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HypoEvolve: Genetic Algorithms Enable Multi-Agent LLMs to Discover Scientific Hypotheses
HypoEvolve couples a generational genetic algorithm with specialized LLM agents to generate drug-repurposing hypotheses, beating six baselines on DepMap selectivity (0.171 vs 0.115).
HypoEvolve coordinates specialized LLM agents through a generational genetic algorithm in which scientific judgments and new proposals reshape a hypothesis population. Evaluation centers on drug repurposing, linking mechanistic explanations to target-level biological claims assessed via external measures adapted from DepMap and Open Targets. Across 34 cancer types, HypoEvolve scores highest against six baselines on both measures, with DepMap selectivity of 0.171 versus 0.115 for the strongest baseline, and gains generalize to held-out cancer types.
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LongAgent: History-Guided Agentic Search for Longitudinal Outcome Prediction
LongAgent autonomously searches variable sets and temporal windows to predict longitudinal medical outcomes, beating the strongest non-agent baseline on synthetic data.
The paper proposes LongAgent, an agent-based method that searches over combinations of variable sets, temporal windows and aggregation functions for outcome prediction on heterogeneous medical longitudinal data. It uses a history memory of previous searches and numerical evidence to guide exploration. On synthetic data it achieves mean RMSE 1.7376, improving over the best non-agent baseline by 0.0151 (95% CI [0.0045, 0.0260]; p=0.0273), and performs comparably to the best baseline on a real clinical dataset.
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When LLM judges agree, should we believe them?
Amazon ICML paper uses Ising models to correct correlated LLM-judge votes, beating accuracy-weighted panels by 9-14%.
Amazon Science describes an ICML paper, "Dependence-aware label aggregation for LLM-as-a-judge via Ising models," addressing how correlated judge outputs inflate majority-vote confidence. The unsupervised method models pairwise dependence between judges, learning both reliability and similarity without human reference labels. Tested on relevance, toxicity, and summarization tasks with 10 judge models at temperature zero, it outperformed accuracy-weighted voting by 9% to 14%.
Hacker News · AI40
Unmasking Cloud Identities: From Behavioral Clustering to Automated Detection
Unit 42 clusters behavior of 40,000+ AWS identities from 125 cloud environments to map functional roles and enable lightweight SQL-based detection.
Palo Alto Unit 42 built an unsupervised behavioral clustering model using UMAP and HDBSCAN on AWS CloudTrail logs to map cloud identities to functional roles such as administrators, backup services, security tooling and DevOps. The study analyzed over 40,000 identities across 125 cloud environments over two months. The researchers show that heuristics extracted from the clustering map can be implemented in standard SQL, enabling role classification at scale without running a continuous ML pipeline. The methodology extends to audit logs from other cloud providers, SaaS and Kubernetes.
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Omni-Streaming Thinking
Omni-Streaming Thinking fixes premature cross-modal commitment in streaming omni-modal models via pending claims verified against modality-specific evidence, beating baselines by over 10%.
The paper identifies 'premature cross-modal commitment', where streaming models keep relaying early visual interpretations even after audio contradicts them. OST generates evidence-linked pending claims with future verification intervals, stores audio and visual evidence separately, and refutes claims when contradictory evidence appears. Built on a frozen Qwen3-Omni-30B-A3B-Instruct backbone with lightweight adaptation, it outperforms open baselines by more than 10% relative on five streaming and audio-visual benchmarks. On the new OST-DiagBench it reaches d-prime 2.95 versus at most 1.38 for open baselines, while reducing vision-induced auditory hallucinations.
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Rethinking Heterogeneous System Disaggregation for Subquadratic Attention
SQD disaggregates LLM inference by quadratic versus subquadratic attention layers, improving energy efficiency up to 56% on heterogeneous systems versus GPU-only baselines.
SQD (SubQuadratic Disaggregation) splits decode not by operator type but by quadratic versus subquadratic attention, matching their distinct arithmetic intensity and memory footprints. For sparse attention LLMs it separates top-k selection (requiring full KV indexing) from top-k attention plus FFN; for linear and sliding-window models it separates dense attention layers from subquadratic layers plus FFN. On an adjusted 8xB200 heterogeneous proxy, tokens-per-joule improves 53% on GLM 5.2, 31% on Nemotron 3 Ultra, and 56% on Gemma 4 31B. A Rubin plus LPX analytical model shows 1.2x-1.5x tighter achievable latencies and up to 3.6x higher throughput versus attention-FFN disaggregation.
