcp-server: sandbox escape in fs_search via a symlinked directory (recursive walker validates only the top level)

iceener/files-stdio-mcp-server allows a read-side sandbox escape: fs_search follows symlinked directories while the recursive walker validates confinement only at the top level.

A vulnerability report describes a read-side sandbox escape in iceener/files-stdio-mcp-server, an MCP server for text-based file access that explicitly promises 'Sandboxed filesystem access. Only these paths are available'. The fs_search tool can follow symlinked directories outside the allowed paths, and the recursive directory-listing walker used by fs_search (and by fs_read) validates confinement only at the top level. The same flaw affects fs_read's directory-listing walker. No CVE identifier was assigned in the provided report text.

oss-security·Sep 10, 01:17 UTC · 6d agoVulnerability

Chainloop: Open-source evidence store and policy engine for the software supply chain

Help Net Security·Aug 10, 00:00 UTC · Aug 10, 2026Policy & legal

LongAgent: History-Guided Agentic Search for Longitudinal Outcome Prediction

LongAgent autonomously searches variable sets and temporal windows to predict longitudinal medical outcomes, beating the strongest non-agent baseline on synthetic data.

The paper proposes LongAgent, an agent-based method that searches over combinations of variable sets, temporal windows and aggregation functions for outcome prediction on heterogeneous medical longitudinal data. It uses a history memory of previous searches and numerical evidence to guide exploration. On synthetic data it achieves mean RMSE 1.7376, improving over the best non-agent baseline by 0.0151 (95% CI [0.0045, 0.0260]; p=0.0273), and performs comparably to the best baseline on a real clinical dataset.

arXiv cs.AI / cs.LG / cs.CL·Sep 14, 16:51 UTC · 2d agoAI research

Testing race conditions with memory access tracing and stack-based delay injection

Google Project Zero released MAccConc, Linux kernel tooling that traces memory accesses to explore and test race condition interleavings.

A Google Project Zero researcher published MAccConc (Memory Access Concurrency), tooling for exploring possible interleavings of multithreaded test cases in the Linux kernel, available on GitHub. The tools use KCOV with ASAN outline-mode instrumentation to record per-access memory traces, enabling automatic testing of all A-B-A interleavings plus terminal and GUI explorers for manual analysis. The work targets confirming race condition candidates, building reliable regression tests, and enabling concurrency fuzzing, drawing on ideas from SKI and Ned Williamson's sockfuzzer.

Google Project Zero·Sep 8, 07:00 UTC · 8d agoResearch1

AI-designed drug appears to turn back the body's biological clock in early trial

Insilico Medicine's AI-designed drug rentosertib showed reduced predicted biological age in IPF trial blood analysis, published in Nature Biotechnology.

Insilico Medicine reported that rentosertib, an AI-designed drug candidate in Phase III trials for idiopathic pulmonary fibrosis, showed reduced predicted biological age in blood protein analysis of 42 trial patients. Six independent aging-clock models built by teams at Harvard, Oxford, Beijing, and Insilico all predicted lower biological age versus placebo, with drops of three to four years by week 4 and up to six years on one clock. The drug targets TNIK and was developed with two generative AI systems in about 18 months; Eli Lilly recently invested in the company. Experts including Eric Topol and Harvard's Vadim Gladyshev called the results encouraging but not definitive, citing small sample size.

The Decoder·Sep 7, 16:34 UTC · 9d agoAI industry

PEEP: A Browser RAT Posing as a Chrome Extension

SOCRadar's STRU analyzed PEEP, an emerging Chromium-based RAT disguised as a Chrome extension enabling post-exploitation control of browsers.

SOCRadar's Threat Research Unit (STRU) identified and analyzed PEEP, a Chromium-based post-exploitation toolkit distributed as a browser extension. PEEP provides RAT-style capabilities while posing as a legitimate Chrome extension. It is assessed as an emerging threat worth monitoring by defenders.

