ZeroHour

Search: “fishbrain”

30 stories

Smart search ranks by meaning as well as keywords (one row per story, last 45 days).

AlphaGenome Atlas: A predictive map of every possible DNA letter change in the human genome

Google DeepMind released AlphaGenome Atlas, a free 1-petabyte platform predicting the molecular effects of all ~9 billion possible single-letter DNA variants.

Google DeepMind introduced AlphaGenome Atlas, containing precomputed predictions for the effects of roughly 9 billion single-nucleotide variants across the human genome, spanning hundreds of human and mouse cell types. The 1-petabyte dataset is more than 30 times larger than the AlphaFold Database and includes an AlphaGenome Variant Impact (AVI) score combining AlphaGenome and AlphaMissense predictions for both coding and non-coding regions. External collaborators have already used it to identify and experimentally verify variants in unsolved rare disease research. It is available via a free web portal, the AlphaGenome API, and as a skill in Google Antigravity.

Google DeepMind · 8d agoAI research 2 sources

Cybercrooks trawl Fishbrain to net password hashes

Fishing app Fishbrain disclosed a breach exposing names, emails, and password hashes with salts for users of its 20-million-member platform.

Fishbrain AB disclosed to the California Attorney General's Office that attackers accessed user data on August 19, 2026, taking names, dates of birth, email addresses, phone numbers, usernames, country information, password hashes, and salts. The company said passwords were not stored in plaintext but some hashes may be susceptible to cracking; it patched the exploited vulnerability, reset all user passwords, and restricted access to the affected environment. Fishbrain, which claims more than 20 million users, did not disclose how many accounts were affected or which hashing algorithm was used.

The Register · Security · 13d agoData breach

The 2026 PNPL Competition: Word Classification and Efficient Cross-Subject Generalisation in LibriBrain100

The 2026 PNPL competition releases LibriBrain100, a MEG speech dataset with 32 extra subjects, targeting word classification and cross-subject BCI generalization.

The 2025 PNPL competition on non-invasive speech decoding from MEG achieved F1-macro scores of 95.6% for speech detection and 73.6% for phoneme classification, built on LibriBrain's ~50 hours of single-subject data. The 2026 edition extends this with LibriBrain100, adding 32 subjects (~40 minutes each) plus ~80 hours of within-subject data. Two tracks target within-subject word classification at scale and cross-subject generalization with subject-specific fine-tuning shrinking from ~40 to ~20 to ~10 minutes, aiming at clinically feasible non-invasive BCIs for people with profound paralysis.

Hugging Face daily papers · 14d agoAI research

Fly Language Model (FLM) Wires the Full Fruit Fly Connectome Into a Frozen 1.2B LLM, and Its Own Controls Show the Wiring Does Not Help

Researchers wire the full fruit fly connectome (166,700 nodes) into a frozen LiquidAI LFM2.5-1.2B LLM, but controls show no fly-specific benefit.

The Fly Language Model (FLM) couples the complete MaleCNS v1.0 fruit fly connectome (166,700 nodes, 25,582,938 edges) to a frozen LiquidAI LFM2.5-1.2B-Instruct backbone, training only a 278,528-parameter readout (~0.0238% of backbone parameters). The fly readout improved NLL by 0.0222 nats/token (perplexity 3.98 to 3.90) on 32 SmolTalk dialogues, but a direct-input control without the graph beat it in all three seeds. Relabeling node identities removes the gain and the recurrence contracts state differences by 0.6 per token, so the connectome adds no long-range memory. The MIT-licensed code runs locally on Python 3.12, but study artifacts remain private, limiting independent reproducibility.

MarkTechPost · 4d agoAI research1

TART: A Modular Tool for Technique-Aware Audio-to-Tablature Guitar Transcription

TART pipeline transcribes guitar audio to tablature with fingering and technique labels, outperforming prior baselines by up to 8.5 Tab F1 points.

