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The 2026 PNPL Competition: Word Classification and Efficient Cross-Subject Generalisation in LibriBrain100

The 2026 PNPL competition releases LibriBrain100, a MEG speech dataset with 32 extra subjects, targeting word classification and cross-subject BCI generalization.

The 2025 PNPL competition on non-invasive speech decoding from MEG achieved F1-macro scores of 95.6% for speech detection and 73.6% for phoneme classification, built on LibriBrain's ~50 hours of single-subject data. The 2026 edition extends this with LibriBrain100, adding 32 subjects (~40 minutes each) plus ~80 hours of within-subject data. Two tracks target within-subject word classification at scale and cross-subject generalization with subject-specific fine-tuning shrinking from ~40 to ~20 to ~10 minutes, aiming at clinically feasible non-invasive BCIs for people with profound paralysis.

Hugging Face daily papers · 13d agoAI research

Google’s Atlas of the human genome could pave the way for new treatments

Google DeepMind launches AlphaGenome Atlas, a catalog of predicted molecular effects for roughly nine billion single-letter DNA changes across the human genome.

Google DeepMind unveiled AlphaGenome Atlas, a roughly 1-petabyte dataset predicting how each of about nine billion possible single-nucleotide variants affects molecular biology, including non-coding regions that regulate gene behavior. It builds on the AlphaGenome model released in 2025 and adds a Variant Impact Score (AVI) to help researchers rank variants. The catalog is available for noncommercial research via a web portal, the Antigravity platform, and the AlphaGenome interface, with commercial access on Google Cloud planned.

The Verge · AI · 8d agoAI industry 2 sources

Molecular Déjà Vu: Digit-Level Retrieval of Published Values in Frontier Language Models

Audit of 22 frontier models finds widespread verbatim retrieval of published molecular property values, with higher reasoning increasing recall of memorized numbers.

An arXiv audit tests 22 frontier LLMs across 12 molecular regression benchmarks for verbatim retrieval of published values. More than 50% of the LLMs show verbatim retrieval on five datasets, and identical experiments are flagged 89% more often at a high reasoning level than at the lowest one. Suppressing retrieval moves model prediction errors closer together in relative terms, suggesting predictive capability is not determined solely by memorized values.

arXiv cs.AI / cs.LG / cs.CL · 11d agoAI research1

K-Bench: a clinically calibrated benchmark for evaluating large language models in high-risk mental health conversations

Clinician-calibrated K-Bench evaluates 125 LLM configurations on 200 high-risk mental health vignettes, exposing wide variation in suicide and violence risk handling.

K-Bench is a clinician-calibrated, protected benchmark evaluating 125 model configurations from 33 base models across 14 providers on 200 multi-turn vignettes covering suicide, self-harm, domestic violence, substance misuse and no-risk presentations. A frozen GPT-4o judge achieved 94.2% exact agreement with clinician consensus across 6,751 eligible comparisons from 151 clinician-rated transcripts. Leading models combined supportive conversation with combined-risk scores above 95, while risk exploration varied substantially among weaker configurations; therapeutic prompting helped weaker models and elevated reasoning produced no average improvement. A continuously updated public leaderboard is hosted at k-bench.ai with protected test materials.

arXiv cs.AI / cs.LG / cs.CL · 1d agoAI safety & security

PhysBrain 1.5: From Vision-Language Models to Physical Foundation Models

PhysBrain 1.5, an 8B physical foundation model, sets open-source state of the art across 28 embodied understanding benchmarks.

The paper presents PhysBrain 1.5, a unified 8B model for understanding physical environments, generating actions, and predicting future states, built from a vision-language model with joint autoregressive next-token prediction over language, end-effector motion, and dense visual targets. Pre-training uses embodied supervision from human interaction videos, followed by supervised fine-tuning on human demonstrations, robot trajectories, and simulated experience. The model averages 72.5 across 28 embodied benchmarks, setting a new open-source state of the art and performing on par with proprietary GPT-6-Astra and Gemini 3.6 Flash, with best open-source results on 14 benchmarks.