SOCRadar·Sep 4, 09:50 UTC · 12d agoMalware

[0day-rubbish] core-admin 1.0.164 (build 16468) Systemic shell command injection via ineffective quote escaping (8.8)

0day Rubbish discloses a CVSS 8.8 shell command injection in core-admin 1.0.164 via ineffective quote escaping, enabling authenticated remote code execution.

0day Rubbish Research Team publicly disclosed a systemic shell command injection (CWE-78) in core-admin 1.0.164 (build 16468). The flaw stems from ineffective quote escaping and scores 8.8 (AV:N/AC:L/PR:L/UI:N/S:U/C:H/I:H/A:H). The disclosure does not mention a CVE identifier or observed exploitation in the wild.

Full Disclosure·Sep 8, 17:31 UTC · 8d agoVulnerability1

NVIDIA Details BioNeMo Inference Runtime (BioIR): 2.90x Higher Boltz-2 Folding Throughput and 58.5K Residues per GPU-Hour on 8xH100

NVIDIA released BioNeMo Inference Runtime (BioIR), an open-source PyTorch-compatible library delivering 2.90x higher Boltz-2 protein-folding throughput on 8xH100 GPUs.

NVIDIA detailed BioIR, a Python library that accelerates Boltz-2, OpenFold2, and OpenFold3 structure-prediction inference on NVIDIA GPUs while preserving standard PyTorch workflows. On a matched benchmark of 1,000 human dimers on 8xH100 80GB GPUs, BioIR delivered 58.5K folded residues per GPU-hour versus 20.2K for a torch.compile baseline, a 2.90x throughput gain. BioIR already powered the AlphaFold Database expansion, generating about 31 million candidate complexes across 4,777 proteomes, with 1.81 million released as high-confidence predictions. Extrapolated to 1 million targets, estimated folding energy drops from 35 MWh to 11 MWh at 8-GPU TDP equivalents.

MarkTechPost·Sep 10, 21:57 UTC · 5d agoAI tools & infra1

PEEP Turns Chrome and Edge Into Post-Compromise Backdoors for Host Command Execution

SOCRadar disclosed PEEP, a post-exploitation Chromium extension toolkit that turns Chrome and Edge into host-level backdoors via native messaging and C2 polling.

SOCRadar researchers detailed PEEP, a Chromium-based post-exploitation toolkit masquerading as a 'Smart Bookmarks' extension injected directly into Chrome and Edge profiles by forging Secure Preferences integrity values, bypassing Web Store checks. A native-messaging host binary (nm_host.exe) extends the browser agent to host-level command execution, file management, credential theft, and session hijacking, while the extension polls C2 endpoints at 206.237.30.232 or xfjcc.fun every 30 seconds over plaintext HTTP and exfiltrates browsing history, cookies, and tab metadata. PEEP is derived from the open-source RedExt red teaming framework, adds PowerShell persistence scripts, and includes a Linux-targeting Python script, suggesting cross-platform intent. The activity is unattributed but contains Chinese-language artifacts; a C2 /health endpoint showed 34 agent entries and 10 active sessions.

The Hacker News·Sep 7, 18:12 UTC · 8d agoMalware in the wild1

Sandworm-Linked Cyclops Blink Returns With Network Scanning and Packet-Sniffing Capabilities

Sophos uncovers a 64-bit Cyclops Blink variant on hacked Cisco FMC appliances, adding internal network scanning and selective packet capture; linked to Sandworm.

Sophos CTU analyzed a new 64-bit x86-64 Cyclops Blink implant (timezone_check) deployed on Cisco Secure Firewall Management Center appliances compromised via CVE-2026-20079 authentication bypass and CVE-2026-20316 low-privileged login. The activity is assessed with high confidence as Russian-nexus, with a moderate-confidence link to Sandworm (IRON VIKING, also tracked as Seashell Blizzard). The implant runs a parent controller plus five worker modules, masquerades as [kworker/0:1], persists via SysV init scripts at /lib/tz/timezone_check, and beacons to hard-coded C2 89.34.96.56 over a custom TLS protocol on ports 43856 and 49172. New module 0x11 scans internal IPv4 networks for SSH, SMB, LDAP, VMware, HTTP/HTTPS and VPN services, while module 0x12 performs filtered packet capture that can expose cleartext credentials, cookies and tokens.