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A Hybrid LSTM-XGBoost Framework for Multi-Horizon Stock Return Prediction Across Diversified Equity Portfolios
Hybrid LSTM-XGBoost model predicts multi-horizon returns for 14 US equities, cutting 30-day RMSE to about one-third of a standalone LSTM baseline.
The paper combines a two-layer LSTM (64 hidden units) processing 60-day windows of five market features with an XGBoost regressor over a 78-dimensional hybrid feature vector including 14 technical indicators. It is trained on pooled data for 14 US equities across six sectors using chronological splits and per-stock MinMaxScaling to prevent look-ahead bias, and evaluated at 30, 90, 252, and 365 trading-day horizons. The hybrid achieves test RMSE of 0.0949 at 30 days, roughly one-third of the standalone LSTM, while 97.6% directional accuracy at 365 days largely tracks the base rate of positive returns.
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TART: A Modular Tool for Technique-Aware Audio-to-Tablature Guitar Transcription
TART pipeline transcribes guitar audio to tablature with fingering and technique labels, outperforming prior baselines by up to 8.5 Tab F1 points.
TART is a modular four-stage pipeline for audio-to-tablature guitar transcription, combining an audio-to-MIDI transcription model, an expressive technique classifier, an audio-conditioned T5 encoder-decoder for string-fret assignment, and an automated tablature generator. In zero-shot evaluation on GuitarSet, EGDB, and two noisy augmented benchmarks, it averages 81.35% audio-to-MIDI F50 (+6.67 over the best baseline), 71.8% string-fret Tab F1 (+8.5), and 54.08% end-to-end Tab F1. The authors state it is the first framework to generate tablature with both fingering and expressive technique annotations directly from guitar audio.
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Model-Aware Schedules Improve Generation via Fiberwise Optimal Transport
Researchers introduce model-aware diffusion schedules via fiberwise optimal transport, cutting flow-matching FID on CIFAR-10 by 38.6% at 16 function evaluations.
The paper proposes constructing diffusion and flow-matching sampling schedules from a fiberwise prediction risk defined via optimal transport, combined with coefficient-path kinetic action, yielding a closed-form time allocation. Across DDPM and flow-matching experiments spanning targets, datasets, and architectures, the schedules beat model-agnostic baselines, including a 38.6% relative FID reduction for flow matching on CIFAR-10 at 16 function evaluations. Normalized fiberwise-risk profiles from independently trained models align closely, suggesting empirical universality, and a frozen analytic allocation template retains most of the gains.
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Speculative Decoding in vLLM on AMD GPUs
vLLM benchmarks speculative decoding on AMD Instinct MI300X and MI355X GPUs across five drafting methods including EAGLE-3 and native MTP.
The vLLM project documents draft-and-verify speculative decoding support for AMD GPUs via ROCm, comparing native MTP, Gemma 4 MTP, EAGLE-3, DFlash, and DSpark drafting approaches. Output-token throughput effects varied with drafting method, proposal length, model family, draft checkpoint, workload, and acceptance behavior. The post also covers how to enable each method plus practical tuning and observability considerations.
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The hidden work of modernizing Malwarebytes
Malwarebytes details its migration of Windows product managed components to .NET 10, citing security, supportability, diagnostics, and performance benefits.
Malwarebytes says it migrated the managed portions of Malwarebytes for Windows to .NET 10 while leaving native drivers and the detection engine untouched. The vendor cites a supported runtime, safer defaults, stronger cryptography, better diagnostics, and JIT/GC performance improvements as benefits. The migration also deprecated Windows 7 support, and the company applies staged rollouts and automated validation because its code runs with elevated privileges on millions of endpoints. No vulnerabilities or incidents are described.
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Turn it off and on again, but for critical infrastructure
KTH researchers trained a reinforcement-learning intrusion response agent on an emulated segmented OT network that autonomously resets hosts and processes to disrupt intruders.
Researchers at KTH Royal Institute of Technology built a containerized replica of a segmented industrial network, attacked it across 14 days, and captured 40,000 30-second traffic intervals to train a defense agent under partial observability. The agent observes six packet-count numbers per interval, maintains 500 running state hypotheses, and can reset supervisory hosts, water tank processes, or entire subnets, with resets rebooting the target, renewing credentials, and changing its IP. The best agent approached a full-visibility baseline but depends on an assumed attacker behavior model; the testbed comprised three supervisory hosts, two PLCs, two tanks, weak credentials, and CVE-2017-7494 exposure. The team released its implementation and plans validation on a real industrial testbed with a partner.