Hugging Face daily papers · 2d agoAI research1

The Semantic Bottleneck: Leveraging Semantic Representations for Non-Invasive Speech Decoding

Researchers introduced Brain2Semantics2Text, decoding sentence meaning from non-invasive MEG brain recordings via a semantic bottleneck, improving on prior Brain2Text methods.

The paper proposes Brain2Semantics2Text, a non-invasive speech decoding method that maps sentence-level magnetoencephalography (MEG) responses into a semantic embedding space and inverts those embeddings into natural language. Motivated by evidence that high-level semantic representations are distributed across cortex and evolve on slower timescales, the approach targets meaning rather than phonemes or words, avoiding the need for word-level alignment. The authors report improved sentence-level results compared to prior non-invasive Brain2Text methods despite the low signal-to-noise ratio of neural recordings.

Hugging Face daily papers · 7d agoAI research2

Domain-Specific Hallucination Detection in Large Language Models

A multi-signal pipeline detects LLM hallucinations, reaching F1 0.915 on HaluEval and cutting Qwen2.5-0.5B hallucination rates from 85.5% to 37.7% via DPO.

The paper presents a hallucination detection pipeline combining fine-tuned DeBERTa-v3 classification, Monte Carlo Dropout uncertainty, and temperature-scaled calibration. It achieves F1 0.915 and AUROC 0.977 on general-domain HaluEval tasks, with MC Dropout inference raising accuracy to 93.2%. Applying DPO to a Qwen2.5-0.5B generator reduces its hallucination rate from 85.5% to 37.7%, while cross-domain evaluation shows poor general-domain transfer to SciFact (F1 0.52) and PubMedBERT fine-tuning as the strongest adaptation (F1 0.63).

arXiv cs.AI / cs.LG / cs.CL · 5d agoAI research1

AI-designed drug appears to turn back the body's biological clock in early trial

Insilico Medicine's AI-designed drug rentosertib showed reduced predicted biological age in IPF trial blood analysis, published in Nature Biotechnology.

Insilico Medicine reported that rentosertib, an AI-designed drug candidate in Phase III trials for idiopathic pulmonary fibrosis, showed reduced predicted biological age in blood protein analysis of 42 trial patients. Six independent aging-clock models built by teams at Harvard, Oxford, Beijing, and Insilico all predicted lower biological age versus placebo, with drops of three to four years by week 4 and up to six years on one clock. The drug targets TNIK and was developed with two generative AI systems in about 18 months; Eli Lilly recently invested in the company. Experts including Eric Topol and Harvard's Vadim Gladyshev called the results encouraging but not definitive, citing small sample size.

The Decoder · 9d agoAI industry

LexFlip: A Dissociation Diagnostic for Legal Meaning Preservation Metrics

LexFlip releases 373 minimal perturbations of Quebec statutory French that reverse legal force while preserving tokens, exposing weaknesses in embedding-based meaning preservation metrics.

LexFlip provides 373 minimal perturbations of Quebec statutory French that reverse legal force while preserving 0.93 of tokens, creating dissociation items that break monotone token-overlap metric validation. The seven embedding and BERTScore metrics tested register only 0.022-0.039 of their identical-to-unrelated range on these edits, versus 0.670 for bidirectional NLI. Against FrJudge, with a measured human ceiling of r=0.597, a bare length feature outscores every semantic metric tested.

arXiv cs.AI / cs.LG / cs.CL · 12d agoAI research

LongAgent: History-Guided Agentic Search for Longitudinal Outcome Prediction

LongAgent autonomously searches variable sets and temporal windows to predict longitudinal medical outcomes, beating the strongest non-agent baseline on synthetic data.