TART is a modular four-stage pipeline for audio-to-tablature guitar transcription, combining an audio-to-MIDI transcription model, an expressive technique classifier, an audio-conditioned T5 encoder-decoder for string-fret assignment, and an automated tablature generator. In zero-shot evaluation on GuitarSet, EGDB, and two noisy augmented benchmarks, it averages 81.35% audio-to-MIDI F50 (+6.67 over the best baseline), 71.8% string-fret Tab F1 (+8.5), and 54.08% end-to-end Tab F1. The authors state it is the first framework to generate tablature with both fingering and expressive technique annotations directly from guitar audio.

arXiv cs.AI / cs.LG / cs.CL · 6d agoAI research2

NVIDIA Details BioNeMo Inference Runtime (BioIR): 2.90x Higher Boltz-2 Folding Throughput and 58.5K Residues per GPU-Hour on 8xH100

NVIDIA released BioNeMo Inference Runtime (BioIR), an open-source PyTorch-compatible library delivering 2.90x higher Boltz-2 protein-folding throughput on 8xH100 GPUs.

NVIDIA detailed BioIR, a Python library that accelerates Boltz-2, OpenFold2, and OpenFold3 structure-prediction inference on NVIDIA GPUs while preserving standard PyTorch workflows. On a matched benchmark of 1,000 human dimers on 8xH100 80GB GPUs, BioIR delivered 58.5K folded residues per GPU-hour versus 20.2K for a torch.compile baseline, a 2.90x throughput gain. BioIR already powered the AlphaFold Database expansion, generating about 31 million candidate complexes across 4,777 proteomes, with 1.81 million released as high-confidence predictions. Extrapolated to 1 million targets, estimated folding energy drops from 35 MWh to 11 MWh at 8-GPU TDP equivalents.

MarkTechPost · 6d agoAI tools & infra1

Evaluating Time-Series Foundation Models and Multimodal Dietary Context for CGM Forecasting

Study finds zero-shot time-series foundation models underperform on CGM forecasting; fine-tuned Chronos-Bolt cuts RMSE up to 18.4% and dietary context adds signal.

The paper evaluates time-series foundation models for continuous glucose monitoring forecasting across eight public datasets covering Type 1 diabetes, Type 2 diabetes, and non-diabetes populations. Under a unified protocol, zero-shot foundation models did not consistently outperform baselines like Elastic Net and PatchTST, but lightweight fine-tuning did, with fine-tuned Chronos-Bolt reducing RMSE by 6.5%-18.4% in the T1D cohort and 8.6%-18.2% in the non-diabetes/T2D cohort. A residual-based fusion framework adding dietary context from CGMacros reduced overall RMSE by about 3% and postprandial RMSE by about 15% versus CGM-only baselines.

arXiv cs.AI / cs.LG / cs.CL · 6d agoAI research

Structural Jailbreaks Generalize but Do Not Compound: A cross-provider and multilingual study of Involuntary In-Context Learning

Researchers show IICL structural jailbreaks generalize to Google Gemini, lifting attack success to 80-100% on harm and financial benchmarks; non-English prompts attenuate it.

The study red-teams two Google Gemini models with Involuntary In-Context Learning (IICL), a structural jailbreak reframing harmful requests as the final cell of a data-labeling task. IICL lifts attack success from at most 6.7% to 80-90% on HarmBench and 97-100% on financial abuse (FinProof), an order of magnitude above prior results on OpenAI's GPT-5.4. Against a compounding hypothesis, forcing IICL output into Spanish, Hindi, or Arabic attenuates the attack in 11 of 12 conditions, attributed to a 'relevance curse' producing lower-quality harmful content in lower-resource languages. Findings replicate under an independent non-Google judge (Cohen's kappa 0.86 over 377 paired verdicts).

arXiv cs.CR · 8d agoAI safety & security

LimiX-2: A Contextual Mechanism Network Towards General Structured-Data Intelligence

LimiX-2 scales Contextual Mechanism Networks pretrained via context-conditional masked modeling, beating tabular foundation models on TabArena, TALENT, and BCCO benchmarks.

LimiX-2 is a new tabular model in the LimiX family, developed through model and data scaling guided by previously established scaling laws under the Contextual Mechanism Networks (CMNs) paradigm. It is pretrained with Context-Conditional Masked Modeling (CCMM) on synthetic datasets generated by structural causal models spanning diverse graph structures, functional mechanisms, and observation processes. It outperforms dataset-specific models and tabular foundation models on TabArena, TALENT, and BCCO, and its feature attention encodes direct causal relationships, enabling accurate causal skeleton recovery.

arXiv cs.AI / cs.LG / cs.CL · 1d agoAI research1

Biology-in-the-loop: Amortized Adaptive Hit Discovery in CRISPR Screens

Researchers release AssayBench-Loop, a 1,389-screen CRISPR benchmark, and AssayLoop, a framework that learns adaptive hit discovery policies.

