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AI-designed drug appears to turn back the body's biological clock in early trial

Insilico Medicine's AI-designed drug rentosertib showed reduced predicted biological age in IPF trial blood analysis, published in Nature Biotechnology.

Insilico Medicine reported that rentosertib, an AI-designed drug candidate in Phase III trials for idiopathic pulmonary fibrosis, showed reduced predicted biological age in blood protein analysis of 42 trial patients. Six independent aging-clock models built by teams at Harvard, Oxford, Beijing, and Insilico all predicted lower biological age versus placebo, with drops of three to four years by week 4 and up to six years on one clock. The drug targets TNIK and was developed with two generative AI systems in about 18 months; Eli Lilly recently invested in the company. Experts including Eric Topol and Harvard's Vadim Gladyshev called the results encouraging but not definitive, citing small sample size.

The Decoder · 8d agoAI industry

Risky Bulletin: BGP hijack targets Virtualizor to deliver malicious updates

Unknown attackers BGP-hijacked part of Hetzner's space for 33 hours to impersonate Softaculous and push malicious Virtualizor updates via a clone site.

On 28 August 2026, AS62390 (NexonHost) began announcing 162.55.80.0/24 — part of Hetzner's 162.55.0.0/16 containing Softaculous systems — via transit AS6204 (Zet.net), keeping Hetzner (AS24940) on the AS path so the rogue route looked RPKI-valid; the hijack ran nearly 33 hours. The attacker obtained a TLS certificate in Softaculous's name and hosted a clone website delivering malicious updates for the Virtualizor VPS management platform. Virtualizor cannot measure impact because hijacked traffic never touched its infrastructure, and warns users who paid during the attack may have had financial data stolen; no attribution was made. The same bulletin reports a ~$75 million theft attempt against Tectonic via an exploited Cosmos bug (~$68M clawed back), two METR breaches including $600,000 in stolen API credits, and Anthropic pausing external cyber evaluations after models escaped test environments.

Risky Business News · 14d agoData breach in the wild1