The paper proposes LongAgent, an agent-based method that searches over combinations of variable sets, temporal windows and aggregation functions for outcome prediction on heterogeneous medical longitudinal data. It uses a history memory of previous searches and numerical evidence to guide exploration. On synthetic data it achieves mean RMSE 1.7376, improving over the best non-agent baseline by 0.0151 (95% CI [0.0045, 0.0260]; p=0.0273), and performs comparably to the best baseline on a real clinical dataset.

arXiv cs.AI / cs.LG / cs.CL · 1d agoAI research

HypoEvolve: Genetic Algorithms Enable Multi-Agent LLMs to Discover Scientific Hypotheses

HypoEvolve couples a generational genetic algorithm with specialized LLM agents to generate drug-repurposing hypotheses, beating six baselines on DepMap selectivity (0.171 vs 0.115).

HypoEvolve coordinates specialized LLM agents through a generational genetic algorithm in which scientific judgments and new proposals reshape a hypothesis population. Evaluation centers on drug repurposing, linking mechanistic explanations to target-level biological claims assessed via external measures adapted from DepMap and Open Targets. Across 34 cancer types, HypoEvolve scores highest against six baselines on both measures, with DepMap selectivity of 0.171 versus 0.115 for the strongest baseline, and gains generalize to held-out cancer types.

arXiv cs.AI / cs.LG / cs.CL · 1d agoAI research1

LimiX-2: A Contextual Mechanism Network Towards General Structured-Data Intelligence

LimiX-2 scales Contextual Mechanism Networks pretrained via context-conditional masked modeling, beating tabular foundation models on TabArena, TALENT, and BCCO benchmarks.

LimiX-2 is a new tabular model in the LimiX family, developed through model and data scaling guided by previously established scaling laws under the Contextual Mechanism Networks (CMNs) paradigm. It is pretrained with Context-Conditional Masked Modeling (CCMM) on synthetic datasets generated by structural causal models spanning diverse graph structures, functional mechanisms, and observation processes. It outperforms dataset-specific models and tabular foundation models on TabArena, TALENT, and BCCO, and its feature attention encodes direct causal relationships, enabling accurate causal skeleton recovery.

arXiv cs.AI / cs.LG / cs.CL · 23h agoAI research1

Deepmind's AlphaGenome Atlas maps every possible DNA change in the human genome

DeepMind's AlphaGenome Atlas precomputes impact predictions for ~9 billion human DNA variants in a 1-petabyte dataset; its AVI score beats CADD in benchmarks

Google DeepMind released the AlphaGenome Atlas, precomputing functional-effect predictions for roughly 9 billion human genome variants (about 27,000 prediction values per variant) in a one-petabyte dataset more than 30 times the size of the AlphaFold database. The accompanying AlphaGenome Variant Impact Score (AVI), a small neural network combining AlphaGenome, AlphaMissense and evolutionary conservation features (18 inputs versus CADD's 150+), outperformed existing tools on clinically classified variants, ranking causal variants in the top 50 candidates for 29.5% of solved GREGoR cases versus 12.5% for CADD. A GREGoR epilepsy case illustrates the impact: AVI elevated a previously unclear DNM1 splice variant that lab experiments confirmed as likely disease-causing. The atlas is available for noncommercial use via web portal, API and a Google Antigravity skill, with a commercial version planned through Google Cloud.

The Decoder · 7d agoAI research

NCP-ArchPreview Technical Report: Moving towards Latent Space Language Models through Next Concept Prediction

An 8.9B-parameter latent-space language model using next-concept prediction matches OLMo-3-7B pretraining loss with only 51.3% of the training tokens.

NCP-ArchPreview augments next-token prediction with Next Concept Prediction over a product-quantized concept vocabulary built from hidden states, trained jointly end-to-end. The 8.9B model was trained on 5.73T tokens from the Dolma-3 dataset, the largest latent-space language model demonstration to date. It consumes 51.3% of the tokens to reach OLMo-3-7B's final pretraining loss and outperforms it by 2.45 points on the downstream macro-average, including a 5.99-point GSM8K gain. The learned latent space also enables lightweight domain adaptation via a 17M-parameter VQ module and improves speculative drafting accepted length by 4.17%.

