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New DDRop Attack Breaks Intel TDX and AMD SEV-SNP With $159 DDR5 Device

DDRop uses a $159 DDR5 RDIMM interposer to silently drop memory writes and break Intel TDX and AMD SEV-SNP confidential VMs.

Researchers published DDRop, a physical attack built from about $159 in parts that uses a custom DDR5 RDIMM interposer to inject parity errors and silently discard selected cache-line writebacks. Intel TDX, Intel Scalable SGX, and AMD SEV-SNP are affected because they lack per-line cryptographic freshness, so processors can accept stale encrypted data as valid state. The team demonstrated deterministic plaintext copying between pages, malicious Secure EPT entry injection, forcing trust domains into debug mode, and forging attestation measurements. The attack requires privileged host control plus brief physical access, and researchers say no simple software patch exists.

Cyber Security News · 1d agoResearch 2 sources

New hardware device can RAM into encrypted memory, expose your data

Researchers built a $200 DDR5 interposer that silently drops memory writes to break TDX, SGX, and SEV-SNP confidential VM integrity, requiring physical access.

Researchers from KU Leuven, ETH Zurich, Durham University, and Google demonstrated DDRop, a hardware interposer costing under $200 that corrupts DDR5 bus commands to silently drop writes to encrypted memory, enabling replay attacks on confidential VMs. Because scalable memory encryption lacks freshness checks, protected VMs keep computing on stale attacker-selected data; on an Intel TDX server the attack forces debug mode for plaintext memory reads or forges attestation reports, succeeding in under two minutes without crashing. Intel and AMD both called the attack out of scope for their cloud threat models, with no mitigation planned, and proposed cache line versioning appears still vulnerable. The full interposer design is being released as open-source hardware.

The Register · Security · 2d agoResearch

DDRop Attack Forces Intel TDX Confidential VMs Into Debug Mode and Exposes Memory

KU Leuven and ETH Zurich researchers released DDRop PoC hardware that forces Intel TDX confidential VMs into debug mode and exposes plaintext memory.

Researchers from KU Leuven, ETH Zurich, Google, and Durham University published proof-of-concept code, hardware designs, and firmware for DDRop, a DDR5 interposer that injects parity errors to drop selected cache-line writebacks. Because Intel TDX, Intel Scalable SGX, and AMD SEV-SNP lack per-line cryptographic freshness, processors decrypt and accept stale DRAM contents as current state. The PoC flips a victim's ATTRIBUTES.DEBUG flag to enable TDX debug mode, then copies victim memory in plaintext and can forge attestation reports. Affected environments include Intel 5th- and 6th-generation Xeon Scalable with TDX; Intel says the attack falls outside its cloud-computing threat model.

GBHackers · 1d agoResearch

Windows 11’s strongest security defenses can be bypassed without a screwdriver

Researchers found a script-only attack, 'Download More RAM', that rewrites DIMM configuration chips to bypass Windows 11 VBS and HVCI security boundaries.

Researchers at the University of Birmingham and Durham University showed that overwriting configuration data on unprotected DDR4/DDR5 module chips creates memory aliases that let attackers with existing privileged access defeat Virtualisation-based Security and HVCI, re-enable blocklisted drivers, kill EDR, and bypass group policy. Microsoft assigned CVE-2026-23670 and shipped mitigations in its April 2026 updates; systems with Secure Boot enabled are protected. Affected unprotected product lines are estimated at more than half of the high-performance consumer memory market and over 70% of the gaming segment.

Help Net Security · Aug 17, 2026VulnerabilityCVE-2026-236701

Thelio Mira AI Linux Workstation: 192 GB GPU Memory

System76 launches the Thelio Mira AI Linux workstation from $3,299 with dual NVIDIA RTX Pro 6000 GPUs and 192 GB GPU memory for local AI workloads.

System76's Thelio Mira AI is a locally built (Denver, Colorado) Linux workstation for AI training, fine-tuning, and inference, starting at $3,299. Configurations go up to a 16-core AMD Ryzen 9000 CPU, 192 GB DDR5 RAM, and dual NVIDIA RTX Pro 6000 Blackwell GPUs delivering 192 GB of (ECC) GPU memory with liquid cooling, dual PCIe 5.0 x16 slots, and up to three M.2 NVMe drives. It ships with Pop!_OS 24.04 LTS or Ubuntu and is positioned as a way to avoid recurring cloud GPU costs.