GBHackers·Sep 14, 09:27 UTC · 2d agoMalware in the wild 11 sourcesCVE-2026-20079CVE-2026-20316

From Infostealer Log to Marketplace Listing: A Technical Walkthrough of the Credential Theft Pipeline

Cyble walkthrough maps how infostealer logs move from endpoint infection through aggregation and enrichment to dark web credential marketplace sales.

Cyble breaks the credential theft pipeline into stages: infostealer execution harvesting browser credential stores, cookies, session tokens, crypto wallets, and FTP configurations; aggregation of stealer logs via C2 panels into bundled archives; parsing and enrichment against previously leaked datasets; and final listing on dark web marketplaces. Enrichment adds employer and role context that raises prices and enables credential stuffing across reused passwords. The report advises SOC teams to monitor stealer logs and marketplace chatter early rather than waiting for breach alerts.

Cyble·Sep 10, 10:45 UTC · 6d agoMalware1

Evaluating Time-Series Foundation Models and Multimodal Dietary Context for CGM Forecasting

Study finds zero-shot time-series foundation models underperform on CGM forecasting; fine-tuned Chronos-Bolt cuts RMSE up to 18.4% and dietary context adds signal.

The paper evaluates time-series foundation models for continuous glucose monitoring forecasting across eight public datasets covering Type 1 diabetes, Type 2 diabetes, and non-diabetes populations. Under a unified protocol, zero-shot foundation models did not consistently outperform baselines like Elastic Net and PatchTST, but lightweight fine-tuning did, with fine-tuned Chronos-Bolt reducing RMSE by 6.5%-18.4% in the T1D cohort and 8.6%-18.2% in the non-diabetes/T2D cohort. A residual-based fusion framework adding dietary context from CGMacros reduced overall RMSE by about 3% and postprandial RMSE by about 15% versus CGM-only baselines.

arXiv cs.AI / cs.LG / cs.CL·Sep 10, 17:43 UTC · 6d agoAI research

C2Looper: A New Backdoor Likely Tied To Ransomware With GitHub C2

Zscaler ThreatLabz identified C2Looper, a new Rust-based backdoor likely tied to ransomware actors and delivered via ClickFix chains, using GitHub for C2.

In July 2026, Zscaler ThreatLabz identified C2Looper, a new Rust-based backdoor family. The malware supports arbitrary command execution, reconnaissance, and deployment of second-stage payloads, and uses GitHub as its command-and-control channel. ThreatLabz assesses with low-to-medium confidence that it is delivered through multi-stage ClickFix infection chains and is likely leveraged by a ransomware-related threat actor. The analysis covers multiple C2Looper variants, their network protocols, and capabilities.

Zscaler ThreatLabz·Aug 17, 14:06 UTC · Aug 17, 2026Malware in the wild1

JSCeal Hides Crypto Malware in V8 Bytecode

Check Point details JSCeal, a crypto-stealing malware delivered as compiled V8 bytecode, and built a decompiler pipeline to expose its capabilities.

JSCeal, tracked by Check Point Research since early 2025, is a cryptocurrency stealer delivered as heavily obfuscated JavaScript compiled to V8 bytecode (.jsc) and run by a bundled Node.js runtime. Check Point, presenting at Black Hat USA 2026, extended the open-source View8 decompiler into a pipeline that recovered readable code from 23 samples, revealing theft of browser credentials and cookies, Telegram sessions, keystrokes, screenshots, HTTPS traffic interception with attacker-controlled certificates, and automated Google account takeover. Targeted overrides rewrite content for Binance, Bybit, and Ledger users. Later samples added AES-256-CBC encryption with externally supplied keys and expanded targeting to macOS.

Security Affairs·Sep 7, 10:19 UTC · 9d agoMalware1

Flextype v1.0.0-alpha.3 Stored Expression Injection Enables PHP Remote Code Execution

Flextype CMS v1.0.0-alpha.3 stored expression injection exposes the mutable registry object, enabling stored PHP remote code execution.