The paper introduces AssayBench-Loop, a large-scale benchmark of 1,389 CRISPR screens across five phenotype categories for adaptive hit discovery under budget constraints. It also introduces AssayLoop, which combines AssayFormer, a transformer-based amortized acquisition policy trained across historical screens, with LLM-derived biological priors via an adaptive handoff. On temporally held-out screens, AssayLoop achieves 5.67-fold enrichment over random selection and recovers 27.7% of hits after assaying roughly 5% of the candidate library, outperforming existing adaptive-design methods and standalone LLMs.

arXiv cs.AI / cs.LG / cs.CL · 6d agoAI research1

XHToken/Spark-X2.5-4B-GGUF — new model trending #30 on Hugging Face

XHToken released GGUF weights of Spark-X2.5-4B, a compact model with 1M-token context and 200+ language support, under Apache 2.0.

The Hugging Face repository provides BF16 GGUF conversions of Spark-X2.5-4B, a compact general-purpose language model for conversation, writing, translation, reasoning, coding, tool use, and agentic workflows. The model uses a hybrid attention architecture, supports a native context length up to 1M tokens, and covers more than 200 languages. Local inference is supported through Ollama and LM Studio via an XHToken llama.cpp fork, with a --think=false flag to disable thinking mode for faster responses. Released under Apache License 2.0; it was trending #30 on Hugging Face at publication.

Hugging Face trending models · 19d agoModel release

Breaking the Seal: Static Deobfuscation of JSCeal’s Compiled V8 Bytecode

Check Point's hasherezade details static deobfuscation of JSCeal, a V8-bytecode stealer targeting cryptocurrency applications since March 2024.

JSCeal is an infostealer distributed as compiled V8 bytecode (.jsc) executed by a bundled Node.js runtime, aimed at cryptocurrency applications. Other vendors track the same family under the names WEEVILPROXY or MeadowLocust. Check Point Research has tracked the campaign since early 2024, with activity dating back to March 2024. The write-up presents a static approach to unpacking the bytecode without executing it.

Check Point Research · 16d agoMalware in the wild1

Dr. Claw: An AI Scientist Workspace for Vibe Research

Researchers release Dr. Claw, an open-source auditable workspace that wraps coding agents like Claude Code for end-to-end AI-assisted research workflows.

Paper 2609.00365 presents Dr. Claw, an open-source workspace that wraps existing coding-agent executors such as Claude Code and Gemini CLI in a controllable, human-in-the-loop research workflow. It uses persistent state objects, a reusable skill library, and multi-executor coordination to make research decisions auditable and recoverable, rather than adding another autonomous agent. Holding the executor fixed, Dr. Claw scores higher on research completeness than a bare command-line agent while preserving an auditable process trail. The code is released under AGPL-3.0 on GitHub (OpenLAIR/dr-claw).

Hugging Face daily papers · 17d agoAI research1

CareMirror: Bringing Caregiver Wellbeing into the Dementia Care Ecosystem

Interview study with 14 dementia caregivers probes CareMirror wellbeing ecosystem, revealing demands for control over clinical sharing and AI boundaries.

CareMirror is an envisioned caregiver wellbeing ecosystem with interconnected caregiver- and clinician-facing interfaces for longitudinal reflection, personalized support, and caregiver-controlled sharing. Semi-structured interviews with 14 family caregivers used the system as a design probe. Caregivers valued wellbeing attention and clinical visibility but found repeated reflection burdensome and worried automatic clinical sharing would inhibit candid disclosure, expecting AI to support rather than replace caregiver and clinician judgment.

arXiv cs.AI / cs.LG / cs.CL · 1d agoAI research

Molecular Déjà Vu: Digit-Level Retrieval of Published Values in Frontier Language Models

Audit of 22 frontier models finds widespread verbatim retrieval of published molecular property values, with higher reasoning increasing recall of memorized numbers.