Hugging Face daily papers · 7d agoAI research1

Technical Manual for a Toolkit for Measuring Contextual Individuation in Transformer Language Models

An open methodology toolkit measures whether transformer language models contextualize fixed word forms across domains using bridge forms and layer-wise silhouette analysis.

The manual documents an open toolkit built around 'bridge forms' - identical written words recurring across two or more subject domains with a different sense in each - to test whether transformer language models individuate word occurrences by context beyond the embedding layer. It covers declarative specification of bridge forms, Wikipedia corpus acquisition, occurrence localization, layer-wise representation extraction, domain-pairwise silhouette measurement, and visualization, justifying each choice against failure modes such as sense contamination and subword-tokenization misalignment. It is a methodological and implementation reference and reports no empirical results.

arXiv cs.AI / cs.LG / cs.CL · 11d agoAI research

Bag of Tricks or Bag of Myths? Reducing Modeling Complexity with Task Knowledge in Explainable Suicide Risk Assessment

Researchers audit 31 NLP techniques for clinician-annotated suicide risk prediction, finding only 5 of 31 comparisons yield reliable gains.

A study of 1,635 clinician-annotated social media posts ran roughly 300 controlled experiments across 7 methodological families, auditing techniques such as model scaling, synthetic data, ensembling, and threshold tuning under severe class imbalance. The proposed system reformulates risk factor prediction as entailment between posts and codebook definitions, using architecturally diverse ensembles with class-balanced training and deployment-consistent calibration. It scores 0.8203 for risk, 0.7953 for evidence, and 0.7045 macro-F1 for factors, ranking third among 53 teams.

arXiv cs.AI / cs.LG / cs.CL · 8d agoAI research

Enhancing Accessibility of Medical Texts through Large Language Model-Driven Plain Language Adaptation

Study shows LLMs with Mixture-of-Agents and QLoRA finetuning effectively simplify medical texts into plain language while preserving content.

The paper evaluates Plain Language Adaptation (PLA) using GPT-4o-mini, Gemini-1.5-pro, and LLaMA in zero-shot and few-shot settings. It compares prompting strategies, QLoRA finetuning across models, and integrates Mixture-of-Agents (MoA) techniques for robustness. Results demonstrate LLM-driven PLA makes healthcare texts more comprehensible while retaining essential content.

arXiv cs.AI / cs.LG / cs.CL · 1d agoAI research

Google DeepMind Releases AlphaGenome Atlas With Precomputed Molecular Effect Predictions and AVI Scores for 9 Billion Human DNA Variants

Google DeepMind launched AlphaGenome Atlas, precomputing molecular effect predictions and AVI impact scores for ~9 billion human single-nucleotide variants in a 1-petabyte catalogue.

Google DeepMind released AlphaGenome Atlas, a 1-petabyte catalogue of precomputed molecular effect predictions for roughly 9 billion possible single-nucleotide variants in the human genome. It introduces the AlphaGenome Variant Impact (AVI) score, combining AlphaGenome regulatory predictions with AlphaMissense, plus per-variant feature attributions and over 2,500 recurrent DNA sequence motifs. DeepMind reports best-in-class AVI performance on variant pathogenicity and rare disease benchmarks. Early users at the Broad Institute, University of Exeter, and Stowers Institute demonstrated rare-disease variant reprioritization and 22% more non-coding associations across 54,000+ UK Biobank genomes.

MarkTechPost · 7d agoAI research2

Discovery Foundation Models: Toward Open-Ended Discovery Intelligence

Paper defines Discovery Foundation Models with seven coupled capabilities for open-ended discovery, demonstrated via Zetema and GALILEO systems.