Flextype CMS v1.0.0-alpha.3 evaluates attacker-controlled entry fields as expressions during entry retrieval when global expression processing is enabled. The expression environment exposes the application's mutable registry() object, which attackers can manipulate. Combined with the PHP entry directive, this enables stored PHP remote code execution from crafted entry content. The flaw was disclosed on the Full Disclosure mailing list on September 3, 2026.

Full Disclosure·Sep 4, 00:13 UTC · 12d agoVulnerability 8 sources

PoisonedRefresh: A Fileless Linux Rootkit That Injects PHP Web Shells Into F5 BIG-IP APM Server Memory

Sophos details PoisonedRefresh, a fileless Linux rootkit that injects a memory-resident PHP web shell into F5 BIG-IP APM after exploitation of CVE-2025-53521.

On September 8, 2026, SophosLabs published an analysis of Linux/Agnt-IC (dubbed PoisonedRefresh by ESET) found in compromised F5 BIG-IP Access Policy Manager environments. Initial access leverages CVE-2025-53521, an unauthenticated RCE in BIG-IP APM when an access policy is configured on a virtual server; F5 confirmed exploitation and links the activity to cluster c05d5254, while Shadowserver observed 795 exposed vulnerable endpoints. A first stage hidden in a modified umount binary modifies /usr/sbin/httpd and SELinux configuration and embeds itself in BIG-IP upgrade images for persistence. The second-stage ELF intercepts __libc_start_main, hooks apr_dso_load, and injects a PHP web shell into libphp memory via mmap manipulation, leaving no disk artifacts, and exposes a /bin/bash shell via a local UNIX domain socket instead of a TCP port.

Security Affairs·Sep 9, 08:50 UTC · 7d agoMalware in the wildCVE-2025-53521

UniH^3: Unifying Hierarchical Homogeneity and Heterogeneity for All-in-One Medical Image Restoration

UniH3 unifies hierarchical homogeneity and heterogeneity modeling for all-in-one medical image restoration across modalities and degradation types.

UniH3 introduces a Hierarchical Homogeneity Memory module that distills shared anatomical priors from high-quality images, injected via a Homogeneity-Guided Attention mechanism. A Hierarchical Heterogeneity Balancer mitigates inter- and intra-task conflicts during multi-task optimization. It achieves state-of-the-art on MedIR-2D-500K and MedIR-3D-3D benchmarks for both all-in-one and single-task restoration, with code released on GitHub.

Hugging Face daily papers·Sep 9, 20:00 UTC · 6d agoAI research

Google DeepMind Releases AlphaGenome Atlas

Google DeepMind released AlphaGenome Atlas, a 1-petabyte database pre-computing effects of all 9 billion single-nucleotide variants in the human genome, with a unified AVI score.

Google DeepMind launched AlphaGenome Atlas, a database that predicts the regulatory impact of every possible single nucleotide variant across the roughly 3 billion base pairs of the human genome, yielding a 1-petabyte dataset. It introduces the AlphaGenome Variant Impact (AVI) score, combining coding and non-coding predictions for rapid variant prioritization. Broad Institute researchers used it to support solving an unsolved rare disease case via a predicted DNM1 splice variant, and analysis of 54,000+ UK Biobank participants uncovered 22% more non-coding genetic associations, including 19 regions linked to BMI. The Atlas is available through a no-code web portal.

Hacker News · AI·Sep 8, 14:55 UTC · 8d agoAI researchHN 44↑ · 4 comments

'Sandworm' Chains Cisco Vulnerabilities to Deploy Cyclops Blink

Russia-linked Sandworm chains Cisco vulnerabilities to deploy an upgraded Cyclops Blink botnet variant the FBI disrupted in 2022.

Dark Reading reports that Sandworm, the notorious Russia-linked threat group, is chaining Cisco vulnerabilities to deploy an upgraded version of the Cyclops Blink botnet malware. The FBI previously disrupted the Cyclops Blink botnet in 2022. The activity signals renewed botnet infrastructure building by the group despite prior law-enforcement action.

Dark Reading·Sep 14, 21:37 UTC · 1d agoThreat actor in the wild