CVE-2025-53521 is a stack-based buffer overflow (CWE-121) in F5 BIG-IP's Access Policy Manager (APM) that allows remote code execution. The flaw is triggered when a virtual server is configured with an APM access policy and receives specific malicious network traffic; no authentication or user interaction is required per the CVSS 4.0 vector. An attacker who exploits it gains remote code execution on the BIG-IP device, and in observed intrusions attackers have deployed a fileless Linux rootkit (dubbed 'PoisonedRefresh') that injects a PHP web shell into server memory to evade disk-based scanning. Any F5 BIG-IP deployment with an APM access policy configured on a virtual server is potentially affected; versions that have reached End of Technical Support are not evaluated by the vendor. The vulnerability is being actively exploited in the wild — it was added to CISA's Known Exploited Vulnerabilities catalog on 2026-03-27, with active exploitation and in-memory malware campaigns confirmed in press reports, though ransomware use is unknown.
What to do: Patch immediately by upgrading affected BIG-IP systems to fixed releases per F5's security advisory (note that versions in End of Technical Support will not be fixed and should be upgraded or retired), prioritizing internet-facing virtual servers with APM access policies. Because observed attacks deploy a memory-resident PHP web shell via the PoisonedRefresh Linux rootkit, disk-only scans may miss compromise — inspect running processes and memory, and hunt for suspicious PHP or rootkit activity on BIG-IP APM devices. Federal agencies must follow the required action in CISA KEV/BOD 22-01: apply vendor mitigations or discontinue use of the product if mitigations are unavailable.
Affected
F5 BIG-IP (BIG-IP Access Policy Manager / APM)
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Estimated exposure
large≈14,000+ internet-exposed F5 BIG-IP devices (per public scan figures cited in press coverage) — Press reporting on the exploitation campaign cites roughly 14,000 F5 BIG-IP devices, consistent with public internet-exposure scans of BIG-IP appliances; only deployments with an APM access policy on a virtual server are vulnerable, so the…
Order-of-magnitude estimate by the model from install counts, market share and public scan data it knows; verify before quoting.
Description
When a BIG-IP APM access policy is configured on a virtual server, specific malicious traffic can lead to Remote Code Execution (RCE). Note: Software versions which have reached End of Technical Support (EoTS) are not evaluated.
CISA Known Exploited Vulnerability
Affected
F5 BIG-IP
Required action
Apply mitigations per vendor instructions, follow applicable BOD 22-01 guidance for cloud services, or discontinue use of the product if mitigations are unavailable.
Sophos analyzed a Linux rootkit, tracked as PoisonedRefresh, on hacked F5 BIG-IP APM devices hiding an in-memory web shell linked to exploited CVE-2025-53521.
Sophos and ESET analyzed an implant (named PoisonedRefresh by ESET) deployed on compromised F5 BIG-IP APM appliances, which serves enterprise, financial, government, and public sector deployments. The second-stage payload intercepts __libc_start_main, hooks Apache's APR module loader (apr_dso_load), RC4-encodes key strings, and rewrites PHP file reads in memory to embed a web shell inside legitimate scripts like apm_css.php3, full_wt.php3, and webtop_popup_css.php3, leaving on-disk files unchanged. A related installer component infects /usr/sbin/httpd, persists across BIG-IP upgrade images, modifies SELinux configuration, and deploys the payload. The malware also creates a Unix domain socket at /run/bigtlog.pipe that hands authenticated local connections to /bin/bash; F5 links the activity to CVE-2025-53521, an unauthenticated RCE in BIG-IP APM already exploited in the wild.
Sophos details PoisonedRefresh, a fileless Linux rootkit that injects a memory-resident PHP web shell into F5 BIG-IP APM after exploitation of CVE-2025-53521.
On September 8, 2026, SophosLabs published an analysis of Linux/Agnt-IC (dubbed PoisonedRefresh by ESET) found in compromised F5 BIG-IP Access Policy Manager environments. Initial access leverages CVE-2025-53521, an unauthenticated RCE in BIG-IP APM when an access policy is configured on a virtual server; F5 confirmed exploitation and links the activity to cluster c05d5254, while Shadowserver observed 795 exposed vulnerable endpoints. A first stage hidden in a modified umount binary modifies /usr/sbin/httpd and SELinux configuration and embeds itself in BIG-IP upgrade images for persistence. The second-stage ELF intercepts __libc_start_main, hooks apr_dso_load, and injects a PHP web shell into libphp memory via mmap manipulation, leaving no disk artifacts, and exposes a /bin/bash shell via a local UNIX domain socket instead of a TCP port.
Sophos analyzed a Linux rootkit on F5 BIG-IP APM devices that injects a fileless PHP web shell, likely after CVE-2025-53521 exploitation.
Sophos analyzed a Linux rootkit targeting F5 BIG-IP APM environments, also tracked by ESET as PoisonedRefresh, which hijacks Apache's apr_dso_load module loader to inject a fileless PHP web shell into memory. The implant intercepts __libc_start_main, hides strings with RC4, creates a password-protected local UNIX socket backdoor for interactive Bash access, and persists across BIG-IP upgrade images while modifying SELinux configuration. It is likely a second-stage payload following exploitation of CVE-2025-53521, a critical RCE flaw F5 reclassified from a DoS issue in March. The ShadowServer Foundation tracked 795 F5 BIG-IP APM endpoints exposed online.
Sophos analyzed a stealth Linux rootkit that hides a web shell in memory on compromised F5 BIG-IP APM identity gateways, evading file-based detection.
Sophos analyzed a second-stage Linux rootkit implant found in compromised F5 BIG-IP APM environments running Apache and PHP, linked to exploitation of CVE-2025-53521, an unauthenticated RCE. The implant hooks Apache's PHP-loading process and serves modified in-memory versions of three legitimate webtop PHP files (apm_css.php3, full_wt.php3, webtop_popup_css.php3), leaving on-disk files untouched so hashes and integrity checks pass. It also establishes access via an authenticated local UNIX socket that can provide an interactive /bin/bash session. Experts warn compromised APM appliances, which handle federated SSO and terminate TLS at enterprise perimeters, could enable SSO token theft and lateral movement to trusted downstream applications.
Sophos found F5 BIG-IP APM malware that injects a PHP web shell into Apache's memory, evading disk scans, linked to exploited CVE-2025-53521.
Sophos's September 7 analysis describes malware tied to F5's c05d5254 activity that hooks apr_dso_load, modifies the libphp PHP module in memory, and injects a PHP web shell when Apache loads apm_css.php3, full_wt.php3 or webtop_popup_css.php3, leaving on-disk files clean. A separate installer infects /usr/sbin/httpd and umount, runs before Apache starts, disables SELinux (per ESET's related PoisonedRefresh analysis), and opens a local socket at /run/bigtlog.pipe for shell access. The activity is linked to CVE-2025-53521 in BIG-IP APM, rated 9.8 CVSS 3.1, patched in October 2025, added to CISA KEV on March 27, 2026.