An arXiv audit tests 22 frontier LLMs across 12 molecular regression benchmarks for verbatim retrieval of published values. More than 50% of the LLMs show verbatim retrieval on five datasets, and identical experiments are flagged 89% more often at a high reasoning level than at the lowest one. Suppressing retrieval moves model prediction errors closer together in relative terms, suggesting predictive capability is not determined solely by memorized values.

arXiv cs.AI / cs.LG / cs.CL · 12d agoAI research1

Mi-Ripple: Restoring Images Degraded by Iterative AI Editing

Mi-Ripple is a diagnosis-guided restoration workflow that removes digital ripple artifacts introduced by iterative AI image editing while preserving structure.

Iterative reference-conditioned image editing can introduce grid-like and granular textures known as digital ripple. Mi-Ripple separates periodic lattice artifacts from content-entangled granular texture, then applies selective spectral notching, structure-aware smoothing, and cleaned-reference regeneration. In fourteen notch-only executions, whole-image residual standard deviation was 0.08-0.44 in CIELAB lightness units, and reference cleaning reduced output debris density by 45% in a paired example.

Hugging Face daily papers · 7d agoAI research

DianShi-RxnDB: A Large-Scale, Fine-Grained Organic Reaction Data Platform Built via a Fully Automated Pipeline for Researchers and AI Agents

Researchers release DianShi-RxnDB, a database of roughly 24 million organic reaction instances extracted automatically from USPTO and EPO patents since 1976.

DianShi-RxnDB is built by a fully automated pipeline integrating patent text, images, and reaction schemes, yielding about 24 million reaction instances, of which 14.8 million (61.7%) pass automated qualification checks. Manual evaluation of 1,300 sampled instances showed 92.95% field-level accuracy, and comparisons with Pistachio found advantages in deduplicated record counts and granularity. The platform offers a web research workbench and a Model Context Protocol (MCP) service enabling AI agents to perform composable structured retrieval.

Hugging Face daily papers · 11d agoAI research

27.5KB language-agnostic WebGPU syntax highlighter

A developer released gpu-lexer, a 27.5KB language-agnostic syntax highlighter that uses a tiny WebGPU model to label code tokens in the browser.

gpu-lexer splits source into words, whitespace, and symbols, then a small WebGPU model uses local and whole-file context to assign nine token classes, working on languages never seen in training. On held-out files, 12.57% of token labels differ from Shiki, though this measures agreement with Shiki rather than objective correctness. In benchmarks against Shiki 4.4.3, Prism.js, Highlight.js, Sugar High, and Starry Night, it highlighted 10 concatenated copies of three.min.js (5.56M characters) about 10x faster on an Apple M4 Pro in Chrome 152. The author frames it as an experiment, not a grammar-equivalent highlighter.

CARDEA: Auditable Reasoning Grounded in Spatial Evidence for End-to-End Coronary Angiography Interpretation

CARDEA, a vision-language model trained only on public data, matches cardiologists on coronary angiography complexity assessment while exposing auditable bounding-box evidence.

CARDEA is a unified large vision-language model serving as the inference core of an end-to-end coronary angiography pipeline from multi-view videos to study-level diagnosis. It was trained on public datasets through visual alignment, self-distilled Chain-of-Box cold start, and reinforcement learning with verifiable rewards encouraging bounding-box reasoning. It reached 0.91 accuracy on dominance classification under domain shift and 0.90 on complexity assessment, comparable to two interventional cardiologists. RLVR raised zero-shot report generation vessel-severity macro-F1 from 0.513 to 0.686, while supervised imitation alone did not.

Hugging Face daily papers · 10d agoAI research

microsoft/VibeVoice-ASR-Streaming-7B — new model trending #27 on Hugging Face

Microsoft released VibeVoice-ASR-Streaming-7B, an open streaming ASR model with speaker attribution, custom hotwords, and support for 10 languages under MIT license.

Microsoft Research released VibeVoice-ASR-Streaming-7B on Hugging Face, a unified streaming speech recognition model that continuously transcribes who said what as speech arrives. The 7B model supports customized hotwords for domain-specific terms and 10 languages including Chinese, English, French, German, Italian, Japanese, Korean, Portuguese, Russian, and Spanish. Code is available at github.com/microsoft/VibeVoice with a live demo, and a technical report is on arXiv (2609.02812). The model is licensed under MIT.