Risky Bulletin: Academics find source code overlaps between Geedge and China's Great Firewall

Academics linked Chinese vendor Geedge Networks' Tiangou Secure Gateway source code to one of the Great Firewall's three traffic filtering capabilities.

US researchers presenting at USENIX Security reconstructed Geedge Networks' Tiangou Secure Gateway firmware from over 100,000 leaked files, including Git repositories with commit history, and matched its filtering behavior to sections of China's Great Firewall. They found only 1 of 3 characterized DNS injectors matched Geedge code, noted the system relies on memory-unsafe C components and copied third-party code, and said its bugs could aid future circumvention tools. Geedge also exports censorship tools to Kazakhstan, Ethiopia, Pakistan, and Myanmar. The newsletter additionally rounds up multiple breaches.

Risky Business News · 26d agoResearch2

GDCM <= 3.2.7: six memory-safety and denial-of-service vulnerabilities, no CVE

Six memory-safety and denial-of-service flaws disclosed in the GDCM DICOM parsing library, affecting versions through 3.2.7.

Researcher Abhinav Agarwal disclosed six vulnerabilities in GDCM (Grassroots DICOM), an open-source C++ library for parsing and processing DICOM files. All six were confirmed against GDCM 3.2.6 using AddressSanitizer and UndefinedBehaviorSanitizer, and source review found the vulnerable patterns through version 3.2.7 and the upstream master snapshot. Potential impacts include heap corruption, process-memory disclosure, stack exhaustion, and process termination in applications parsing untrusted DICOM files. No CVE identifiers have been assigned at the time of disclosure.

oss-security · 6d agoVulnerability

openbmb/MiniCPM5-2B — new model trending #4 on Hugging Face

OpenBMB released MiniCPM5-2B, a dense 2B open-weights Transformer claiming 2B-class open-source SOTA for on-device deployment.

OpenBMB released MiniCPM5-2B, the second model in the MiniCPM5 series following MiniCPM5-1B, and it is trending #4 on Hugging Face. The dense 2B Transformer targets on-device, local, and resource-constrained deployment and claims 2B-class open-source SOTA while remaining competitive with 4B-class models. Reported strengths include coding, mathematics, long-context understanding, tool use, and agentic tasks; a tech report (arXiv 2506.07900), GitHub repo, and online demo accompany the release.

Hugging Face trending models · 10d agoModel release

Saving Jet Fuel

Tutorial optimizes flight paths to cut jet fuel costs using open-source Scikit-decide planning framework and OpenAP aircraft performance models.

A technical walkthrough demonstrates wind-aware flight path optimization using Scikit-decide, an open-source framework for reinforcement learning and automated planning, paired with OpenAP fuel-consumption models built by Dr. Junzi Sun at TU Delft and NOAA wind data. A Boeing 787-9 flying EWR to FCO can require roughly $68K in fuel, and adjusted routing could save thousands. The post uses Python 3.12, DuckDB with spatial extensions, and QGIS for map rendering.

openbmb/MiniCPM5-2B-GGUF — new model trending #30 on Hugging Face

OpenBMB released MiniCPM5-2B, a dense 2B on-device model claiming open-source SOTA among 2B-class models.

OpenBMB released MiniCPM5-2B, the second model in the MiniCPM5 series following MiniCPM5-1B, as a dense 2B Transformer built for on-device and resource-constrained deployment with GGUF weights on Hugging Face. The team claims 2B-class open-source state-of-the-art performance, remaining competitive with 4B-class models in coding, mathematics, long-context understanding, tool use and agentic tasks. The release includes a tech report, GitHub repository and online demo, and is currently trending on Hugging Face.

Hugging Face trending models · 11d agoModel release1

OpenBMB Releases MiniCPM5-2B: A 2.52B Dense Model Averaging 53.9 Across 34 Benchmarks and Built to Run On Device

OpenBMB released MiniCPM5-2B, a 2.52B-parameter Apache 2.0 on-device model averaging 53.9 across 34 benchmarks, ahead of Qwen3.5-4B.

OpenBMB released MiniCPM5-2B, a 2,516,756,480-parameter dense LlamaForCausalLM model with grouped-query attention and a 131,072-token context, under Apache 2.0, runnable via vLLM, SGLang, llama.cpp, and Ollama. It averages 53.9 across 34 benchmarks versus 51.1 for Qwen3.5-4B, with strong tool-use (97.1 on tau2-Bench Telecom) and code results (69.1 LiveCodeBench v6, 46.4 SWE-bench Verified). Training combined 400B tokens of deep-thinking SFT, critic-based JustRL II RL teachers, and on-policy distillation merging 16 RL experts; datasets and intermediate checkpoints were published alongside the weights.