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Cognition Releases SWE-2: A Kimi K3 Post-Trained Coding Model That Matches Fable 5.1 on FrontierCode at 64% Lower Cost
Cognition released SWE-2, an RL post-trained coding model from Kimi K3, scoring 50.0% on FrontierCode 1.1 Main and available only inside Devin.
Cognition released SWE-2, its most capable coding model, post-trained with reinforcement learning from Moonshot AI's 2.8T-parameter Kimi K3 base. It scores 50.0% on FrontierCode 1.1 Main, within 1 point of Fable 5.1 at 64% lower cost, and RL reportedly adds 5-6 points over the K3 base on many benchmarks. It is the first Cognition model with selectable reasoning-effort levels all trained in a single RL run using Pareto-slope-matched cost penalties. There are no open weights and no standalone API; it runs only inside Devin (Desktop, CLI, with Web and Fusion rolling out), free for paid tiers through October 10, 2026.
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OmniHarness: Harnessing Generalizable Visual Generation via Symbolic Policy Learning
OmniHarness learns symbolic policies for visual generation agents, reaching a 95.0% resolve rate on ComfyBench Creative tasks, 27.5 points above the strongest baseline.
OmniHarness abstracts verified executions into symbolic policies for visual generation task families, which are instantiated, adapted, and composed for new tasks while model parameters remain fixed. Intermediate verification guides refinement and failure recovery during execution, and self-directed inquiry generates practice tasks near capability limits before downstream objectives are specified. Experiments across six benchmarks, three MLLM backbones, and three visual agent frameworks show strong performance; on ComfyBench Creative tasks it achieves a 95.0% resolve rate, exceeding the strongest baseline by 27.5 percentage points. Frozen policy snapshots improve existing visual agent systems through plug-and-play reuse.
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A Feature-Rich Embedded NIDS with eBPF/XDP: Detector and Architecture Trade-offs
eBPF/XDP-based NIDS with Isolation Forest reaches 0.965 live F1 on DDoS replay; gRPC microservices match monolithic accuracy within 2ms overhead.
The paper presents a DDoS-focused network intrusion detection system for transport networks built with Ericsson, combining a statistical baseline with an Isolation Forest trained on flow features from GoFlowMeter, an open-source Go implementation of CICFlowMeter, plus eBPF/XDP kernel-level traffic filtering. On a Raspberry Pi 5 testbed replaying CIC-DDoS2019 as real traffic, the Isolation Forest achieves 0.965 recall/F1 live in the monolithic variant, catching low-volume attack windows the baseline misses. gRPC microservices nearly match monolithic accuracy adding under 2ms per window, while the Kafka pipeline trails by roughly nine percentage points and adds about 27ms.
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Top 10 Best Cloud Security Posture Management (CSPM) Tools in 2026
2026 CSPM comparison ranks Wiz atop cloud posture tools and recaps Google's pending roughly $32 billion acquisition of Wiz.
An editorial guide rates ten cloud security posture management (CSPM) tools, with Wiz ranked first for agentless visibility and attack-path context, Microsoft Defender for Cloud highlighted for Azure-centric economics, and Palo Alto Prisma Cloud noted for the broadest code-to-cloud module set. The article's biggest market note is Google's agreement to acquire Wiz for approximately $32 billion, described as the largest deal in security history, still progressing through regulatory review. It advises buyers to include roadmap-protection language in multi-year commitments and to press on multicloud neutrality post-close.
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3D Point Splatting for mmWave Radar Novel View Synthesis
Researchers propose 3DPS, a differentiable point renderer for mmWave radar novel view synthesis that outperforms optical-NVS baselines by 1.7x-5.2x.
The paper introduces 3D Point Splatting (3DPS), the first differentiable point renderer for radar, derived from the solid-angle form of the radar equation with ITU-R P.2040 material models and complex phasor splatting. On six outdoor ColoRadar scenes it reaches 0.587 mean Pearson correlation on held-out range-azimuth images, between 1.7x and 5.2x the RadarSplat, Radar Fields, and DART baselines. The same optimized scene produces ADC, complex range profile, and RA outputs via standard FFT pipelines, and training takes about 3 minutes per scene on an RTX 4090.
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