Hugging Face trending models · 14d agoModel release1

Google DeepMind Releases AlphaGenome Atlas With Precomputed Molecular Effect Predictions and AVI Scores for 9 Billion Human DNA Variants

Google DeepMind launched AlphaGenome Atlas, precomputing molecular effect predictions and AVI impact scores for ~9 billion human single-nucleotide variants in a 1-petabyte catalogue.

Google DeepMind released AlphaGenome Atlas, a 1-petabyte catalogue of precomputed molecular effect predictions for roughly 9 billion possible single-nucleotide variants in the human genome. It introduces the AlphaGenome Variant Impact (AVI) score, combining AlphaGenome regulatory predictions with AlphaMissense, plus per-variant feature attributions and over 2,500 recurrent DNA sequence motifs. DeepMind reports best-in-class AVI performance on variant pathogenicity and rare disease benchmarks. Early users at the Broad Institute, University of Exeter, and Stowers Institute demonstrated rare-disease variant reprioritization and 22% more non-coding associations across 54,000+ UK Biobank genomes.

MarkTechPost · 8d agoAI research2

Fake bank websites play dead to evade security scanners

Fortra uncovered Chameleon SEO Poisoning: cloaked typosquat bank sites rank on Google and Bing to steal credentials while evading scanners, with cases up 40% in Q2 2026.

Fortra's threat intelligence unit FIRE spent three months tracking Chameleon SEO Poisoning, a phishing method that ranks recently registered typosquat domains on second-level domains like .ph.com and .gr.com above legitimate bank sites on Google and Bing. The technique uses presentation control (cloaking by referrer): direct visits get a dead, offline-looking page, while search-referred clicks receive a convincing fake bank login page, letting poisoned results persist for days or weeks. Fortra recorded a 40% jump in cases during the second quarter of 2026 and recommends referrer-spoofed URL testing, faster SLD takedowns, and bookmarking bank logins.

Help Net Security · 23d agoPhishing & fraud in the wild

HypoEvolve: Genetic Algorithms Enable Multi-Agent LLMs to Discover Scientific Hypotheses

HypoEvolve couples a generational genetic algorithm with specialized LLM agents to generate drug-repurposing hypotheses, beating six baselines on DepMap selectivity (0.171 vs 0.115).

HypoEvolve coordinates specialized LLM agents through a generational genetic algorithm in which scientific judgments and new proposals reshape a hypothesis population. Evaluation centers on drug repurposing, linking mechanistic explanations to target-level biological claims assessed via external measures adapted from DepMap and Open Targets. Across 34 cancer types, HypoEvolve scores highest against six baselines on both measures, with DepMap selectivity of 0.171 versus 0.115 for the strongest baseline, and gains generalize to held-out cancer types.

arXiv cs.AI / cs.LG / cs.CL · 2d agoAI research1

K-Bench: a clinically calibrated benchmark for evaluating large language models in high-risk mental health conversations

Clinician-calibrated K-Bench evaluates 125 LLM configurations on 200 high-risk mental health vignettes, exposing wide variation in suicide and violence risk handling.

K-Bench is a clinician-calibrated, protected benchmark evaluating 125 model configurations from 33 base models across 14 providers on 200 multi-turn vignettes covering suicide, self-harm, domestic violence, substance misuse and no-risk presentations. A frozen GPT-4o judge achieved 94.2% exact agreement with clinician consensus across 6,751 eligible comparisons from 151 clinician-rated transcripts. Leading models combined supportive conversation with combined-risk scores above 95, while risk exploration varied substantially among weaker configurations; therapeutic prompting helped weaker models and elevated reasoning produced no average improvement. A continuously updated public leaderboard is hosted at k-bench.ai with protected test materials.

Multi-Task Learning for Sparsely-Labeled Time Series: A Case Study on Cold-Hardiness Modeling

Multi-task RNN architectures pooling sparse cultivar data improve grape cold-hardiness and budbreak prediction over single-task and scientific baselines.

Researchers apply recurrent neural networks to daily grape cold-hardiness prediction from weather time series, where per-cultivar labels are temporally sparse and limited. They design multiple multi-task learning architectures that treat cultivars as tasks and evaluate them in both MTL and transfer learning settings. Certain architectures consistently outperform single-task learning and state-of-the-art scientific models, and a single MTL model jointly learning cold hardiness and budbreak improves accuracy on both tasks.

arXiv cs.AI / cs.LG / cs.CL · 8d agoAI research

JSCeal Hides Crypto Malware in V8 Bytecode

Check Point details JSCeal, a crypto-stealing malware delivered as compiled V8 bytecode, and built a decompiler pipeline to expose its capabilities.