MarkTechPost · 9d agoModel release

Decoy Direction Optimization: A Post-Hoc Defense Against LLM Abliteration

Researchers introduce Decoy Direction Optimization, a cheap weight-editing defense that blinds refusal-direction ablation attacks against open-weight LLM safety guardrails.

Refusal Feature Ablation bypasses safety guardrails in open-weight LLMs by projecting out a linear refusal direction, often with high attack success rates. Decoy Direction Optimization injects a high-magnitude nonlinear decoy into MLP neurons so attackers' contrastive estimators ablate a harmless orthogonal feature instead. Evaluated across six model families, DDO keeps ASR below 10% under standard RFA and on Llama-3-8B-Instruct reduces Heretic weight-level attack ASR from 88.7% to 18%. It costs 30 to 450 times less per configuration than trained defense baselines.

[AINews] Hot Chips: OpenAI’s Jalapeño, Cerebras CS-5, Groq 3 LPX, Apple M6

OpenAI unveiled Jalapeno custom inference chip claiming 1.5-1.9x better perf-per-watt than NVIDIA GB200/GB300, deploying in-house by year-end.

At the 37th Hot Chips conference, OpenAI published first benchmark details for its custom Jalapeno inference chip, claiming 1.5-1.9x more work per watt, 1.7-3.6x lower end-to-end latency, and 2.1-4.1x higher interactive-workload performance versus NVIDIA GB200/GB300, with the 700W-rated part staying at or below 550W in tests. Deployment into OpenAI's own infrastructure begins by year-end, with Gen 2 deep in development and Gen 3 underway. OpenAI also said GPT-Astra and Codex helped write low-level kernels, reportedly 1.5-1.8x faster than human-expert code for selected attention and MoE blocks. Cerebras CS-5, Groq 3 LPX and Apple M6 were also featured at the conference.

Latent Space · 20d agoAI industry

CVE-2026-67211: Apache OpenNLP: OOM DoS via Unbounded Array Allocation in SymSpellModelSerializer

Apache OpenNLP CVE-2026-67211: unbounded map pre-sizing in SymSpellModelSerializer enables out-of-memory denial of service in opennlp-symspell 3.0.0-M4/M5.

CVE-2026-67211 affects the opennlp-symspell artifact in versions 3.0.0-M4 and 3.0.0-M5 only. The SymSpellModelSerializer.create() method performs unbounded map pre-sizing, allowing crafted input to trigger out-of-memory denial of service. Releases 1.x and 2.x are unaffected because the spellcheck extension was introduced in 3.0.0-M4; the issue is resolved in 3.0.0-M6.

BTR Reforged: Weaponizing Defender’s Remediation Driver as a Kernel Operation Primitive

Check Point shows attackers can abuse Microsoft Defender's signed remediation driver for arbitrary Ring 0 file and registry operations without exploiting any vulnerability.

Check Point Research presents BTR Reforged, a technique that repurposes Microsoft Defender's trusted remediation driver into an attacker-controlled kernel operation primitive. The signed driver can be instructed to execute arbitrary file and registry operations from Ring 0 without exploits, vulnerabilities, or memory corruption. The work demonstrates how trusted security components can be turned into attacker primitives, which is relevant for defenders assessing driver abuse risks.

Check Point Research · 27d agoResearch

Hackers breach F5 BIG-IP APM devices to deploy Linux rootkit

Sophos analyzed a Linux rootkit on F5 BIG-IP APM devices that injects a fileless PHP web shell, likely after CVE-2025-53521 exploitation.

Sophos analyzed a Linux rootkit targeting F5 BIG-IP APM environments, also tracked by ESET as PoisonedRefresh, which hijacks Apache's apr_dso_load module loader to inject a fileless PHP web shell into memory. The implant intercepts __libc_start_main, hides strings with RC4, creates a password-protected local UNIX socket backdoor for interactive Bash access, and persists across BIG-IP upgrade images while modifying SELinux configuration. It is likely a second-stage payload following exploitation of CVE-2025-53521, a critical RCE flaw F5 reclassified from a DoS issue in March. The ShadowServer Foundation tracked 795 F5 BIG-IP APM endpoints exposed online.

BleepingComputer · 8d agoMalware in the wildCVE-2025-53521

Speculative Decoding in vLLM on AMD GPUs

vLLM benchmarks speculative decoding on AMD Instinct MI300X and MI355X GPUs across five drafting methods including EAGLE-3 and native MTP.