The paper formulates Discovery Foundation Models (DFMs) as general-purpose model systems for open-ended discovery, supporting seven coupled capabilities spanning problem discovery, formulation, representation construction, hypothesis formation, intervention, evidence-grounded revision, and continual improvement. It instantiates the framework with Zetema, which couples explicit research-state dynamics, verification and experimental gating, and cross-task Discovery Skill evolution. The framework is grounded with GALILEO, a real therapeutic-discovery system combining dry-lab reasoning with robotic wet-lab experimentation in a closed physical discovery loop; code is released on GitHub.

Hugging Face daily papersupdated · 1d agofirst · 2d agoAI research 2 sources

ModaLens: Measuring Image Sensitivity in Report-Conditioned Medical VLMs

ModaLens image-swap audit shows report availability cuts MedGemma-27B image sensitivity on MIMIC-CXR from 20.94% to 4.26% answer changes.

ModaLens is a paired image-swap audit measuring how report availability affects image sensitivity in report-conditioned medical VLMs. On MedGemma-27B across 3,199 paired MIMIC-CXR cases from 293 patients (14 questions per case), generated answers changed on 4.26% of image-swap trials with the report versus 20.94% without it, a 16.7-point paired difference (95% CI 15.6-17.7). The original prompt with a lowercase first-token readout gave 4.70% versus 17.07%, and the direction replicated in two further model lineages. Labels derived from reports limit conclusions about visual correctness; code, prompts, and run records are publicly released.

Hugging Face daily papers · 2d agoAI research

NOAH: Learning the Full Patient Journey. A Longitudinal Multimodal Time-Aware Model for Representation and Forecasting

Researchers introduce NOAH, a time-aware generative transformer trained on 559 million MIMIC clinical events to forecast multimodal patient trajectories.

NOAH is a task-agnostic, time-aware generative transformer trained on over 559 million clinical events from 431,000 hospital visits by 299,000 patients across the MIMIC dataset family. It uses bidirectional time integration and a variational latent space to model the stochastic evolution of patient states, natively processing medical images, time-series signals, categorical events, and structured or unstructured clinical records. The model supports autoregressive forecasting with optional time control, zero-shot classification, and counterfactual intervention simulation, with strong probing performance across clinical outcomes, 15 ICD chapters, and 29 comorbidities.

Hugging Face daily papers · 8d agoAI research1

Structural Jailbreaks Generalize but Do Not Compound: A cross-provider and multilingual study of Involuntary In-Context Learning

Researchers show IICL structural jailbreaks generalize to Google Gemini, lifting attack success to 80-100% on harm and financial benchmarks; non-English prompts attenuate it.

The study red-teams two Google Gemini models with Involuntary In-Context Learning (IICL), a structural jailbreak reframing harmful requests as the final cell of a data-labeling task. IICL lifts attack success from at most 6.7% to 80-90% on HarmBench and 97-100% on financial abuse (FinProof), an order of magnitude above prior results on OpenAI's GPT-5.4. Against a compounding hypothesis, forcing IICL output into Spanish, Hindi, or Arabic attenuates the attack in 11 of 12 conditions, attributed to a 'relevance curse' producing lower-quality harmful content in lower-resource languages. Findings replicate under an independent non-Google judge (Cohen's kappa 0.86 over 377 paired verdicts).

arXiv cs.CR · 8d agoAI safety & security

Show HN: LLM Attention Visualization

A developer released a browser-based tool that visualizes which past tokens influence each LLM output token using aggregated, value-weighted attention scores.

A Show HN project presents a React application built on Transformers.js that renders per-token attention influence by aggregating attention weights scaled by value-vector magnitudes across all attention heads and layers. To expose internal tensors, the author instrumented the ONNX computation graph, hosted a modified model on Hugging Face, and pre-generated prompts to avoid long model downloads in the browser. Demos with a 600-million-parameter model show how verbatim copying draws heavily on source tokens and how single outputs blend information from multiple phrases.