JSCeal, tracked by Check Point Research since early 2025, is a cryptocurrency stealer delivered as heavily obfuscated JavaScript compiled to V8 bytecode (.jsc) and run by a bundled Node.js runtime. Check Point, presenting at Black Hat USA 2026, extended the open-source View8 decompiler into a pipeline that recovered readable code from 23 samples, revealing theft of browser credentials and cookies, Telegram sessions, keystrokes, screenshots, HTTPS traffic interception with attacker-controlled certificates, and automated Google account takeover. Targeted overrides rewrite content for Binance, Bybit, and Ledger users. Later samples added AES-256-CBC encryption with externally supplied keys and expanded targeting to macOS.

Security Affairs · 9d agoMalware1

Deepmind's AlphaGenome Atlas maps every possible DNA change in the human genome

DeepMind's AlphaGenome Atlas precomputes impact predictions for ~9 billion human DNA variants in a 1-petabyte dataset; its AVI score beats CADD in benchmarks

Google DeepMind released the AlphaGenome Atlas, precomputing functional-effect predictions for roughly 9 billion human genome variants (about 27,000 prediction values per variant) in a one-petabyte dataset more than 30 times the size of the AlphaFold database. The accompanying AlphaGenome Variant Impact Score (AVI), a small neural network combining AlphaGenome, AlphaMissense and evolutionary conservation features (18 inputs versus CADD's 150+), outperformed existing tools on clinically classified variants, ranking causal variants in the top 50 candidates for 29.5% of solved GREGoR cases versus 12.5% for CADD. A GREGoR epilepsy case illustrates the impact: AVI elevated a previously unclear DNM1 splice variant that lab experiments confirmed as likely disease-causing. The atlas is available for noncommercial use via web portal, API and a Google Antigravity skill, with a commercial version planned through Google Cloud.

The Decoder · 7d agoAI research

Kaininja: Extending Native 3D Generators to the Part Level

KaiNinja extends TRELLIS.2 native 3D generation to part-level assets via a dual-volume O-Voxel representation, cutting whole-object Chamfer distance by 40%.

KaiNinja extends the TRELLIS.2 native 3D generator to produce part-level assets instead of one fused mesh, enabling downstream editing, rigging, and simulation. A dual-volume form of the O-Voxel representation solves the problem that a single volume cannot represent interfaces where two parts touch. The model needs no segmentation network, is partly trained on LLM-agent-authored part data, lowers whole-object Chamfer distance by 40%, and raises strict part F-score by 16% versus other part-generation pipelines.

Hugging Face daily papers · 3d agoAI research

Metasploit Wrap Up: Payloads and Exploits, and Scanners, Oh my!

Rapid7's weekly Metasploit roundup highlights newly added exploit modules, payloads, and scanners in the Metasploit Framework.

Rapid7 published its weekly Metasploit Wrap Up summarizing community contributions to the Metasploit Framework, including new exploit modules, payloads, and scanners. No article text was available; the post serves as a routine digest for practitioners tracking newly packaged modules.

Rapid7 Blog · 19d agoTools

YuE2 · Frontier Music with Symbolic Planning

YuE2, a 3.59B-parameter music generation model, scores 6.9632 on SongBench, beating Suno v5 via symbolic planning.

YuE2 is a music generation model of roughly 3.59B parameters and 28 layers supporting song creation, covering, and agentic editing through editable ABC symbolic scores. Its best-of-8 setting reaches 6.9632 on SongBench, the highest mean among 15 evaluated settings on WildSongBench (192 prompts), ahead of Suno v5 at 6.8721. The project also introduces MERT2, whose 632M-parameter encoders achieve state of the art on 14 of 15 MARBLE metrics, and SheetSage2, which transcribes beats, downbeats, key, chords, structure, and melody with SOTA on 10 of 13 benchmark metrics.

Hacker News · AIupdated · 5d agofirst · 5d agoModel release 2 sourcesHN 43↑ · 35 comments