The vLLM project documents draft-and-verify speculative decoding support for AMD GPUs via ROCm, comparing native MTP, Gemma 4 MTP, EAGLE-3, DFlash, and DSpark drafting approaches. Output-token throughput effects varied with drafting method, proposal length, model family, draft checkpoint, workload, and acceptance behavior. The post also covers how to enable each method plus practical tuning and observability considerations.

F5 BIG-IP APM Malware Injects a PHP Web Shell Into Memory, Evading Disk Scans

Sophos found F5 BIG-IP APM malware that injects a PHP web shell into Apache's memory, evading disk scans, linked to exploited CVE-2025-53521.

Sophos's September 7 analysis describes malware tied to F5's c05d5254 activity that hooks apr_dso_load, modifies the libphp PHP module in memory, and injects a PHP web shell when Apache loads apm_css.php3, full_wt.php3 or webtop_popup_css.php3, leaving on-disk files clean. A separate installer infects /usr/sbin/httpd and umount, runs before Apache starts, disables SELinux (per ESET's related PoisonedRefresh analysis), and opens a local socket at /run/bigtlog.pipe for shell access. The activity is linked to CVE-2025-53521 in BIG-IP APM, rated 9.8 CVSS 3.1, patched in October 2025, added to CISA KEV on March 27, 2026.

The Hacker News · 7d agoMalware in the wildCVE-2025-53521

DeepZero: Open-source hunting for vulnerable Windows drivers

DeepZero, a new open-source engine, automates discovery of exploitable Windows kernel drivers for BYOVD attacks using Ghidra, Semgrep, and an LLM.

DeepZero is a free, open-source Python pipeline orchestrator that automates hunting for exploitable Windows kernel drivers relevant to BYOVD (bring your own vulnerable driver) attacks. Its seven-stage YAML pipeline parses PE headers, filters for kernel-mode drivers with IOCTL surfaces, excludes drivers listed on loldrivers.io, then runs headless Ghidra decompilation, Semgrep scanning, and an LLM-based exploitability assessment. The maintainer reports multiple verified vulnerabilities in the Snappy Driver Installer corpus, some still in the disclosure process, and notes findings involving plug-and-play-created device objects may need physical hardware to confirm.

Help Net Security · 18h agoTools

OpenVDN/vdn-minimax-h3 — new model trending #12 on Hugging Face

OpenVDN releases VDN-H3, an open hybrid-attention video model on MiniMax H3 that renders a 14.4-second 768p clip in 11.23 seconds on 8 B200 GPUs.

VDN-Minimax-H3 (VDN-H3) adds a frame-wise linear attention branch plus two LoRA adapters to MiniMax H3, distilled into 8-step and 50-step variants. It generates 768p, 14.4-second clips in 11.23 seconds on 8 B200 GPUs (90.5 seconds on one H200) using 8 denoising steps. Weights (about 82 GB total, including the 72 GB H3 base), the optimized inference stack, and training code are fully open-source under the MiniMax H3 Community License, which excludes the EU, UK, Korea, and US.

Hugging Face trending models · 14d agoModel release1

Anatomical Grounding and Leakage-Aware Multimodal Contrastive Learning for Alzheimer's Disease Classification from Structural MRI

Study of label leakage and anatomical grounding in multimodal MRI models for Alzheimer's staging shows cognitive-score fusion accuracy of 87.3% is leakage-driven.

The authors train a ResNet18 slice-based encoder with a one-layer Transformer on 1,075 ADNI-1 T1 MRI scans, using FastSurfer segmentations and YOLOv8 localization (mAP_50 above 0.96) as anatomical reference. Grad-CAM shows the image-only classifier often attends to skull and background rather than disease-relevant structures. A CLIP-style image-tabular contrastive framework organized along a label-leakage spectrum yields 87.3% three-way accuracy with cognitive scores versus 73.0% with regional volumes, and cropping to the medial temporal lobe raises image-only accuracy from 58.7% to 65.1%. Results come from single runs on a small balanced test set with reported confidence intervals.

arXiv cs.AI / cs.LG / cs.CL · 2d agoAI research1

WarmBloodAban/Minimax-h3_Singularity — new model trending #22 on Hugging Face

Community fine-tune Minimax-h3_Singularity enhances MiniMax-H3 video generation with HDR quality, distant face restoration, and improved motion, trending #22 on Hugging Face.