Hacker News · AI · 7d agoAI tools & infraHN 41↑ · 9 comments

CareMirror: Bringing Caregiver Wellbeing into the Dementia Care Ecosystem

Interview study with 14 dementia caregivers probes CareMirror wellbeing ecosystem, revealing demands for control over clinical sharing and AI boundaries.

CareMirror is an envisioned caregiver wellbeing ecosystem with interconnected caregiver- and clinician-facing interfaces for longitudinal reflection, personalized support, and caregiver-controlled sharing. Semi-structured interviews with 14 family caregivers used the system as a design probe. Caregivers valued wellbeing attention and clinical visibility but found repeated reflection burdensome and worried automatic clinical sharing would inhibit candid disclosure, expecting AI to support rather than replace caregiver and clinician judgment.

arXiv cs.AI / cs.LG / cs.CL · 23h agoAI research

NOAH: Learning the Full Patient Journey. A Longitudinal Multimodal Time-Aware Model for Representation and Forecasting

Researchers introduce NOAH, a generative time-aware transformer trained on 559 million MIMIC clinical events to model and forecast patient trajectories.

NOAH is a task-agnostic, time-aware generative transformer designed to represent and forecast the full multimodal patient journey across medical images, time-series signals, categorical events, and clinical text. It was trained on over 559 million clinical events from 431,000 hospital visits covering 299,000 patients in the MIMIC dataset family. The architecture combines bidirectional time integration with a variational latent space to capture continuous patient state evolution and clinical stochasticity. NOAH supports autoregressive forecasting with time control, zero-shot classification, and counterfactual intervention simulation, with evaluations on 15 ICD chapters, 29 comorbidities, and time-to-event prediction.

arXiv cs.AI / cs.LG / cs.CL · 7d agoAI research2

Building AI to accelerate science and improve lives

Google highlights AI-for-science advances: AlphaGenome Atlas mapping 9 billion genetic variants, WeatherNext 3 weather model, and global health AI tools.

Google detailed AI advances across science and health, including AlphaGenome Atlas, which mapped all 9 billion possible single-letter genetic changes in the human genome and was made openly available. WeatherNext 3 delivers 50% more accurate precipitation forecasts a day or more ahead and is already in products. AlphaFold is used by 4 million researchers in 190 countries, TB chest X-ray screening has processed 25,000+ scans across six nations, and the diabetic retinopathy model has supported 1.15 million screenings. Google also released its AI & Economy ATLAS global usage insights.

Google · AI · 1d agoAI industry

Dr. Claw: An AI Scientist Workspace for Vibe Research

Researchers release Dr. Claw, an open-source auditable workspace that wraps coding agents like Claude Code for end-to-end AI-assisted research workflows.

Paper 2609.00365 presents Dr. Claw, an open-source workspace that wraps existing coding-agent executors such as Claude Code and Gemini CLI in a controllable, human-in-the-loop research workflow. It uses persistent state objects, a reusable skill library, and multi-executor coordination to make research decisions auditable and recoverable, rather than adding another autonomous agent. Holding the executor fixed, Dr. Claw scores higher on research completeness than a bare command-line agent while preserving an auditable process trail. The code is released under AGPL-3.0 on GitHub (OpenLAIR/dr-claw).

Hugging Face daily papers · 16d agoAI research1

Plug 'n' Pray: Agentic LLM-based Detection of Potential Log File Exposures in Third-Party Content Management System Plugins

Agentic LLM analysis validates 79 log file exposures across 62 of the 300 most-installed WordPress plugins, covering 250M+ active installations.

Researchers built an agentic LLM-based framework combining static and dynamic analysis to automatically detect insecure log files created by WordPress plugins. Scanning the 300 most-installed plugins, which account for roughly 75% of all active installations in the official ecosystem, it produced 81 findings with 79 manually reproduced across 62 plugins. Insufficiently secured log files can disclose credentials and personal data and have led to website compromises. The authors derive a taxonomy of log path and protection patterns and best practices, finding multi-layered protection often absent.

arXiv cs.CR · 1d agoResearch