Minimax-h3_Singularity is a community fusion fine-tune of the MiniMax-H3 multimodal video generation model, built from multiple checkpoints and refined with pruning and weight optimization. It supports Text-to-Video, Image-to-Video, Reference-to-Video, and Video-to-Video workflows in ComfyUI, and claims improvements in HDR clarity, distant face restoration, motion fluidity, and fantasy VFX. The authors recommend pairing it with the minimax_h3_ref2v_turbo_4step_v0.1 LoRA for four-step accelerated inference, and an online demo is available via RunningHub.

Hugging Face trending models · 11d agoModel release7· 1 read

NVIDIA NVLink Fusion Expands With NVHBM Custom High-Bandwidth Memory

NVIDIA expands NVLink Fusion with NVHBM custom high-bandwidth memory for hyperscalers building trillion-parameter and agentic AI infrastructure.

NVIDIA announced that NVLink Fusion will expand to support NVHBM, a custom high-bandwidth memory option. The offering targets hyperscalers and AI innovators building next-generation systems where agentic AI and trillion-parameter workloads are mainstream. NVIDIA frames the announcement around co-designing compute, memory, storage, networking, and software as a unified system.

NVIDIA Blog · 21d agoAI industry

VU#687587: AOMEI Backupper amwrtdrv.sys local privilege escalation vulnerability allows arbitrary writes to physical disks

AOMEI Backupper 8.4.0 driver flaw CVE-2026-12780 lets unprivileged users write physical disks and execute UEFI code, bypassing HVCI and EDR.

CERT/CC issued VU#687587 for CVE-2026-12780, an incorrect permission assignment (CWE-732) in the amwrtdrv.sys kernel driver shipped with AOMEI Backupper 8.4.0. The driver exposes a world-accessible device object without a security descriptor, allowing any unprivileged user to write arbitrary physical disk sectors; with Secure Boot disabled, an attacker can modify the GPT and inject a UEFI payload that executes before the OS loads, bypassing HVCI, EDR, Windows Defender and Hyper-V isolation. On TPM-only BitLocker configurations the attack can capture Volume Master Key material during pre-boot. AOMEI has shipped patches; users who cannot update should uninstall the software or disable the amwrtdrv.sys service, and enabling Secure Boot adds defense in depth.

PoisonedRefresh: A Fileless Linux Rootkit That Injects PHP Web Shells Into F5 BIG-IP APM Server Memory

Sophos details PoisonedRefresh, a fileless Linux rootkit that injects a memory-resident PHP web shell into F5 BIG-IP APM after exploitation of CVE-2025-53521.

On September 8, 2026, SophosLabs published an analysis of Linux/Agnt-IC (dubbed PoisonedRefresh by ESET) found in compromised F5 BIG-IP Access Policy Manager environments. Initial access leverages CVE-2025-53521, an unauthenticated RCE in BIG-IP APM when an access policy is configured on a virtual server; F5 confirmed exploitation and links the activity to cluster c05d5254, while Shadowserver observed 795 exposed vulnerable endpoints. A first stage hidden in a modified umount binary modifies /usr/sbin/httpd and SELinux configuration and embeds itself in BIG-IP upgrade images for persistence. The second-stage ELF intercepts __libc_start_main, hooks apr_dso_load, and injects a PHP web shell into libphp memory via mmap manipulation, leaving no disk artifacts, and exposes a /bin/bash shell via a local UNIX domain socket instead of a TCP port.

Security Affairs · 7d agoMalware in the wildCVE-2025-53521

Fine-tuning a 350M Model for Better Structured Outputs in 100 GRPO Steps

Hugging Face guide fine-tunes a 350M-parameter model with 100 GRPO steps to improve structured output reliability.

A Hugging Face blog post demonstrates fine-tuning a 350M-parameter model using GRPO (Group Relative Policy Optimization) with TRL over 100 training steps. The stated goal is more reliable structured outputs from small language models. No article body was available, so details beyond the title are limited.

Hugging Face Blog · 14d agoAI tools & infra

Towards Standardized Evaluation of GPU Memory Safety with GMSBench

GMSBench provides 149 CUDA tests covering spatial, temporal, and concurrency GPU memory errors, exposing detection gaps in Compute Sanitizer.

GMSBench is a GPU memory safety benchmark comprising 149 self-contained CUDA tests spanning spatial, temporal, and concurrency errors across different GPU memory spaces and execution scenarios. The authors evaluate NVIDIA's Compute Sanitizer across multiple GPU architectures using the suite, exposing gaps in its detection coverage. The benchmark offers a standardized foundation for comparative evaluation of GPU memory safety mechanisms.

arXiv cs.CR · 8d agoResearch

Chaotic Eclipse Released GreenSection, A PoC For NVIDIA Memory Corruption Zero-Day

Researcher Chaotic Eclipse released GreenSection, a PoC exploiting an unpatched out-of-bounds write in NVIDIA Windows user-mode shared memory.

Security researcher Chaotic Eclipse disclosed an out-of-bounds write in NVIDIA's Windows user-mode components, which share a global memory section (\BaseNamedObjects\{52813408-3561-4705-820a-2b3b78be92ba}) with full read/write access to all users. The PoC crashes applications running Vulkan or OpenGL; the researcher says the bug could cross user boundaries or compromise dwm.exe but did not fully assess the impact. No CVE has been assigned and no patch is mentioned. The researcher recently released zero-day PoCs against Kaspersky, Avast, and CrowdStrike Falcon.

Security Affairs · 9d agoExploit / PoC 2 sources

When LLM Decompilers Recompile More and Preserve Less

Researchers show LLM decompiler outputs can recompile yet diverge behaviorally, proposing the Decompile-Diverge fuzzing oracle to catch hidden changes.

The paper demonstrates that LLM-based decompilers can produce code that recompiles and passes all shipped tests yet diverges on other legitimate inputs—4.9% overall and up to 13% for one system—and can make disclosed vulnerabilities vanish without a visible crash. Across 300 real GitHub functions and 287 CVE-grounded functions, a refinement LLM lifted Ghidra's build rate from 75% to 90% while Matched rate fell from 74% to 62%, with up to one tenth of vulnerabilities showing Crash Absence. Decompile-Diverge detects these gaps by synthesizing drivers, growing fuzzing corpora from the reference, and rerunning decompiled code on identical inputs.

arXiv cs.CR · 12d agoResearch

Do Input-Level Defenses Transfer to Observation-Level Attacks on VideoLLMs?

A systematic study shows input-level adversarial defenses provide inconsistent, often near-zero protection against observation-level attacks on video LLMs.

Researchers introduce DefTEval, a controlled framework testing eleven input-level defenses against five attack types across five video LLMs. Harmful-content detection rates are frequently near zero, and defenses fail even when attacks embed harmful signals in every sampled frame. Token compression discards localized safety features and modality fusion down-weights weakened visual signals, with defense outcomes dominated by model architecture rather than the defense method.

arXiv cs.CR · 8d agoAI safety & security

CertiFlash: A Formal Verification Framework for Flash Translation Layers in Computational Solid State Drives

CertiFlash provides machine-checked formal verification of SSD flash translation layers, proving isolation, integrity, and ownership invariants to prevent tenant data leaks.

CertiFlash is an open-source formal verification framework for Flash Translation Layers (FTL) in computational SSDs, mechanized in the Rocq proof assistant. It shows that a faulty FTL can corrupt device state at five surfaces (e.g., leaking data between tenants or dropping integrity tags), demonstrated on a DaisyPlus OpenSSD. Designers prove once that every operation of a general FTL model preserves a global invariant covering mapping, isolation, integrity, ownership, and allocation; new designs need only discharge five hypotheses. Across four case studies, added effort was 27-3,231 lines against a 16,489-line framework.

arXiv cs.CR · 7d agoResearch1

NVIDIA Details BioNeMo Inference Runtime (BioIR): 2.90x Higher Boltz-2 Folding Throughput and 58.5K Residues per GPU-Hour on 8xH100

NVIDIA released BioNeMo Inference Runtime (BioIR), an open-source PyTorch-compatible library delivering 2.90x higher Boltz-2 protein-folding throughput on 8xH100 GPUs.

NVIDIA detailed BioIR, a Python library that accelerates Boltz-2, OpenFold2, and OpenFold3 structure-prediction inference on NVIDIA GPUs while preserving standard PyTorch workflows. On a matched benchmark of 1,000 human dimers on 8xH100 80GB GPUs, BioIR delivered 58.5K folded residues per GPU-hour versus 20.2K for a torch.compile baseline, a 2.90x throughput gain. BioIR already powered the AlphaFold Database expansion, generating about 31 million candidate complexes across 4,777 proteomes, with 1.81 million released as high-confidence predictions. Extrapolated to 1 million targets, estimated folding energy drops from 35 MWh to 11 MWh at 8-GPU TDP equivalents.

MarkTechPost · 6d agoAI tools & infra1